Hub : Genes

ZMAT3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1320 0.0540 4.9e-03 0.058 NA 0.020 NA 0.042 2.1e-04 NA 2.0e-02 NA 1.3e-03
2 NTR Blood 0.0421 0.0133 1.4e-06 0.006 0.018 0.017 0.017 0.018 3.2e-03 1.6e-06 2.2e-06 1.7e-06 1.7e-06
3 YFS Blood 0.2076 0.0403 0.0e+00 0.051 0.099 0.101 0.108 0.093 2.5e-16 1.1e-30 2.2e-31 2.6e-33 7.2e-29
4 TCGA Breast Invasive Carcinoma 0.0235 0.0143 2.0e-04 0.010 0.018 0.024 NA 0.016 3.6e-03 1.0e-04 1.0e-05 NA 2.2e-04
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.1190 0.0490 1.9e-04 0.095 0.054 0.063 NA 0.060 4.6e-06 5.1e-04 1.7e-04 NA 2.4e-04
6 TCGA Prostate Adenocarcinoma 0.0623 0.0351 7.8e-04 0.019 0.022 0.019 NA 0.029 4.0e-03 1.8e-03 4.0e-03 NA 5.0e-04
7 TCGA Skin Cutaneous Melanoma 0.5950 0.1940 8.1e-03 -0.009 0.049 0.081 NA 0.013 6.8e-01 1.9e-02 3.5e-03 NA 1.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 1.2 1.8 4.0 -1.1 -2.0 -1.2 -1.4 -1.1 -1.8 -0.0
Bipolar Disorder or Schizophrenia 0.1 0.2 0.7 -0.2 0.2 -0.5 -0.8 -0.4 -0.6 0.1
Depressed Affect (Nagel 2018) 0.4 0.8 1.5 -1.1 -0.8 1.2 0.8 0.5 1.0 -0.1
Depression (Nagel 2018) 0.8 1.2 3.1 -0.8 -0.2 -0.1 1.2 1.6 1.8 0.6
Intelligence (Savage-Jansen 2018) 0.4 1.1 5.7 -0.5 -0.7 0.6 -0.0 0.4 -0.8 2.4
Neuroticism (Nagel 2018) 1.0 2.4 5.2 -0.7 0.3 1.7 1.9 2.1 2.3 0.5
Schizophrenia (2018) 0.3 0.6 3.4 0.6 1.8 0.3 0.1 0.3 0.6 0.1
Schizophrenia vs Biploar Disorder 2.6 3.4 5.6 1.1 2.4 2.3 1.9 1.0 2.3 -1.2
Worry (Nagel 2018) 0.5 1.0 2.2 -0.2 0.3 1.2 0.7 1.5 1.5 0.8
Alzheimer’s Disease (in mother) 0.8 1.0 2.0 0.1 -1.4 0.4 -1.2 -0.6 -1.1 1.3
Alzheimer’s Disease (in father) 0.6 0.7 2.0 0.1 0.8 0.3 1.0 0.9 1.4 -0.4
Alzheimer’s Disease (including proxy) 0.1 0.1 0.4 0.5 -0.1 0.2 -0.5 -0.2 -0.3 0.6
Crohns Disease (2017) 0.3 0.7 1.3 0.1 1.1 -1.1 0.1 0.9 0.9 -0.8
Irritable Bowel Disease (IBD) 0.3 0.7 2.0 0.9 0.7 -0.3 0.4 1.4 0.7 0.9
Ulcerative Colitis (UC) 0.6 1.2 5.6 1.2 -0.3 0.3 0.2 0.9 -0.3 2.4
Major Depression (MDD) 1.3 1.6 4.7 -2.2 -0.4 1.1 1.9 0.1 0.2 -1.1
Reaction Time 0.3 0.5 1.2 0.5 -1.0 0.6 0.7 -0.5 0.1 -1.1
Verbal and Numeric Reasoning (VNR) 0.4 0.8 3.7 0.2 -1.0 0.6 -0.0 0.2 -0.8 1.9
Breast Cancer 1.4 3.5 12.6 0.8 3.5 -2.3 -0.7 0.1 0.9 -2.1
Ovarian Cancer 1.3 1.8 3.9 -0.1 1.0 1.5 2.0 1.4 1.5 -1.0
Prostate Cancer 2.0 2.8 5.9 -2.1 -2.3 -2.4 -1.4 -0.4 -1.5 0.2
Age at First Birth 0.9 1.3 3.3 1.0 0.2 -0.3 -1.5 -1.8 -1.6 -0.2
Bipolar Disorder (2011) 0.3 0.3 0.9 0.5 -1.0 0.4 -0.5 0.7 0.2 0.5
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 1.3 -0.8 -0.2 -0.8 -0.8 -1.0 0.7
Coronary Artery Disease (CAD) 0.5 0.6 1.9 0.3 -1.4 0.3 -0.5 -0.0 -0.6 1.2
Crohns Disease (2012) 0.3 0.4 1.3 1.1 0.1 0.4 -0.1 0.7 1.0 -0.0
Mean Putamen Volume 0.7 0.8 2.3 0.7 1.1 -0.6 0.3 0.7 0.8 -1.5
Fasting Glucose 0.7 0.8 2.4 1.6 0.5 -0.3 -0.6 -1.2 -0.9 0.2
HbA1C 0.2 0.3 1.1 1.1 -0.3 -0.5 -0.2 -0.1 -0.4 -0.4
HDL Cholesterol 0.9 1.5 3.3 -1.3 -0.4 -0.6 -1.6 -1.8 -1.5 -0.4
LDL Cholesterol 0.5 0.8 1.3 -0.9 0.7 -0.9 1.1 1.1 0.9 -0.1
Lupus 0.9 1.3 1.9 1.1 1.0 1.3 0.2 1.4 1.4 1.2
Neuroticism (2016) 3.4 4.9 10.3 -2.1 2.4 0.1 2.5 2.9 3.2 0.2
Primary Biliary Cirrhosis 0.9 1.3 2.6 -0.1 0.6 1.6 1.5 1.3 0.8 1.3
Rheumatoid Arthritis 0.2 0.2 0.8 -0.6 -0.9 0.1 0.4 0.4 0.3 -0.3
Schizophrenia (2014) 0.2 0.4 1.9 1.4 0.6 0.1 -0.2 0.2 0.3 0.2
Triglycerides 0.2 0.3 0.7 0.2 -0.0 0.0 0.8 0.7 0.7 -0.7
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.1 1.2 -0.5 0.0 -1.7 -1.3 -1.8 -0.1
Ulcerative Colitis 0.9 1.2 5.7 1.3 -0.6 0.7 0.0 0.6 -0.3 2.4
Blood Eosinophil Count 1.0 7.7 20.8 -2.5 -1.2 -4.6 -3.5 -2.0 -2.9 0.9
Blood Platelet Count 6.7 77.2 148.8 -2.2 -8.0 -10.4 -12.2 -9.1 -11.3 2.2
Blood Red Count 1.9 18.0 37.0 -1.4 -4.0 -4.3 -6.1 -4.3 -5.6 1.6
Blood White Count 0.7 5.5 12.0 -1.3 -1.9 -3.5 -3.4 -1.9 -2.4 0.3
Heel T-Score 0.8 6.6 14.0 0.0 -2.1 -2.6 -3.1 -3.7 -3.3 -1.0
BMI 0.3 1.8 4.5 -1.9 -2.1 1.3 0.2 -0.8 -1.4 0.6
Height 0.3 6.1 20.9 -0.9 1.4 0.8 2.0 3.5 1.6 4.6
Waist Hip Ratio (WHR) 0.7 2.9 6.7 -1.5 -1.7 0.3 -2.0 -2.1 -2.6 -0.5
Systolic Blood Pressure 0.4 2.1 6.0 0.3 0.9 -1.9 -1.3 -1.4 -0.4 -2.5
Smoking Status 1.2 2.8 6.1 -0.2 0.7 -2.4 -2.5 -1.4 -2.2 -0.6
Allergy or Eczema 0.5 1.3 4.4 0.1 0.3 0.9 0.3 1.7 0.8 2.1
Cardiovascular Disease 0.7 2.4 8.4 1.3 -0.5 -2.9 -1.5 -1.5 -0.4 -1.3
Hypothyroidism (self reported) 0.2 0.4 2.4 0.3 0.0 1.6 0.3 0.2 -0.3 0.6
Respiratory disease 0.6 1.3 2.2 -1.4 -0.8 -1.5 -1.3 -0.9 -0.8 -1.2
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.9 0.5 -0.1 -0.6 -1.4 -0.7 -0.5 0.3
Lung FEV1/FVC ratio 0.1 0.6 1.4 1.2 -0.5 0.4 0.3 0.7 1.1 1.0
Lung FVC 0.1 0.7 1.5 -0.2 -1.1 -0.2 -1.2 -0.3 -0.8 1.1
Neuroticism 1.7 4.1 10.6 -0.5 1.2 2.1 2.3 2.6 3.3 -0.0
Chronotype (morning person) 0.6 1.4 3.1 -1.8 1.5 -0.2 -1.6 -0.9 -0.1 -1.2
Hair Pigment 0.1 4.0 12.2 1.2 -0.8 -0.3 -3.5 -2.2 -2.8 0.7
Tanning 0.1 0.9 2.1 -0.8 1.0 -0.8 0.0 1.5 1.1 0.9
Hand grip strength (left) 0.1 0.3 0.9 0.6 -0.1 0.7 0.3 -0.1 -0.7 0.9
Number of treatments/medications taken 0.5 0.9 3.0 -1.7 -0.7 0.0 -0.5 -0.8 -0.3 -1.4
Average weekly spirits intake 0.3 0.4 0.9 0.2 0.9 0.3 0.7 0.3 0.6 -0.9
Sensitivity / hurt feelings 2.2 3.7 9.1 0.3 1.4 1.4 2.8 2.3 3.0 -0.5
Frequency of depressed mood in last 2 weeks 0.9 1.2 3.2 -0.7 -0.3 0.8 1.1 1.6 1.8 0.6
Hearing difficulty/problems: Yes 0.0 0.0 0.2 -0.2 -0.1 -0.0 0.3 -0.1 -0.2 -0.4
Relative age of first facial hair 0.3 0.6 3.0 -1.7 0.1 0.1 -0.0 0.6 0.0 0.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.1 -0.6 0.2 0.2 0.2 1.0 0.9 0.4
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.2 1.1 0.2 0.4 -0.1 -0.7 -0.6 -1.0
Ever had hysterectomy (womb removed) 0.4 0.5 1.5 0.0 0.1 0.3 0.4 1.2 1.2 0.6
Systolic blood pressure, automated reading 0.4 1.2 5.7 -0.1 1.2 -0.9 -0.0 -0.0 0.6 -2.4
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.4 -0.1 1.5 0.2 1.0 1.2 1.6 -0.8
Angina 1.2 1.6 3.0 -1.1 1.1 1.4 1.2 1.7 1.7 -0.1
Medication for hormone replacement therapy 1.1 1.2 2.4 1.6 -1.2 -1.1 -1.2 -0.9 -1.1 0.4
Vitamin and mineral supplements 0.6 0.8 1.9 0.8 -1.2 -0.6 -0.7 -1.4 -0.9 -0.0
Supplements: Zinc 0.7 0.8 2.6 1.1 1.6 1.1 -0.6 0.3 0.1 -0.1
Medication: Co-codamol 0.3 0.4 1.4 -0.0 0.6 1.2 0.6 0.5 0.5 0.0
Medication: Metformin 1.3 1.9 4.2 1.5 -0.6 -0.7 -2.0 -2.0 -1.4 -0.6
Diabetes (father) 1.7 2.1 4.7 -0.5 2.2 1.5 1.8 0.7 1.6 -1.1
Diabetes (mother) 0.9 1.1 2.9 -0.5 1.7 0.2 1.2 0.6 1.1 -1.2
Severe depression (siblings) 0.6 0.7 1.6 1.2 1.2 -0.5 -0.5 0.0 0.0 -1.1
Pack years adult smoking proportion 1.0 1.5 4.5 -1.5 0.3 -0.2 2.1 1.2 1.2 -0.5
Impedance of leg (right) 0.2 0.8 3.0 1.3 0.4 0.5 -0.4 -0.2 0.7 -1.7
Leg fat-free mass (left) 0.5 2.8 9.2 -1.8 -0.1 1.4 1.6 1.5 0.3 3.0
Trunk fat percentage 0.2 0.7 1.5 -0.9 -0.6 1.2 1.0 0.7 0.5 0.5
Hand grip strength (right) 0.2 0.5 1.8 0.9 0.5 -0.1 -0.1 -0.0 -0.6 1.4
Townsend deprivation index at recruitment 0.3 0.5 1.4 0.7 1.2 0.7 0.7 0.5 0.4 0.2
Current tobacco smoking 1.2 2.0 6.7 -0.3 2.6 -2.4 -0.7 0.9 0.6 -0.1
Average weekly fortified wine intake 0.5 0.6 1.2 0.6 0.2 0.8 0.8 0.9 1.1 0.9
Maternal smoking around birth 1.1 1.6 7.5 -0.9 0.6 -2.7 -1.3 -0.6 0.1 -0.9
Fed-up feelings 1.3 2.4 5.8 -1.3 0.7 2.0 1.4 1.4 2.4 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.9 -1.3 -0.5 -1.7 -0.0 1.2 1.1 0.4
Relative age voice broke 1.5 2.3 5.8 0.3 0.5 1.8 0.8 2.4 1.8 1.6
Taking other prescription medications 0.5 0.8 2.2 -1.5 1.0 0.5 0.4 0.7 1.1 -0.5
Age when periods started (menarche) 0.2 0.4 1.4 0.6 -0.0 -1.2 -0.5 0.8 -0.0 0.3
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.2 -0.0 -0.2 -0.8 -1.5 -1.1 -1.0 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 3.1 0.8 -1.1 0.7 -0.1 0.0 -0.6 1.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 3.4 0.3 0.3 -0.3 -0.2 -0.7 0.4 -1.9
Qualifications: CSEs or equivalent 0.9 1.2 3.9 0.5 -0.3 -1.9 -0.6 0.4 0.4 2.0
Serious illness, injury or assault to yourself 1.4 1.7 4.9 -1.0 -1.3 -2.2 -1.4 -0.1 -1.1 1.2
High blood pressure 0.7 1.9 8.0 0.4 -0.6 -2.8 -1.6 -0.9 -0.7 -1.1
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.2 -0.0 -0.7 0.5 -0.1 1.3 0.0 1.5
Multivitamins +/- minerals 0.3 0.3 1.1 -0.3 1.1 -0.1 -0.4 0.7 0.2 0.6
Stomach or abdominal pain in last month 1.6 2.0 3.5 -0.2 1.8 1.9 1.2 1.8 1.7 0.3
Supplements: Glucosamine 0.2 0.3 0.8 0.6 0.4 -0.7 0.0 0.9 0.2 0.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 2.5 0.4 -0.0 0.4 0.6 -0.5 -0.1 -1.6
Medication: Atenolol 1.3 1.6 3.5 -0.7 0.2 1.9 1.2 1.7 1.3 1.0
Medication: Levothyroxine sodium 0.1 0.1 0.4 0.6 -0.2 -0.2 -0.1 0.4 -0.2 0.6
Sitting height 0.2 1.2 7.1 -0.0 0.4 0.6 0.3 0.5 -0.4 2.7
Chronic bronchitis/emphysema (father) 0.4 0.4 1.2 -0.0 0.6 -1.1 -0.3 -0.7 -0.5 -0.8
High blood pressure (mother) 1.0 1.4 2.9 0.9 -1.7 -0.4 -1.4 -1.1 -1.3 1.2
Body mass index (BMI) 0.2 0.9 2.2 -1.5 -1.0 1.1 1.0 0.2 -0.3 1.0
Impedance of leg (left) 0.2 0.9 3.3 1.2 0.3 -0.1 -0.9 -0.5 0.3 -1.8
Leg predicted mass (left) 0.5 2.5 8.5 -1.7 -0.1 1.4 1.5 1.3 0.1 2.9
Trunk fat mass 0.2 1.1 1.8 -1.3 -0.7 1.3 1.0 0.8 0.3 1.3
Waist circumference 0.3 1.0 2.5 -1.6 -1.2 1.0 0.2 -0.2 -1.0 1.2
Number of incorrect matches in round 0.2 0.3 0.8 -0.9 -0.6 -0.1 -0.7 -0.8 -0.3 -0.1
Past tobacco smoking 1.0 1.9 5.1 -1.1 -0.4 0.9 1.9 1.4 2.3 -0.2
Alcohol usually taken with meals 0.2 0.3 0.6 0.7 -0.1 0.4 -0.3 -0.7 -0.8 -0.7
Nervous feelings 0.7 1.3 3.7 0.7 0.4 1.9 0.2 1.2 1.0 1.4
Frequency of tenseness / restlessness in last 2 weeks 1.2 1.9 3.7 -1.3 0.3 1.2 1.1 1.9 1.9 1.4
Hearing difficulty/problems with background noise 1.2 2.0 4.4 1.4 2.1 1.8 1.4 1.4 0.7 0.0
Hair/balding pattern: Pattern 2 0.2 0.2 0.9 0.2 0.9 -0.1 0.2 -0.0 0.1 -0.8
Had menopause 0.6 0.7 1.6 -0.2 0.2 -0.4 -1.2 -1.3 -1.2 -0.5
Had other major operations 0.3 0.4 2.1 0.1 0.4 -0.1 -0.2 1.4 0.3 0.7
Forced vital capacity (FVC) 0.3 1.2 6.2 -0.9 0.2 0.5 -0.4 0.8 -0.2 2.5
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 3.5 1.2 -1.1 0.0 -1.6 -0.8 -1.1 1.9
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 2.8 -0.4 1.7 1.3 1.1 1.4 1.6 -0.2
Qualifications: None of the above 1.2 2.5 11.2 -0.5 1.4 -1.3 -0.1 -1.1 0.9 -3.3
Financial difficulties in last 2 years 0.7 0.9 5.2 -0.6 -0.4 -2.3 -0.7 0.3 0.1 -0.3
Mouth/teeth dental problems 1.1 1.8 4.4 -0.6 -0.5 -2.1 -1.8 -0.1 -0.6 1.9
Heart attack 0.2 0.3 0.7 -0.8 0.7 0.7 0.4 -0.2 0.1 -0.2
Allergy 0.4 0.9 2.9 0.3 0.1 -0.9 -0.7 -1.7 -0.7 -1.3
Pain all over the body in last month 1.3 1.3 7.5 -2.7 -0.3 -0.8 -0.4 -0.8 -0.1 -0.7
Diabetes (self-reported) 0.4 0.6 3.0 0.7 0.2 -0.7 -1.7 -0.5 -0.3 0.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.9 0.6 -0.5 0.8 0.7 1.4 1.2 0.6
Medication: Ramipril 0.4 0.5 1.5 -0.6 1.2 -0.4 0.4 0.7 0.9 -0.3
Medication: Simvastatin 0.9 1.3 2.8 -0.2 -0.6 -1.5 -1.4 -1.7 -1.1 -0.8
Fluid intelligence score 0.5 1.1 4.1 0.6 -0.8 0.1 -0.6 -0.3 -1.4 2.0
Illnesses of siblings 1.5 2.0 5.2 1.4 -2.3 -0.3 -1.5 -1.1 -1.5 1.1
Neuroticism score 3.0 6.3 15.2 -0.4 1.6 2.4 3.1 3.3 3.9 0.0
Weight 0.4 1.8 5.3 -1.5 -0.7 1.6 1.1 0.9 -0.1 2.3
Impedance of arm (right) 0.3 1.5 8.3 2.9 0.9 -0.0 -0.8 -0.2 0.2 -0.9
Arm fat percentage (right) 0.1 0.5 1.6 -0.4 -0.9 1.3 0.6 -0.1 -0.4 0.5
Trunk fat-free mass 0.4 2.5 8.9 -1.9 -0.4 1.3 1.3 1.1 -0.2 3.0
Hip circumference 0.6 2.6 4.6 -0.8 0.0 1.7 2.1 2.2 1.4 2.0
Time employed in main current job 0.3 0.4 0.9 -1.0 -0.4 0.9 -0.3 -0.5 -0.3 0.5
Alcohol intake versus 10 years previously 0.7 1.1 3.1 0.8 -1.1 -1.8 -1.1 -0.8 -0.8 -0.2
Father’s age at death 0.5 0.7 3.0 0.9 0.7 1.7 0.8 0.1 -0.0 -0.4
Worrier / anxious feelings 0.9 1.7 3.6 -0.8 1.1 1.7 1.0 1.5 1.9 0.7
Frequency of tiredness / lethargy in last 2 weeks 2.4 4.0 10.2 0.1 2.4 0.1 2.1 2.7 3.2 0.3
Falls in the last year 0.4 0.5 1.5 1.0 1.2 0.8 -0.2 0.2 -0.5 0.1
Hair/balding pattern: Pattern 3 1.2 1.8 4.5 0.0 -2.1 -1.2 -1.6 -1.4 -1.5 -0.0
Number of live births 0.2 0.3 0.8 -0.7 0.9 0.5 0.7 0.4 0.2 0.2
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 7.6 -0.1 -0.5 0.1 -0.8 0.5 -0.7 2.8
Pulse rate 0.5 0.9 2.7 -0.9 1.1 -1.6 0.3 -0.1 0.6 -1.0
Happiness 1.5 1.8 5.1 -1.0 -0.1 1.4 2.3 1.1 1.5 -0.8
Noisy workplace 0.3 0.3 0.8 0.5 0.2 -0.9 0.3 0.8 0.8 -0.1
Qualifications: A levels/AS levels or equivalent 0.8 1.9 6.6 0.2 0.2 2.6 1.2 1.6 0.6 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.4 -0.6 0.2 0.7 0.6 -0.0 0.5
Mouth/teeth dental problems: Dentures 3.0 5.1 19.7 0.2 2.7 1.6 1.6 -0.0 1.8 -4.4
Asthma 0.2 0.5 1.2 -1.0 -0.2 -0.7 -0.7 -0.4 -0.2 -1.1
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 7.4 -0.5 -0.9 -2.7 -1.1 -1.0 -1.1 -0.4
Medication: Cholesterol lowering 0.2 0.4 1.1 -0.2 0.2 -1.0 0.5 0.5 1.1 -0.2
Depression (self-reported) 1.0 1.2 3.0 -1.7 0.9 1.2 0.9 1.0 1.1 0.4
Medication: Lansoprazole 4.9 5.6 10.8 -1.0 2.3 2.7 3.3 2.0 2.9 -1.6
Prospective memory result 1.5 1.8 2.7 -1.6 1.6 1.5 0.9 1.2 1.6 -0.2
Lung cancer (father) 0.6 0.7 2.6 -1.6 0.7 -0.4 -0.8 -0.7 -0.2 -0.9
Illnesses of mother 0.5 0.7 1.4 0.4 0.2 -0.7 -0.9 -1.2 -1.0 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 7.7 -0.6 -1.0 0.9 0.3 1.0 -0.1 2.8
Pulse wave Arterial Stiffness index 0.5 0.6 1.0 -0.9 0.2 -0.8 -0.9 -0.9 -1.0 0.5
Impedance of arm (left) 0.3 1.2 6.0 2.4 1.2 0.2 -0.4 0.4 0.7 -0.3
Arm fat mass (right) 0.3 1.2 2.6 -1.6 -0.7 1.5 1.1 0.6 0.0 1.2
Trunk predicted mass 0.4 2.4 8.5 -1.9 -0.5 1.3 1.2 1.1 -0.2 2.9
Standing height 0.2 2.4 9.7 -0.5 0.9 1.2 0.8 1.9 0.8 3.1
Length of working week for main job 0.3 0.3 0.9 -0.0 0.4 0.7 1.0 0.6 0.6 0.2
Exposure to tobacco smoke at home 0.3 0.3 0.9 -0.6 -0.6 -1.0 0.1 -0.2 0.2 -0.7
Breastfed as a baby 0.4 0.5 1.5 -0.8 -0.3 1.2 1.0 0.3 0.5 0.2
Tense / ‘highly strung’ 0.2 0.4 1.1 -0.4 -0.9 -0.6 -0.5 0.2 0.1 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 3.4 0.0 0.6 1.8 -0.5 -0.1 0.1 -0.2
Hair/balding pattern: Pattern 4 1.0 2.4 5.9 1.6 2.4 1.6 1.6 1.1 1.5 -0.2
Birth weight of first child 0.7 1.2 4.5 -0.8 -2.1 0.5 -0.3 -0.0 -0.4 1.7
Peak expiratory flow (PEF) 0.6 1.3 3.3 1.8 -0.1 -0.2 -1.3 -0.4 -1.4 1.5
Pulse wave reflection index 2.4 3.0 5.4 -1.2 -0.3 -1.5 -2.3 -2.3 -2.3 -1.1
Ever highly irritable/argumentative for 2 days 1.9 2.2 4.3 0.9 2.1 1.3 1.9 1.4 1.6 -0.9
Loud music exposure frequency 4.4 4.8 13.2 -0.4 0.4 1.1 3.1 3.0 3.6 -0.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 5.2 0.6 -0.8 0.8 0.5 1.0 -0.6 2.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.6 -0.8 -0.5 0.7 0.2 -0.0 -0.1 0.4
Blood clot in the leg (DVT) 1.4 1.8 3.8 1.0 1.3 1.9 1.4 0.9 0.5 1.7
Medication: Paracetamol 0.3 0.4 1.3 -0.0 -1.1 -0.5 -0.3 -0.4 -0.1 1.0
Headache pain in last month 0.9 1.5 3.5 -0.4 -0.5 1.9 1.9 1.4 1.0 -0.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.5 0.5 -0.8 1.2 0.3 -0.0 -0.7 0.5
Glaucoma (self-reported) 0.5 0.6 0.9 -1.0 -0.5 -1.0 -0.9 0.6 0.8 -0.1
Gout (self-reported) 0.4 0.5 1.9 -0.8 -0.1 -0.5 -0.4 -0.4 0.4 -1.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 -0.1 -0.2 0.8 0.5 0.5 -0.1 0.8
Medication: Amlodipine 3.1 4.3 9.1 -1.7 -0.4 -3.0 -2.8 -2.6 -1.9 -0.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.3 -0.2 0.0 -0.5 -1.1 -1.0 -0.9 -0.7
Birth weight 0.3 0.7 2.8 -0.5 -0.4 1.7 1.2 0.3 -0.3 0.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.2 -1.0 1.1 -0.7 -0.1 -0.0 0.4 -1.1
High blood pressure (siblings) 0.9 1.3 2.7 -1.1 1.6 -0.1 1.6 0.8 1.1 -1.1
Forced vital capacity (FVC), Best measure 0.3 1.1 4.5 -1.1 -0.1 0.7 0.5 1.1 0.1 2.1
Body fat percentage 0.1 0.5 1.7 -0.8 -0.7 1.3 0.7 0.4 0.2 0.3
Leg fat percentage (right) 0.2 0.7 2.2 -1.0 -1.1 1.5 0.4 -0.3 -0.2 -0.0
Arm fat-free mass (right) 0.6 3.0 7.1 -2.7 -0.4 1.0 1.6 1.6 0.5 2.7
Exposure to tobacco smoke outside home 0.7 0.9 4.2 -0.2 0.5 -1.1 0.3 -0.6 0.2 -2.1
Comparative body size at age 10 0.1 0.2 0.9 -0.2 -0.3 0.4 -0.1 0.2 -0.1 1.0
Number of full brothers 1.3 1.6 2.8 1.3 -0.3 -1.6 -1.4 -1.5 -1.7 0.3
Worry too long after embarrassment 2.5 4.2 8.7 2.1 0.1 2.0 1.8 2.6 1.6 3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.1 1.0 0.3 0.9 -0.5 0.0 -0.0 0.1
Wheeze or whistling in the chest in last year 0.5 0.9 3.4 0.2 0.3 -0.8 1.0 1.1 1.8 -0.4
Number of children fathered 0.3 0.4 0.7 -0.8 0.0 0.6 0.2 -0.6 -0.8 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.8 -1.7 0.0 -0.6 -0.5 0.9 0.7 1.1
Age at first live birth 0.3 0.5 2.8 0.2 -0.4 -0.0 -0.6 -0.0 -0.4 1.7
Pulse wave peak to peak time 0.7 0.9 1.8 0.8 0.2 1.0 1.0 1.1 1.3 -0.3
Health satisfaction 1.0 1.3 2.6 -1.5 -0.1 -0.0 0.7 1.6 1.4 1.4
Shortness of breath walking on level ground 0.8 0.9 1.8 -0.3 -0.3 1.2 1.4 1.1 0.2 1.3
Qualifications: College or University degree 0.8 2.4 7.8 0.1 -0.5 2.8 0.2 1.7 0.5 2.4
Eye problems/disorders: None of the above 1.3 1.5 8.5 2.9 0.7 -0.4 0.5 -0.3 0.2 -0.8
Mouth/teeth dental problems: Loose teeth 1.4 1.7 3.4 1.9 1.1 0.9 1.7 1.2 1.4 0.0
Emphysema/chronic bronchitis 0.4 0.4 1.3 -1.0 -0.5 0.3 0.2 0.4 0.2 1.1
Medication for pain relief, constipation, heartburn 0.8 1.4 3.2 1.0 1.7 1.8 1.1 0.8 0.8 -0.1
Neck or shoulder pain in last month 0.8 1.1 3.5 0.2 0.6 -0.6 0.6 1.7 1.9 0.3
Medication: Blood pressure 0.4 0.7 2.5 -0.3 0.9 -1.6 -0.4 0.0 0.7 -0.9
Angina (self-reported) 1.1 1.5 2.8 -0.9 1.1 1.2 1.2 1.7 1.6 0.0
Migraine (self-reported) 0.5 0.6 2.5 -1.6 0.6 0.2 -0.7 -0.3 -0.7 0.3
Medication: Ibuprofen 1.0 1.2 4.0 -1.0 -0.6 -2.0 -1.1 -0.9 -1.0 -0.7
Medication: Allopurinol 0.4 0.6 2.4 -1.5 -0.3 -0.1 0.5 0.2 0.8 -0.7
Medication: Omeprazole 0.3 0.4 1.6 -0.4 -1.3 -0.2 -0.4 0.0 -0.3 -0.7
Medication: Seretide 50 evohaler 1.8 2.1 3.9 1.1 -1.8 -0.9 -1.3 -2.0 -1.6 -0.8
Mean time to correctly identify matches 0.6 1.1 2.1 1.2 -1.0 1.3 0.3 -1.1 -0.3 -1.4
Heart disease (mother) 1.5 1.9 4.1 -1.4 -1.0 1.1 2.0 1.4 1.1 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 4.5 2.1 -0.2 -0.3 -0.5 -0.8 -0.4 -0.6
Whole body fat mass 0.3 1.1 2.4 -1.1 -0.8 1.6 1.0 0.8 0.2 1.3
Leg fat mass (right) 0.3 1.1 2.4 -1.4 -0.9 1.6 0.9 0.4 0.1 1.0
Arm predicted mass (right) 0.7 3.3 8.3 -2.7 -0.5 1.2 1.7 1.7 0.5 2.9
Pulse rate, automated reading 0.6 1.9 9.1 -0.4 1.2 -3.0 0.2 0.3 1.2 -1.0
Alcohol intake frequency. 0.4 1.0 2.4 -0.2 -0.5 -0.5 -0.6 -1.5 -1.3 -1.4
Comparative height size at age 10 0.3 1.4 3.6 -0.1 0.3 1.4 1.9 1.5 1.2 0.9
Number of full sisters 0.6 0.7 2.5 -0.6 0.1 -1.0 -0.0 -1.2 -0.2 -1.6
Suffer from ‘nerves’ 1.9 3.0 5.9 -0.4 1.9 2.4 1.2 2.0 2.4 0.6
Overall health rating 0.4 0.8 3.5 -1.9 0.4 -0.4 0.3 0.7 1.1 -0.0
Chest pain or discomfort 0.8 1.2 3.2 0.0 0.5 1.0 1.4 1.4 1.8 -0.2
Had major operations 0.6 0.7 2.2 0.2 -1.1 -0.4 -1.5 -0.2 -0.5 0.9
Age at last live birth 0.4 0.7 2.3 -0.3 -0.7 -0.5 -0.7 -0.3 -0.9 1.5
Family relationship satisfaction 0.4 0.5 1.2 0.3 1.1 -0.4 -0.2 0.8 1.0 0.2
Leg pain on walking 1.2 1.5 4.9 -2.2 0.0 -1.3 -1.3 -0.2 -0.4 1.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.3 0.8 0.6 -0.1 0.4 -0.3 0.2 -1.5
Commuting to job workplace: Car/motor vehicle 1.8 2.0 4.3 -2.1 -1.8 -1.9 -0.7 -1.3 -0.4 -0.9
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 8.6 1.3 0.7 2.9 0.2 -0.7 -0.5 0.1
Medication: Aspirin 0.2 0.2 1.2 -0.1 -1.1 0.2 0.3 -0.2 -0.1 -0.5
Supplements: Vitamin C 2.3 2.7 5.3 1.1 2.3 1.3 1.9 1.9 1.8 -0.6
Knee pain experienced in last month 0.5 0.7 2.3 0.5 1.1 0.2 0.5 1.0 1.5 0.2
Hypertension (Self-reported) 0.6 1.6 7.3 0.8 -0.3 -2.7 -1.2 -0.7 -0.4 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.5 -1.5 0.1 -0.1 0.2 -0.1 0.4 -1.6
Illnesses of father: Heart disease 0.5 0.6 1.7 -0.1 -0.0 0.7 1.3 0.8 0.7 1.0
Illnesses of siblings: Diabetes 1.1 1.4 5.4 0.9 2.3 0.2 0.4 1.1 1.3 0.6
Smoking status: Previous 1.4 2.1 5.8 1.1 -0.8 0.2 -1.6 -2.0 -2.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.8 0.1 0.6 0.2 -0.3 0.1 -0.3 0.9
Whole body fat-free mass 0.5 2.7 9.5 -2.0 -0.3 1.2 1.5 1.4 0.0 3.1
Leg fat-free mass (right) 0.4 2.4 8.7 -1.8 -0.0 1.0 1.4 1.4 0.1 3.0
Arm fat percentage (left) 0.1 0.6 2.0 -0.6 -0.8 1.4 0.7 0.2 -0.2 0.7
Average weekly red wine intake 0.9 1.3 4.2 1.1 2.1 0.7 0.6 1.3 0.8 -0.2
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.8 0.7 0.6 1.3 0.7 0.9 0.6 0.6
Mood swings 1.9 3.5 7.2 -0.0 0.6 2.7 2.3 2.4 2.2 0.9
Loneliness, isolation 0.4 0.6 1.1 -0.7 0.5 0.7 0.8 1.0 1.1 -0.1
Long-standing illness, disability or infirmity 0.2 0.3 0.6 0.4 0.2 0.1 -0.5 -0.8 -0.7 -0.6
Ever had bowel cancer screening 0.4 0.5 3.0 -0.3 -0.4 1.7 0.3 0.3 -0.1 -0.3
Diabetes diagnosed by doctor 0.5 0.8 3.1 0.1 -0.3 -0.9 -1.8 -1.0 -0.8 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.5 0.1 0.1 -1.1 -0.3 0.4 -0.4 1.6
Friendships satisfaction 1.6 2.0 5.1 0.8 0.1 0.8 2.2 1.6 2.2 -0.8
Qualifications: nursing, teaching 1.1 1.6 7.1 0.2 -0.5 2.7 1.4 0.8 0.2 1.1
Commuting to job workplace: Walk 0.3 0.3 0.7 0.3 0.7 0.8 -0.3 0.1 -0.4 0.7
Eye problems/disorders: Cataract 0.9 1.1 4.3 -2.1 0.8 1.6 -0.1 0.2 0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 2.6 0.7 -0.4 1.3 1.6 0.5 0.3 -0.0
Medication for cholesterol 1.4 2.0 3.6 -1.0 1.9 1.9 1.5 1.4 1.4 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 -1.5 -0.7 -0.8 -0.4 -0.9 -0.9 -0.8
Back pain experienced in last month 0.8 1.2 2.4 -1.0 1.1 1.1 1.6 0.6 1.3 -0.7
Mineral and other dietary supplements 0.7 1.0 4.2 -0.2 -2.0 -0.4 0.2 -0.5 -0.5 1.3
Breast cancer (self-reported) 1.5 1.8 3.8 -1.2 -0.7 -0.4 -1.9 -1.3 -1.9 1.1
Asthma (self-reported) 0.4 0.8 1.7 -0.8 -0.2 -1.3 -1.2 -0.7 -0.5 -1.0
Osteoporosis (self-reported) 2.9 3.6 8.0 -1.1 2.8 1.1 1.5 2.4 2.4 1.1
Osteoarthritis (self-reported) 0.1 0.2 0.5 -0.7 0.5 -0.4 -0.5 0.1 -0.1 0.4
Medication: Aspirin 0.3 0.4 1.6 0.1 -1.3 -0.5 -0.5 -0.6 -0.5 -0.4
Medication: Gliclazide 1.7 2.0 6.0 0.8 -0.6 -0.8 -1.7 -2.4 -1.6 -0.6
Illnesses of father: None of the above (group 1) 0.2 0.3 1.0 0.1 -1.0 0.6 -0.5 0.4 0.1 0.5
Smoking status: Current 1.1 1.8 6.6 -0.3 2.2 -2.6 -0.7 0.7 0.3 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.6 -0.6 -1.3 0.7 0.6 0.0 -0.6 0.2
Whole body water mass 0.5 2.8 9.2 -2.2 -0.4 1.2 1.5 1.3 0.0 3.0
Leg predicted mass (right) 0.5 2.5 9.1 -1.8 0.0 1.1 1.4 1.4 0.2 3.0
Arm fat mass (left) 0.3 1.4 2.9 -1.7 -0.5 1.5 1.3 0.9 0.2 1.4
Number of self-reported non-cancer illnesses 0.8 1.4 3.3 -1.0 1.4 0.3 0.9 1.7 1.8 -0.3
Average weekly champagne plus white wine intake 0.7 1.0 2.6 -1.6 -0.7 0.2 -0.9 -0.8 -1.4 0.7
Miserableness 0.7 1.2 2.7 0.4 -0.9 0.7 1.6 1.4 1.6 0.4
Guilty feelings 1.8 2.6 5.8 -0.6 1.3 1.2 2.2 2.0 2.4 -0.6
Wears glasses or contact lenses 0.2 0.2 0.7 0.2 0.2 -0.2 -0.8 0.6 0.4 0.5
Ever taken oral contraceptive pill 0.5 0.5 1.6 -0.7 -0.1 -1.3 0.4 0.7 0.6 0.7
Hearing aid user 0.9 1.0 3.4 -0.9 1.5 0.1 0.1 -0.5 0.1 -1.9
Mother’s age at death 1.8 2.3 9.4 1.7 1.4 3.1 0.6 0.4 0.8 -0.7
Financial situation satisfaction 1.7 2.1 5.7 -1.2 0.0 -0.6 1.4 2.1 2.4 1.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.7 1.3 1.0 0.1 -0.4 0.3 0.4 0.4
Commuting to job workplace: Public transport 0.3 0.4 1.1 0.1 0.6 0.8 0.0 0.7 0.1 1.1
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 -0.5 -0.0 0.1 -0.7 0.4 0.5 -0.4
Medication: Blood pressure 1.2 2.3 4.9 -0.1 -1.7 -2.2 -1.8 -1.5 -1.5 -0.7
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.4 -0.1 -0.8 1.2 0.2 -0.1 0.0 0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.6 2.2 0.5 1.5 0.9 -0.1 -0.1 -0.1 -0.9
High cholesterol (Self-reported) 1.1 1.9 4.4 -0.4 -1.5 -2.1 -1.4 -1.8 -0.9 -0.8
Medication: Bendroflumethiazide 0.2 0.2 0.5 -0.5 -0.6 -0.7 -0.1 0.1 0.6 0.4
Medication: Paracetamol 0.3 0.5 1.8 0.2 -1.3 0.2 -0.3 -0.4 -0.3 1.2
Medication: Lisinopril 0.2 0.3 0.6 0.4 0.7 -0.1 -0.2 0.7 0.8 0.3
Medication: Atorvastatin 0.3 0.4 1.0 0.0 -0.5 -0.3 0.7 1.0 0.4 1.0
Illnesses of father: High blood pressure 1.0 1.2 3.8 2.0 -0.4 -1.5 -0.7 0.0 -1.0 1.0
Alcohol drinker status: Never 1.8 2.2 9.1 -3.0 -0.9 -0.3 -0.4 -1.3 -1.1 -1.4
Ever smoked 0.6 1.0 2.1 1.0 0.9 -1.2 -1.1 0.1 -1.4 1.0
Basal metabolic rate 0.5 2.7 8.8 -2.0 -0.5 1.5 1.5 1.3 0.0 3.0
Leg fat percentage (left) 0.2 0.6 1.6 -1.1 -1.1 1.3 0.2 -0.3 -0.2 -0.0
Arm fat-free mass (left) 0.5 2.7 8.3 -2.9 -0.7 1.0 1.3 1.1 -0.0 2.4
Number of operations (self-reported) 0.3 0.5 1.7 0.2 -0.4 -1.3 -0.5 0.7 0.0 1.0
Average weekly beer plus cider intake 0.4 0.5 1.1 -0.1 0.8 -1.0 0.2 0.9 1.0 0.1
Irritability 2.8 4.7 8.7 0.5 1.3 2.6 2.6 3.0 2.8 1.1
Risk taking 0.5 0.8 3.4 -1.2 0.5 -1.9 -0.4 -0.2 -0.5 0.5
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.8 1.7 1.1 0.8 -0.8 -0.2 -0.4 -0.1
Fractured/broken bones in last 5 years 0.4 0.5 2.5 -1.6 0.5 -0.3 0.0 0.7 0.1 0.4
Age started oral contraceptive pill 1.1 1.3 4.4 -1.7 1.1 2.1 0.7 0.2 0.4 -0.4
Diastolic blood pressure, automated reading 0.2 0.6 1.1 0.4 0.4 -0.9 0.7 0.7 1.0 -1.1
Ever depressed for a whole week 0.8 1.0 1.9 1.1 1.4 0.7 0.6 1.1 1.1 -0.6
Unable to work because of sickness or disability 0.5 0.6 1.8 -0.6 1.3 0.2 0.6 0.2 0.7 -1.2
Commuting to job workplace: Cycle 1.0 1.2 3.1 1.0 1.8 -0.3 0.1 1.3 1.1 1.0
Myopia 0.7 1.0 1.7 1.0 1.0 -1.3 -1.1 -0.6 -1.2 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.3 5.5 -0.2 0.3 2.4 1.4 0.6 0.5 1.0
Cholesterol lowering medication 0.3 0.5 1.1 -0.0 -0.4 -0.8 -0.9 -1.0 -0.9 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.9 0.2 -0.6 0.2 -0.4 -0.2 -0.2 -0.9
Pain experienced in last month 0.3 0.5 1.8 1.3 -0.3 0.5 -0.5 -0.1 -0.9 0.6
Supplements: Calcium 0.5 0.6 2.5 -0.4 1.6 -0.6 -0.7 0.2 0.1 -0.7
Basal cell carcinoma (self-reported) 0.4 0.4 0.8 0.9 -0.4 -0.7 -0.9 -0.6 -0.6 -0.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.6 -0.6 0.8 0.7 0.3 -0.3 -0.1 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 4.0 1.0 1.3 2.0 1.2 0.7 0.3 1.2
Heart disease (siblings) 0.2 0.2 0.7 -0.8 0.1 0.0 -0.1 -0.1 -0.5 -0.6
Alcohol drinker status: Previous 0.2 0.2 0.5 -0.3 -0.2 -0.1 -0.6 -0.7 -0.1 0.4
Pack years of smoking 1.0 1.4 4.1 -1.6 0.3 0.1 2.0 1.2 1.3 -0.4
Impedance of whole body 0.2 1.2 4.3 2.1 0.9 -0.2 -0.7 0.1 0.7 -1.4
Leg fat mass (left) 0.3 1.1 2.3 -1.5 -0.9 1.5 0.8 0.5 0.0 1.1
Arm predicted mass (left) 0.5 2.7 7.9 -2.8 -0.7 0.9 1.4 1.2 0.0 2.4