Hub : Genes

ZMAT3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1320	0.0540	4.9e-03	0.058	NA	0.020	NA	0.042	2.1e-04	NA	2.0e-02	NA	1.3e-03
2	NTR	Blood	0.0421	0.0133	1.4e-06	0.006	0.018	0.017	0.017	0.018	3.2e-03	1.6e-06	2.2e-06	1.7e-06	1.7e-06
3	YFS	Blood	0.2076	0.0403	0.0e+00	0.051	0.099	0.101	0.108	0.093	2.5e-16	1.1e-30	2.2e-31	2.6e-33	7.2e-29
4	TCGA	Breast Invasive Carcinoma	0.0235	0.0143	2.0e-04	0.010	0.018	0.024	NA	0.016	3.6e-03	1.0e-04	1.0e-05	NA	2.2e-04
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1190	0.0490	1.9e-04	0.095	0.054	0.063	NA	0.060	4.6e-06	5.1e-04	1.7e-04	NA	2.4e-04
6	TCGA	Prostate Adenocarcinoma	0.0623	0.0351	7.8e-04	0.019	0.022	0.019	NA	0.029	4.0e-03	1.8e-03	4.0e-03	NA	5.0e-04
7	TCGA	Skin Cutaneous Melanoma	0.5950	0.1940	8.1e-03	-0.009	0.049	0.081	NA	0.013	6.8e-01	1.9e-02	3.5e-03	NA	1.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.2	1.8	4.0	-1.1	-2.0	-1.2	-1.4	-1.1	-1.8	-0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.7	-0.2	0.2	-0.5	-0.8	-0.4	-0.6	0.1
Depressed Affect (Nagel 2018)	0.4	0.8	1.5	-1.1	-0.8	1.2	0.8	0.5	1.0	-0.1
Depression (Nagel 2018)	0.8	1.2	3.1	-0.8	-0.2	-0.1	1.2	1.6	1.8	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.1	5.7	-0.5	-0.7	0.6	-0.0	0.4	-0.8	2.4
Neuroticism (Nagel 2018)	1.0	2.4	5.2	-0.7	0.3	1.7	1.9	2.1	2.3	0.5
Schizophrenia (2018)	0.3	0.6	3.4	0.6	1.8	0.3	0.1	0.3	0.6	0.1
Schizophrenia vs Biploar Disorder	2.6	3.4	5.6	1.1	2.4	2.3	1.9	1.0	2.3	-1.2
Worry (Nagel 2018)	0.5	1.0	2.2	-0.2	0.3	1.2	0.7	1.5	1.5	0.8
Alzheimer’s Disease (in mother)	0.8	1.0	2.0	0.1	-1.4	0.4	-1.2	-0.6	-1.1	1.3
Alzheimer’s Disease (in father)	0.6	0.7	2.0	0.1	0.8	0.3	1.0	0.9	1.4	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.5	-0.1	0.2	-0.5	-0.2	-0.3	0.6
Crohns Disease (2017)	0.3	0.7	1.3	0.1	1.1	-1.1	0.1	0.9	0.9	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	2.0	0.9	0.7	-0.3	0.4	1.4	0.7	0.9
Ulcerative Colitis (UC)	0.6	1.2	5.6	1.2	-0.3	0.3	0.2	0.9	-0.3	2.4
Major Depression (MDD)	1.3	1.6	4.7	-2.2	-0.4	1.1	1.9	0.1	0.2	-1.1
Reaction Time	0.3	0.5	1.2	0.5	-1.0	0.6	0.7	-0.5	0.1	-1.1
Verbal and Numeric Reasoning (VNR)	0.4	0.8	3.7	0.2	-1.0	0.6	-0.0	0.2	-0.8	1.9
Breast Cancer	1.4	3.5	12.6	0.8	3.5	-2.3	-0.7	0.1	0.9	-2.1
Ovarian Cancer	1.3	1.8	3.9	-0.1	1.0	1.5	2.0	1.4	1.5	-1.0
Prostate Cancer	2.0	2.8	5.9	-2.1	-2.3	-2.4	-1.4	-0.4	-1.5	0.2
Age at First Birth	0.9	1.3	3.3	1.0	0.2	-0.3	-1.5	-1.8	-1.6	-0.2
Bipolar Disorder (2011)	0.3	0.3	0.9	0.5	-1.0	0.4	-0.5	0.7	0.2	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	1.3	-0.8	-0.2	-0.8	-0.8	-1.0	0.7
Coronary Artery Disease (CAD)	0.5	0.6	1.9	0.3	-1.4	0.3	-0.5	-0.0	-0.6	1.2
Crohns Disease (2012)	0.3	0.4	1.3	1.1	0.1	0.4	-0.1	0.7	1.0	-0.0
Mean Putamen Volume	0.7	0.8	2.3	0.7	1.1	-0.6	0.3	0.7	0.8	-1.5
Fasting Glucose	0.7	0.8	2.4	1.6	0.5	-0.3	-0.6	-1.2	-0.9	0.2
HbA1C	0.2	0.3	1.1	1.1	-0.3	-0.5	-0.2	-0.1	-0.4	-0.4
HDL Cholesterol	0.9	1.5	3.3	-1.3	-0.4	-0.6	-1.6	-1.8	-1.5	-0.4
LDL Cholesterol	0.5	0.8	1.3	-0.9	0.7	-0.9	1.1	1.1	0.9	-0.1
Lupus	0.9	1.3	1.9	1.1	1.0	1.3	0.2	1.4	1.4	1.2
Neuroticism (2016)	3.4	4.9	10.3	-2.1	2.4	0.1	2.5	2.9	3.2	0.2
Primary Biliary Cirrhosis	0.9	1.3	2.6	-0.1	0.6	1.6	1.5	1.3	0.8	1.3
Rheumatoid Arthritis	0.2	0.2	0.8	-0.6	-0.9	0.1	0.4	0.4	0.3	-0.3
Schizophrenia (2014)	0.2	0.4	1.9	1.4	0.6	0.1	-0.2	0.2	0.3	0.2
Triglycerides	0.2	0.3	0.7	0.2	-0.0	0.0	0.8	0.7	0.7	-0.7
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.1	1.2	-0.5	0.0	-1.7	-1.3	-1.8	-0.1
Ulcerative Colitis	0.9	1.2	5.7	1.3	-0.6	0.7	0.0	0.6	-0.3	2.4
Blood Eosinophil Count	1.0	7.7	20.8	-2.5	-1.2	-4.6	-3.5	-2.0	-2.9	0.9
Blood Platelet Count	6.7	77.2	148.8	-2.2	-8.0	-10.4	-12.2	-9.1	-11.3	2.2
Blood Red Count	1.9	18.0	37.0	-1.4	-4.0	-4.3	-6.1	-4.3	-5.6	1.6
Blood White Count	0.7	5.5	12.0	-1.3	-1.9	-3.5	-3.4	-1.9	-2.4	0.3
Heel T-Score	0.8	6.6	14.0	0.0	-2.1	-2.6	-3.1	-3.7	-3.3	-1.0
BMI	0.3	1.8	4.5	-1.9	-2.1	1.3	0.2	-0.8	-1.4	0.6
Height	0.3	6.1	20.9	-0.9	1.4	0.8	2.0	3.5	1.6	4.6
Waist Hip Ratio (WHR)	0.7	2.9	6.7	-1.5	-1.7	0.3	-2.0	-2.1	-2.6	-0.5
Systolic Blood Pressure	0.4	2.1	6.0	0.3	0.9	-1.9	-1.3	-1.4	-0.4	-2.5
Smoking Status	1.2	2.8	6.1	-0.2	0.7	-2.4	-2.5	-1.4	-2.2	-0.6
Allergy or Eczema	0.5	1.3	4.4	0.1	0.3	0.9	0.3	1.7	0.8	2.1
Cardiovascular Disease	0.7	2.4	8.4	1.3	-0.5	-2.9	-1.5	-1.5	-0.4	-1.3
Hypothyroidism (self reported)	0.2	0.4	2.4	0.3	0.0	1.6	0.3	0.2	-0.3	0.6
Respiratory disease	0.6	1.3	2.2	-1.4	-0.8	-1.5	-1.3	-0.9	-0.8	-1.2
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.9	0.5	-0.1	-0.6	-1.4	-0.7	-0.5	0.3
Lung FEV1/FVC ratio	0.1	0.6	1.4	1.2	-0.5	0.4	0.3	0.7	1.1	1.0
Lung FVC	0.1	0.7	1.5	-0.2	-1.1	-0.2	-1.2	-0.3	-0.8	1.1
Neuroticism	1.7	4.1	10.6	-0.5	1.2	2.1	2.3	2.6	3.3	-0.0
Chronotype (morning person)	0.6	1.4	3.1	-1.8	1.5	-0.2	-1.6	-0.9	-0.1	-1.2
Hair Pigment	0.1	4.0	12.2	1.2	-0.8	-0.3	-3.5	-2.2	-2.8	0.7
Tanning	0.1	0.9	2.1	-0.8	1.0	-0.8	0.0	1.5	1.1	0.9
Hand grip strength (left)	0.1	0.3	0.9	0.6	-0.1	0.7	0.3	-0.1	-0.7	0.9
Number of treatments/medications taken	0.5	0.9	3.0	-1.7	-0.7	0.0	-0.5	-0.8	-0.3	-1.4
Average weekly spirits intake	0.3	0.4	0.9	0.2	0.9	0.3	0.7	0.3	0.6	-0.9
Sensitivity / hurt feelings	2.2	3.7	9.1	0.3	1.4	1.4	2.8	2.3	3.0	-0.5
Frequency of depressed mood in last 2 weeks	0.9	1.2	3.2	-0.7	-0.3	0.8	1.1	1.6	1.8	0.6
Hearing difficulty/problems: Yes	0.0	0.0	0.2	-0.2	-0.1	-0.0	0.3	-0.1	-0.2	-0.4
Relative age of first facial hair	0.3	0.6	3.0	-1.7	0.1	0.1	-0.0	0.6	0.0	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.1	-0.6	0.2	0.2	0.2	1.0	0.9	0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	1.1	0.2	0.4	-0.1	-0.7	-0.6	-1.0
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	0.0	0.1	0.3	0.4	1.2	1.2	0.6
Systolic blood pressure, automated reading	0.4	1.2	5.7	-0.1	1.2	-0.9	-0.0	-0.0	0.6	-2.4
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.4	-0.1	1.5	0.2	1.0	1.2	1.6	-0.8
Angina	1.2	1.6	3.0	-1.1	1.1	1.4	1.2	1.7	1.7	-0.1
Medication for hormone replacement therapy	1.1	1.2	2.4	1.6	-1.2	-1.1	-1.2	-0.9	-1.1	0.4
Vitamin and mineral supplements	0.6	0.8	1.9	0.8	-1.2	-0.6	-0.7	-1.4	-0.9	-0.0
Supplements: Zinc	0.7	0.8	2.6	1.1	1.6	1.1	-0.6	0.3	0.1	-0.1
Medication: Co-codamol	0.3	0.4	1.4	-0.0	0.6	1.2	0.6	0.5	0.5	0.0
Medication: Metformin	1.3	1.9	4.2	1.5	-0.6	-0.7	-2.0	-2.0	-1.4	-0.6
Diabetes (father)	1.7	2.1	4.7	-0.5	2.2	1.5	1.8	0.7	1.6	-1.1
Diabetes (mother)	0.9	1.1	2.9	-0.5	1.7	0.2	1.2	0.6	1.1	-1.2
Severe depression (siblings)	0.6	0.7	1.6	1.2	1.2	-0.5	-0.5	0.0	0.0	-1.1
Pack years adult smoking proportion	1.0	1.5	4.5	-1.5	0.3	-0.2	2.1	1.2	1.2	-0.5
Impedance of leg (right)	0.2	0.8	3.0	1.3	0.4	0.5	-0.4	-0.2	0.7	-1.7
Leg fat-free mass (left)	0.5	2.8	9.2	-1.8	-0.1	1.4	1.6	1.5	0.3	3.0
Trunk fat percentage	0.2	0.7	1.5	-0.9	-0.6	1.2	1.0	0.7	0.5	0.5
Hand grip strength (right)	0.2	0.5	1.8	0.9	0.5	-0.1	-0.1	-0.0	-0.6	1.4
Townsend deprivation index at recruitment	0.3	0.5	1.4	0.7	1.2	0.7	0.7	0.5	0.4	0.2
Current tobacco smoking	1.2	2.0	6.7	-0.3	2.6	-2.4	-0.7	0.9	0.6	-0.1
Average weekly fortified wine intake	0.5	0.6	1.2	0.6	0.2	0.8	0.8	0.9	1.1	0.9
Maternal smoking around birth	1.1	1.6	7.5	-0.9	0.6	-2.7	-1.3	-0.6	0.1	-0.9
Fed-up feelings	1.3	2.4	5.8	-1.3	0.7	2.0	1.4	1.4	2.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.9	-1.3	-0.5	-1.7	-0.0	1.2	1.1	0.4
Relative age voice broke	1.5	2.3	5.8	0.3	0.5	1.8	0.8	2.4	1.8	1.6
Taking other prescription medications	0.5	0.8	2.2	-1.5	1.0	0.5	0.4	0.7	1.1	-0.5
Age when periods started (menarche)	0.2	0.4	1.4	0.6	-0.0	-1.2	-0.5	0.8	-0.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.2	-0.0	-0.2	-0.8	-1.5	-1.1	-1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.1	0.8	-1.1	0.7	-0.1	0.0	-0.6	1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	3.4	0.3	0.3	-0.3	-0.2	-0.7	0.4	-1.9
Qualifications: CSEs or equivalent	0.9	1.2	3.9	0.5	-0.3	-1.9	-0.6	0.4	0.4	2.0
Serious illness, injury or assault to yourself	1.4	1.7	4.9	-1.0	-1.3	-2.2	-1.4	-0.1	-1.1	1.2
High blood pressure	0.7	1.9	8.0	0.4	-0.6	-2.8	-1.6	-0.9	-0.7	-1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.2	-0.0	-0.7	0.5	-0.1	1.3	0.0	1.5
Multivitamins +/- minerals	0.3	0.3	1.1	-0.3	1.1	-0.1	-0.4	0.7	0.2	0.6
Stomach or abdominal pain in last month	1.6	2.0	3.5	-0.2	1.8	1.9	1.2	1.8	1.7	0.3
Supplements: Glucosamine	0.2	0.3	0.8	0.6	0.4	-0.7	0.0	0.9	0.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.5	0.4	-0.0	0.4	0.6	-0.5	-0.1	-1.6
Medication: Atenolol	1.3	1.6	3.5	-0.7	0.2	1.9	1.2	1.7	1.3	1.0
Medication: Levothyroxine sodium	0.1	0.1	0.4	0.6	-0.2	-0.2	-0.1	0.4	-0.2	0.6
Sitting height	0.2	1.2	7.1	-0.0	0.4	0.6	0.3	0.5	-0.4	2.7
Chronic bronchitis/emphysema (father)	0.4	0.4	1.2	-0.0	0.6	-1.1	-0.3	-0.7	-0.5	-0.8
High blood pressure (mother)	1.0	1.4	2.9	0.9	-1.7	-0.4	-1.4	-1.1	-1.3	1.2
Body mass index (BMI)	0.2	0.9	2.2	-1.5	-1.0	1.1	1.0	0.2	-0.3	1.0
Impedance of leg (left)	0.2	0.9	3.3	1.2	0.3	-0.1	-0.9	-0.5	0.3	-1.8
Leg predicted mass (left)	0.5	2.5	8.5	-1.7	-0.1	1.4	1.5	1.3	0.1	2.9
Trunk fat mass	0.2	1.1	1.8	-1.3	-0.7	1.3	1.0	0.8	0.3	1.3
Waist circumference	0.3	1.0	2.5	-1.6	-1.2	1.0	0.2	-0.2	-1.0	1.2
Number of incorrect matches in round	0.2	0.3	0.8	-0.9	-0.6	-0.1	-0.7	-0.8	-0.3	-0.1
Past tobacco smoking	1.0	1.9	5.1	-1.1	-0.4	0.9	1.9	1.4	2.3	-0.2
Alcohol usually taken with meals	0.2	0.3	0.6	0.7	-0.1	0.4	-0.3	-0.7	-0.8	-0.7
Nervous feelings	0.7	1.3	3.7	0.7	0.4	1.9	0.2	1.2	1.0	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.7	-1.3	0.3	1.2	1.1	1.9	1.9	1.4
Hearing difficulty/problems with background noise	1.2	2.0	4.4	1.4	2.1	1.8	1.4	1.4	0.7	0.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	0.2	0.9	-0.1	0.2	-0.0	0.1	-0.8
Had menopause	0.6	0.7	1.6	-0.2	0.2	-0.4	-1.2	-1.3	-1.2	-0.5
Had other major operations	0.3	0.4	2.1	0.1	0.4	-0.1	-0.2	1.4	0.3	0.7
Forced vital capacity (FVC)	0.3	1.2	6.2	-0.9	0.2	0.5	-0.4	0.8	-0.2	2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.5	1.2	-1.1	0.0	-1.6	-0.8	-1.1	1.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	2.8	-0.4	1.7	1.3	1.1	1.4	1.6	-0.2
Qualifications: None of the above	1.2	2.5	11.2	-0.5	1.4	-1.3	-0.1	-1.1	0.9	-3.3
Financial difficulties in last 2 years	0.7	0.9	5.2	-0.6	-0.4	-2.3	-0.7	0.3	0.1	-0.3
Mouth/teeth dental problems	1.1	1.8	4.4	-0.6	-0.5	-2.1	-1.8	-0.1	-0.6	1.9
Heart attack	0.2	0.3	0.7	-0.8	0.7	0.7	0.4	-0.2	0.1	-0.2
Allergy	0.4	0.9	2.9	0.3	0.1	-0.9	-0.7	-1.7	-0.7	-1.3
Pain all over the body in last month	1.3	1.3	7.5	-2.7	-0.3	-0.8	-0.4	-0.8	-0.1	-0.7
Diabetes (self-reported)	0.4	0.6	3.0	0.7	0.2	-0.7	-1.7	-0.5	-0.3	0.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.9	0.6	-0.5	0.8	0.7	1.4	1.2	0.6
Medication: Ramipril	0.4	0.5	1.5	-0.6	1.2	-0.4	0.4	0.7	0.9	-0.3
Medication: Simvastatin	0.9	1.3	2.8	-0.2	-0.6	-1.5	-1.4	-1.7	-1.1	-0.8
Fluid intelligence score	0.5	1.1	4.1	0.6	-0.8	0.1	-0.6	-0.3	-1.4	2.0
Illnesses of siblings	1.5	2.0	5.2	1.4	-2.3	-0.3	-1.5	-1.1	-1.5	1.1
Neuroticism score	3.0	6.3	15.2	-0.4	1.6	2.4	3.1	3.3	3.9	0.0
Weight	0.4	1.8	5.3	-1.5	-0.7	1.6	1.1	0.9	-0.1	2.3
Impedance of arm (right)	0.3	1.5	8.3	2.9	0.9	-0.0	-0.8	-0.2	0.2	-0.9
Arm fat percentage (right)	0.1	0.5	1.6	-0.4	-0.9	1.3	0.6	-0.1	-0.4	0.5
Trunk fat-free mass	0.4	2.5	8.9	-1.9	-0.4	1.3	1.3	1.1	-0.2	3.0
Hip circumference	0.6	2.6	4.6	-0.8	0.0	1.7	2.1	2.2	1.4	2.0
Time employed in main current job	0.3	0.4	0.9	-1.0	-0.4	0.9	-0.3	-0.5	-0.3	0.5
Alcohol intake versus 10 years previously	0.7	1.1	3.1	0.8	-1.1	-1.8	-1.1	-0.8	-0.8	-0.2
Father’s age at death	0.5	0.7	3.0	0.9	0.7	1.7	0.8	0.1	-0.0	-0.4
Worrier / anxious feelings	0.9	1.7	3.6	-0.8	1.1	1.7	1.0	1.5	1.9	0.7
Frequency of tiredness / lethargy in last 2 weeks	2.4	4.0	10.2	0.1	2.4	0.1	2.1	2.7	3.2	0.3
Falls in the last year	0.4	0.5	1.5	1.0	1.2	0.8	-0.2	0.2	-0.5	0.1
Hair/balding pattern: Pattern 3	1.2	1.8	4.5	0.0	-2.1	-1.2	-1.6	-1.4	-1.5	-0.0
Number of live births	0.2	0.3	0.8	-0.7	0.9	0.5	0.7	0.4	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	7.6	-0.1	-0.5	0.1	-0.8	0.5	-0.7	2.8
Pulse rate	0.5	0.9	2.7	-0.9	1.1	-1.6	0.3	-0.1	0.6	-1.0
Happiness	1.5	1.8	5.1	-1.0	-0.1	1.4	2.3	1.1	1.5	-0.8
Noisy workplace	0.3	0.3	0.8	0.5	0.2	-0.9	0.3	0.8	0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.9	6.6	0.2	0.2	2.6	1.2	1.6	0.6	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.4	-0.6	0.2	0.7	0.6	-0.0	0.5
Mouth/teeth dental problems: Dentures	3.0	5.1	19.7	0.2	2.7	1.6	1.6	-0.0	1.8	-4.4
Asthma	0.2	0.5	1.2	-1.0	-0.2	-0.7	-0.7	-0.4	-0.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	7.4	-0.5	-0.9	-2.7	-1.1	-1.0	-1.1	-0.4
Medication: Cholesterol lowering	0.2	0.4	1.1	-0.2	0.2	-1.0	0.5	0.5	1.1	-0.2
Depression (self-reported)	1.0	1.2	3.0	-1.7	0.9	1.2	0.9	1.0	1.1	0.4
Medication: Lansoprazole	4.9	5.6	10.8	-1.0	2.3	2.7	3.3	2.0	2.9	-1.6
Prospective memory result	1.5	1.8	2.7	-1.6	1.6	1.5	0.9	1.2	1.6	-0.2
Lung cancer (father)	0.6	0.7	2.6	-1.6	0.7	-0.4	-0.8	-0.7	-0.2	-0.9
Illnesses of mother	0.5	0.7	1.4	0.4	0.2	-0.7	-0.9	-1.2	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	7.7	-0.6	-1.0	0.9	0.3	1.0	-0.1	2.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.0	-0.9	0.2	-0.8	-0.9	-0.9	-1.0	0.5
Impedance of arm (left)	0.3	1.2	6.0	2.4	1.2	0.2	-0.4	0.4	0.7	-0.3
Arm fat mass (right)	0.3	1.2	2.6	-1.6	-0.7	1.5	1.1	0.6	0.0	1.2
Trunk predicted mass	0.4	2.4	8.5	-1.9	-0.5	1.3	1.2	1.1	-0.2	2.9
Standing height	0.2	2.4	9.7	-0.5	0.9	1.2	0.8	1.9	0.8	3.1
Length of working week for main job	0.3	0.3	0.9	-0.0	0.4	0.7	1.0	0.6	0.6	0.2
Exposure to tobacco smoke at home	0.3	0.3	0.9	-0.6	-0.6	-1.0	0.1	-0.2	0.2	-0.7
Breastfed as a baby	0.4	0.5	1.5	-0.8	-0.3	1.2	1.0	0.3	0.5	0.2
Tense / ‘highly strung’	0.2	0.4	1.1	-0.4	-0.9	-0.6	-0.5	0.2	0.1	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.4	0.0	0.6	1.8	-0.5	-0.1	0.1	-0.2
Hair/balding pattern: Pattern 4	1.0	2.4	5.9	1.6	2.4	1.6	1.6	1.1	1.5	-0.2
Birth weight of first child	0.7	1.2	4.5	-0.8	-2.1	0.5	-0.3	-0.0	-0.4	1.7
Peak expiratory flow (PEF)	0.6	1.3	3.3	1.8	-0.1	-0.2	-1.3	-0.4	-1.4	1.5
Pulse wave reflection index	2.4	3.0	5.4	-1.2	-0.3	-1.5	-2.3	-2.3	-2.3	-1.1
Ever highly irritable/argumentative for 2 days	1.9	2.2	4.3	0.9	2.1	1.3	1.9	1.4	1.6	-0.9
Loud music exposure frequency	4.4	4.8	13.2	-0.4	0.4	1.1	3.1	3.0	3.6	-0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	5.2	0.6	-0.8	0.8	0.5	1.0	-0.6	2.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	-0.8	-0.5	0.7	0.2	-0.0	-0.1	0.4
Blood clot in the leg (DVT)	1.4	1.8	3.8	1.0	1.3	1.9	1.4	0.9	0.5	1.7
Medication: Paracetamol	0.3	0.4	1.3	-0.0	-1.1	-0.5	-0.3	-0.4	-0.1	1.0
Headache pain in last month	0.9	1.5	3.5	-0.4	-0.5	1.9	1.9	1.4	1.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.5	0.5	-0.8	1.2	0.3	-0.0	-0.7	0.5
Glaucoma (self-reported)	0.5	0.6	0.9	-1.0	-0.5	-1.0	-0.9	0.6	0.8	-0.1
Gout (self-reported)	0.4	0.5	1.9	-0.8	-0.1	-0.5	-0.4	-0.4	0.4	-1.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.1	-0.2	0.8	0.5	0.5	-0.1	0.8
Medication: Amlodipine	3.1	4.3	9.1	-1.7	-0.4	-3.0	-2.8	-2.6	-1.9	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	-0.2	0.0	-0.5	-1.1	-1.0	-0.9	-0.7
Birth weight	0.3	0.7	2.8	-0.5	-0.4	1.7	1.2	0.3	-0.3	0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-1.0	1.1	-0.7	-0.1	-0.0	0.4	-1.1
High blood pressure (siblings)	0.9	1.3	2.7	-1.1	1.6	-0.1	1.6	0.8	1.1	-1.1
Forced vital capacity (FVC), Best measure	0.3	1.1	4.5	-1.1	-0.1	0.7	0.5	1.1	0.1	2.1
Body fat percentage	0.1	0.5	1.7	-0.8	-0.7	1.3	0.7	0.4	0.2	0.3
Leg fat percentage (right)	0.2	0.7	2.2	-1.0	-1.1	1.5	0.4	-0.3	-0.2	-0.0
Arm fat-free mass (right)	0.6	3.0	7.1	-2.7	-0.4	1.0	1.6	1.6	0.5	2.7
Exposure to tobacco smoke outside home	0.7	0.9	4.2	-0.2	0.5	-1.1	0.3	-0.6	0.2	-2.1
Comparative body size at age 10	0.1	0.2	0.9	-0.2	-0.3	0.4	-0.1	0.2	-0.1	1.0
Number of full brothers	1.3	1.6	2.8	1.3	-0.3	-1.6	-1.4	-1.5	-1.7	0.3
Worry too long after embarrassment	2.5	4.2	8.7	2.1	0.1	2.0	1.8	2.6	1.6	3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	1.0	0.3	0.9	-0.5	0.0	-0.0	0.1
Wheeze or whistling in the chest in last year	0.5	0.9	3.4	0.2	0.3	-0.8	1.0	1.1	1.8	-0.4
Number of children fathered	0.3	0.4	0.7	-0.8	0.0	0.6	0.2	-0.6	-0.8	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.8	-1.7	0.0	-0.6	-0.5	0.9	0.7	1.1
Age at first live birth	0.3	0.5	2.8	0.2	-0.4	-0.0	-0.6	-0.0	-0.4	1.7
Pulse wave peak to peak time	0.7	0.9	1.8	0.8	0.2	1.0	1.0	1.1	1.3	-0.3
Health satisfaction	1.0	1.3	2.6	-1.5	-0.1	-0.0	0.7	1.6	1.4	1.4
Shortness of breath walking on level ground	0.8	0.9	1.8	-0.3	-0.3	1.2	1.4	1.1	0.2	1.3
Qualifications: College or University degree	0.8	2.4	7.8	0.1	-0.5	2.8	0.2	1.7	0.5	2.4
Eye problems/disorders: None of the above	1.3	1.5	8.5	2.9	0.7	-0.4	0.5	-0.3	0.2	-0.8
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.4	1.9	1.1	0.9	1.7	1.2	1.4	0.0
Emphysema/chronic bronchitis	0.4	0.4	1.3	-1.0	-0.5	0.3	0.2	0.4	0.2	1.1
Medication for pain relief, constipation, heartburn	0.8	1.4	3.2	1.0	1.7	1.8	1.1	0.8	0.8	-0.1
Neck or shoulder pain in last month	0.8	1.1	3.5	0.2	0.6	-0.6	0.6	1.7	1.9	0.3
Medication: Blood pressure	0.4	0.7	2.5	-0.3	0.9	-1.6	-0.4	0.0	0.7	-0.9
Angina (self-reported)	1.1	1.5	2.8	-0.9	1.1	1.2	1.2	1.7	1.6	0.0
Migraine (self-reported)	0.5	0.6	2.5	-1.6	0.6	0.2	-0.7	-0.3	-0.7	0.3
Medication: Ibuprofen	1.0	1.2	4.0	-1.0	-0.6	-2.0	-1.1	-0.9	-1.0	-0.7
Medication: Allopurinol	0.4	0.6	2.4	-1.5	-0.3	-0.1	0.5	0.2	0.8	-0.7
Medication: Omeprazole	0.3	0.4	1.6	-0.4	-1.3	-0.2	-0.4	0.0	-0.3	-0.7
Medication: Seretide 50 evohaler	1.8	2.1	3.9	1.1	-1.8	-0.9	-1.3	-2.0	-1.6	-0.8
Mean time to correctly identify matches	0.6	1.1	2.1	1.2	-1.0	1.3	0.3	-1.1	-0.3	-1.4
Heart disease (mother)	1.5	1.9	4.1	-1.4	-1.0	1.1	2.0	1.4	1.1	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	4.5	2.1	-0.2	-0.3	-0.5	-0.8	-0.4	-0.6
Whole body fat mass	0.3	1.1	2.4	-1.1	-0.8	1.6	1.0	0.8	0.2	1.3
Leg fat mass (right)	0.3	1.1	2.4	-1.4	-0.9	1.6	0.9	0.4	0.1	1.0
Arm predicted mass (right)	0.7	3.3	8.3	-2.7	-0.5	1.2	1.7	1.7	0.5	2.9
Pulse rate, automated reading	0.6	1.9	9.1	-0.4	1.2	-3.0	0.2	0.3	1.2	-1.0
Alcohol intake frequency.	0.4	1.0	2.4	-0.2	-0.5	-0.5	-0.6	-1.5	-1.3	-1.4
Comparative height size at age 10	0.3	1.4	3.6	-0.1	0.3	1.4	1.9	1.5	1.2	0.9
Number of full sisters	0.6	0.7	2.5	-0.6	0.1	-1.0	-0.0	-1.2	-0.2	-1.6
Suffer from ‘nerves’	1.9	3.0	5.9	-0.4	1.9	2.4	1.2	2.0	2.4	0.6
Overall health rating	0.4	0.8	3.5	-1.9	0.4	-0.4	0.3	0.7	1.1	-0.0
Chest pain or discomfort	0.8	1.2	3.2	0.0	0.5	1.0	1.4	1.4	1.8	-0.2
Had major operations	0.6	0.7	2.2	0.2	-1.1	-0.4	-1.5	-0.2	-0.5	0.9
Age at last live birth	0.4	0.7	2.3	-0.3	-0.7	-0.5	-0.7	-0.3	-0.9	1.5
Family relationship satisfaction	0.4	0.5	1.2	0.3	1.1	-0.4	-0.2	0.8	1.0	0.2
Leg pain on walking	1.2	1.5	4.9	-2.2	0.0	-1.3	-1.3	-0.2	-0.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	0.8	0.6	-0.1	0.4	-0.3	0.2	-1.5
Commuting to job workplace: Car/motor vehicle	1.8	2.0	4.3	-2.1	-1.8	-1.9	-0.7	-1.3	-0.4	-0.9
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	8.6	1.3	0.7	2.9	0.2	-0.7	-0.5	0.1
Medication: Aspirin	0.2	0.2	1.2	-0.1	-1.1	0.2	0.3	-0.2	-0.1	-0.5
Supplements: Vitamin C	2.3	2.7	5.3	1.1	2.3	1.3	1.9	1.9	1.8	-0.6
Knee pain experienced in last month	0.5	0.7	2.3	0.5	1.1	0.2	0.5	1.0	1.5	0.2
Hypertension (Self-reported)	0.6	1.6	7.3	0.8	-0.3	-2.7	-1.2	-0.7	-0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.5	-1.5	0.1	-0.1	0.2	-0.1	0.4	-1.6
Illnesses of father: Heart disease	0.5	0.6	1.7	-0.1	-0.0	0.7	1.3	0.8	0.7	1.0
Illnesses of siblings: Diabetes	1.1	1.4	5.4	0.9	2.3	0.2	0.4	1.1	1.3	0.6
Smoking status: Previous	1.4	2.1	5.8	1.1	-0.8	0.2	-1.6	-2.0	-2.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	0.1	0.6	0.2	-0.3	0.1	-0.3	0.9
Whole body fat-free mass	0.5	2.7	9.5	-2.0	-0.3	1.2	1.5	1.4	0.0	3.1
Leg fat-free mass (right)	0.4	2.4	8.7	-1.8	-0.0	1.0	1.4	1.4	0.1	3.0
Arm fat percentage (left)	0.1	0.6	2.0	-0.6	-0.8	1.4	0.7	0.2	-0.2	0.7
Average weekly red wine intake	0.9	1.3	4.2	1.1	2.1	0.7	0.6	1.3	0.8	-0.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.8	0.7	0.6	1.3	0.7	0.9	0.6	0.6
Mood swings	1.9	3.5	7.2	-0.0	0.6	2.7	2.3	2.4	2.2	0.9
Loneliness, isolation	0.4	0.6	1.1	-0.7	0.5	0.7	0.8	1.0	1.1	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.6	0.4	0.2	0.1	-0.5	-0.8	-0.7	-0.6
Ever had bowel cancer screening	0.4	0.5	3.0	-0.3	-0.4	1.7	0.3	0.3	-0.1	-0.3
Diabetes diagnosed by doctor	0.5	0.8	3.1	0.1	-0.3	-0.9	-1.8	-1.0	-0.8	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.5	0.1	0.1	-1.1	-0.3	0.4	-0.4	1.6
Friendships satisfaction	1.6	2.0	5.1	0.8	0.1	0.8	2.2	1.6	2.2	-0.8
Qualifications: nursing, teaching	1.1	1.6	7.1	0.2	-0.5	2.7	1.4	0.8	0.2	1.1
Commuting to job workplace: Walk	0.3	0.3	0.7	0.3	0.7	0.8	-0.3	0.1	-0.4	0.7
Eye problems/disorders: Cataract	0.9	1.1	4.3	-2.1	0.8	1.6	-0.1	0.2	0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.6	0.7	-0.4	1.3	1.6	0.5	0.3	-0.0
Medication for cholesterol	1.4	2.0	3.6	-1.0	1.9	1.9	1.5	1.4	1.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	-1.5	-0.7	-0.8	-0.4	-0.9	-0.9	-0.8
Back pain experienced in last month	0.8	1.2	2.4	-1.0	1.1	1.1	1.6	0.6	1.3	-0.7
Mineral and other dietary supplements	0.7	1.0	4.2	-0.2	-2.0	-0.4	0.2	-0.5	-0.5	1.3
Breast cancer (self-reported)	1.5	1.8	3.8	-1.2	-0.7	-0.4	-1.9	-1.3	-1.9	1.1
Asthma (self-reported)	0.4	0.8	1.7	-0.8	-0.2	-1.3	-1.2	-0.7	-0.5	-1.0
Osteoporosis (self-reported)	2.9	3.6	8.0	-1.1	2.8	1.1	1.5	2.4	2.4	1.1
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.7	0.5	-0.4	-0.5	0.1	-0.1	0.4
Medication: Aspirin	0.3	0.4	1.6	0.1	-1.3	-0.5	-0.5	-0.6	-0.5	-0.4
Medication: Gliclazide	1.7	2.0	6.0	0.8	-0.6	-0.8	-1.7	-2.4	-1.6	-0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	1.0	0.1	-1.0	0.6	-0.5	0.4	0.1	0.5
Smoking status: Current	1.1	1.8	6.6	-0.3	2.2	-2.6	-0.7	0.7	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.6	-0.6	-1.3	0.7	0.6	0.0	-0.6	0.2
Whole body water mass	0.5	2.8	9.2	-2.2	-0.4	1.2	1.5	1.3	0.0	3.0
Leg predicted mass (right)	0.5	2.5	9.1	-1.8	0.0	1.1	1.4	1.4	0.2	3.0
Arm fat mass (left)	0.3	1.4	2.9	-1.7	-0.5	1.5	1.3	0.9	0.2	1.4
Number of self-reported non-cancer illnesses	0.8	1.4	3.3	-1.0	1.4	0.3	0.9	1.7	1.8	-0.3
Average weekly champagne plus white wine intake	0.7	1.0	2.6	-1.6	-0.7	0.2	-0.9	-0.8	-1.4	0.7
Miserableness	0.7	1.2	2.7	0.4	-0.9	0.7	1.6	1.4	1.6	0.4
Guilty feelings	1.8	2.6	5.8	-0.6	1.3	1.2	2.2	2.0	2.4	-0.6
Wears glasses or contact lenses	0.2	0.2	0.7	0.2	0.2	-0.2	-0.8	0.6	0.4	0.5
Ever taken oral contraceptive pill	0.5	0.5	1.6	-0.7	-0.1	-1.3	0.4	0.7	0.6	0.7
Hearing aid user	0.9	1.0	3.4	-0.9	1.5	0.1	0.1	-0.5	0.1	-1.9
Mother’s age at death	1.8	2.3	9.4	1.7	1.4	3.1	0.6	0.4	0.8	-0.7
Financial situation satisfaction	1.7	2.1	5.7	-1.2	0.0	-0.6	1.4	2.1	2.4	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.7	1.3	1.0	0.1	-0.4	0.3	0.4	0.4
Commuting to job workplace: Public transport	0.3	0.4	1.1	0.1	0.6	0.8	0.0	0.7	0.1	1.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	-0.5	-0.0	0.1	-0.7	0.4	0.5	-0.4
Medication: Blood pressure	1.2	2.3	4.9	-0.1	-1.7	-2.2	-1.8	-1.5	-1.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.4	-0.1	-0.8	1.2	0.2	-0.1	0.0	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.2	0.5	1.5	0.9	-0.1	-0.1	-0.1	-0.9
High cholesterol (Self-reported)	1.1	1.9	4.4	-0.4	-1.5	-2.1	-1.4	-1.8	-0.9	-0.8
Medication: Bendroflumethiazide	0.2	0.2	0.5	-0.5	-0.6	-0.7	-0.1	0.1	0.6	0.4
Medication: Paracetamol	0.3	0.5	1.8	0.2	-1.3	0.2	-0.3	-0.4	-0.3	1.2
Medication: Lisinopril	0.2	0.3	0.6	0.4	0.7	-0.1	-0.2	0.7	0.8	0.3
Medication: Atorvastatin	0.3	0.4	1.0	0.0	-0.5	-0.3	0.7	1.0	0.4	1.0
Illnesses of father: High blood pressure	1.0	1.2	3.8	2.0	-0.4	-1.5	-0.7	0.0	-1.0	1.0
Alcohol drinker status: Never	1.8	2.2	9.1	-3.0	-0.9	-0.3	-0.4	-1.3	-1.1	-1.4
Ever smoked	0.6	1.0	2.1	1.0	0.9	-1.2	-1.1	0.1	-1.4	1.0
Basal metabolic rate	0.5	2.7	8.8	-2.0	-0.5	1.5	1.5	1.3	0.0	3.0
Leg fat percentage (left)	0.2	0.6	1.6	-1.1	-1.1	1.3	0.2	-0.3	-0.2	-0.0
Arm fat-free mass (left)	0.5	2.7	8.3	-2.9	-0.7	1.0	1.3	1.1	-0.0	2.4
Number of operations (self-reported)	0.3	0.5	1.7	0.2	-0.4	-1.3	-0.5	0.7	0.0	1.0
Average weekly beer plus cider intake	0.4	0.5	1.1	-0.1	0.8	-1.0	0.2	0.9	1.0	0.1
Irritability	2.8	4.7	8.7	0.5	1.3	2.6	2.6	3.0	2.8	1.1
Risk taking	0.5	0.8	3.4	-1.2	0.5	-1.9	-0.4	-0.2	-0.5	0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.8	1.7	1.1	0.8	-0.8	-0.2	-0.4	-0.1
Fractured/broken bones in last 5 years	0.4	0.5	2.5	-1.6	0.5	-0.3	0.0	0.7	0.1	0.4
Age started oral contraceptive pill	1.1	1.3	4.4	-1.7	1.1	2.1	0.7	0.2	0.4	-0.4
Diastolic blood pressure, automated reading	0.2	0.6	1.1	0.4	0.4	-0.9	0.7	0.7	1.0	-1.1
Ever depressed for a whole week	0.8	1.0	1.9	1.1	1.4	0.7	0.6	1.1	1.1	-0.6
Unable to work because of sickness or disability	0.5	0.6	1.8	-0.6	1.3	0.2	0.6	0.2	0.7	-1.2
Commuting to job workplace: Cycle	1.0	1.2	3.1	1.0	1.8	-0.3	0.1	1.3	1.1	1.0
Myopia	0.7	1.0	1.7	1.0	1.0	-1.3	-1.1	-0.6	-1.2	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	5.5	-0.2	0.3	2.4	1.4	0.6	0.5	1.0
Cholesterol lowering medication	0.3	0.5	1.1	-0.0	-0.4	-0.8	-0.9	-1.0	-0.9	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.9	0.2	-0.6	0.2	-0.4	-0.2	-0.2	-0.9
Pain experienced in last month	0.3	0.5	1.8	1.3	-0.3	0.5	-0.5	-0.1	-0.9	0.6
Supplements: Calcium	0.5	0.6	2.5	-0.4	1.6	-0.6	-0.7	0.2	0.1	-0.7
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	0.9	-0.4	-0.7	-0.9	-0.6	-0.6	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.6	0.8	0.7	0.3	-0.3	-0.1	-0.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	4.0	1.0	1.3	2.0	1.2	0.7	0.3	1.2
Heart disease (siblings)	0.2	0.2	0.7	-0.8	0.1	0.0	-0.1	-0.1	-0.5	-0.6
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.3	-0.2	-0.1	-0.6	-0.7	-0.1	0.4
Pack years of smoking	1.0	1.4	4.1	-1.6	0.3	0.1	2.0	1.2	1.3	-0.4
Impedance of whole body	0.2	1.2	4.3	2.1	0.9	-0.2	-0.7	0.1	0.7	-1.4
Leg fat mass (left)	0.3	1.1	2.3	-1.5	-0.9	1.5	0.8	0.5	0.0	1.1
Arm predicted mass (left)	0.5	2.7	7.9	-2.8	-0.7	0.9	1.4	1.2	0.0	2.4