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chr4:85,698,680-89,152,063

Best TWAS P=3.95e-34 · Best GWAS P=5.25e-36 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HSD17B11	0.15	0.05	lasso	8	0.08	1.4e-09	-7.12	7.8	6.6e-15	0.66	0.03	0.97	TRUE
2	CommonMind	Brain Pre-frontal Cortex	HSD17B13	0.32	0.28	bslmm	424	0.29	2.8e-35	12.31	11.2	6.1e-29	0.66	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	HSD17B11	0.13	0.01	lasso	4	0.03	8.0e-03	10.89	12.0	2.5e-33	0.75	0.06	0.83	TRUE
4	GTEx	Artery Aorta	MAPK10	0.15	0.17	enet	16	0.17	1.4e-09	-6.93	6.9	4.4e-12	0.10	0.01	0.99	FALSE
5	GTEx	Artery Aorta	ARHGAP24	0.24	0.13	enet	8	0.14	2.2e-08	5.13	6.0	1.5e-09	0.10	0.96	0.04	TRUE
6	GTEx	Artery Aorta	RP13-514E23.2	0.26	0.09	lasso	6	0.10	2.2e-06	5.80	5.9	3.9e-09	0.10	0.92	0.08	FALSE
7	GTEx	Artery Tibial	ARHGAP24	0.26	0.19	enet	14	0.21	2.7e-16	5.80	5.7	1.3e-08	0.07	0.86	0.14	FALSE
8	GTEx	Artery Tibial	HSD17B11	0.24	0.10	lasso	7	0.07	4.7e-06	-3.84	5.3	1.1e-07	0.41	0.90	0.08	FALSE
9	GTEx	Artery Tibial	RP13-514E23.2	0.22	0.16	enet	10	0.18	1.2e-13	5.80	5.9	4.1e-09	0.08	0.87	0.13	FALSE
10	GTEx	Brain Cerebellar Hemisphere	HSD17B13	0.37	0.21	lasso	11	0.12	4.7e-04	12.13	10.9	1.3e-27	0.49	0.05	0.81	FALSE
11	GTEx	Brain Cerebellum	HSD17B13	0.26	0.21	lasso	4	0.18	5.8e-06	12.13	12.0	2.4e-33	0.69	0.04	0.93	FALSE
12	GTEx	Brain Cortex	HSD17B13	0.28	0.23	enet	10	0.26	8.9e-08	12.13	10.8	5.7e-27	0.59	0.05	0.89	FALSE
13	GTEx	Breast Mammary Tissue	RP11-529H2.2	0.22	0.07	enet	9	0.06	6.3e-04	9.39	9.8	1.4e-22	0.87	0.01	0.97	TRUE
14	GTEx	Breast Mammary Tissue (Female)	RP11-529H2.2	0.07	0.03	lasso	1	-0.01	8.0e-01	10.63	10.6	2.2e-26	0.90	0.03	0.30	FALSE
15	GTEx	Colon Sigmoid	MAPK10	0.25	0.11	lasso	8	0.07	1.6e-03	-6.95	5.9	3.1e-09	0.10	0.01	0.97	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	HSD17B11	0.20	-0.01	enet	28	0.02	5.7e-02	12.11	6.2	5.9e-10	0.51	0.02	0.79	FALSE
17	GTEx	Esophagus Mucosa	HSD17B11	0.09	0.04	lasso	6	0.07	2.3e-05	9.39	8.9	8.1e-19	0.69	0.26	0.58	TRUE
18	GTEx	Esophagus Mucosa	RP11-529H2.2	0.12	0.00	lasso	7	0.00	1.6e-01	9.39	6.1	1.2e-09	0.69	0.08	0.16	FALSE
19	GTEx	Esophagus Muscularis	HSD17B13	0.12	0.04	lasso	5	0.02	1.9e-02	-8.65	8.7	3.6e-18	0.72	0.07	0.21	FALSE
20	GTEx	Esophagus Muscularis	HSD17B11	0.29	0.05	enet	66	0.07	6.9e-05	10.83	6.2	4.6e-10	0.52	0.05	0.93	FALSE
21	GTEx	Lung	HSD17B13	0.07	0.01	lasso	4	0.00	1.8e-01	12.52	-10.6	2.3e-26	-0.88	0.01	0.97	FALSE
22	GTEx	Nerve Tibial	HSD17B13	0.46	0.07	lasso	9	0.27	3.6e-19	7.00	5.9	3.6e-09	0.12	0.85	0.15	FALSE
23	GTEx	Ovary	HSD17B13	0.34	0.19	enet	24	0.11	1.0e-03	12.37	9.1	7.8e-20	0.45	0.05	0.75	FALSE
24	GTEx	Pancreas	NUDT9	0.21	0.05	enet	18	0.07	1.0e-03	4.42	-7.1	1.5e-12	-0.41	0.15	0.18	FALSE
25	GTEx	Skin Sun Exposed Lower leg	HSD17B13	0.11	0.09	lasso	5	0.08	2.2e-07	10.88	-10.9	9.9e-28	-0.91	0.24	0.75	FALSE
26	GTEx	Thyroid	PTPN13	0.41	0.31	lasso	6	0.30	3.2e-23	-6.99	-7.1	1.7e-12	-0.14	1.00	0.00	TRUE
27	GTEx	Thyroid	HSD17B11	0.15	0.04	enet	16	0.05	1.6e-04	9.39	6.6	5.1e-11	0.67	0.07	0.76	TRUE
28	GTEx	Thyroid	RP11-529H2.2	0.10	0.06	lasso	5	0.04	4.4e-04	9.39	9.8	1.4e-22	0.85	0.06	0.92	FALSE
29	METSIM	Adipose	HSD17B13	0.20	0.10	bslmm	416	0.12	7.3e-18	-8.65	7.5	8.2e-14	0.60	1.00	0.00	FALSE
30	NTR	Blood	HSD17B13	0.04	0.04	bslmm	425	0.04	9.1e-14	12.37	12.2	3.9e-34	0.68	0.04	0.96	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	SPARCL1	0.17	0.11	lasso	7	0.10	6.2e-13	5.22	-5.3	1.4e-07	-0.26	1.00	0.00	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	NUDT9	0.09	0.00	bslmm	472	0.05	1.3e-06	4.42	-6.2	5.9e-10	-0.28	0.39	0.09	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	HSD17B13	0.45	0.42	lasso	9	0.46	1.2e-66	12.31	11.0	2.4e-28	0.59	0.02	0.98	FALSE
34	YFS	Blood	HSD17B13	0.24	0.19	bslmm	407	0.20	7.5e-63	12.31	11.6	5.2e-31	0.62	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD17B11	0.12	0.02	enet	16	0.06	1.7e-12	11.24	9.3	1.1e-20	0.59	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C4orf36	0.02	0.01	blup	36	0.01	3.7e-02	4.08	-5.6	1.8e-08	-0.17	0.01	0.58	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HSD17B11	0.05	0.02	enet	9	0.04	2.6e-05	-4.43	9.2	5.9e-20	0.72	0.02	0.84	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HSD17B11	0.16	0.07	blup	51	0.06	1.9e-04	-4.36	9.5	3.1e-21	0.70	0.10	0.54	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	HSD17B13	0.11	0.01	blup	43	0.07	1.3e-04	7.00	7.1	9.1e-13	0.48	0.02	0.25	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B11	0.35	0.01	enet	11	0.07	8.2e-09	-0.48	5.2	2.0e-07	0.47	0.02	0.53	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	HSD17B13	0.07	0.01	blup	43	0.03	1.7e-04	12.31	7.0	1.8e-12	0.18	0.06	0.90	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	HSD17B13	0.05	0.07	enet	8	0.07	5.4e-09	10.63	-11.0	3.0e-28	-0.91	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD17B11	0.06	0.02	blup	51	0.05	2.2e-04	12.52	9.1	1.4e-19	0.83	0.00	0.88	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	HSD17B11	0.04	0.03	blup	50	0.00	3.3e-01	-4.47	5.7	9.6e-09	0.57	0.06	0.23	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B11	0.14	0.11	blup	51	0.16	7.0e-15	10.63	7.1	1.4e-12	0.70	0.45	0.55	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	HSD17B13	0.04	0.01	blup	43	0.02	3.2e-03	1.88	-6.7	2.0e-11	-0.79	0.02	0.59	TRUE