TWAS hub - HPGDS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0629	0.0234	1.9e-05	0.047	0.032	0.038	0.033	0.045	8.8e-07	5.4e-05	1.0e-05	3.3e-05	1.8e-06
2	TCGA	Prostate Adenocarcinoma	0.0728	0.0400	7.7e-09	0.084	0.096	0.090	NA	0.086	3.9e-09	2.8e-10	1.2e-09	NA	2.5e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Relative age voice broke	17.8	27.2	31.5	-5.6	-4.8
Age when periods started (menarche)	15.5	37.3	42.8	-5.6	-6.5
Relative age of first facial hair	12.3	25.4	27.9	-5.3	-4.8
Wheeze or whistling in the chest in last year	6.9	12.3	13.7	3.7	3.3
Chronic bronchitis/emphysema (father)	6.8	8.0	8.2	2.9	2.8
Bipolar Disorder (2011)	5.9	5.7	6.6	-2.6	-2.2
Qualifications: None of the above	5.5	11.7	12.7	3.6	3.3
Commuting to job workplace: Walk	5.4	5.8	6.6	2.6	2.2
Risk taking	5.3	7.8	8.2	-2.7	-2.9
Overall health rating	5.2	11.1	12.5	3.5	3.1
Medication: Atorvastatin	4.8	5.9	6.0	2.4	2.5
Medication: Amlodipine	4.4	6.2	6.8	2.6	2.4
Qualifications: College or University degree	4.4	13.9	17.5	-4.2	-3.2
Illnesses of father: High blood pressure	4.1	5.1	6.1	2.0	2.5
Friendships satisfaction	4.0	5.0	5.5	-2.1	-2.4
Pack years adult smoking proportion	3.8	5.8	6.2	2.5	2.3
Diverticular disease/diverticulitis (self-reported)	3.6	4.2	4.4	2.0	2.1
Hypertension (Self-reported)	3.6	9.9	10.1	3.1	3.2
Medication: Blood pressure	3.5	6.7	7.7	2.8	2.4
Pain type(s) experienced in last month: Hip pain	3.5	4.4	5.9	1.7	2.4
Schizophrenia (2014)	3.4	7.5	7.8	-2.8	-2.7
Back pain experienced in last month	3.4	4.9	5.5	2.3	2.1
Mouth/teeth dental problems	3.3	5.1	5.3	-2.2	-2.3
Cardiovascular Disease	3.2	10.6	11.7	3.1	3.4
Exposure to tobacco smoke outside home	3.2	4.2	5.4	1.8	2.3
Crohns Disease (2012)	3.1	5.0	5.0	-2.2	-2.2
Fasting Glucose	3.0	3.6	3.9	1.8	2.0
Leg fat percentage (left)	3.0	10.9	12.2	3.5	3.1
Unable to work because of sickness or disability	3.0	3.9	4.8	2.2	1.7
Rheumatoid Arthritis	2.9	4.0	4.6	-1.8	-2.1
Mouth/teeth dental problems: Dentures	2.9	4.9	5.1	2.2	2.3
Prospective memory result	2.8	3.5	4.0	2.0	1.7
Mouth/teeth dental problems: Loose teeth	2.8	3.3	4.0	1.6	2.0
Pulse rate, automated reading	2.8	9.0	9.8	2.9	3.1
Average weekly red wine intake	2.8	4.2	6.0	-2.5	-1.5
Medication for cholesterol	2.8	4.2	5.3	-2.3	-1.7
Illnesses of father: None of the above (group 1)	2.8	3.5	4.0	-2.0	-1.7
High blood pressure	2.7	7.4	7.9	2.6	2.8
Bipolar Disorder or Schizophrenia	2.6	6.3	6.7	-2.4	-2.6
Tense / ‘highly strung’	2.6	4.2	4.8	-2.2	-1.9
Leg fat percentage (right)	2.5	9.0	10.2	3.2	2.8
Hearing aid user	2.5	2.8	3.2	1.8	1.6
Pack years of smoking	2.5	3.6	4.2	2.0	1.7
Leg fat mass (left)	2.5	9.9	10.2	3.2	3.1
Blood Platelet Count	2.4	27.4	27.4	5.2	5.2
Medication: Bendroflumethiazide	2.4	3.6	4.4	2.1	1.7
Irritability	2.4	4.1	4.6	-2.1	-1.9
Primary Biliary Cirrhosis	2.3	3.3	4.7	-2.2	-1.4
Neuroticism	2.3	5.5	7.8	-2.8	-1.8
Hand grip strength (left)	2.3	5.9	7.1	-2.7	-2.2
High blood pressure (mother)	2.3	3.2	4.6	1.4	2.1
Comparative height size at age 10	2.3	12.9	13.1	3.6	3.6
Ever had bowel cancer screening	2.3	2.7	4.0	2.0	1.2
Mouth/teeth dental problems: Mouth ulcers	2.3	3.7	4.8	1.6	2.2
Vascular/heart problems diagnosed by doctor	2.3	6.2	7.0	-2.6	-2.3
Medication: Atenolol	2.2	2.8	3.3	1.5	1.8
Medication: Ibuprofen	2.2	2.6	4.6	-2.2	-0.8
Leg fat mass (right)	2.2	8.4	8.9	3.0	2.8
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	4.5	-0.9	-2.1
Ever taken oral contraceptive pill	2.2	2.5	2.8	-1.5	-1.7
Diastolic blood pressure, automated reading	2.2	6.7	6.8	2.6	2.6
Wears glasses or contact lenses	2.1	2.4	3.6	1.1	1.9
Bipolar Disorder (2018)	2.0	3.1	3.3	-1.8	-1.7
Reaction Time	2.0	3.7	5.4	1.4	2.3
LDL Cholesterol	2.0	3.1	3.5	-1.7	-1.9
Medication: Paracetamol	2.0	3.2	4.4	2.1	1.4
Mean time to correctly identify matches	1.9	3.6	4.6	1.6	2.1
Happiness	1.8	2.1	3.6	-1.9	-0.9
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	3.5	-1.9	-1.5
Irritable Bowel Disease (IBD)	1.7	4.0	4.7	-1.8	-2.2
HDL Cholesterol	1.7	2.9	3.9	1.3	2.0
Hand grip strength (right)	1.7	4.6	5.7	-2.4	-1.9
Hearing difficulty/problems with background noise	1.7	2.7	2.9	1.7	1.6
Pulse rate	1.7	2.8	3.4	1.5	1.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	3.0	-1.7	-1.5
Comparative body size at age 10	1.7	4.6	5.5	1.9	2.3
Medication: Blood pressure	1.7	2.9	3.4	1.8	1.6
Smoking status: Current	1.7	2.7	3.2	1.8	1.5
Mother’s age at death	1.7	2.2	2.3	-1.5	-1.4
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.6	1.2	1.6
Current tobacco smoking	1.6	2.6	3.3	1.8	1.4
Waist circumference	1.6	6.0	6.3	2.5	2.4
Body fat percentage	1.6	6.5	7.6	2.8	2.3
Schizophrenia (2018)	1.5	3.2	3.8	-1.6	-1.9
Medication: Co-codamol	1.5	1.7	2.6	1.6	0.9
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.7	1.1	1.6
Serious illness, injury or assault to yourself	1.4	1.7	2.1	-1.1	-1.4
Neuroticism score	1.4	3.0	4.7	-2.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.1	-1.8	-0.7
High blood pressure (siblings)	1.4	2.0	2.4	1.6	1.3
Medication: Lisinopril	1.4	1.8	3.7	-0.2	-1.9
Type 2 Diabetes (T2D) (2018)	1.3	2.5	2.6	1.5	1.6
Trunk fat percentage	1.3	5.2	6.3	2.5	2.0
Number of incorrect matches in round	1.3	2.1	2.3	-1.4	-1.5
Suffer from ‘nerves’	1.3	2.1	2.7	1.2	1.6
Osteoporosis (self-reported)	1.3	1.6	1.7	1.3	1.2
Heart disease (siblings)	1.3	1.6	2.0	1.4	1.1
Body Mass Index (BMI) (2010)	1.2	1.6	1.9	1.4	1.2
HbA1C	1.2	1.3	1.8	0.9	1.3
Systolic blood pressure, automated reading	1.2	3.5	3.6	1.9	1.8
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.1	1.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.3	0.7	1.5
Ever highly irritable/argumentative for 2 days	1.2	1.4	1.7	-1.3	-1.0
Whole body fat mass	1.2	5.0	5.6	2.4	2.1
Smoking status: Previous	1.2	1.8	2.6	-1.6	-1.0
Long-standing illness, disability or infirmity	1.2	1.8	3.1	1.8	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	1.8	-1.3	-0.9
Breast cancer (self-reported)	1.2	1.4	2.3	0.7	1.5
Ovarian Cancer	1.1	1.4	2.5	0.6	1.6
Waist Hip Ratio (WHR)	1.1	5.1	7.1	2.7	1.7
Trunk fat mass	1.1	4.6	5.3	2.3	2.0
Heart attack	1.1	1.4	2.2	-0.8	-1.5
Medication: Ramipril	1.1	1.4	1.5	1.2	1.2
Birth weight of first child	1.1	2.0	2.3	1.5	1.3
Guilty feelings	1.1	1.7	2.9	-1.7	-0.7
Commuting to job workplace: Public transport	1.1	1.4	2.0	0.9	1.4
Medication: Paracetamol	1.1	1.7	2.4	1.6	1.0
Diabetes (mother)	1.0	1.3	2.1	0.8	1.4
Illnesses of siblings	1.0	1.4	1.4	-1.2	-1.2
Time employed in main current job	1.0	1.1	1.7	1.3	0.8
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.5	-1.0	-1.2
Average weekly champagne plus white wine intake	1.0	1.3	2.2	1.5	0.6
Ulcerative Colitis (UC)	0.9	1.6	1.7	-1.3	-1.3
Breast Cancer	0.9	2.1	2.4	-1.6	-1.3
Lung FEV1/FVC ratio	0.9	4.6	4.7	2.2	2.1
Body mass index (BMI)	0.9	4.0	4.1	2.0	2.0
Had other major operations	0.9	1.2	1.7	0.8	1.3
Pain all over the body in last month	0.9	1.0	1.4	1.2	0.7
Arm fat percentage (right)	0.9	3.7	4.3	2.1	1.8
Illnesses of mother	0.9	1.2	1.3	-1.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.9	1.2	1.3	1.1	1.0
Arm fat percentage (left)	0.9	3.6	4.1	2.0	1.8
Medication: Aspirin	0.9	1.2	2.0	1.4	0.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.7	-1.3	-0.5
Supplements: Calcium	0.9	1.0	1.4	-0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	1.7	1.3	0.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.4	-1.2	-0.7
Lung cancer (father)	0.8	0.9	1.3	-1.1	-0.7
Arm fat mass (right)	0.8	3.3	3.3	1.8	1.8
Chest pain or discomfort	0.8	1.1	1.4	1.2	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.2	-1.1	-0.8
Arm fat mass (left)	0.8	3.3	3.4	1.8	1.8
Financial situation satisfaction	0.8	1.0	1.1	-0.9	-1.0
Ever depressed for a whole week	0.8	1.0	1.7	-1.3	-0.6
Cholesterol lowering medication	0.8	1.2	1.8	1.3	0.8
Heart attack/myocardial infarction (self-reported)	0.8	1.1	1.6	-0.7	-1.3
Crohns Disease (2017)	0.7	1.5	1.9	-1.0	-1.4
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.1	1.0	1.5
Systolic Blood Pressure	0.7	3.7	4.5	1.7	2.1
Diabetes (father)	0.7	0.9	1.7	0.0	-1.3
Past tobacco smoking	0.7	1.2	1.8	1.3	0.8
Medication: Lansoprazole	0.7	0.8	1.1	-1.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.1	-1.0	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	1.1	1.0	0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.0	-1.0	-0.8
Medication: Aspirin	0.7	0.9	1.6	1.3	0.5
Mood swings	0.7	1.2	2.2	0.4	1.5
Loneliness, isolation	0.7	1.0	1.3	0.9	1.2
Osteoarthritis (self-reported)	0.7	0.9	1.2	1.1	0.8
Prostate Cancer	0.6	0.8	1.0	-0.8	-1.0
Age at First Birth	0.6	0.9	1.0	0.9	1.0
Heel T-Score	0.6	5.0	9.8	-0.4	-3.1
BMI	0.6	3.4	3.7	1.7	1.9
Respiratory disease	0.6	1.4	1.9	1.4	0.9
Sensitivity / hurt feelings	0.6	1.1	1.8	-1.3	-0.6
Vitamin and mineral supplements	0.6	0.9	0.9	1.0	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.2	-0.6	-1.1
Blood clot in the leg (DVT)	0.6	0.8	1.1	-0.7	-1.0
Diabetes diagnosed by doctor	0.6	1.1	1.6	1.2	0.8
Commuting to job workplace: Cycle	0.6	0.7	1.1	-1.0	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.1	-0.5	-1.1
Blood Eosinophil Count	0.5	4.0	5.5	-2.3	-1.6
Number of treatments/medications taken	0.5	1.0	1.7	1.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.7	0.8	0.7
Worrier / anxious feelings	0.5	0.9	1.5	0.5	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	0.9	1.0	0.9
Number of live births	0.5	0.7	0.9	0.8	0.9
Medication: Cholesterol lowering	0.5	0.8	0.9	0.9	0.8
Worry too long after embarrassment	0.5	0.8	1.3	-1.2	-0.6
Leg pain on walking	0.5	0.6	0.9	1.0	0.5
Miserableness	0.5	0.9	1.1	-1.1	-0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.8	-0.8	-0.9
Average weekly beer plus cider intake	0.5	0.8	1.1	0.7	1.0
Worry (Nagel 2018)	0.4	0.9	1.6	-1.3	-0.5
Alzheimer’s Disease (in father)	0.4	0.5	0.8	0.3	0.9
Alzheimer’s Disease (including proxy)	0.4	0.7	0.8	0.7	0.9
Major Depression (MDD)	0.4	0.4	0.7	-0.8	-0.4
Triglycerides	0.4	0.7	1.1	-0.6	-1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.7	0.4	0.8
Ulcerative Colitis	0.4	0.5	0.9	-0.9	-0.4
Height	0.4	7.1	9.2	-2.3	-3.0
Average weekly fortified wine intake	0.4	0.5	0.5	0.7	0.7
Impedance of leg (left)	0.4	2.1	3.0	1.7	1.1
Medication: Simvastatin	0.4	0.6	1.0	1.0	0.3
Depression (self-reported)	0.4	0.5	0.8	0.9	0.3
Impedance of arm (left)	0.4	1.7	3.0	-0.6	-1.7
Standing height	0.4	3.8	4.0	-1.9	-2.0
Loud music exposure frequency	0.4	0.4	0.7	-0.4	-0.8
Health satisfaction	0.4	0.5	0.7	-0.8	-0.6
Medication for pain relief, constipation, heartburn	0.4	0.8	0.8	-0.9	-0.8
Migraine (self-reported)	0.4	0.5	0.5	-0.7	-0.7
Medication: Allopurinol	0.4	0.5	0.5	0.7	0.7
Qualifications: nursing, teaching	0.4	0.5	0.9	-0.9	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.8	0.9	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	-0.5	-0.9
Neuroticism (Nagel 2018)	0.3	0.8	1.4	-1.2	-0.4
Qualifications: CSEs or equivalent	0.3	0.4	0.6	0.6	0.7
Had menopause	0.3	0.4	0.5	-0.5	-0.7
Diabetes (self-reported)	0.3	0.5	0.9	1.0	0.3
Weight	0.3	1.3	1.3	1.1	1.1
Impedance of arm (right)	0.3	1.6	3.0	-0.4	-1.7
Alcohol intake versus 10 years previously	0.3	0.4	0.7	0.8	-0.3
Length of working week for main job	0.3	0.3	0.5	-0.3	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	0.9	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.2	0.8
Age at first live birth	0.3	0.5	0.5	-0.7	-0.7
Heart disease (mother)	0.3	0.4	0.6	0.8	0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.5	-0.7	-0.6
Mineral and other dietary supplements	0.3	0.4	0.6	0.3	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.5	0.5	0.7
Pain experienced in last month	0.3	0.5	0.6	-0.7	-0.8
Depression (Nagel 2018)	0.2	0.2	0.3	0.4	0.6
Mean Putamen Volume	0.2	0.2	0.2	0.5	-0.5
Lupus	0.2	0.3	0.6	-0.8	-0.2
Allergy or Eczema	0.2	0.6	1.1	0.1	-1.1
Hypothyroidism (self reported)	0.2	0.4	0.7	0.4	0.8
Chronotype (morning person)	0.2	0.4	0.8	-0.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.5	0.3
Medication for hormone replacement therapy	0.2	0.3	0.4	0.7	0.3
Supplements: Zinc	0.2	0.2	0.4	0.7	0.2
Impedance of leg (right)	0.2	0.9	1.6	1.3	0.4
Maternal smoking around birth	0.2	0.3	0.3	-0.5	-0.6
Taking other prescription medications	0.2	0.3	0.7	0.1	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	-0.5	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.1	-0.9
Multivitamins +/- minerals	0.2	0.3	0.3	-0.6	-0.5
Financial difficulties in last 2 years	0.2	0.2	0.5	-0.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.8	0.0
Hip circumference	0.2	0.8	1.2	0.6	1.1
Father’s age at death	0.2	0.3	0.5	-0.7	-0.1
Hair/balding pattern: Pattern 4	0.2	0.5	0.6	0.7	0.8
Pulse wave reflection index	0.2	0.3	0.6	0.1	0.7
Headache pain in last month	0.2	0.4	0.7	0.3	0.8
Glaucoma (self-reported)	0.2	0.2	0.3	-0.6	0.1
Forced vital capacity (FVC), Best measure	0.2	0.9	1.0	-1.0	-0.9
Number of full brothers	0.2	0.2	0.5	0.0	-0.7
Pulse wave peak to peak time	0.2	0.2	0.2	-0.4	-0.5
Shortness of breath walking on level ground	0.2	0.3	0.4	0.6	-0.3
Alcohol intake frequency.	0.2	0.6	1.1	1.0	-0.2
Illnesses of father: Heart disease	0.2	0.3	0.4	0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.5	-0.7	-0.7
Eye problems/disorders: Cataract	0.2	0.3	0.5	0.7	0.2
Medication: Gliclazide	0.2	0.3	0.3	-0.6	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.2	-0.4	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.3	0.6
High cholesterol (Self-reported)	0.2	0.3	0.5	0.7	0.5
Alcohol drinker status: Never	0.2	0.2	0.2	0.4	-0.5
Ever smoked	0.2	0.3	0.6	-0.8	-0.3
Number of operations (self-reported)	0.2	0.3	0.5	0.3	0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.7	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.6	0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	0.3	0.3
Neuroticism (2016)	0.1	0.1	0.2	-0.4	0.0
Blood Red Count	0.1	1.3	2.6	-0.2	-1.6
Smoking Status	0.1	0.2	0.3	0.2	0.5
Lung FVC	0.1	0.7	0.7	0.9	0.8
Tanning	0.1	1.5	2.5	1.6	0.7
Average weekly spirits intake	0.1	0.2	0.2	-0.4	-0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.1	0.3	0.3
Angina	0.1	0.2	0.4	0.6	-0.0
Medication: Metformin	0.1	0.1	0.1	0.3	0.4
Severe depression (siblings)	0.1	0.1	0.3	0.5	-0.1
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.0	0.5
Fed-up feelings	0.1	0.2	0.3	-0.2	0.6
Stomach or abdominal pain in last month	0.1	0.2	0.2	-0.5	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.5	0.2
Alcohol usually taken with meals	0.1	0.2	0.2	-0.5	-0.3
Nervous feelings	0.1	0.1	0.2	-0.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.1	0.7
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.2	-0.8
Allergy	0.1	0.1	0.3	-0.5	0.1
Fluid intelligence score	0.1	0.1	0.2	-0.5	-0.0
Falls in the last year	0.1	0.1	0.1	-0.1	-0.4
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	-0.1	-0.4
Noisy workplace	0.1	0.1	0.2	0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.3	-0.5	0.1
Asthma	0.1	0.1	0.2	0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.7	-0.3
Peak expiratory flow (PEF)	0.1	0.3	0.3	-0.5	0.5
Gout (self-reported)	0.1	0.1	0.1	0.2	0.4
Birth weight	0.1	0.3	0.4	0.6	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.2	0.4
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.2	-0.3
Angina (self-reported)	0.1	0.2	0.3	0.6	-0.1
Arm predicted mass (right)	0.1	0.3	0.6	0.1	0.8
Number of full sisters	0.1	0.1	0.2	-0.5	-0.0
Had major operations	0.1	0.1	0.3	-0.1	-0.5
Age at last live birth	0.1	0.2	0.3	-0.6	-0.3
Family relationship satisfaction	0.1	0.1	0.2	-0.4	0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	0.4	-0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	0.2
Arm fat-free mass (left)	0.1	0.3	0.6	0.2	0.8
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	-0.5
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.0	0.5
Arm predicted mass (left)	0.1	0.4	0.7	0.4	0.8
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.1	0.2	0.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.1	0.2
Blood White Count	0.0	0.0	0.0	0.2	0.2
Hair Pigment	0.0	0.7	1.0	-1.0	-0.6
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.1	-0.1
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.0	-0.3
Leg fat-free mass (left)	0.0	0.0	0.1	-0.3	0.1
Supplements: Glucosamine	0.0	0.0	0.1	0.0	-0.3
Sitting height	0.0	0.3	0.4	-0.4	-0.6
Leg predicted mass (left)	0.0	0.0	0.0	-0.2	0.2
Forced vital capacity (FVC)	0.0	0.1	0.2	-0.4	-0.3
Trunk fat-free mass	0.0	0.2	0.5	-0.7	-0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.0	0.0	-0.2	0.2
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.1	0.2
Trunk predicted mass	0.0	0.3	0.5	-0.7	-0.1
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.2	0.1
Breastfed as a baby	0.0	0.0	0.0	-0.1	0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.1	0.2
Arm fat-free mass (right)	0.0	0.2	0.4	0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.3	-0.2
Number of children fathered	0.0	0.1	0.1	0.2	-0.2
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.0	-0.2
Medication: Omeprazole	0.0	0.0	0.0	-0.1	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	-0.2	-0.2
Supplements: Vitamin C	0.0	0.0	0.1	-0.3	-0.1
Knee pain experienced in last month	0.0	0.0	0.0	0.2	0.1
Whole body fat-free mass	0.0	0.1	0.2	-0.4	0.2
Leg fat-free mass (right)	0.0	0.1	0.1	-0.4	0.2
Asthma (self-reported)	0.0	0.1	0.1	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.3	0.1
Whole body water mass	0.0	0.1	0.2	-0.4	0.2
Leg predicted mass (right)	0.0	0.1	0.1	-0.3	0.2
Basal metabolic rate	0.0	0.1	0.2	-0.0	0.4
Myopia	0.0	0.0	0.1	-0.1	-0.3
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.2	-0.0
Impedance of whole body	0.0	0.2	0.3	0.4	-0.5

Hub : Genes

HPGDS

Models

Trait associations