Best TWAS P=2.34e-14 · Best GWAS P=6.37e-19 conditioned to 3.59e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ALKBH3 | 0.20 | 0.17 | lasso | 6 | 0.19 | 2.9e-22 | -5.9 | -6.3 | 3.8e-10 | 0.75 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | ALKBH3 | 0.31 | 0.06 | lasso | 6 | 0.06 | 1.1e-02 | -5.9 | -7.6 | 2.3e-14 | 0.88 | 0.01 | 0.96 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | ALKBH3 | 0.40 | 0.04 | enet | 43 | 0.06 | 1.0e-02 | -8.7 | -5.5 | 2.9e-08 | 0.64 | 0.01 | 0.92 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | ALKBH3 | 0.13 | 0.08 | enet | 18 | 0.11 | 3.9e-14 | -8.9 | -7.2 | 4.4e-13 | 0.81 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | ALKBH3 | 0.23 | 0.00 | blup | 94 | 0.10 | 6.7e-04 | -2.7 | -5.7 | 1.6e-08 | 0.53 | 0.03 | 0.33 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ALX4 | 0.04 | 0.01 | lasso | 4 | 0.01 | 1.3e-02 | 7.2 | 6.8 | 1.4e-11 | 0.03 | 0.00 | 0.96 | TRUE |