TWAS hub - ALX4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1060	0.0260	1.2e-06	0.031	0.039	0.046	0.052	0.055	0.0001	1.3e-05	2.4e-06	6.4e-07	3.1e-07
2	TCGA	Prostate Adenocarcinoma	0.0352	0.0175	8.0e-03	0.009	0.012	0.008	NA	0.014	0.0380	1.6e-02	4.5e-02	NA	1.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Relative age of first facial hair	17.1	35.2	70.4	0.1	8.4
Relative age voice broke	7.3	11.2	22.4	-0.2	4.7
Back pain experienced in last month	4.9	7.1	12.4	3.5	-1.3
Average weekly spirits intake	4.0	4.9	7.0	1.7	-2.6
Hair/balding pattern: Pattern 4	4.0	9.8	14.2	-3.8	2.3
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	6.0	2.3	-2.5
Time employed in main current job	3.4	4.0	7.1	-0.9	2.7
Medication: Atenolol	3.2	4.0	6.4	1.3	2.5
Friendships satisfaction	3.2	3.9	5.5	-2.3	1.5
Alcohol drinker status: Previous	3.1	3.6	6.7	2.6	-0.7
Shortness of breath walking on level ground	3.0	3.5	5.6	2.4	-1.2
Eye problems/disorders: Cataract	2.9	3.3	6.1	0.7	-2.5
Type 2 Diabetes (T2D) (2012)	2.8	3.2	5.5	1.0	2.3
Average weekly fortified wine intake	2.8	3.3	4.0	2.0	-1.6
Osteoporosis (self-reported)	2.7	3.3	4.5	2.1	-1.5
Financial difficulties in last 2 years	2.6	3.5	4.9	2.2	-1.4
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	3.2	1.8	-1.8
Smoking status: Current	2.5	4.0	7.9	-0.2	2.8
Supplements: Calcium	2.5	2.8	4.5	1.0	-2.1
Medication: Co-codamol	2.4	2.7	4.2	1.1	-2.1
Current tobacco smoking	2.3	3.8	7.7	0.0	2.8
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	4.8	-2.2	0.2
Osteoarthritis (self-reported)	2.3	3.0	5.8	0.6	-2.4
Family relationship satisfaction	2.2	2.8	5.5	-2.3	0.3
Ever had bowel cancer screening	2.2	2.6	4.9	-0.5	-2.2
Pain type(s) experienced in last month: Hip pain	2.1	2.6	3.1	1.8	-1.5
Leg fat mass (left)	2.1	8.0	9.9	3.1	-2.5
Alzheimer’s Disease (in father)	2.0	2.2	4.0	-2.0	0.6
Depression (self-reported)	2.0	2.4	4.7	-0.0	2.2
Chest pain or discomfort	2.0	2.8	5.3	2.3	-0.6
Chronic bronchitis/emphysema (mother)	1.9	2.3	3.6	-1.9	0.9
Migraine (self-reported)	1.9	2.3	4.5	0.4	-2.1
Leg fat mass (right)	1.9	7.5	9.4	3.1	-2.4
Had other major operations	1.8	2.2	3.9	-0.7	2.0
Happiness	1.8	2.1	3.4	-1.9	0.9
Arm predicted mass (right)	1.8	9.0	16.6	4.1	-1.2
Medication: Bendroflumethiazide	1.8	2.7	5.2	2.3	-0.4
Sitting height	1.7	12.1	23.9	4.9	-0.5
Weight	1.7	8.2	12.3	3.5	-2.0
Arm fat-free mass (right)	1.7	8.7	16.0	4.0	-1.2
Whole body fat mass	1.7	6.9	8.8	3.0	-2.2
Wears glasses or contact lenses	1.7	1.9	3.8	1.9	0.2
Hip circumference	1.6	6.8	9.1	3.0	-2.1
Comparative height size at age 10	1.6	8.9	13.0	3.6	-2.2
Tinnitus: Yes, now most or all of the time	1.6	1.9	2.3	-1.2	1.5
Lung FVC	1.5	7.5	12.2	-3.5	1.7
Leg fat-free mass (left)	1.5	7.8	13.6	3.7	-1.4
Age when periods started (menarche)	1.5	3.6	5.0	-1.5	2.2
Leg predicted mass (left)	1.5	8.0	14.0	3.7	-1.5
Waist circumference	1.5	5.6	6.4	2.5	-2.2
Illnesses of siblings	1.5	2.1	2.6	1.3	-1.6
Medication: Cholesterol lowering	1.5	2.4	3.9	2.0	-0.9
Pulse wave Arterial Stiffness index	1.5	1.7	2.9	1.7	-0.7
Breastfed as a baby	1.5	1.9	2.6	-1.6	1.1
High blood pressure (siblings)	1.5	2.2	3.4	-1.9	1.0
Age at last live birth	1.5	2.2	4.4	0.0	2.1
Leg predicted mass (right)	1.5	7.9	13.6	3.7	-1.5
Financial situation satisfaction	1.5	1.8	2.8	-1.7	-0.9
Illnesses of father: High blood pressure	1.5	1.9	2.2	-1.5	1.2
Basal metabolic rate	1.5	8.3	15.1	3.9	-1.2
Arm fat-free mass (left)	1.5	7.5	14.2	3.8	-0.9
Myopia	1.5	2.1	3.9	-2.0	0.6
Arm predicted mass (left)	1.5	7.9	14.6	3.8	-1.1
Age at First Birth	1.4	2.0	3.0	1.7	1.0
Angina	1.4	1.8	3.1	1.8	-0.7
Medication: Levothyroxine sodium	1.4	2.4	4.5	-0.4	2.1
Trunk fat mass	1.4	6.2	7.7	2.8	-2.2
Leg fat-free mass (right)	1.4	7.6	13.0	3.6	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	2.3	-1.5	-1.4
Leg fat percentage (left)	1.4	4.9	6.4	1.9	-2.5
Unable to work because of sickness or disability	1.4	1.8	2.0	1.4	-1.2
Ulcerative Colitis (UC)	1.3	2.4	3.0	1.3	-1.7
Angina (self-reported)	1.3	1.7	3.0	1.7	-0.7
Whole body fat-free mass	1.3	7.5	14.2	3.8	-0.9
Medication: Gliclazide	1.3	1.5	2.9	1.7	0.3
Whole body water mass	1.3	7.5	14.1	3.8	-0.9
Commuting to job workplace: Public transport	1.3	1.6	2.0	-1.1	1.4
Eye problems/disorders: Glaucoma	1.3	1.5	2.8	1.7	0.4
Coronary Artery Disease (CAD)	1.2	1.4	2.8	-1.7	0.1
LDL Cholesterol	1.2	1.9	2.9	-0.9	1.7
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.6	0.5	-1.6
Chronic bronchitis/emphysema (father)	1.2	1.4	2.2	-1.5	0.8
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.1	-1.0	1.4
Trunk fat-free mass	1.2	6.9	13.5	3.7	-0.6
Falls in the last year	1.2	1.6	2.4	0.9	-1.5
Trunk predicted mass	1.2	6.7	13.2	3.6	-0.5
Exposure to tobacco smoke at home	1.2	1.4	2.3	1.5	-0.6
Medication: Paracetamol	1.2	2.0	3.8	-0.3	-1.9
Glaucoma (self-reported)	1.2	1.4	2.4	0.5	1.6
Leg fat percentage (right)	1.2	4.5	5.3	1.9	-2.3
Health satisfaction	1.2	1.6	1.6	-1.3	1.3
Pain experienced in last month	1.2	2.0	3.1	-1.7	1.0
Pack years of smoking	1.2	1.7	2.2	1.5	-1.1
Fasting Glucose	1.1	1.4	2.1	0.8	-1.5
Arm fat mass (right)	1.1	4.5	5.6	2.4	-1.8
Body fat percentage	1.1	4.2	4.9	1.9	-2.2
Pulse rate, automated reading	1.1	3.4	5.9	2.4	-1.0
Loneliness, isolation	1.1	1.5	2.9	1.7	-0.3
Medication: Aspirin	1.1	1.5	2.3	1.5	0.8
Illnesses of father: None of the above (group 1)	1.1	1.4	2.6	1.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	3.9	-0.7	2.0
Risk taking	1.1	1.7	3.2	-1.8	-0.5
Bipolar Disorder (2018)	1.0	1.6	2.6	-0.8	1.6
Lung FEV1/FVC ratio	1.0	5.2	6.0	-2.1	2.4
Trunk fat percentage	1.0	3.9	4.2	1.9	-2.0
Taking other prescription medications	1.0	1.6	3.1	1.8	0.2
Body mass index (BMI)	1.0	4.3	4.9	2.2	-1.9
Alcohol usually taken with meals	1.0	1.6	2.9	-1.7	0.6
Suffer from ‘nerves’	1.0	1.6	3.2	1.8	-0.2
Medication: Aspirin	1.0	1.3	2.3	1.5	0.5
Long-standing illness, disability or infirmity	1.0	1.5	3.0	1.7	0.3
Mother’s age at death	1.0	1.3	1.9	-1.4	0.8
Qualifications: CSEs or equivalent	0.9	1.1	1.2	1.0	-1.1
Mouth/teeth dental problems: Dentures	0.9	1.6	3.1	0.2	-1.8
Loud music exposure frequency	0.9	0.9	1.6	-0.5	-1.3
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.5	-1.0	1.6
Pulse wave peak to peak time	0.9	1.0	1.7	-1.3	0.6
Medication: Ibuprofen	0.9	1.1	2.2	-1.5	0.2
Breast cancer (self-reported)	0.9	1.1	1.7	1.3	-0.7
Average weekly beer plus cider intake	0.9	1.2	2.5	-1.6	0.1
Cholesterol lowering medication	0.9	1.4	2.7	0.3	1.6
Bipolar Disorder (2011)	0.8	0.7	1.5	-1.2	0.0
Allergy or Eczema	0.8	2.1	2.5	1.3	1.6
Chronotype (morning person)	0.8	1.8	3.3	-1.8	0.5
Hair Pigment	0.8	23.4	45.7	-1.1	6.8
Number of treatments/medications taken	0.8	1.5	2.4	1.5	-0.7
Impedance of arm (right)	0.8	3.7	7.1	-2.7	0.6
Pulse rate	0.8	1.3	1.7	1.0	1.3
Noisy workplace	0.8	1.0	1.4	0.7	-1.2
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.8	0.9	-1.7
Length of working week for main job	0.8	0.8	1.0	-1.0	0.8
Peak expiratory flow (PEF)	0.8	1.9	3.6	-1.9	0.5
Birth weight	0.8	1.7	3.3	-1.8	-0.3
Medication: Seretide 50 evohaler	0.8	1.0	1.5	1.2	0.6
Had major operations	0.8	1.0	1.9	-0.0	1.4
Knee pain experienced in last month	0.8	1.3	1.5	1.0	-1.2
Smoking status: Previous	0.8	1.2	1.5	-0.9	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.6	1.2	-0.6
Arm fat mass (left)	0.8	3.3	4.1	2.0	-1.6
Ever taken oral contraceptive pill	0.8	0.8	1.1	-0.8	1.0
Number of operations (self-reported)	0.8	1.2	1.8	-1.3	0.8
Age started oral contraceptive pill	0.8	1.0	1.9	0.2	1.4
HbA1C	0.7	0.8	0.8	0.9	-0.9
Schizophrenia (2014)	0.7	1.6	2.4	-0.9	1.5
Pack years adult smoking proportion	0.7	1.0	1.1	1.1	-0.9
Pain all over the body in last month	0.7	0.7	1.4	0.0	-1.2
Hair/balding pattern: Pattern 3	0.7	1.0	1.8	-0.5	-1.3
Impedance of arm (left)	0.7	3.2	6.2	-2.5	0.5
Emphysema/chronic bronchitis	0.7	0.8	0.9	1.0	-0.8
Heart disease (mother)	0.7	0.8	1.6	0.3	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.3	1.5	-0.6
Arm fat percentage (left)	0.7	2.7	3.8	1.2	-1.9
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.2	0.7	-1.1
Miserableness	0.7	1.3	1.6	-1.0	1.3
Hearing aid user	0.7	0.8	0.9	0.9	-0.9
High cholesterol (Self-reported)	0.7	1.3	1.8	1.3	-0.9
Medication: Paracetamol	0.7	1.0	1.2	-1.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.6	-1.2	-0.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	1.1	-0.4
Irritable Bowel Disease (IBD)	0.6	1.4	2.2	1.5	-0.7
Reaction Time	0.6	1.2	2.2	1.5	0.4
Ovarian Cancer	0.6	0.7	1.2	0.5	1.1
Crohns Disease (2012)	0.6	1.0	1.7	-0.5	1.3
Hypothyroidism (self reported)	0.6	1.4	2.7	-0.2	1.6
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	0.6	-1.1
Number of incorrect matches in round	0.6	1.0	2.0	-0.3	1.4
Mouth/teeth dental problems	0.6	0.9	1.7	0.4	1.3
Medication: Simvastatin	0.6	0.8	1.6	1.3	-0.1
Worrier / anxious feelings	0.6	1.1	1.9	0.5	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.4	-1.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.7	-1.3	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.4	0.3	-1.2
Number of full sisters	0.6	0.8	1.0	-1.0	0.8
Average weekly red wine intake	0.6	0.9	1.6	1.3	-0.4
Crohns Disease (2017)	0.5	1.1	1.7	1.3	0.7
BMI	0.5	3.1	4.2	1.4	-2.0
Height	0.5	10.0	20.0	4.5	-0.2
Neuroticism	0.5	1.2	2.1	1.5	-0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.2	0.5	1.1
Systolic blood pressure, automated reading	0.5	1.5	3.1	0.1	-1.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-0.4	0.9
Hand grip strength (right)	0.5	1.3	1.8	1.4	-0.9
Hair/balding pattern: Pattern 2	0.5	0.7	1.1	0.5	-1.1
Arm fat percentage (right)	0.5	2.0	2.8	1.1	-1.7
Medication: Lansoprazole	0.5	0.5	1.0	0.3	-1.0
Lung cancer (father)	0.5	0.6	1.2	-1.1	0.2
Standing height	0.5	5.0	9.9	3.1	-0.2
Comparative body size at age 10	0.5	1.5	2.9	-0.1	-1.7
Number of full brothers	0.5	0.7	1.3	-0.0	1.2
Illnesses of siblings: Diabetes	0.5	0.6	1.2	1.1	0.1
Number of self-reported non-cancer illnesses	0.5	0.8	1.6	-0.2	1.3
Medication: Atorvastatin	0.5	0.6	1.2	1.1	-0.2
Ever smoked	0.5	0.9	1.0	-0.8	1.0
Impedance of whole body	0.5	2.7	5.1	-2.3	0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	1.2	-0.9	1.1
Prostate Cancer	0.4	0.5	0.7	0.9	-0.6
Rheumatoid Arthritis	0.4	0.5	1.0	-0.2	-1.0
Medication for hormone replacement therapy	0.4	0.4	0.7	-0.9	-0.3
Impedance of leg (right)	0.4	1.7	2.8	-1.7	0.8
Townsend deprivation index at recruitment	0.4	0.5	0.5	0.7	0.7
Fed-up feelings	0.4	0.8	1.0	-1.0	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	0.9	0.5
Hearing difficulty/problems with background noise	0.4	0.6	1.1	-1.1	-0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.8	-0.9	0.4
Heart attack	0.4	0.5	0.8	0.4	-0.9
Medication: Ramipril	0.4	0.5	0.9	0.9	0.4
Father’s age at death	0.4	0.5	0.7	-0.6	0.8
Prospective memory result	0.4	0.5	1.0	0.1	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	-1.1	-0.0
Gout (self-reported)	0.4	0.6	0.9	-0.6	-0.9
Medication: Amlodipine	0.4	0.6	1.2	0.1	1.1
Exposure to tobacco smoke outside home	0.4	0.5	0.7	0.9	-0.6
Alcohol intake frequency.	0.4	0.8	1.6	1.3	-0.3
Qualifications: nursing, teaching	0.4	0.7	0.9	-0.7	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.5	-0.7	-0.6
Heart disease (siblings)	0.4	0.4	0.7	-0.4	0.8
Depressed Affect (Nagel 2018)	0.3	0.5	1.0	1.0	-0.3
Depression (Nagel 2018)	0.3	0.5	1.0	1.0	-0.2
Neuroticism (Nagel 2018)	0.3	0.7	1.1	1.1	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	0.7	-0.8	-0.8
Breast Cancer	0.3	0.6	1.0	1.0	-0.5
Body Mass Index (BMI) (2010)	0.3	0.5	0.9	-0.0	-1.0
Neuroticism (2016)	0.3	0.5	0.8	0.4	0.9
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.4	0.8
Diabetes (mother)	0.3	0.3	0.4	-0.5	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.6	0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.2	-1.1	-0.5
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.8	0.9	0.8
Multivitamins +/- minerals	0.3	0.4	0.6	0.8	0.3
High blood pressure (mother)	0.3	0.4	0.8	-0.1	0.9
Impedance of leg (left)	0.3	1.6	2.9	-1.7	0.5
Nervous feelings	0.3	0.6	0.8	0.6	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.6	0.8	-0.5
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.9	0.2
Number of live births	0.3	0.4	0.7	0.3	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.4	-1.2	0.7
Illnesses of mother	0.3	0.4	0.8	0.9	0.2
Pulse wave reflection index	0.3	0.4	0.8	-0.1	-0.9
Worry too long after embarrassment	0.3	0.6	1.2	-0.0	1.1
Wheeze or whistling in the chest in last year	0.3	0.6	0.7	0.8	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	0.8	-0.2
Medication: Allopurinol	0.3	0.3	0.6	-0.3	-0.8
Medication: Omeprazole	0.3	0.3	0.5	-0.7	-0.4
Supplements: Vitamin C	0.3	0.4	0.5	-0.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.2	-0.8
Guilty feelings	0.3	0.5	0.9	0.9	0.3
Medication: Blood pressure	0.3	0.6	0.7	0.7	0.8
Alcohol drinker status: Never	0.3	0.4	0.7	0.3	-0.8
Ever depressed for a whole week	0.3	0.3	0.6	-0.8	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.9	-1.4	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	0.4	0.6
Worry (Nagel 2018)	0.2	0.3	0.6	0.8	-0.1
Alzheimer’s Disease (including proxy)	0.2	0.2	0.4	-0.6	-0.2
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.1
Ulcerative Colitis	0.2	0.3	0.7	0.1	-0.8
Blood Eosinophil Count	0.2	1.3	2.3	-1.5	0.4
Blood Platelet Count	0.2	2.9	3.0	1.7	-1.6
Smoking Status	0.2	0.6	0.6	-0.8	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.7	-0.3
Hand grip strength (left)	0.2	0.4	0.7	0.8	-0.5
Past tobacco smoking	0.2	0.4	0.7	0.8	0.2
Forced vital capacity (FVC)	0.2	0.7	1.1	-0.6	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	0.9	-0.9	-0.5
Qualifications: None of the above	0.2	0.4	0.8	-0.9	-0.2
Diabetes (self-reported)	0.2	0.3	0.4	-0.7	-0.3
Asthma	0.2	0.4	0.8	-0.9	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.8	-0.7	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	-0.3	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.8	1.2	-0.6	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.1	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.1	0.6
Mean time to correctly identify matches	0.2	0.5	0.9	1.0	-0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.2	0.4	-0.4
Hypertension (Self-reported)	0.2	0.4	0.7	0.8	0.4
Illnesses of father: Heart disease	0.2	0.2	0.3	-0.6	0.4
Asthma (self-reported)	0.2	0.4	0.7	-0.9	-0.1
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.7	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.4	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.3	0.4	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.2	-0.3	-0.5
Schizophrenia (2018)	0.1	0.1	0.2	-0.5	0.0
HDL Cholesterol	0.1	0.1	0.2	-0.4	0.1
Lupus	0.1	0.1	0.2	-0.4	-0.1
Heel T-Score	0.1	0.7	1.3	-1.1	-0.4
Waist Hip Ratio (WHR)	0.1	0.2	0.5	0.1	-0.7
Systolic Blood Pressure	0.1	0.6	1.3	-0.0	-1.1
Cardiovascular Disease	0.1	0.2	0.4	0.2	-0.7
Tanning	0.1	1.5	2.3	-0.9	-1.5
Hearing difficulty/problems: Yes	0.1	0.2	0.2	-0.4	-0.5
Supplements: Zinc	0.1	0.1	0.2	-0.5	-0.2
Medication: Metformin	0.1	0.2	0.4	0.6	0.2
Severe depression (siblings)	0.1	0.1	0.1	-0.3	0.2
Maternal smoking around birth	0.1	0.1	0.2	-0.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	0.6	-0.0
High blood pressure	0.1	0.2	0.4	0.6	0.3
Supplements: Glucosamine	0.1	0.1	0.3	0.5	-0.1
Had menopause	0.1	0.1	0.1	-0.2	0.4
Neuroticism score	0.1	0.3	0.6	0.8	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	0.2
Birth weight of first child	0.1	0.2	0.2	0.4	0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.1	0.5
Headache pain in last month	0.1	0.2	0.3	-0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.2	-0.4
Number of children fathered	0.1	0.1	0.1	0.1	0.4
Age at first live birth	0.1	0.2	0.2	0.5	0.3
Qualifications: College or University degree	0.1	0.4	0.8	-0.9	0.1
Medication: Blood pressure	0.1	0.2	0.3	0.4	0.5
Leg pain on walking	0.1	0.2	0.3	0.6	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.4	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.6	0.1
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	0.3
Medication for cholesterol	0.1	0.1	0.1	-0.4	0.3
Mineral and other dietary supplements	0.1	0.1	0.1	0.1	0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.2	-0.4	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.4	-0.2
Medication: Lisinopril	0.1	0.2	0.2	-0.5	-0.3
Irritability	0.1	0.3	0.4	-0.3	0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.1	0.5
Major Depression (MDD)	0.0	0.0	0.0	-0.1	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.1	-0.2
Triglycerides	0.0	0.1	0.2	-0.0	0.4
Blood Red Count	0.0	0.0	0.1	0.3	0.1
Blood White Count	0.0	0.3	0.5	0.7	0.3
Respiratory disease	0.0	0.0	0.0	-0.2	0.2
Sensitivity / hurt feelings	0.0	0.0	0.0	0.1	-0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	0.1	-0.3
Vitamin and mineral supplements	0.0	0.0	0.1	0.0	-0.3
Diabetes (father)	0.0	0.1	0.1	-0.2	-0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.3	-0.1
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.0	0.2
Allergy	0.0	0.0	0.1	-0.0	0.3
Fluid intelligence score	0.0	0.0	0.1	0.0	0.2
Tense / ‘highly strung’	0.0	0.1	0.1	-0.3	0.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.2	-0.0
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.1	0.1
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	0.2	0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	0.3	0.1
Overall health rating	0.0	0.0	0.0	0.1	-0.2
Mood swings	0.0	0.0	0.0	0.0	-0.0
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.2	-0.3

Hub : Genes

ALX4

Models

Trait associations