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chr11:46,010,847-48,133,526

Best TWAS P=1.27e-15 · Best GWAS P=1.82e-12 conditioned to 0.784

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	6.6	-5.8	5.3e-09	-0.54	0.07	0.81	FALSE
2	GTEx	Adipose Visceral Omentum	ACP2	0.08	0.05	lasso	5	0.05	1.4e-03	7.0	-7.2	5.4e-13	-0.87	0.02	0.94	FALSE
3	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	6.6	-6.9	5.8e-12	-0.62	0.06	0.86	FALSE
4	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	5.9	-6.8	1.0e-11	-0.77	0.06	0.40	FALSE
5	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	7.0	-6.6	4.2e-11	-0.68	0.03	0.88	FALSE
6	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	6.7	6.7	2.2e-11	0.65	0.06	0.62	FALSE
7	GTEx	Brain Putamen basal ganglia	CKAP5	0.25	0.07	lasso	3	0.14	4.4e-04	6.7	6.5	5.7e-11	0.77	0.03	0.47	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	ACP2	0.17	0.03	lasso	6	0.03	4.2e-02	6.7	-6.2	5.4e-10	-0.82	0.04	0.87	FALSE
9	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	7.0	-6.6	3.6e-11	-0.57	0.02	0.97	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	CKAP5	0.11	0.04	lasso	3	0.03	2.1e-02	4.2	5.6	2.0e-08	0.59	0.13	0.56	FALSE
11	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	6.8	-7.3	3.3e-13	-0.91	0.03	0.97	FALSE
12	GTEx	Esophagus Mucosa	C11orf49	0.19	0.05	enet	21	0.12	3.2e-08	6.3	5.4	7.7e-08	0.63	0.42	0.47	FALSE
13	GTEx	Heart Atrial Appendage	ACP2	0.10	0.12	enet	7	0.10	2.7e-05	6.8	-7.0	2.6e-12	-0.70	0.03	0.92	FALSE
14	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	6.8	-6.2	6.4e-10	-0.69	0.06	0.88	FALSE
15	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	6.8	-8.0	1.3e-15	-0.86	0.05	0.94	TRUE
16	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	6.1	-5.6	2.1e-08	-0.69	0.02	0.89	FALSE
17	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	6.6	-7.4	1.1e-13	-0.85	0.04	0.94	FALSE
18	GTEx	Nerve Tibial	LRP4	0.28	0.24	enet	24	0.30	3.5e-21	-3.2	5.1	2.7e-07	0.62	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	C11orf49	0.17	0.01	enet	21	0.05	9.5e-05	6.8	6.7	2.1e-11	0.76	0.09	0.80	FALSE
20	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	4.2	-5.2	2.3e-07	-0.63	0.74	0.20	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	DDB2	0.07	0.02	enet	13	0.04	3.5e-03	6.6	5.2	1.5e-07	0.61	0.08	0.47	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	SLC39A13	0.07	0.11	lasso	2	0.10	5.2e-06	5.2	5.3	1.4e-07	0.77	0.24	0.39	FALSE
23	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	6.6	-6.3	2.9e-10	-0.61	0.10	0.90	FALSE
24	GTEx	Spleen	ACP2	0.19	-0.01	lasso	5	0.04	4.1e-02	6.1	-5.4	8.5e-08	-0.70	0.09	0.28	FALSE
25	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	6.5	-6.8	1.5e-11	-0.73	0.07	0.89	FALSE
26	GTEx	Thyroid	ACP2	0.19	0.14	lasso	4	0.12	3.0e-09	7.0	-7.3	2.7e-13	-0.86	0.01	0.99	FALSE
27	METSIM	Adipose	ACP2	0.05	0.04	blup	302	0.06	1.7e-09	-2.3	-5.7	1.6e-08	-0.60	0.16	0.84	FALSE
28	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	6.8	-7.0	1.8e-12	-0.87	0.03	0.93	FALSE
29	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	6.1	-6.9	4.7e-12	-0.92	0.05	0.84	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	5.9	6.2	7.9e-10	0.84	0.44	0.55	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	-2.4	-6.5	7.9e-11	-0.70	0.08	0.82	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	4.3	5.9	4.5e-09	0.74	0.55	0.41	FALSE
33	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	6.7	-6.1	9.8e-10	-0.47	0.08	0.92	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACP2	0.02	0.01	blup	44	0.02	2.7e-04	7.0	-7.1	1.1e-12	-0.69	0.01	0.71	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf49	0.05	0.00	blup	90	0.02	3.0e-04	6.2	5.3	1.2e-07	0.60	0.00	0.98	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACP2	0.02	0.03	lasso	1	0.02	1.5e-03	7.0	-7.0	2.1e-12	-0.88	0.01	0.88	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	6.5	-6.8	8.3e-12	-0.81	0.05	0.94	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACP2	0.09	0.04	enet	12	0.06	5.0e-07	6.6	-6.0	1.8e-09	-0.59	0.06	0.93	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDB2	0.02	0.03	lasso	1	0.02	1.0e-03	6.7	6.7	2.7e-11	0.65	0.04	0.74	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	ACP2	0.08	0.06	enet	7	0.06	1.6e-04	4.3	-7.0	2.6e-12	-0.59	0.02	0.32	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	6.8	-6.3	3.9e-10	-0.86	0.02	0.75	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	DDB2	0.06	0.04	enet	17	0.03	1.3e-03	6.8	6.2	4.6e-10	0.84	0.02	0.97	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	6.8	-6.2	7.3e-10	-0.72	0.02	0.67	FALSE