Best TWAS P=7.16e-17 · Best GWAS P=3.85e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GNS | 0.23 | 0.28 | lasso | 4 | 0.27 | 2.0e-15 | -7.93 | -8.0 | 1.3e-15 | 0.97 | 0.04 | 0.96 | FALSE |
| 2 | GTEx | Artery Tibial | GNS | 0.24 | 0.24 | lasso | 7 | 0.25 | 5.9e-20 | -7.93 | -8.0 | 1.4e-15 | 0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Muscularis | GNS | 0.23 | 0.22 | lasso | 1 | 0.21 | 5.5e-13 | -7.93 | -7.9 | 2.3e-15 | 0.96 | 0.06 | 0.94 | FALSE |
| 4 | GTEx | Nerve Tibial | GNS | 0.14 | 0.16 | lasso | 2 | 0.14 | 2.6e-10 | -7.93 | -8.0 | 1.9e-15 | 0.97 | 0.02 | 0.98 | FALSE |
| 5 | METSIM | Adipose | GNS | 0.10 | 0.13 | lasso | 2 | 0.13 | 7.7e-19 | -7.81 | 8.1 | 4.9e-16 | -0.99 | 0.01 | 0.99 | FALSE |
| 6 | NTR | Blood | GNS | 0.04 | 0.05 | lasso | 5 | 0.05 | 1.4e-14 | -7.61 | 7.6 | 2.4e-14 | -0.97 | 0.04 | 0.96 | FALSE |
| 7 | NTR | Blood | TBC1D30 | 0.01 | 0.00 | bslmm | 327 | 0.00 | 1.6e-02 | 0.98 | 6.6 | 3.4e-11 | -0.52 | 0.03 | 0.58 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GNS | 0.02 | 0.01 | blup | 38 | 0.02 | 1.7e-03 | -8.06 | 8.3 | 7.2e-17 | -0.96 | 0.01 | 0.86 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GNS | 0.05 | 0.03 | blup | 38 | 0.04 | 3.6e-03 | -7.48 | 6.3 | 3.2e-10 | -0.89 | 0.02 | 0.71 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GNS | 0.04 | 0.00 | blup | 38 | 0.02 | 9.0e-03 | -0.22 | -5.8 | 6.9e-09 | 0.60 | 0.01 | 0.24 | FALSE |