TWAS hub - GNS

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2260	0.0540	6.8e-09	0.275	NA	0.260	NA	0.274	1.9e-15	NA	1.4e-14	NA	2.0e-15
2	GTEx	Artery Tibial	0.2369	0.0445	7.7e-14	0.240	NA	0.245	NA	0.254	9.2e-19	NA	3.3e-19	NA	5.9e-20
3	GTEx	Esophagus Mucosa	0.1280	0.0440	2.2e-04	-0.004	NA	0.022	NA	0.007	1.0e+00	NA	1.3e-02	NA	1.0e-01
4	GTEx	Esophagus Muscularis	0.2340	0.0550	7.3e-08	0.217	NA	0.166	NA	0.212	2.6e-13	NA	2.7e-10	NA	5.5e-13
5	GTEx	Nerve Tibial	0.1426	0.0391	1.6e-06	0.162	NA	0.120	NA	0.143	1.3e-11	NA	8.4e-09	NA	2.6e-10
6	METSIM	Adipose	0.1026	0.0258	1.9e-12	0.132	0.094	0.127	0.119	0.129	3.0e-19	6.5e-14	2.0e-18	2.4e-17	7.7e-19
7	NTR	Blood	0.0406	0.0109	2.3e-11	0.051	0.037	0.041	0.042	0.046	6.2e-16	4.2e-12	4.7e-13	2.0e-13	1.4e-14
8	YFS	Blood	0.0207	0.0101	2.1e-03	0.003	0.005	0.008	0.006	0.009	2.6e-02	7.6e-03	6.4e-04	3.8e-03	4.5e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0229	0.0153	5.9e-03	0.011	0.021	0.013	NA	0.014	1.9e-02	1.7e-03	1.0e-02	NA	8.1e-03
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0460	0.0290	4.8e-03	0.030	0.037	0.016	NA	0.019	7.6e-03	3.5e-03	4.1e-02	NA	2.9e-02
11	TCGA	Prostate Adenocarcinoma	0.0416	0.0237	4.3e-03	-0.001	0.015	0.003	NA	0.000	4.5e-01	9.0e-03	1.5e-01	NA	3.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Medication: Laxatives (e.g. Dulcolax, Senokot)	9.0	10.6	17.6	-3.3	-3.4	-3.4	-3.2	-3.2	3.8	3.7	2.3	3.3	4.2	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	7.6	9.8	13.5	-3.6	-3.5	-2.0	-3.6	-3.6	3.3	3.2	0.2	3.7	2.5	-3.3
Stomach or abdominal pain in last month	6.3	7.9	11.2	-3.1	-3.1	-3.3	-3.1	-3.1	2.8	2.8	0.8	3.0	3.3	-0.4
Had major operations	6.0	7.1	10.7	-2.8	-2.8	-2.6	-2.8	-2.8	2.8	3.3	0.2	2.7	2.7	-2.5
Hair/balding pattern: Pattern 2	5.1	6.4	7.9	-2.7	-2.6	-2.8	-2.7	-2.7	2.4	2.6	2.4	2.3	2.4	-2.3
Pulse rate	5.0	8.4	13.5	-2.9	-2.9	-3.7	-2.9	-2.9	3.2	3.1	1.6	3.3	3.4	0.2
Ever highly irritable/argumentative for 2 days	4.9	5.9	7.8	-2.7	-2.8	-2.2	-2.7	-2.7	2.5	2.5	1.1	2.6	2.4	-2.0
Number of operations (self-reported)	4.8	7.2	9.9	-2.9	-3.0	-2.4	-3.0	-3.0	2.7	3.1	-0.8	2.6	2.8	-2.4
Illnesses of father: High blood pressure	4.2	5.3	7.3	-2.7	-2.6	-1.5	-2.7	-2.7	2.3	2.4	0.1	2.6	2.5	-1.8
Forced vital capacity (FVC), Best measure	3.8	13.8	18.4	4.2	4.3	4.1	4.2	4.2	-3.5	-3.9	0.1	-4.0	-4.3	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.5	18.0	3.8	3.8	3.8	3.8	3.8	-3.2	-3.5	0.4	-3.6	-4.2	0.3
Suffer from ‘nerves’	3.6	5.7	7.5	-2.7	-2.6	-2.7	-2.7	-2.6	2.6	2.3	-0.4	2.4	2.7	-1.4
Medication: Paracetamol	3.6	5.6	10.4	-2.5	-2.5	-3.0	-2.5	-2.5	2.4	2.3	-0.0	2.4	3.2	0.0
Forced vital capacity (FVC)	3.5	13.6	17.9	4.1	4.2	3.8	4.2	4.2	-3.7	-4.2	0.1	-3.8	-4.2	1.7
Alzheimer’s Disease (including proxy)	3.4	5.0	7.1	2.5	2.4	2.0	2.4	2.4	-2.7	-2.3	-0.9	-2.3	-2.1	2.1
Fasting Glucose	3.4	4.0	6.1	-2.4	-2.4	-1.4	-2.4	-2.4	2.1	2.0	0.6	2.5	1.9	-1.0
Depressed Affect (Nagel 2018)	3.3	6.9	9.3	-3.0	-3.0	-2.2	-3.0	-3.0	2.7	2.8	-1.5	2.5	2.8	-1.8
Medication: Atenolol	3.3	4.1	5.9	-2.2	-2.2	-1.8	-2.2	-2.2	2.1	2.4	0.3	2.3	2.3	-1.1
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	17.2	3.6	3.7	3.6	3.7	3.7	-3.4	-3.8	0.3	-3.3	-4.1	0.9
Standing height	3.3	32.3	47.6	6.3	6.3	6.9	6.3	6.3	-5.7	-5.7	0.7	-5.7	-6.9	2.0
Overall health rating	3.2	6.9	10.0	-2.9	-2.9	-1.7	-2.9	-2.9	2.9	2.9	1.4	3.0	3.2	-0.6
Illnesses of father: None of the above (group 1)	3.2	4.0	5.7	2.2	2.2	0.2	2.2	2.2	-2.4	-2.2	0.6	-2.4	-2.1	1.8
Basal cell carcinoma (self-reported)	3.2	3.8	5.1	2.2	2.2	1.8	2.2	2.2	-2.0	-2.1	0.9	-2.1	-2.1	1.0
Worry (Nagel 2018)	3.1	6.6	9.8	-2.7	-2.7	-3.1	-2.7	-2.7	2.4	2.4	-2.7	2.5	2.7	-1.2
Medication: Paracetamol	3.1	5.1	11.2	-2.3	-2.3	-3.2	-2.3	-2.3	2.0	2.0	-0.6	2.1	3.3	1.0
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	6.6	-2.4	-2.3	-1.9	-2.4	-2.3	2.5	2.3	-0.2	2.2	2.6	-0.9
Hair/balding pattern: Pattern 3	2.8	4.2	8.9	2.0	2.1	3.0	2.1	2.1	-2.1	-2.2	-0.7	-2.1	-2.2	1.1
Height	2.7	52.7	73.0	7.9	8.0	8.5	7.9	7.9	-7.7	-7.5	-1.1	-7.4	-8.5	3.3
Taking other prescription medications	2.6	3.9	5.4	-2.3	-2.3	-1.9	-2.3	-2.3	1.9	2.1	-0.3	2.0	2.0	-1.5
Medication: Lansoprazole	2.6	3.0	6.4	-1.9	-1.9	-2.5	-1.9	-1.9	1.5	1.5	-0.8	1.7	1.6	-1.2
Blood clot in the leg (DVT)	2.6	3.3	4.4	2.1	2.0	0.7	2.1	2.1	-1.8	-2.1	-1.7	-2.1	-1.8	1.0
Illnesses of siblings: Diabetes	2.6	3.2	11.5	1.7	1.6	0.6	1.7	1.7	-1.4	-1.2	-3.4	-1.5	-0.9	2.4
Neuroticism (Nagel 2018)	2.5	5.9	7.0	-2.6	-2.6	-2.6	-2.6	-2.6	2.3	2.6	-2.0	2.5	2.5	-1.5
Loneliness, isolation	2.5	3.5	4.8	-2.2	-2.1	-1.7	-2.2	-2.2	2.0	1.8	0.1	2.1	2.2	-0.1
Neuroticism score	2.3	4.7	7.6	-2.3	-2.3	-2.8	-2.3	-2.3	2.2	2.0	-2.1	2.0	2.3	-1.1
Pulse wave peak to peak time	2.3	2.7	5.3	1.9	1.8	1.4	1.9	1.9	-1.7	-1.7	-0.1	-1.4	-2.3	0.0
Medication for pain relief, constipation, heartburn	2.3	3.9	8.5	1.9	1.9	2.9	1.8	1.9	-1.8	-1.9	-0.1	-1.9	-2.9	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	6.6	2.4	2.5	2.1	2.4	2.4	-2.4	-2.5	-0.3	-2.6	-2.3	1.0
Allergy or Eczema	2.2	5.7	7.3	-2.6	-2.7	-2.7	-2.6	-2.6	2.4	2.4	-0.4	2.1	2.1	-2.6
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	11.8	-1.6	-1.5	-3.4	-1.7	-1.7	1.4	1.4	-0.5	1.5	1.6	-0.5
Falls in the last year	2.2	3.0	4.2	-1.8	-1.9	-1.4	-1.8	-1.8	2.1	2.0	-0.8	2.0	1.8	-1.0
Qualifications: A levels/AS levels or equivalent	2.2	4.9	15.8	-2.3	-2.2	-0.8	-2.3	-2.3	2.2	2.2	1.4	2.1	1.2	-4.0
Health satisfaction	2.2	2.8	4.4	-1.9	-1.8	-0.6	-1.9	-1.9	1.9	1.6	0.9	1.8	1.3	-2.1
Medication: Omeprazole	2.2	2.6	2.9	-1.7	-1.7	-1.5	-1.7	-1.7	1.6	1.7	1.6	1.6	1.7	-1.3
Hypertension (Self-reported)	2.2	6.1	8.5	-2.8	-2.8	-1.8	-2.9	-2.9	2.6	2.7	0.7	2.6	2.9	-1.5
Alzheimer’s Disease (in mother)	2.1	2.5	4.6	1.7	1.6	0.6	1.7	1.6	-2.1	-1.5	-0.4	-1.8	-1.3	1.9
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.5	1.8	1.4	1.3	2.1	2.1	-1.1	-1.3	-1.0	-1.4	-1.0	1.8
High blood pressure	2.1	5.9	8.1	-2.8	-2.8	-1.9	-2.8	-2.8	2.5	2.6	0.6	2.5	2.9	-1.4
Worrier / anxious feelings	2.1	3.9	10.8	-1.8	-1.7	-2.6	-1.8	-1.8	1.6	1.6	-3.3	2.1	1.6	-0.7
Trunk predicted mass	2.1	11.8	16.3	3.8	3.8	4.0	3.7	3.7	-3.6	-3.5	0.3	-3.7	-3.8	1.7
Comparative height size at age 10	2.1	11.6	16.2	3.8	3.7	4.0	3.8	3.8	-3.6	-3.3	1.2	-3.7	-3.6	1.8
Commuting to job workplace: Public transport	2.1	2.5	7.1	-1.5	-1.4	-1.9	-1.5	-1.5	1.4	1.3	2.7	1.2	1.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	2.1	2.6	4.2	1.8	1.8	0.3	1.8	1.8	-1.5	-1.8	-2.0	-1.8	-1.5	1.0
Lung FVC	2.0	10.1	13.7	3.4	3.4	3.6	3.4	3.4	-3.3	-3.5	1.2	-3.7	-2.6	2.7
Diabetes (mother)	2.0	2.5	4.9	1.6	1.8	0.6	1.6	1.6	-1.7	-2.2	-1.3	-1.7	-1.4	1.6
Trunk fat-free mass	2.0	11.3	15.4	3.7	3.7	3.9	3.7	3.7	-3.5	-3.4	0.1	-3.7	-3.7	1.8
Mean time to correctly identify matches	2.0	3.8	6.5	2.1	2.1	2.2	2.1	2.1	-2.2	-2.1	0.2	-1.9	-2.5	-0.2
Number of self-reported non-cancer illnesses	2.0	3.5	4.8	-2.0	-2.0	-1.5	-2.0	-2.0	2.2	2.1	0.3	2.1	2.1	-1.2
Vascular/heart problems diagnosed by doctor	2.0	5.5	8.7	2.6	2.7	2.1	2.7	2.7	-2.3	-2.6	-0.8	-2.4	-3.0	1.0
HbA1C	1.9	2.2	4.2	-1.4	-1.5	-0.6	-1.4	-1.4	1.6	1.3	2.0	2.0	0.9	-1.4
Lupus	1.9	2.9	3.8	2.0	1.9	1.5	1.9	1.9	-1.8	-1.8	-1.1	-1.8	-1.9	0.9
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.7	-1.8	-1.7	-0.5	-1.8	-1.8	1.6	1.7	0.4	1.6	1.1	-2.2
Had menopause	1.9	2.3	6.2	1.4	1.4	2.5	1.3	1.3	-1.7	-1.5	0.3	-1.9	-1.0	1.4
Number of full brothers	1.9	2.4	6.9	1.6	1.5	-0.4	1.6	1.6	-1.4	-1.6	0.5	-2.0	-0.3	2.6
Eye problems/disorders: None of the above	1.9	2.2	8.7	1.4	1.2	0.8	1.4	1.4	-0.7	-0.9	3.0	-1.0	-0.6	2.1
Supplements: Calcium	1.9	2.1	5.8	-1.4	-1.4	-0.2	-1.4	-1.4	1.6	1.3	0.9	1.9	0.5	-2.4
Severe depression (siblings)	1.8	2.0	5.5	1.2	1.3	1.6	1.2	1.2	-1.4	-1.3	2.3	-1.4	-1.4	0.4
Fed-up feelings	1.8	3.2	4.6	-2.1	-2.0	-1.6	-2.1	-2.1	1.6	1.5	-1.6	1.7	1.6	-1.6
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.2	-1.4	-1.4	-1.1	-1.4	-1.4	2.1	1.6	0.4	1.6	1.4	-0.7
Hair Pigment	1.7	48.7	69.6	-8.0	-8.0	-3.1	-7.9	-8.0	8.1	7.6	2.4	8.3	6.3	-5.8
Heel T-Score	1.6	13.0	17.1	-4.1	-4.1	-3.0	-4.1	-4.1	3.8	3.7	1.3	3.7	3.7	-2.9
Supplements: Glucosamine	1.6	2.1	4.5	1.6	1.5	2.0	1.6	1.5	-1.4	-1.2	0.1	-1.1	-2.1	-0.2
Headache pain in last month	1.6	2.7	4.1	-1.8	-1.8	-1.7	-1.8	-1.8	1.8	1.7	-0.2	1.9	2.0	-0.3
Eye problems/disorders: Cataract	1.6	1.9	3.4	-1.4	-1.5	-1.2	-1.5	-1.5	1.3	1.4	-1.1	1.1	1.1	-1.8
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.9	1.4	1.5	2.2	1.4	1.4	-1.6	-1.5	0.3	-1.0	-2.0	0.6
Unable to work because of sickness or disability	1.6	2.1	3.4	-1.5	-1.6	-1.7	-1.5	-1.5	1.7	1.5	-0.3	1.6	1.9	-0.5
Blood Platelet Count	1.5	16.8	26.9	4.4	4.3	4.0	4.3	4.3	-4.3	-5.1	-3.2	-3.6	-5.2	-0.3
Cardiovascular Disease	1.5	5.0	6.8	-2.5	-2.6	-1.8	-2.5	-2.5	2.5	2.5	-0.2	2.3	2.6	-1.4
Frequency of depressed mood in last 2 weeks	1.5	2.2	3.6	-1.6	-1.6	-1.2	-1.6	-1.6	1.7	1.5	0.3	1.6	1.9	-0.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.2	-1.4	-1.4	-0.5	-1.4	-1.4	1.5	1.2	-0.7	1.5	1.0	-2.0
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.8	-1.8	-1.9	-2.8	-1.8	-1.8	1.8	1.8	-0.1	1.7	1.4	-1.7
Pulse rate, automated reading	1.5	4.7	12.3	-1.4	-1.5	-3.5	-1.4	-1.4	1.7	1.9	1.6	1.9	3.1	3.1
Ever taken oral contraceptive pill	1.5	1.7	4.2	1.4	1.3	0.3	1.3	1.3	-1.2	-1.4	2.0	-1.5	-1.4	0.3
Pain all over the body in last month	1.4	1.5	2.6	-1.4	-1.4	-0.4	-1.4	-1.4	1.3	1.2	0.6	1.6	1.2	-0.6
Tense / ‘highly strung’	1.4	2.4	3.3	-1.8	-1.7	-1.6	-1.8	-1.8	1.6	1.4	-1.3	1.4	1.8	-0.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.7	1.2	1.2	1.2	1.2	1.2	-1.3	-1.1	-0.9	-0.8	-0.7	2.2
Age at First Birth	1.3	1.9	3.2	1.5	1.4	1.7	1.6	1.5	-1.1	-1.2	-0.9	-1.3	-1.8	-0.1
Neuroticism	1.3	3.2	6.9	-1.8	-1.7	-2.6	-1.8	-1.8	1.6	1.6	-2.2	1.3	2.1	-0.5
Sensitivity / hurt feelings	1.3	2.2	8.0	-1.4	-1.4	-2.8	-1.5	-1.5	1.3	1.2	-0.2	1.2	1.6	-0.3
Maternal smoking around birth	1.3	1.9	3.1	-1.5	-1.5	-1.1	-1.5	-1.5	1.7	1.5	-0.4	1.6	1.8	0.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.2	-1.5	-1.4	-1.1	-1.5	-1.5	1.2	1.0	-2.3	1.3	0.9	-1.7
Mouth/teeth dental problems: Dentures	1.3	2.2	3.6	1.6	1.7	-0.3	1.6	1.6	-1.5	-1.8	-0.5	-1.9	-1.2	1.4
Illnesses of father: Heart disease	1.3	1.8	3.4	-1.3	-1.4	0.6	-1.3	-1.3	1.8	1.5	-0.3	1.4	1.2	-1.7
Whole body fat-free mass	1.3	7.6	9.5	3.1	3.1	3.1	3.1	3.0	-2.9	-2.7	-0.2	-3.0	-3.0	1.6
Long-standing illness, disability or infirmity	1.3	2.1	3.7	-1.7	-1.6	-0.8	-1.7	-1.7	1.2	1.4	0.2	1.6	1.0	-1.9
Mineral and other dietary supplements	1.3	1.8	5.4	-1.3	-1.3	-2.3	-1.3	-1.3	1.2	1.1	-0.4	0.8	2.0	0.3
Whole body water mass	1.3	7.5	9.6	3.0	3.0	3.1	3.0	3.0	-2.8	-2.7	-0.2	-3.0	-3.0	1.5
Rheumatoid Arthritis	1.2	1.6	4.0	-1.3	-1.3	-2.0	-1.4	-1.4	1.2	1.3	-0.2	1.2	1.4	-0.4
Number of live births	1.2	1.6	3.4	1.3	1.3	0.1	1.3	1.3	-1.6	-1.5	-0.6	-1.3	-0.9	1.8
Noisy workplace	1.2	1.5	2.0	-1.3	-1.3	-1.1	-1.2	-1.2	1.4	1.3	-0.7	1.2	1.1	-1.2
Arm fat-free mass (right)	1.2	6.1	9.4	2.7	2.7	3.1	2.7	2.7	-2.5	-2.4	-0.3	-2.7	-2.5	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	6.5	1.5	1.5	2.1	1.5	1.5	-1.2	-1.2	0.2	-1.3	-2.5	-1.3
Arm fat-free mass (left)	1.2	6.0	9.5	2.6	2.7	3.1	2.6	2.6	-2.6	-2.4	0.3	-2.6	-2.5	1.8
Schizophrenia (2014)	1.1	2.5	3.3	1.8	1.7	1.6	1.8	1.8	-1.6	-1.5	-0.9	-1.7	-1.5	0.9
Age when periods started (menarche)	1.1	2.7	4.1	1.8	1.9	0.6	1.8	1.8	-1.9	-2.0	0.8	-1.0	-1.9	1.6
Serious illness, injury or assault to yourself	1.1	1.4	2.2	1.5	1.3	1.0	1.5	1.5	-1.1	-0.9	-0.4	-0.8	-1.2	1.2
Medication: Simvastatin	1.1	1.6	5.7	1.1	1.2	0.3	1.1	1.1	-1.4	-1.2	-2.4	-1.1	-1.3	0.7
Pulse wave Arterial Stiffness index	1.1	1.2	2.9	-1.3	-1.2	-0.9	-1.3	-1.3	1.1	1.1	0.1	0.9	1.7	0.3
Worry too long after embarrassment	1.1	1.8	5.1	-1.3	-1.3	-2.3	-1.3	-1.3	1.4	1.3	0.7	1.5	1.3	-0.6
Number of children fathered	1.1	1.3	3.2	-0.9	-1.0	-1.8	-0.9	-0.9	1.4	1.3	-0.6	1.2	1.3	0.4
Medication: Allopurinol	1.1	1.5	2.6	-1.6	-1.4	-0.9	-1.6	-1.6	0.6	1.1	1.3	0.9	1.4	-0.2
Heart disease (mother)	1.1	1.4	6.4	-0.8	-0.8	-0.6	-0.8	-0.8	0.9	0.9	-2.5	0.5	0.3	-1.9
Arm predicted mass (right)	1.1	5.8	8.5	2.6	2.6	2.9	2.6	2.6	-2.5	-2.3	-0.3	-2.7	-2.3	1.9
Medication: Bendroflumethiazide	1.1	1.7	3.1	-1.4	-1.5	-0.2	-1.4	-1.4	1.7	1.5	0.5	1.4	1.8	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.9	-1.1	-1.2	-1.2	-1.1	-1.1	1.1	1.2	1.7	1.0	1.0	-1.2
Crohns Disease (2017)	1.0	2.2	5.0	-1.7	-1.5	-2.2	-1.7	-1.7	1.5	1.2	0.9	1.4	1.5	-0.2
Current tobacco smoking	1.0	1.6	4.6	1.6	1.4	0.0	1.6	1.6	-0.8	-1.0	0.1	-1.4	-0.5	2.1
Sitting height	1.0	7.2	14.4	2.9	2.9	3.8	2.9	2.9	-2.4	-2.6	0.4	-2.6	-3.4	0.3
Nervous feelings	1.0	1.9	6.3	-1.3	-1.3	-0.9	-1.3	-1.3	1.2	1.3	-2.5	1.2	1.5	-0.3
Hair/balding pattern: Pattern 4	1.0	2.4	3.9	-1.7	-1.8	-0.9	-1.7	-1.7	1.8	1.8	0.8	2.0	1.6	-0.7
Peak expiratory flow (PEF)	1.0	2.3	4.9	1.4	1.6	1.7	1.4	1.5	-1.6	-1.8	0.0	-1.4	-2.2	-0.7
Mood swings	1.0	1.7	5.3	-1.1	-1.2	-0.6	-1.1	-1.1	1.3	1.1	-2.3	0.9	0.8	-1.9
Asthma (self-reported)	1.0	2.0	8.3	-1.3	-1.2	-2.9	-1.3	-1.3	1.0	0.8	1.2	1.2	1.5	0.4
Basal metabolic rate	1.0	5.5	7.0	2.6	2.6	2.5	2.6	2.6	-2.4	-2.3	-0.0	-2.6	-2.5	1.7
Diastolic blood pressure, automated reading	1.0	3.2	6.9	-1.6	-1.6	-2.6	-1.6	-1.6	1.8	1.7	0.3	1.7	2.6	1.2
Arm predicted mass (left)	1.0	5.1	7.6	2.5	2.5	2.8	2.5	2.5	-2.3	-2.2	0.1	-2.5	-2.2	1.8
Irritable Bowel Disease (IBD)	0.9	2.1	3.0	-1.7	-1.6	-1.0	-1.7	-1.7	1.4	1.1	1.4	1.3	1.0	-1.6
Asthma	0.9	1.7	7.9	-1.1	-1.1	-2.8	-1.1	-1.1	0.9	0.8	1.4	1.1	1.3	0.2
Illnesses of mother	0.9	1.1	2.2	-0.9	-0.9	-1.1	-0.9	-0.9	1.2	0.9	1.5	1.1	1.2	-0.2
Medication: Amlodipine	0.9	1.3	2.2	-1.1	-1.1	-1.3	-1.1	-1.1	1.4	1.1	-0.3	1.5	1.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	6.4	-1.1	-1.1	-2.5	-1.1	-1.1	1.1	0.8	0.1	1.0	1.1	-0.9
Hand grip strength (left)	0.8	2.2	3.1	1.6	1.7	1.0	1.6	1.6	-1.6	-1.6	-0.3	-1.8	-1.6	1.1
Hearing difficulty/problems with background noise	0.8	1.2	2.4	1.2	1.2	-0.0	1.2	1.2	-1.1	-0.9	-1.0	-1.2	-0.8	1.6
Mouth/teeth dental problems	0.8	1.2	2.9	-1.0	-1.1	1.7	-0.9	-0.9	1.1	1.4	-0.6	1.2	1.0	-0.3
Happiness	0.8	1.0	2.1	-1.1	-1.1	-0.8	-1.1	-1.1	1.2	1.1	0.2	1.5	0.8	-0.6
Prospective memory result	0.8	0.9	4.1	0.9	0.9	-0.3	0.9	0.9	-0.5	-0.7	-2.0	-0.7	-0.5	1.1
Gout (self-reported)	0.8	1.1	1.7	-1.3	-1.1	-1.3	-1.3	-1.3	0.5	0.8	1.0	0.7	1.0	-0.6
Exposure to tobacco smoke outside home	0.8	1.0	7.3	-0.3	-0.2	-0.8	-0.3	-0.3	0.4	0.5	2.7	0.0	0.1	-1.6
Shortness of breath walking on level ground	0.8	1.0	1.4	-1.1	-1.1	-0.3	-1.1	-1.1	1.0	1.0	1.1	1.2	0.9	-1.0
Qualifications: College or University degree	0.8	2.5	15.9	-1.3	-1.2	0.5	-1.3	-1.3	1.1	1.2	-0.6	1.1	-0.3	-4.0
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.5	1.1	1.1	-0.0	1.1	1.1	-0.8	-1.0	-1.1	-1.2	-0.7	1.0
Hearing aid user	0.8	0.9	4.6	0.7	0.8	-0.1	0.7	0.7	-1.0	-1.0	0.4	-1.0	0.2	2.1
Bipolar Disorder or Schizophrenia	0.7	1.7	3.4	1.2	1.3	1.9	1.2	1.2	-1.4	-1.3	-0.9	-1.5	-1.4	0.1
Depression (Nagel 2018)	0.7	1.0	1.7	-1.2	-1.1	-0.8	-1.2	-1.2	1.0	1.0	0.1	1.1	1.3	-0.0
Ovarian Cancer	0.7	0.9	1.4	1.1	1.1	-0.1	1.2	1.2	-0.8	-1.2	-0.8	-1.0	-0.9	0.4
Body Mass Index (BMI) (2010)	0.7	0.9	2.8	-0.8	-0.9	-1.7	-0.8	-0.8	0.9	0.8	1.4	0.5	1.2	-0.1
BMI	0.7	4.0	6.5	-2.2	-2.2	-2.0	-2.2	-2.2	2.2	2.3	0.1	2.0	2.5	-0.6
Number of treatments/medications taken	0.7	1.3	2.3	-1.3	-1.2	-1.5	-1.3	-1.3	0.8	0.8	-0.8	1.4	1.2	-0.1
Average weekly spirits intake	0.7	0.9	1.7	0.8	0.9	0.9	0.8	0.8	-1.3	-1.1	-0.6	-0.9	-1.3	0.1
Supplements: Zinc	0.7	0.7	1.0	-0.9	-0.9	-0.5	-1.0	-1.0	0.6	1.0	1.0	0.8	0.6	-0.9
Allergy	0.7	1.6	6.9	1.2	1.2	2.6	1.2	1.2	-1.1	-1.1	-0.4	-1.0	-1.1	0.7
Breastfed as a baby	0.7	0.8	2.1	0.8	0.8	0.6	0.8	0.8	-0.8	-0.8	1.4	-1.1	-0.4	1.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.0	0.8	0.7	-1.2	0.8	0.8	-0.7	-0.9	-0.6	-0.7	-0.1	1.7
High blood pressure (siblings)	0.7	1.1	2.8	-1.0	-0.9	-1.7	-1.0	-1.0	0.9	0.8	-0.7	0.7	1.5	0.7
Medication: Blood pressure	0.7	1.2	2.0	-1.3	-1.3	-1.0	-1.2	-1.2	0.9	1.0	-0.4	1.4	1.0	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	7.3	0.3	0.3	-0.5	0.2	0.3	-0.6	-0.5	0.2	-0.0	0.7	2.7
Smoking status: Current	0.7	1.1	5.2	1.2	1.0	-0.8	1.2	1.1	-0.4	-0.6	-0.1	-0.8	0.1	2.3
Miserableness	0.7	1.3	1.7	-1.3	-1.2	-1.0	-1.3	-1.3	1.2	1.1	-0.9	1.0	0.9	-1.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	0.6	0.8	0.7	0.7	0.7	-0.6	-0.7	-1.4	-0.5	-1.4	-1.2
Schizophrenia (2018)	0.6	1.3	2.3	1.2	1.2	1.5	1.2	1.2	-1.3	-1.0	-0.3	-1.2	-1.4	0.4
Mean Putamen Volume	0.6	0.7	1.1	-0.9	-0.8	-0.8	-0.8	-0.8	1.0	0.8	-0.9	1.1	0.8	-0.5
Triglycerides	0.6	1.0	4.0	0.9	1.0	0.4	0.8	0.8	-1.1	-1.0	-0.6	-0.9	-0.4	2.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	-0.9	-1.0	-0.1	-0.9	-0.9	0.8	0.8	0.0	1.0	0.9	-0.6
Medication: Co-codamol	0.6	0.7	2.3	0.8	0.9	-0.1	0.7	0.7	-0.8	-1.0	-1.5	-0.9	-0.8	0.2
Leg fat-free mass (left)	0.6	3.3	4.3	2.1	2.1	1.6	2.1	2.1	-1.9	-1.8	-0.2	-2.1	-2.0	1.1
Townsend deprivation index at recruitment	0.6	0.9	5.5	0.6	0.6	-0.3	0.6	0.6	-0.4	-0.5	2.4	-0.3	-0.2	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.7	-1.2	-1.2	-0.6	-1.2	-1.2	1.6	1.1	-0.7	1.0	1.3	-0.9
Leg predicted mass (left)	0.6	3.4	4.4	2.1	2.1	1.5	2.1	2.1	-1.9	-1.8	-0.3	-2.1	-2.0	1.2
Illnesses of siblings	0.6	0.9	2.2	0.9	0.8	1.1	0.9	0.9	-0.9	-0.8	0.6	-0.8	-1.5	-1.0
Time employed in main current job	0.6	0.7	1.3	0.8	0.8	-0.1	0.8	0.8	-1.1	-1.1	-0.8	-1.0	-0.7	0.8
Loud music exposure frequency	0.6	0.7	1.3	-0.8	-0.8	-0.8	-0.7	-0.7	1.1	0.9	0.6	1.1	0.8	-0.5
Neck or shoulder pain in last month	0.6	0.8	3.3	-0.7	-0.7	0.5	-0.7	-0.7	0.7	1.1	1.8	0.6	0.7	-1.0
Migraine (self-reported)	0.6	0.7	4.6	0.7	0.7	-0.6	0.7	0.7	-0.6	-0.6	0.1	-0.4	-0.1	2.1
Alcohol intake frequency.	0.6	1.4	2.1	-1.5	-1.4	-1.2	-1.5	-1.5	1.1	0.9	0.6	1.3	1.2	-0.6
Family relationship satisfaction	0.6	0.7	2.0	-0.7	-0.7	0.8	-0.7	-0.7	0.8	0.8	1.4	1.1	0.4	-0.8
Medication for cholesterol	0.6	0.9	2.2	0.9	1.0	0.8	1.0	1.0	-0.8	-0.8	-0.7	-0.8	-1.5	-0.5
Average weekly beer plus cider intake	0.6	0.9	3.7	-0.3	-0.3	-1.9	-0.3	-0.3	0.4	0.1	1.8	-0.1	0.8	1.4
Ulcerative Colitis (UC)	0.5	0.9	3.5	-1.0	-0.9	0.4	-1.0	-1.0	0.8	0.4	0.8	0.8	0.2	-1.9
Bipolar Disorder (2011)	0.5	0.5	3.1	-0.5	-0.5	0.4	-0.5	-0.5	0.4	0.5	-1.8	0.7	0.6	0.0
Respiratory disease	0.5	1.2	5.6	-1.0	-1.0	-2.4	-1.0	-1.0	0.9	0.8	-0.0	0.8	1.2	0.1
Tanning	0.5	6.4	14.0	-2.6	-2.8	-2.3	-2.7	-2.7	2.6	2.8	-0.1	2.7	3.7	0.8
Systolic blood pressure, automated reading	0.5	1.4	3.0	-1.3	-1.3	-0.6	-1.3	-1.3	1.2	1.3	-0.9	1.0	1.7	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.9	0.3	0.4	1.7	0.3	0.3	-0.8	-0.7	0.0	-0.4	-1.0	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.9	-1.0	-0.8	-0.8	-0.9	-0.9	0.9	0.6	-0.6	0.9	0.8	-0.1
Qualifications: CSEs or equivalent	0.5	0.7	2.4	-0.7	-0.6	-1.5	-0.6	-0.6	0.7	0.6	1.1	1.1	0.6	0.6
Multivitamins +/- minerals	0.5	0.6	1.0	-0.8	-0.9	0.1	-0.9	-0.9	0.9	0.7	0.6	0.6	1.0	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.8	-0.7	-1.1	-0.8	-0.8	0.8	0.6	-0.6	0.6	0.4	-1.0
High blood pressure (mother)	0.5	0.7	2.7	-0.9	-0.8	0.3	-0.9	-0.9	0.4	0.7	1.2	0.3	0.1	-1.6
Alcohol usually taken with meals	0.5	0.8	5.8	0.5	0.5	2.4	0.5	0.5	-0.5	0.0	-1.1	-0.2	-0.7	-0.1
Had other major operations	0.5	0.7	1.3	-1.1	-1.0	-0.8	-1.1	-1.1	0.2	0.7	0.6	0.4	0.9	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	-1.1	-1.1	-0.3	-1.1	-1.1	1.4	1.1	-1.1	0.9	1.1	-0.9
Weight	0.5	2.5	3.5	1.8	1.8	1.5	1.7	1.7	-1.8	-1.5	0.3	-1.9	-1.6	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.8	0.5	0.5	-1.4	0.5	0.5	-0.2	-0.6	0.4	-0.4	0.3	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.7	0.4	0.4	-1.6	0.5	0.5	-0.4	-0.3	-0.0	-0.1	0.4	1.6
Medication: Ibuprofen	0.5	0.6	2.9	0.6	0.6	-1.1	0.6	0.6	-0.7	-0.6	0.3	-0.1	-0.1	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.7	-0.7	-1.0	-0.7	-0.7	0.6	0.9	-1.1	0.8	0.6	-0.1
Age at last live birth	0.5	0.7	2.9	0.5	0.6	1.7	0.5	0.5	-0.9	-0.6	1.0	-0.3	-0.9	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.8	-0.9	-0.4	-0.8	-0.8	1.0	0.8	0.4	1.0	1.0	-0.2
Leg fat-free mass (right)	0.5	2.7	3.6	1.9	1.9	1.4	1.9	1.9	-1.7	-1.5	-0.4	-1.8	-1.9	1.0
Average weekly red wine intake	0.5	0.8	3.9	0.6	0.5	1.6	0.6	0.6	-0.4	-0.2	-2.0	-0.6	-0.2	0.5
Breast cancer (self-reported)	0.5	0.6	2.9	-0.7	-0.6	-0.4	-0.7	-0.7	0.2	0.1	-1.7	0.5	0.9	0.6
Leg predicted mass (right)	0.5	2.8	3.7	1.9	1.9	1.5	1.9	1.9	-1.7	-1.6	-0.5	-1.8	-1.9	1.0
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.6	-0.7	-0.8	-0.6	-0.6	1.1	0.9	0.7	1.2	0.8	0.1
Age started oral contraceptive pill	0.5	0.6	1.7	0.6	0.7	0.4	0.6	0.6	-0.8	-0.8	1.2	-0.6	-0.5	1.3
Ever depressed for a whole week	0.5	0.7	3.7	-0.7	-0.6	0.6	-0.6	-0.6	0.6	0.5	0.4	1.0	-0.2	-1.9
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.7	-0.7	-0.6	-0.8	-0.8	0.6	0.5	-1.1	0.7	0.8	-0.1
Crohns Disease (2012)	0.4	0.6	1.1	-0.8	-0.7	-0.6	-0.8	-0.8	0.8	0.7	0.5	1.0	0.9	0.5
Waist Hip Ratio (WHR)	0.4	1.9	7.9	1.4	1.4	-0.2	1.4	1.4	-1.0	-1.1	-0.5	-1.3	-0.3	2.8
Lung FEV1/FVC ratio	0.4	2.1	9.4	0.7	0.7	2.0	0.7	0.7	-0.5	-0.5	1.2	-0.3	-2.4	-3.1
Angina	0.4	0.5	1.5	0.5	0.6	-1.2	0.5	0.5	-1.0	-0.7	-0.7	-0.9	-0.5	-0.1
Qualifications: None of the above	0.4	0.9	3.2	-0.5	-0.7	-1.8	-0.5	-0.5	0.8	0.6	-0.9	0.2	1.6	1.1
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.7	0.7	-0.4	0.7	0.7	-0.7	-0.5	-0.8	-0.7	-0.3	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	3.5	-0.5	-0.4	0.8	-0.4	-0.5	0.4	0.6	1.9	0.6	0.1	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	0.7	0.7	1.2	0.7	0.7	-0.4	-0.6	1.4	-0.9	-0.7	0.0
Comparative body size at age 10	0.4	1.2	2.6	-1.1	-1.2	0.1	-1.1	-1.1	1.3	1.3	-1.1	1.0	1.6	0.2
Emphysema/chronic bronchitis	0.4	0.4	2.1	-0.4	-0.5	-0.8	-0.4	-0.4	0.5	0.3	1.4	0.2	0.7	0.2
Number of full sisters	0.4	0.5	2.1	0.7	0.5	1.4	0.6	0.6	-0.1	0.1	1.1	-0.9	-0.0	-0.1
Chest pain or discomfort	0.4	0.6	2.4	-0.6	-0.7	-0.2	-0.5	-0.6	0.9	0.7	1.6	0.6	0.7	-1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	4.0	-0.3	-0.3	0.4	-0.2	-0.2	0.3	0.4	0.2	0.1	-0.6	-2.0
Ever had bowel cancer screening	0.4	0.4	0.7	-0.8	-0.7	0.3	-0.8	-0.8	0.3	0.6	0.6	0.8	0.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.7	0.7	-0.7	0.8	0.8	-0.5	-0.4	0.4	-0.5	-0.2	1.0
Qualifications: nursing, teaching	0.4	0.7	2.9	-0.5	-0.5	0.1	-0.5	-0.5	0.6	0.7	1.7	0.4	0.3	-1.5
Medication: Gliclazide	0.4	0.5	4.5	-0.1	0.0	-0.9	-0.1	-0.1	-0.3	-0.1	-2.1	0.2	-0.1	0.0
Guilty feelings	0.4	0.6	1.3	-0.7	-0.7	-0.8	-0.8	-0.8	0.8	0.5	0.5	0.8	1.1	0.8
Mother’s age at death	0.4	0.5	3.6	-0.3	-0.3	1.9	-0.3	-0.3	0.0	0.4	0.3	0.1	-0.2	-1.1
Financial situation satisfaction	0.4	0.5	1.4	-0.4	-0.5	0.1	-0.4	-0.4	1.1	0.9	0.7	1.2	0.2	-0.5
Medication: Atorvastatin	0.4	0.5	0.8	-0.8	-0.7	-0.9	-0.7	-0.7	0.6	0.6	-0.3	0.8	0.8	-0.3
Risk taking	0.4	0.7	4.0	-0.6	-0.7	-0.1	-0.6	-0.6	0.4	0.7	0.9	0.2	-0.2	-2.0
Bipolar Disorder (2018)	0.3	0.5	1.3	0.4	0.6	1.1	0.4	0.4	-0.7	-0.8	-1.1	-0.9	-0.4	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	0.6	0.6	-0.0	0.5	0.6	-0.8	-0.7	0.7	-0.6	-0.8	-0.1
Reaction Time	0.3	0.6	1.7	0.6	0.7	1.0	0.6	0.6	-0.9	-1.1	-0.3	-0.2	-1.3	-0.6
HDL Cholesterol	0.3	0.4	1.0	-0.7	-0.7	0.0	-0.7	-0.7	0.5	0.8	-0.5	0.7	0.3	-1.0
Neuroticism (2016)	0.3	0.4	0.9	0.5	0.7	-0.3	0.6	0.6	-0.8	-0.9	-0.9	-0.7	-0.7	0.2
Diabetes (father)	0.3	0.4	2.0	-0.3	-0.3	-0.4	-0.3	-0.3	0.4	0.4	1.4	0.3	-0.1	-1.0
Impedance of leg (right)	0.3	1.5	3.3	1.1	1.2	1.8	1.1	1.2	-1.0	-1.4	1.6	-0.9	-1.0	1.1
Average weekly fortified wine intake	0.3	0.3	0.8	-0.4	-0.4	-0.5	-0.4	-0.4	0.4	0.8	0.6	0.4	0.9	0.7
Waist circumference	0.3	1.1	5.3	1.1	1.0	0.2	1.0	1.0	-1.0	-0.7	0.1	-1.2	-0.2	2.3
Medication: Ramipril	0.3	0.4	0.8	-0.6	-0.7	-0.4	-0.5	-0.5	0.8	0.8	0.3	0.9	0.8	0.4
Alcohol intake versus 10 years previously	0.3	0.4	3.8	-0.3	-0.3	-0.1	-0.4	-0.4	0.2	0.1	2.0	0.5	-0.0	-0.1
Medication: Cholesterol lowering	0.3	0.4	2.7	0.4	0.4	-0.2	0.4	0.4	-0.7	-0.4	-1.6	-0.2	-0.3	0.5
Lung cancer (father)	0.3	0.4	0.9	0.5	0.6	-0.6	0.6	0.5	-0.6	-0.7	-0.6	-0.9	-0.7	-0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.5	0.4	0.5	-1.1	0.4	0.4	-0.6	-0.7	1.2	-0.3	-0.6	0.1
Birth weight	0.3	0.6	1.5	0.8	0.8	1.2	0.7	0.7	-0.5	-0.8	1.1	-0.9	-0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	-0.6	-0.7	1.0	-0.6	-0.6	0.2	0.8	0.4	0.5	0.3	-0.4
Age at first live birth	0.3	0.5	2.3	0.6	0.6	1.5	0.6	0.6	-0.6	-0.4	0.0	-0.4	-0.8	-0.2
Leg pain on walking	0.3	0.4	0.8	-0.7	-0.6	-0.2	-0.7	-0.7	0.6	0.5	0.3	0.9	0.4	-0.7
Knee pain experienced in last month	0.3	0.5	1.4	0.7	0.6	0.7	0.7	0.7	-0.5	-0.4	-1.2	-0.3	-0.6	0.7
Smoking status: Previous	0.3	0.5	2.0	-0.5	-0.4	1.0	-0.5	-0.5	0.3	0.5	-0.6	0.5	-0.3	-1.4
Average weekly champagne plus white wine intake	0.3	0.5	1.3	0.8	0.8	0.2	0.8	0.8	-0.5	-0.5	-0.6	-0.3	-1.1	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	-0.3	-0.3	0.0	-0.3	-0.3	0.2	0.2	-1.1	0.8	0.4	1.0
Alcohol drinker status: Never	0.3	0.3	2.2	0.3	0.3	-0.4	0.2	0.2	-0.2	-0.5	0.7	-0.2	0.3	1.5
Irritability	0.3	0.5	3.3	-0.5	-0.4	-0.1	-0.5	-0.5	0.6	0.4	-1.8	0.4	0.1	-0.9
Myopia	0.3	0.4	2.8	0.2	0.1	0.6	0.1	0.1	-0.2	-0.0	1.7	-0.6	-0.1	-0.7
Pain experienced in last month	0.3	0.5	0.8	0.6	0.8	0.6	0.6	0.6	-0.7	-0.8	-0.1	-0.8	-0.9	-0.7
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.6	-0.6	-0.1	-0.6	-0.6	0.6	0.3	-1.0	0.5	0.2	-0.8
Pack years of smoking	0.3	0.4	1.2	0.7	0.6	-0.1	0.7	0.7	-0.5	-0.6	0.0	-1.1	-0.1	1.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-0.6	-0.8	0.7	-0.6	-0.6	0.7	1.0	0.1	0.9	0.5	-0.2
Blood Eosinophil Count	0.2	1.5	6.6	0.3	-0.2	-1.4	0.5	0.4	0.3	0.5	2.6	-0.3	1.4	2.2
Hypothyroidism (self reported)	0.2	0.4	2.8	-0.3	-0.4	0.5	-0.3	-0.3	0.4	0.8	1.7	0.2	0.3	-0.2
Chronotype (morning person)	0.2	0.4	2.6	-0.4	-0.3	-0.5	-0.4	-0.4	0.5	0.3	-1.6	0.3	0.5	0.1
Relative age of first facial hair	0.2	0.3	1.9	-0.3	-0.4	1.4	-0.3	-0.3	0.4	0.3	-0.2	0.6	-0.1	-0.8
Pack years adult smoking proportion	0.2	0.3	1.0	0.5	0.5	-0.5	0.5	0.5	-0.3	-0.4	-0.4	-0.9	0.1	1.0
Hand grip strength (right)	0.2	0.5	1.0	0.7	0.8	0.4	0.7	0.7	-0.8	-0.8	-0.1	-0.9	-1.0	-0.1
Relative age voice broke	0.2	0.4	1.5	-0.5	-0.5	0.8	-0.5	-0.5	0.4	0.5	0.0	0.6	0.1	-1.2
Medication: Levothyroxine sodium	0.2	0.3	1.4	0.1	0.0	0.8	0.1	0.1	0.1	0.3	1.2	0.1	-0.4	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	1.2	0.0	0.1	-1.1	0.1	0.1	-0.1	-0.1	-0.8	0.1	0.3	0.6
Body mass index (BMI)	0.2	0.8	1.9	-0.9	-0.9	-1.4	-1.0	-1.0	0.6	0.9	-0.0	0.5	1.4	0.6
Impedance of leg (left)	0.2	0.8	2.9	0.8	0.8	1.7	0.8	0.8	-0.5	-0.8	1.2	-0.5	-0.6	0.8
Heart attack	0.2	0.2	1.2	0.3	0.3	0.1	0.2	0.3	-1.1	-0.4	-0.2	-0.7	-0.6	-0.0
Diabetes (self-reported)	0.2	0.4	0.6	-0.8	-0.7	-0.4	-0.8	-0.8	0.3	0.5	0.5	0.7	0.7	0.0
Father’s age at death	0.2	0.2	1.0	0.2	0.3	-0.1	0.2	0.2	-0.5	-0.3	0.7	-0.6	0.1	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.5	-0.5	-0.5	-0.4	-0.4	0.7	0.5	-0.7	0.8	0.4	-0.7
Pulse wave reflection index	0.2	0.2	0.5	-0.4	-0.3	-0.7	-0.4	-0.4	0.0	0.0	-0.6	-0.2	0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	2.0	-0.3	-0.1	-1.4	-0.3	-0.2	-0.0	-0.2	0.3	0.2	0.1	-0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.4	-0.5	-0.6	-0.4	-0.4	0.5	0.5	0.3	0.6	0.9	1.0
Angina (self-reported)	0.2	0.3	1.2	0.2	0.3	-1.1	0.1	0.2	-0.7	-0.5	-0.5	-0.5	-0.3	-0.4
Leg fat mass (right)	0.2	0.7	2.4	0.8	0.8	0.4	0.8	0.8	-0.9	-0.7	0.6	-1.1	-0.2	1.5
Medication: Aspirin	0.2	0.3	2.0	0.2	0.2	1.4	0.2	0.2	-0.5	-0.2	0.3	0.0	-0.6	-0.1
Arm fat percentage (left)	0.2	0.7	3.5	-0.7	-0.7	-1.9	-0.7	-0.7	0.4	0.6	0.4	0.3	1.1	0.8
Friendships satisfaction	0.2	0.2	1.1	0.1	0.1	-0.9	0.1	0.1	0.2	-0.2	-0.0	0.4	0.2	1.0
Osteoporosis (self-reported)	0.2	0.2	0.7	0.4	0.3	0.4	0.4	0.4	-0.5	-0.4	0.5	0.0	-0.5	0.8
Osteoarthritis (self-reported)	0.2	0.2	1.4	0.3	0.4	0.2	0.3	0.3	-0.1	-0.2	0.4	-0.2	-0.5	-1.2
Medication: Aspirin	0.2	0.3	1.9	0.2	0.2	1.4	0.2	0.2	-0.5	-0.1	0.1	-0.1	-0.6	-0.3
Wears glasses or contact lenses	0.2	0.2	0.7	0.5	0.4	0.8	0.5	0.5	-0.3	-0.0	0.3	-0.2	-0.1	0.3
High cholesterol (Self-reported)	0.2	0.4	2.1	0.2	0.3	-1.2	0.2	0.2	-0.2	-0.2	-1.4	-0.0	-0.0	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	2.2	0.2	0.1	1.5	0.2	0.2	-0.1	0.2	0.1	0.1	-0.3	0.3
LDL Cholesterol	0.1	0.2	0.4	-0.3	-0.3	-0.2	-0.3	-0.3	0.4	0.4	0.0	0.5	0.6	0.6
Primary Biliary Cirrhosis	0.1	0.2	1.7	-0.1	-0.1	-0.1	-0.1	-0.1	0.2	0.1	1.3	-0.0	0.1	0.2
Ulcerative Colitis	0.1	0.2	1.1	-0.3	-0.3	0.3	-0.3	-0.3	0.3	-0.0	0.6	0.0	-0.0	-1.0
Blood Red Count	0.1	0.9	3.6	0.6	0.7	-0.2	0.6	0.6	-1.0	-1.1	-1.1	-1.1	0.2	1.9
Blood White Count	0.1	0.5	1.6	0.4	0.3	-1.2	0.4	0.4	-0.0	0.2	1.3	-0.5	0.6	1.3
Systolic Blood Pressure	0.1	0.6	1.0	-0.8	-0.9	0.2	-0.8	-0.8	1.0	0.8	0.1	0.9	1.0	-0.7
Smoking Status	0.1	0.2	0.3	0.5	0.5	0.5	0.6	0.6	0.1	-0.1	0.2	-0.2	-0.3	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	2.1	0.3	0.3	0.0	0.3	0.3	-0.1	-0.2	-0.2	0.0	0.3	1.4
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.3	-0.3	-0.0	-0.3	-0.3	0.2	0.5	-0.2	0.1	0.5	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.4	-0.4	0.2	0.2	-0.3	0.0	0.5	-0.2
Vitamin and mineral supplements	0.1	0.2	0.3	0.4	0.5	-0.4	0.4	0.4	-0.5	-0.4	-0.3	-0.3	-0.5	0.5
Medication: Metformin	0.1	0.1	1.4	-0.1	-0.1	0.1	-0.1	-0.1	0.0	-0.0	-1.2	0.2	-0.2	-0.2
Trunk fat percentage	0.1	0.6	1.1	-0.5	-0.6	-1.0	-0.6	-0.6	0.5	0.8	1.0	0.3	1.1	0.9
Trunk fat mass	0.1	0.5	1.9	0.6	0.6	0.2	0.6	0.6	-0.7	-0.3	0.8	-0.8	-0.2	1.4
Number of incorrect matches in round	0.1	0.1	0.5	-0.2	-0.0	0.7	-0.2	-0.2	-0.4	-0.4	0.2	0.0	-0.1	0.3
Past tobacco smoking	0.1	0.2	1.0	0.1	-0.0	-0.7	0.0	0.0	0.1	-0.0	1.0	-0.1	0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	1.4	-0.1	-0.1	-0.4	-0.1	-0.1	0.1	0.1	1.2	0.4	-0.3	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.4	0.2	0.2	-0.7	0.2	0.2	0.1	-0.2	-0.5	-0.0	-0.3	0.0
Fluid intelligence score	0.1	0.1	0.3	-0.4	-0.3	0.5	-0.4	-0.4	-0.1	0.2	0.1	0.2	-0.2	-0.5
Impedance of arm (right)	0.1	0.3	1.1	0.4	0.5	0.2	0.4	0.4	-0.4	-0.5	1.0	-0.2	-0.9	-0.4
Arm fat percentage (right)	0.1	0.5	2.3	-0.5	-0.5	-1.5	-0.5	-0.5	0.1	0.4	0.5	0.1	0.9	0.8
Hip circumference	0.1	0.3	0.7	0.6	0.5	0.6	0.5	0.5	-0.6	-0.3	0.8	-0.6	-0.6	0.4
Depression (self-reported)	0.1	0.1	0.5	-0.1	-0.2	0.2	-0.1	-0.1	0.3	0.1	0.7	0.2	-0.1	-0.4
Impedance of arm (left)	0.1	0.3	0.6	-0.4	-0.3	-0.8	-0.3	-0.3	0.4	0.2	0.8	0.7	-0.1	-0.8
Arm fat mass (right)	0.1	0.2	1.3	0.4	0.3	-0.3	0.3	0.3	-0.5	-0.2	0.4	-0.6	0.1	1.2
Length of working week for main job	0.1	0.1	0.5	-0.3	-0.3	-0.7	-0.3	-0.3	0.3	0.2	0.6	0.1	0.5	0.1
Birth weight of first child	0.1	0.2	1.7	0.0	0.1	1.3	0.0	0.0	-0.0	0.1	-0.5	-0.3	-0.3	-0.5
Glaucoma (self-reported)	0.1	0.1	0.6	-0.4	-0.3	-0.8	-0.4	-0.4	0.0	-0.2	0.3	-0.1	0.1	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.9	-0.2	-0.3	0.5	-0.2	-0.2	0.4	0.7	1.4	0.2	0.2	-0.0
Body fat percentage	0.1	0.5	1.1	-0.5	-0.5	-1.0	-0.5	-0.5	0.4	0.6	1.0	0.2	1.0	0.9
Leg fat percentage (right)	0.1	0.4	2.4	-0.0	-0.0	-0.5	-0.1	-0.1	-0.1	0.0	1.1	-0.4	0.9	1.6
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.4	-0.3	-0.5	0.5	-0.3	-0.6	-0.4
Whole body fat mass	0.1	0.5	1.7	0.7	0.6	0.2	0.6	0.6	-0.7	-0.5	0.7	-0.8	-0.2	1.3
Supplements: Vitamin C	0.1	0.1	0.3	-0.2	-0.1	0.5	-0.2	-0.2	-0.1	-0.1	-0.6	0.1	-0.1	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	0.1	0.0	0.8	0.1	0.1	0.2	0.4	0.1	0.2	0.2	0.0
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.1	0.2	0.5	0.2	0.2	-0.4	-0.3	0.4	-0.2	-0.1	0.5
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.2	-0.2	0.4	-0.2	-0.2	0.1	-0.1	-0.7	-0.2	-0.1	-0.6
Back pain experienced in last month	0.1	0.1	0.5	-0.1	-0.2	-0.6	-0.1	-0.1	0.3	0.4	0.7	0.3	0.4	0.1
Arm fat mass (left)	0.1	0.3	1.5	0.2	0.2	-0.7	0.2	0.2	-0.4	-0.1	0.5	-0.4	0.2	1.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	-0.2	-0.0	-0.5	-0.2	-0.2	-0.3	-0.4	-0.8	-0.3	-0.1	-0.5
Medication: Blood pressure	0.1	0.3	0.8	-0.4	-0.5	-0.6	-0.5	-0.5	0.4	0.4	0.5	0.2	0.9	0.6
Medication: Lisinopril	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.5	-0.5	0.1	0.3	0.2	0.4	0.3	-0.3
Ever smoked	0.1	0.3	0.7	-0.5	-0.5	0.4	-0.5	-0.5	0.4	0.6	-0.5	0.5	0.1	-0.9
Leg fat percentage (left)	0.1	0.5	1.7	-0.5	-0.5	-0.7	-0.5	-0.5	0.4	0.6	0.9	-0.0	1.3	1.2
Commuting to job workplace: Cycle	0.1	0.1	0.7	-0.2	-0.2	-0.5	-0.1	-0.1	0.3	0.2	-0.8	0.3	0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.8	0.1	0.0	0.1	0.0	0.0	-0.9	-0.2	0.1	-0.5	-0.4	-0.2
Heart disease (siblings)	0.1	0.1	0.4	0.3	0.5	0.1	0.3	0.3	-0.5	-0.5	0.2	-0.2	-0.6	-0.1
Leg fat mass (left)	0.1	0.5	1.8	0.6	0.6	0.5	0.6	0.6	-0.7	-0.4	0.4	-1.0	-0.1	1.4
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	0.2	0.2	0.2	0.1	0.0	-0.1	-0.2	0.0	-0.0	0.2
Major Depression (MDD)	0.0	0.0	0.2	-0.1	-0.2	-0.0	-0.1	-0.1	0.1	0.2	-0.4	-0.1	0.4	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Medication for hormone replacement therapy	0.0	0.1	0.4	0.1	0.0	0.1	0.1	0.1	-0.2	-0.3	-0.6	-0.3	0.1	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.2	-0.0	-0.0	-0.5	0.0	-0.0	0.0	-0.2	-0.4	0.1	0.1	0.1
Cholesterol lowering medication	0.0	0.1	0.2	-0.0	0.1	-0.3	-0.1	-0.1	-0.5	-0.4	-0.2	-0.2	-0.3	0.3
Impedance of whole body	0.0	0.2	1.6	-0.0	0.1	0.1	0.0	0.0	0.1	-0.1	1.3	0.3	-0.2	-0.1

Hub : Genes

GNS

Models

Trait associations