Hub : Genes

GNS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2260	0.0540	6.8e-09	0.275	NA	0.260	NA	0.274	1.9e-15	NA	1.4e-14	NA	2.0e-15
2	GTEx	Artery Tibial	0.2369	0.0445	7.7e-14	0.240	NA	0.245	NA	0.254	9.2e-19	NA	3.3e-19	NA	5.9e-20
3	GTEx	Esophagus Mucosa	0.1280	0.0440	2.2e-04	-0.004	NA	0.022	NA	0.007	1.0e+00	NA	1.3e-02	NA	1.0e-01
4	GTEx	Esophagus Muscularis	0.2340	0.0550	7.3e-08	0.217	NA	0.166	NA	0.212	2.6e-13	NA	2.7e-10	NA	5.5e-13
5	GTEx	Nerve Tibial	0.1426	0.0391	1.6e-06	0.162	NA	0.120	NA	0.143	1.3e-11	NA	8.4e-09	NA	2.6e-10
6	METSIM	Adipose	0.1026	0.0258	1.9e-12	0.132	0.094	0.127	0.119	0.129	3.0e-19	6.5e-14	2.0e-18	2.4e-17	7.7e-19
7	NTR	Blood	0.0406	0.0109	2.3e-11	0.051	0.037	0.041	0.042	0.046	6.2e-16	4.2e-12	4.7e-13	2.0e-13	1.4e-14
8	YFS	Blood	0.0207	0.0101	2.1e-03	0.003	0.005	0.008	0.006	0.009	2.6e-02	7.6e-03	6.4e-04	3.8e-03	4.5e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0229	0.0153	5.9e-03	0.011	0.021	0.013	NA	0.014	1.9e-02	1.7e-03	1.0e-02	NA	8.1e-03
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0460	0.0290	4.8e-03	0.030	0.037	0.016	NA	0.019	7.6e-03	3.5e-03	4.1e-02	NA	2.9e-02
11	TCGA	Prostate Adenocarcinoma	0.0416	0.0237	4.3e-03	-0.001	0.015	0.003	NA	0.000	4.5e-01	9.0e-03	1.5e-01	NA	3.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.3	0.5	1.3	0.4	0.6	1.1	0.4	0.4	-0.7	-0.8	-1.1	-0.9	-0.4	-0.3
Bipolar Disorder or Schizophrenia	0.7	1.7	3.4	1.2	1.3	1.9	1.2	1.2	-1.4	-1.3	-0.9	-1.5	-1.4	0.1
Depressed Affect (Nagel 2018)	3.3	6.9	9.3	-3.0	-3.0	-2.2	-3.0	-3.0	2.7	2.8	-1.5	2.5	2.8	-1.8
Depression (Nagel 2018)	0.7	1.0	1.7	-1.2	-1.1	-0.8	-1.2	-1.2	1.0	1.0	0.1	1.1	1.3	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	2.2	0.2	0.1	1.5	0.2	0.2	-0.1	0.2	0.1	0.1	-0.3	0.3
Neuroticism (Nagel 2018)	2.5	5.9	7.0	-2.6	-2.6	-2.6	-2.6	-2.6	2.3	2.6	-2.0	2.5	2.5	-1.5
Schizophrenia (2018)	0.6	1.3	2.3	1.2	1.2	1.5	1.2	1.2	-1.3	-1.0	-0.3	-1.2	-1.4	0.4
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	0.6	0.6	-0.0	0.5	0.6	-0.8	-0.7	0.7	-0.6	-0.8	-0.1
Worry (Nagel 2018)	3.1	6.6	9.8	-2.7	-2.7	-3.1	-2.7	-2.7	2.4	2.4	-2.7	2.5	2.7	-1.2
Alzheimer’s Disease (in mother)	2.1	2.5	4.6	1.7	1.6	0.6	1.7	1.6	-2.1	-1.5	-0.4	-1.8	-1.3	1.9
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	0.2	0.2	0.2	0.1	0.0	-0.1	-0.2	0.0	-0.0	0.2
Alzheimer’s Disease (including proxy)	3.4	5.0	7.1	2.5	2.4	2.0	2.4	2.4	-2.7	-2.3	-0.9	-2.3	-2.1	2.1
Crohns Disease (2017)	1.0	2.2	5.0	-1.7	-1.5	-2.2	-1.7	-1.7	1.5	1.2	0.9	1.4	1.5	-0.2
Irritable Bowel Disease (IBD)	0.9	2.1	3.0	-1.7	-1.6	-1.0	-1.7	-1.7	1.4	1.1	1.4	1.3	1.0	-1.6
Ulcerative Colitis (UC)	0.5	0.9	3.5	-1.0	-0.9	0.4	-1.0	-1.0	0.8	0.4	0.8	0.8	0.2	-1.9
Major Depression (MDD)	0.0	0.0	0.2	-0.1	-0.2	-0.0	-0.1	-0.1	0.1	0.2	-0.4	-0.1	0.4	0.0
Reaction Time	0.3	0.6	1.7	0.6	0.7	1.0	0.6	0.6	-0.9	-1.1	-0.3	-0.2	-1.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.1	-0.6	-0.8	0.7	-0.6	-0.6	0.7	1.0	0.1	0.9	0.5	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.7	0.9	1.4	1.1	1.1	-0.1	1.2	1.2	-0.8	-1.2	-0.8	-1.0	-0.9	0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.3	1.9	3.2	1.5	1.4	1.7	1.6	1.5	-1.1	-1.2	-0.9	-1.3	-1.8	-0.1
Bipolar Disorder (2011)	0.5	0.5	3.1	-0.5	-0.5	0.4	-0.5	-0.5	0.4	0.5	-1.8	0.7	0.6	0.0
Body Mass Index (BMI) (2010)	0.7	0.9	2.8	-0.8	-0.9	-1.7	-0.8	-0.8	0.9	0.8	1.4	0.5	1.2	-0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.7	-0.7	-0.6	-0.8	-0.8	0.6	0.5	-1.1	0.7	0.8	-0.1
Crohns Disease (2012)	0.4	0.6	1.1	-0.8	-0.7	-0.6	-0.8	-0.8	0.8	0.7	0.5	1.0	0.9	0.5
Mean Putamen Volume	0.6	0.7	1.1	-0.9	-0.8	-0.8	-0.8	-0.8	1.0	0.8	-0.9	1.1	0.8	-0.5
Fasting Glucose	3.4	4.0	6.1	-2.4	-2.4	-1.4	-2.4	-2.4	2.1	2.0	0.6	2.5	1.9	-1.0
HbA1C	1.9	2.2	4.2	-1.4	-1.5	-0.6	-1.4	-1.4	1.6	1.3	2.0	2.0	0.9	-1.4
HDL Cholesterol	0.3	0.4	1.0	-0.7	-0.7	0.0	-0.7	-0.7	0.5	0.8	-0.5	0.7	0.3	-1.0
LDL Cholesterol	0.1	0.2	0.4	-0.3	-0.3	-0.2	-0.3	-0.3	0.4	0.4	0.0	0.5	0.6	0.6
Lupus	1.9	2.9	3.8	2.0	1.9	1.5	1.9	1.9	-1.8	-1.8	-1.1	-1.8	-1.9	0.9
Neuroticism (2016)	0.3	0.4	0.9	0.5	0.7	-0.3	0.6	0.6	-0.8	-0.9	-0.9	-0.7	-0.7	0.2
Primary Biliary Cirrhosis	0.1	0.2	1.7	-0.1	-0.1	-0.1	-0.1	-0.1	0.2	0.1	1.3	-0.0	0.1	0.2
Rheumatoid Arthritis	1.2	1.6	4.0	-1.3	-1.3	-2.0	-1.4	-1.4	1.2	1.3	-0.2	1.2	1.4	-0.4
Schizophrenia (2014)	1.1	2.5	3.3	1.8	1.7	1.6	1.8	1.8	-1.6	-1.5	-0.9	-1.7	-1.5	0.9
Triglycerides	0.6	1.0	4.0	0.9	1.0	0.4	0.8	0.8	-1.1	-1.0	-0.6	-0.9	-0.4	2.0
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.5	1.8	1.4	1.3	2.1	2.1	-1.1	-1.3	-1.0	-1.4	-1.0	1.8
Ulcerative Colitis	0.1	0.2	1.1	-0.3	-0.3	0.3	-0.3	-0.3	0.3	-0.0	0.6	0.0	-0.0	-1.0
Blood Eosinophil Count	0.2	1.5	6.6	0.3	-0.2	-1.4	0.5	0.4	0.3	0.5	2.6	-0.3	1.4	2.2
Blood Platelet Count	1.5	16.8	26.9	4.4	4.3	4.0	4.3	4.3	-4.3	-5.1	-3.2	-3.6	-5.2	-0.3
Blood Red Count	0.1	0.9	3.6	0.6	0.7	-0.2	0.6	0.6	-1.0	-1.1	-1.1	-1.1	0.2	1.9
Blood White Count	0.1	0.5	1.6	0.4	0.3	-1.2	0.4	0.4	-0.0	0.2	1.3	-0.5	0.6	1.3
Heel T-Score	1.6	13.0	17.1	-4.1	-4.1	-3.0	-4.1	-4.1	3.8	3.7	1.3	3.7	3.7	-2.9
BMI	0.7	4.0	6.5	-2.2	-2.2	-2.0	-2.2	-2.2	2.2	2.3	0.1	2.0	2.5	-0.6
Height	2.7	52.7	73.0	7.9	8.0	8.5	7.9	7.9	-7.7	-7.5	-1.1	-7.4	-8.5	3.3
Waist Hip Ratio (WHR)	0.4	1.9	7.9	1.4	1.4	-0.2	1.4	1.4	-1.0	-1.1	-0.5	-1.3	-0.3	2.8
Systolic Blood Pressure	0.1	0.6	1.0	-0.8	-0.9	0.2	-0.8	-0.8	1.0	0.8	0.1	0.9	1.0	-0.7
Smoking Status	0.1	0.2	0.3	0.5	0.5	0.5	0.6	0.6	0.1	-0.1	0.2	-0.2	-0.3	0.3
Allergy or Eczema	2.2	5.7	7.3	-2.6	-2.7	-2.7	-2.6	-2.6	2.4	2.4	-0.4	2.1	2.1	-2.6
Cardiovascular Disease	1.5	5.0	6.8	-2.5	-2.6	-1.8	-2.5	-2.5	2.5	2.5	-0.2	2.3	2.6	-1.4
Hypothyroidism (self reported)	0.2	0.4	2.8	-0.3	-0.4	0.5	-0.3	-0.3	0.4	0.8	1.7	0.2	0.3	-0.2
Respiratory disease	0.5	1.2	5.6	-1.0	-1.0	-2.4	-1.0	-1.0	0.9	0.8	-0.0	0.8	1.2	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	2.1	0.3	0.3	0.0	0.3	0.3	-0.1	-0.2	-0.2	0.0	0.3	1.4
Lung FEV1/FVC ratio	0.4	2.1	9.4	0.7	0.7	2.0	0.7	0.7	-0.5	-0.5	1.2	-0.3	-2.4	-3.1
Lung FVC	2.0	10.1	13.7	3.4	3.4	3.6	3.4	3.4	-3.3	-3.5	1.2	-3.7	-2.6	2.7
Neuroticism	1.3	3.2	6.9	-1.8	-1.7	-2.6	-1.8	-1.8	1.6	1.6	-2.2	1.3	2.1	-0.5
Chronotype (morning person)	0.2	0.4	2.6	-0.4	-0.3	-0.5	-0.4	-0.4	0.5	0.3	-1.6	0.3	0.5	0.1
Hair Pigment	1.7	48.7	69.6	-8.0	-8.0	-3.1	-7.9	-8.0	8.1	7.6	2.4	8.3	6.3	-5.8
Tanning	0.5	6.4	14.0	-2.6	-2.8	-2.3	-2.7	-2.7	2.6	2.8	-0.1	2.7	3.7	0.8
Hand grip strength (left)	0.8	2.2	3.1	1.6	1.7	1.0	1.6	1.6	-1.6	-1.6	-0.3	-1.8	-1.6	1.1
Number of treatments/medications taken	0.7	1.3	2.3	-1.3	-1.2	-1.5	-1.3	-1.3	0.8	0.8	-0.8	1.4	1.2	-0.1
Average weekly spirits intake	0.7	0.9	1.7	0.8	0.9	0.9	0.8	0.8	-1.3	-1.1	-0.6	-0.9	-1.3	0.1
Sensitivity / hurt feelings	1.3	2.2	8.0	-1.4	-1.4	-2.8	-1.5	-1.5	1.3	1.2	-0.2	1.2	1.6	-0.3
Frequency of depressed mood in last 2 weeks	1.5	2.2	3.6	-1.6	-1.6	-1.2	-1.6	-1.6	1.7	1.5	0.3	1.6	1.9	-0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.3	-0.3	-0.0	-0.3	-0.3	0.2	0.5	-0.2	0.1	0.5	0.2
Relative age of first facial hair	0.2	0.3	1.9	-0.3	-0.4	1.4	-0.3	-0.3	0.4	0.3	-0.2	0.6	-0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.7	-1.8	-1.7	-0.5	-1.8	-1.8	1.6	1.7	0.4	1.6	1.1	-2.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	-0.4	-0.2	-0.4	-0.4	0.2	0.2	-0.3	0.0	0.5	-0.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	-0.9	-1.0	-0.1	-0.9	-0.9	0.8	0.8	0.0	1.0	0.9	-0.6
Systolic blood pressure, automated reading	0.5	1.4	3.0	-1.3	-1.3	-0.6	-1.3	-1.3	1.2	1.3	-0.9	1.0	1.7	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.9	0.3	0.4	1.7	0.3	0.3	-0.8	-0.7	0.0	-0.4	-1.0	-0.5
Angina	0.4	0.5	1.5	0.5	0.6	-1.2	0.5	0.5	-1.0	-0.7	-0.7	-0.9	-0.5	-0.1
Medication for hormone replacement therapy	0.0	0.1	0.4	0.1	0.0	0.1	0.1	0.1	-0.2	-0.3	-0.6	-0.3	0.1	-0.0
Vitamin and mineral supplements	0.1	0.2	0.3	0.4	0.5	-0.4	0.4	0.4	-0.5	-0.4	-0.3	-0.3	-0.5	0.5
Supplements: Zinc	0.7	0.7	1.0	-0.9	-0.9	-0.5	-1.0	-1.0	0.6	1.0	1.0	0.8	0.6	-0.9
Medication: Co-codamol	0.6	0.7	2.3	0.8	0.9	-0.1	0.7	0.7	-0.8	-1.0	-1.5	-0.9	-0.8	0.2
Medication: Metformin	0.1	0.1	1.4	-0.1	-0.1	0.1	-0.1	-0.1	0.0	-0.0	-1.2	0.2	-0.2	-0.2
Diabetes (father)	0.3	0.4	2.0	-0.3	-0.3	-0.4	-0.3	-0.3	0.4	0.4	1.4	0.3	-0.1	-1.0
Diabetes (mother)	2.0	2.5	4.9	1.6	1.8	0.6	1.6	1.6	-1.7	-2.2	-1.3	-1.7	-1.4	1.6
Severe depression (siblings)	1.8	2.0	5.5	1.2	1.3	1.6	1.2	1.2	-1.4	-1.3	2.3	-1.4	-1.4	0.4
Pack years adult smoking proportion	0.2	0.3	1.0	0.5	0.5	-0.5	0.5	0.5	-0.3	-0.4	-0.4	-0.9	0.1	1.0
Impedance of leg (right)	0.3	1.5	3.3	1.1	1.2	1.8	1.1	1.2	-1.0	-1.4	1.6	-0.9	-1.0	1.1
Leg fat-free mass (left)	0.6	3.3	4.3	2.1	2.1	1.6	2.1	2.1	-1.9	-1.8	-0.2	-2.1	-2.0	1.1
Trunk fat percentage	0.1	0.6	1.1	-0.5	-0.6	-1.0	-0.6	-0.6	0.5	0.8	1.0	0.3	1.1	0.9
Hand grip strength (right)	0.2	0.5	1.0	0.7	0.8	0.4	0.7	0.7	-0.8	-0.8	-0.1	-0.9	-1.0	-0.1
Townsend deprivation index at recruitment	0.6	0.9	5.5	0.6	0.6	-0.3	0.6	0.6	-0.4	-0.5	2.4	-0.3	-0.2	1.4
Current tobacco smoking	1.0	1.6	4.6	1.6	1.4	0.0	1.6	1.6	-0.8	-1.0	0.1	-1.4	-0.5	2.1
Average weekly fortified wine intake	0.3	0.3	0.8	-0.4	-0.4	-0.5	-0.4	-0.4	0.4	0.8	0.6	0.4	0.9	0.7
Maternal smoking around birth	1.3	1.9	3.1	-1.5	-1.5	-1.1	-1.5	-1.5	1.7	1.5	-0.4	1.6	1.8	0.0
Fed-up feelings	1.8	3.2	4.6	-2.1	-2.0	-1.6	-2.1	-2.1	1.6	1.5	-1.6	1.7	1.6	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.9	-1.0	-0.8	-0.8	-0.9	-0.9	0.9	0.6	-0.6	0.9	0.8	-0.1
Relative age voice broke	0.2	0.4	1.5	-0.5	-0.5	0.8	-0.5	-0.5	0.4	0.5	0.0	0.6	0.1	-1.2
Taking other prescription medications	2.6	3.9	5.4	-2.3	-2.3	-1.9	-2.3	-2.3	1.9	2.1	-0.3	2.0	2.0	-1.5
Age when periods started (menarche)	1.1	2.7	4.1	1.8	1.9	0.6	1.8	1.8	-1.9	-2.0	0.8	-1.0	-1.9	1.6
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.2	-1.4	-1.4	-0.5	-1.4	-1.4	1.5	1.2	-0.7	1.5	1.0	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.7	-1.2	-1.2	-0.6	-1.2	-1.2	1.6	1.1	-0.7	1.0	1.3	-0.9
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.2	-1.4	-1.4	-1.1	-1.4	-1.4	2.1	1.6	0.4	1.6	1.4	-0.7
Qualifications: CSEs or equivalent	0.5	0.7	2.4	-0.7	-0.6	-1.5	-0.6	-0.6	0.7	0.6	1.1	1.1	0.6	0.6
Serious illness, injury or assault to yourself	1.1	1.4	2.2	1.5	1.3	1.0	1.5	1.5	-1.1	-0.9	-0.4	-0.8	-1.2	1.2
High blood pressure	2.1	5.9	8.1	-2.8	-2.8	-1.9	-2.8	-2.8	2.5	2.6	0.6	2.5	2.9	-1.4
Hayfever, allergic rhinitis or eczema	1.5	3.2	7.8	-1.8	-1.9	-2.8	-1.8	-1.8	1.8	1.8	-0.1	1.7	1.4	-1.7
Multivitamins +/- minerals	0.5	0.6	1.0	-0.8	-0.9	0.1	-0.9	-0.9	0.9	0.7	0.6	0.6	1.0	-0.5
Stomach or abdominal pain in last month	6.3	7.9	11.2	-3.1	-3.1	-3.3	-3.1	-3.1	2.8	2.8	0.8	3.0	3.3	-0.4
Supplements: Glucosamine	1.6	2.1	4.5	1.6	1.5	2.0	1.6	1.5	-1.4	-1.2	0.1	-1.1	-2.1	-0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	-0.8	-0.7	-1.1	-0.8	-0.8	0.8	0.6	-0.6	0.6	0.4	-1.0
Medication: Atenolol	3.3	4.1	5.9	-2.2	-2.2	-1.8	-2.2	-2.2	2.1	2.4	0.3	2.3	2.3	-1.1
Medication: Levothyroxine sodium	0.2	0.3	1.4	0.1	0.0	0.8	0.1	0.1	0.1	0.3	1.2	0.1	-0.4	-0.8
Sitting height	1.0	7.2	14.4	2.9	2.9	3.8	2.9	2.9	-2.4	-2.6	0.4	-2.6	-3.4	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	1.2	0.0	0.1	-1.1	0.1	0.1	-0.1	-0.1	-0.8	0.1	0.3	0.6
High blood pressure (mother)	0.5	0.7	2.7	-0.9	-0.8	0.3	-0.9	-0.9	0.4	0.7	1.2	0.3	0.1	-1.6
Body mass index (BMI)	0.2	0.8	1.9	-0.9	-0.9	-1.4	-1.0	-1.0	0.6	0.9	-0.0	0.5	1.4	0.6
Impedance of leg (left)	0.2	0.8	2.9	0.8	0.8	1.7	0.8	0.8	-0.5	-0.8	1.2	-0.5	-0.6	0.8
Leg predicted mass (left)	0.6	3.4	4.4	2.1	2.1	1.5	2.1	2.1	-1.9	-1.8	-0.3	-2.1	-2.0	1.2
Trunk fat mass	0.1	0.5	1.9	0.6	0.6	0.2	0.6	0.6	-0.7	-0.3	0.8	-0.8	-0.2	1.4
Waist circumference	0.3	1.1	5.3	1.1	1.0	0.2	1.0	1.0	-1.0	-0.7	0.1	-1.2	-0.2	2.3
Number of incorrect matches in round	0.1	0.1	0.5	-0.2	-0.0	0.7	-0.2	-0.2	-0.4	-0.4	0.2	0.0	-0.1	0.3
Past tobacco smoking	0.1	0.2	1.0	0.1	-0.0	-0.7	0.0	0.0	0.1	-0.0	1.0	-0.1	0.4	0.6
Alcohol usually taken with meals	0.5	0.8	5.8	0.5	0.5	2.4	0.5	0.5	-0.5	0.0	-1.1	-0.2	-0.7	-0.1
Nervous feelings	1.0	1.9	6.3	-1.3	-1.3	-0.9	-1.3	-1.3	1.2	1.3	-2.5	1.2	1.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	2.9	4.5	6.6	-2.4	-2.3	-1.9	-2.4	-2.3	2.5	2.3	-0.2	2.2	2.6	-0.9
Hearing difficulty/problems with background noise	0.8	1.2	2.4	1.2	1.2	-0.0	1.2	1.2	-1.1	-0.9	-1.0	-1.2	-0.8	1.6
Hair/balding pattern: Pattern 2	5.1	6.4	7.9	-2.7	-2.6	-2.8	-2.7	-2.7	2.4	2.6	2.4	2.3	2.4	-2.3
Had menopause	1.9	2.3	6.2	1.4	1.4	2.5	1.3	1.3	-1.7	-1.5	0.3	-1.9	-1.0	1.4
Had other major operations	0.5	0.7	1.3	-1.1	-1.0	-0.8	-1.1	-1.1	0.2	0.7	0.6	0.4	0.9	-0.3
Forced vital capacity (FVC)	3.5	13.6	17.9	4.1	4.2	3.8	4.2	4.2	-3.7	-4.2	0.1	-3.8	-4.2	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	-1.1	-1.1	-0.3	-1.1	-1.1	1.4	1.1	-1.1	0.9	1.1	-0.9
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	1.4	-0.1	-0.1	-0.4	-0.1	-0.1	0.1	0.1	1.2	0.4	-0.3	-0.1
Qualifications: None of the above	0.4	0.9	3.2	-0.5	-0.7	-1.8	-0.5	-0.5	0.8	0.6	-0.9	0.2	1.6	1.1
Financial difficulties in last 2 years	0.1	0.1	0.4	0.2	0.2	-0.7	0.2	0.2	0.1	-0.2	-0.5	-0.0	-0.3	0.0
Mouth/teeth dental problems	0.8	1.2	2.9	-1.0	-1.1	1.7	-0.9	-0.9	1.1	1.4	-0.6	1.2	1.0	-0.3
Heart attack	0.2	0.2	1.2	0.3	0.3	0.1	0.2	0.3	-1.1	-0.4	-0.2	-0.7	-0.6	-0.0
Allergy	0.7	1.6	6.9	1.2	1.2	2.6	1.2	1.2	-1.1	-1.1	-0.4	-1.0	-1.1	0.7
Pain all over the body in last month	1.4	1.5	2.6	-1.4	-1.4	-0.4	-1.4	-1.4	1.3	1.2	0.6	1.6	1.2	-0.6
Diabetes (self-reported)	0.2	0.4	0.6	-0.8	-0.7	-0.4	-0.8	-0.8	0.3	0.5	0.5	0.7	0.7	0.0
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	11.8	-1.6	-1.5	-3.4	-1.7	-1.7	1.4	1.4	-0.5	1.5	1.6	-0.5
Medication: Ramipril	0.3	0.4	0.8	-0.6	-0.7	-0.4	-0.5	-0.5	0.8	0.8	0.3	0.9	0.8	0.4
Medication: Simvastatin	1.1	1.6	5.7	1.1	1.2	0.3	1.1	1.1	-1.4	-1.2	-2.4	-1.1	-1.3	0.7
Fluid intelligence score	0.1	0.1	0.3	-0.4	-0.3	0.5	-0.4	-0.4	-0.1	0.2	0.1	0.2	-0.2	-0.5
Illnesses of siblings	0.6	0.9	2.2	0.9	0.8	1.1	0.9	0.9	-0.9	-0.8	0.6	-0.8	-1.5	-1.0
Neuroticism score	2.3	4.7	7.6	-2.3	-2.3	-2.8	-2.3	-2.3	2.2	2.0	-2.1	2.0	2.3	-1.1
Weight	0.5	2.5	3.5	1.8	1.8	1.5	1.7	1.7	-1.8	-1.5	0.3	-1.9	-1.6	1.4
Impedance of arm (right)	0.1	0.3	1.1	0.4	0.5	0.2	0.4	0.4	-0.4	-0.5	1.0	-0.2	-0.9	-0.4
Arm fat percentage (right)	0.1	0.5	2.3	-0.5	-0.5	-1.5	-0.5	-0.5	0.1	0.4	0.5	0.1	0.9	0.8
Trunk fat-free mass	2.0	11.3	15.4	3.7	3.7	3.9	3.7	3.7	-3.5	-3.4	0.1	-3.7	-3.7	1.8
Hip circumference	0.1	0.3	0.7	0.6	0.5	0.6	0.5	0.5	-0.6	-0.3	0.8	-0.6	-0.6	0.4
Time employed in main current job	0.6	0.7	1.3	0.8	0.8	-0.1	0.8	0.8	-1.1	-1.1	-0.8	-1.0	-0.7	0.8
Alcohol intake versus 10 years previously	0.3	0.4	3.8	-0.3	-0.3	-0.1	-0.4	-0.4	0.2	0.1	2.0	0.5	-0.0	-0.1
Father’s age at death	0.2	0.2	1.0	0.2	0.3	-0.1	0.2	0.2	-0.5	-0.3	0.7	-0.6	0.1	1.0
Worrier / anxious feelings	2.1	3.9	10.8	-1.8	-1.7	-2.6	-1.8	-1.8	1.6	1.6	-3.3	2.1	1.6	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.2	-1.5	-1.4	-1.1	-1.5	-1.5	1.2	1.0	-2.3	1.3	0.9	-1.7
Falls in the last year	2.2	3.0	4.2	-1.8	-1.9	-1.4	-1.8	-1.8	2.1	2.0	-0.8	2.0	1.8	-1.0
Hair/balding pattern: Pattern 3	2.8	4.2	8.9	2.0	2.1	3.0	2.1	2.1	-2.1	-2.2	-0.7	-2.1	-2.2	1.1
Number of live births	1.2	1.6	3.4	1.3	1.3	0.1	1.3	1.3	-1.6	-1.5	-0.6	-1.3	-0.9	1.8
Forced expiratory volume in 1-second (FEV1)	3.3	11.1	17.2	3.6	3.7	3.6	3.7	3.7	-3.4	-3.8	0.3	-3.3	-4.1	0.9
Pulse rate	5.0	8.4	13.5	-2.9	-2.9	-3.7	-2.9	-2.9	3.2	3.1	1.6	3.3	3.4	0.2
Happiness	0.8	1.0	2.1	-1.1	-1.1	-0.8	-1.1	-1.1	1.2	1.1	0.2	1.5	0.8	-0.6
Noisy workplace	1.2	1.5	2.0	-1.3	-1.3	-1.1	-1.2	-1.2	1.4	1.3	-0.7	1.2	1.1	-1.2
Qualifications: A levels/AS levels or equivalent	2.2	4.9	15.8	-2.3	-2.2	-0.8	-2.3	-2.3	2.2	2.2	1.4	2.1	1.2	-4.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.8	0.5	0.5	-1.4	0.5	0.5	-0.2	-0.6	0.4	-0.4	0.3	1.7
Mouth/teeth dental problems: Dentures	1.3	2.2	3.6	1.6	1.7	-0.3	1.6	1.6	-1.5	-1.8	-0.5	-1.9	-1.2	1.4
Asthma	0.9	1.7	7.9	-1.1	-1.1	-2.8	-1.1	-1.1	0.9	0.8	1.4	1.1	1.3	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.7	0.4	0.4	-1.6	0.5	0.5	-0.4	-0.3	-0.0	-0.1	0.4	1.6
Medication: Cholesterol lowering	0.3	0.4	2.7	0.4	0.4	-0.2	0.4	0.4	-0.7	-0.4	-1.6	-0.2	-0.3	0.5
Depression (self-reported)	0.1	0.1	0.5	-0.1	-0.2	0.2	-0.1	-0.1	0.3	0.1	0.7	0.2	-0.1	-0.4
Medication: Lansoprazole	2.6	3.0	6.4	-1.9	-1.9	-2.5	-1.9	-1.9	1.5	1.5	-0.8	1.7	1.6	-1.2
Prospective memory result	0.8	0.9	4.1	0.9	0.9	-0.3	0.9	0.9	-0.5	-0.7	-2.0	-0.7	-0.5	1.1
Lung cancer (father)	0.3	0.4	0.9	0.5	0.6	-0.6	0.6	0.5	-0.6	-0.7	-0.6	-0.9	-0.7	-0.1
Illnesses of mother	0.9	1.1	2.2	-0.9	-0.9	-1.1	-0.9	-0.9	1.2	0.9	1.5	1.1	1.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.5	18.0	3.8	3.8	3.8	3.8	3.8	-3.2	-3.5	0.4	-3.6	-4.2	0.3
Pulse wave Arterial Stiffness index	1.1	1.2	2.9	-1.3	-1.2	-0.9	-1.3	-1.3	1.1	1.1	0.1	0.9	1.7	0.3
Impedance of arm (left)	0.1	0.3	0.6	-0.4	-0.3	-0.8	-0.3	-0.3	0.4	0.2	0.8	0.7	-0.1	-0.8
Arm fat mass (right)	0.1	0.2	1.3	0.4	0.3	-0.3	0.3	0.3	-0.5	-0.2	0.4	-0.6	0.1	1.2
Trunk predicted mass	2.1	11.8	16.3	3.8	3.8	4.0	3.7	3.7	-3.6	-3.5	0.3	-3.7	-3.8	1.7
Standing height	3.3	32.3	47.6	6.3	6.3	6.9	6.3	6.3	-5.7	-5.7	0.7	-5.7	-6.9	2.0
Length of working week for main job	0.1	0.1	0.5	-0.3	-0.3	-0.7	-0.3	-0.3	0.3	0.2	0.6	0.1	0.5	0.1
Exposure to tobacco smoke at home	0.4	0.4	0.6	0.7	0.7	-0.4	0.7	0.7	-0.7	-0.5	-0.8	-0.7	-0.3	0.5
Breastfed as a baby	0.7	0.8	2.1	0.8	0.8	0.6	0.8	0.8	-0.8	-0.8	1.4	-1.1	-0.4	1.2
Tense / ‘highly strung’	1.4	2.4	3.3	-1.8	-1.7	-1.6	-1.8	-1.8	1.6	1.4	-1.3	1.4	1.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	-0.5	-0.5	-0.5	-0.4	-0.4	0.7	0.5	-0.7	0.8	0.4	-0.7
Hair/balding pattern: Pattern 4	1.0	2.4	3.9	-1.7	-1.8	-0.9	-1.7	-1.7	1.8	1.8	0.8	2.0	1.6	-0.7
Birth weight of first child	0.1	0.2	1.7	0.0	0.1	1.3	0.0	0.0	-0.0	0.1	-0.5	-0.3	-0.3	-0.5
Peak expiratory flow (PEF)	1.0	2.3	4.9	1.4	1.6	1.7	1.4	1.5	-1.6	-1.8	0.0	-1.4	-2.2	-0.7
Pulse wave reflection index	0.2	0.2	0.5	-0.4	-0.3	-0.7	-0.4	-0.4	0.0	0.0	-0.6	-0.2	0.6	0.5
Ever highly irritable/argumentative for 2 days	4.9	5.9	7.8	-2.7	-2.8	-2.2	-2.7	-2.7	2.5	2.5	1.1	2.6	2.4	-2.0
Loud music exposure frequency	0.6	0.7	1.3	-0.8	-0.8	-0.8	-0.7	-0.7	1.1	0.9	0.6	1.1	0.8	-0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	3.5	-0.5	-0.4	0.8	-0.4	-0.5	0.4	0.6	1.9	0.6	0.1	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.5	0.4	0.5	-1.1	0.4	0.4	-0.6	-0.7	1.2	-0.3	-0.6	0.1
Blood clot in the leg (DVT)	2.6	3.3	4.4	2.1	2.0	0.7	2.1	2.1	-1.8	-2.1	-1.7	-2.1	-1.8	1.0
Medication: Paracetamol	3.1	5.1	11.2	-2.3	-2.3	-3.2	-2.3	-2.3	2.0	2.0	-0.6	2.1	3.3	1.0
Headache pain in last month	1.6	2.7	4.1	-1.8	-1.8	-1.7	-1.8	-1.8	1.8	1.7	-0.2	1.9	2.0	-0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.9	0.7	0.7	1.2	0.7	0.7	-0.4	-0.6	1.4	-0.9	-0.7	0.0
Glaucoma (self-reported)	0.1	0.1	0.6	-0.4	-0.3	-0.8	-0.4	-0.4	0.0	-0.2	0.3	-0.1	0.1	-0.6
Gout (self-reported)	0.8	1.1	1.7	-1.3	-1.1	-1.3	-1.3	-1.3	0.5	0.8	1.0	0.7	1.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.9	-0.2	-0.3	0.5	-0.2	-0.2	0.4	0.7	1.4	0.2	0.2	-0.0
Medication: Amlodipine	0.9	1.3	2.2	-1.1	-1.1	-1.3	-1.1	-1.1	1.4	1.1	-0.3	1.5	1.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	2.0	-0.3	-0.1	-1.4	-0.3	-0.2	-0.0	-0.2	0.3	0.2	0.1	-0.1
Birth weight	0.3	0.6	1.5	0.8	0.8	1.2	0.7	0.7	-0.5	-0.8	1.1	-0.9	-0.5	0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.0	0.8	0.7	-1.2	0.8	0.8	-0.7	-0.9	-0.6	-0.7	-0.1	1.7
High blood pressure (siblings)	0.7	1.1	2.8	-1.0	-0.9	-1.7	-1.0	-1.0	0.9	0.8	-0.7	0.7	1.5	0.7
Forced vital capacity (FVC), Best measure	3.8	13.8	18.4	4.2	4.3	4.1	4.2	4.2	-3.5	-3.9	0.1	-4.0	-4.3	1.3
Body fat percentage	0.1	0.5	1.1	-0.5	-0.5	-1.0	-0.5	-0.5	0.4	0.6	1.0	0.2	1.0	0.9
Leg fat percentage (right)	0.1	0.4	2.4	-0.0	-0.0	-0.5	-0.1	-0.1	-0.1	0.0	1.1	-0.4	0.9	1.6
Arm fat-free mass (right)	1.2	6.1	9.4	2.7	2.7	3.1	2.7	2.7	-2.5	-2.4	-0.3	-2.7	-2.5	1.7
Exposure to tobacco smoke outside home	0.8	1.0	7.3	-0.3	-0.2	-0.8	-0.3	-0.3	0.4	0.5	2.7	0.0	0.1	-1.6
Comparative body size at age 10	0.4	1.2	2.6	-1.1	-1.2	0.1	-1.1	-1.1	1.3	1.3	-1.1	1.0	1.6	0.2
Number of full brothers	1.9	2.4	6.9	1.6	1.5	-0.4	1.6	1.6	-1.4	-1.6	0.5	-2.0	-0.3	2.6
Worry too long after embarrassment	1.1	1.8	5.1	-1.3	-1.3	-2.3	-1.3	-1.3	1.4	1.3	0.7	1.5	1.3	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	7.6	9.8	13.5	-3.6	-3.5	-2.0	-3.6	-3.6	3.3	3.2	0.2	3.7	2.5	-3.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	-0.4	-0.5	-0.6	-0.4	-0.4	0.5	0.5	0.3	0.6	0.9	1.0
Number of children fathered	1.1	1.3	3.2	-0.9	-1.0	-1.8	-0.9	-0.9	1.4	1.3	-0.6	1.2	1.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	-0.6	-0.7	1.0	-0.6	-0.6	0.2	0.8	0.4	0.5	0.3	-0.4
Age at first live birth	0.3	0.5	2.3	0.6	0.6	1.5	0.6	0.6	-0.6	-0.4	0.0	-0.4	-0.8	-0.2
Pulse wave peak to peak time	2.3	2.7	5.3	1.9	1.8	1.4	1.9	1.9	-1.7	-1.7	-0.1	-1.4	-2.3	0.0
Health satisfaction	2.2	2.8	4.4	-1.9	-1.8	-0.6	-1.9	-1.9	1.9	1.6	0.9	1.8	1.3	-2.1
Shortness of breath walking on level ground	0.8	1.0	1.4	-1.1	-1.1	-0.3	-1.1	-1.1	1.0	1.0	1.1	1.2	0.9	-1.0
Qualifications: College or University degree	0.8	2.5	15.9	-1.3	-1.2	0.5	-1.3	-1.3	1.1	1.2	-0.6	1.1	-0.3	-4.0
Eye problems/disorders: None of the above	1.9	2.2	8.7	1.4	1.2	0.8	1.4	1.4	-0.7	-0.9	3.0	-1.0	-0.6	2.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.5	1.1	1.1	-0.0	1.1	1.1	-0.8	-1.0	-1.1	-1.2	-0.7	1.0
Emphysema/chronic bronchitis	0.4	0.4	2.1	-0.4	-0.5	-0.8	-0.4	-0.4	0.5	0.3	1.4	0.2	0.7	0.2
Medication for pain relief, constipation, heartburn	2.3	3.9	8.5	1.9	1.9	2.9	1.8	1.9	-1.8	-1.9	-0.1	-1.9	-2.9	-1.0
Neck or shoulder pain in last month	0.6	0.8	3.3	-0.7	-0.7	0.5	-0.7	-0.7	0.7	1.1	1.8	0.6	0.7	-1.0
Medication: Blood pressure	0.7	1.2	2.0	-1.3	-1.3	-1.0	-1.2	-1.2	0.9	1.0	-0.4	1.4	1.0	-0.8
Angina (self-reported)	0.2	0.3	1.2	0.2	0.3	-1.1	0.1	0.2	-0.7	-0.5	-0.5	-0.5	-0.3	-0.4
Migraine (self-reported)	0.6	0.7	4.6	0.7	0.7	-0.6	0.7	0.7	-0.6	-0.6	0.1	-0.4	-0.1	2.1
Medication: Ibuprofen	0.5	0.6	2.9	0.6	0.6	-1.1	0.6	0.6	-0.7	-0.6	0.3	-0.1	-0.1	1.7
Medication: Allopurinol	1.1	1.5	2.6	-1.6	-1.4	-0.9	-1.6	-1.6	0.6	1.1	1.3	0.9	1.4	-0.2
Medication: Omeprazole	2.2	2.6	2.9	-1.7	-1.7	-1.5	-1.7	-1.7	1.6	1.7	1.6	1.6	1.7	-1.3
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.4	0.4	0.4	0.4	0.4	-0.3	-0.5	0.5	-0.3	-0.6	-0.4
Mean time to correctly identify matches	2.0	3.8	6.5	2.1	2.1	2.2	2.1	2.1	-2.2	-2.1	0.2	-1.9	-2.5	-0.2
Heart disease (mother)	1.1	1.4	6.4	-0.8	-0.8	-0.6	-0.8	-0.8	0.9	0.9	-2.5	0.5	0.3	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.7	-0.7	-1.0	-0.7	-0.7	0.6	0.9	-1.1	0.8	0.6	-0.1
Whole body fat mass	0.1	0.5	1.7	0.7	0.6	0.2	0.6	0.6	-0.7	-0.5	0.7	-0.8	-0.2	1.3
Leg fat mass (right)	0.2	0.7	2.4	0.8	0.8	0.4	0.8	0.8	-0.9	-0.7	0.6	-1.1	-0.2	1.5
Arm predicted mass (right)	1.1	5.8	8.5	2.6	2.6	2.9	2.6	2.6	-2.5	-2.3	-0.3	-2.7	-2.3	1.9
Pulse rate, automated reading	1.5	4.7	12.3	-1.4	-1.5	-3.5	-1.4	-1.4	1.7	1.9	1.6	1.9	3.1	3.1
Alcohol intake frequency.	0.6	1.4	2.1	-1.5	-1.4	-1.2	-1.5	-1.5	1.1	0.9	0.6	1.3	1.2	-0.6
Comparative height size at age 10	2.1	11.6	16.2	3.8	3.7	4.0	3.8	3.8	-3.6	-3.3	1.2	-3.7	-3.6	1.8
Number of full sisters	0.4	0.5	2.1	0.7	0.5	1.4	0.6	0.6	-0.1	0.1	1.1	-0.9	-0.0	-0.1
Suffer from ‘nerves’	3.6	5.7	7.5	-2.7	-2.6	-2.7	-2.7	-2.6	2.6	2.3	-0.4	2.4	2.7	-1.4
Overall health rating	3.2	6.9	10.0	-2.9	-2.9	-1.7	-2.9	-2.9	2.9	2.9	1.4	3.0	3.2	-0.6
Chest pain or discomfort	0.4	0.6	2.4	-0.6	-0.7	-0.2	-0.5	-0.6	0.9	0.7	1.6	0.6	0.7	-1.1
Had major operations	6.0	7.1	10.7	-2.8	-2.8	-2.6	-2.8	-2.8	2.8	3.3	0.2	2.7	2.7	-2.5
Age at last live birth	0.5	0.7	2.9	0.5	0.6	1.7	0.5	0.5	-0.9	-0.6	1.0	-0.3	-0.9	0.4
Family relationship satisfaction	0.6	0.7	2.0	-0.7	-0.7	0.8	-0.7	-0.7	0.8	0.8	1.4	1.1	0.4	-0.8
Leg pain on walking	0.3	0.4	0.8	-0.7	-0.6	-0.2	-0.7	-0.7	0.6	0.5	0.3	0.9	0.4	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	7.3	0.3	0.3	-0.5	0.2	0.3	-0.6	-0.5	0.2	-0.0	0.7	2.7
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.7	1.2	1.2	1.2	1.2	1.2	-1.3	-1.1	-0.9	-0.8	-0.7	2.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	4.0	-0.3	-0.3	0.4	-0.2	-0.2	0.3	0.4	0.2	0.1	-0.6	-2.0
Medication: Aspirin	0.2	0.3	2.0	0.2	0.2	1.4	0.2	0.2	-0.5	-0.2	0.3	0.0	-0.6	-0.1
Supplements: Vitamin C	0.1	0.1	0.3	-0.2	-0.1	0.5	-0.2	-0.2	-0.1	-0.1	-0.6	0.1	-0.1	-0.4
Knee pain experienced in last month	0.3	0.5	1.4	0.7	0.6	0.7	0.7	0.7	-0.5	-0.4	-1.2	-0.3	-0.6	0.7
Hypertension (Self-reported)	2.2	6.1	8.5	-2.8	-2.8	-1.8	-2.9	-2.9	2.6	2.7	0.7	2.6	2.9	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.8	-0.9	-0.4	-0.8	-0.8	1.0	0.8	0.4	1.0	1.0	-0.2
Illnesses of father: Heart disease	1.3	1.8	3.4	-1.3	-1.4	0.6	-1.3	-1.3	1.8	1.5	-0.3	1.4	1.2	-1.7
Illnesses of siblings: Diabetes	2.6	3.2	11.5	1.7	1.6	0.6	1.7	1.7	-1.4	-1.2	-3.4	-1.5	-0.9	2.4
Smoking status: Previous	0.3	0.5	2.0	-0.5	-0.4	1.0	-0.5	-0.5	0.3	0.5	-0.6	0.5	-0.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	6.5	1.5	1.5	2.1	1.5	1.5	-1.2	-1.2	0.2	-1.3	-2.5	-1.3
Whole body fat-free mass	1.3	7.6	9.5	3.1	3.1	3.1	3.1	3.0	-2.9	-2.7	-0.2	-3.0	-3.0	1.6
Leg fat-free mass (right)	0.5	2.7	3.6	1.9	1.9	1.4	1.9	1.9	-1.7	-1.5	-0.4	-1.8	-1.9	1.0
Arm fat percentage (left)	0.2	0.7	3.5	-0.7	-0.7	-1.9	-0.7	-0.7	0.4	0.6	0.4	0.3	1.1	0.8
Average weekly red wine intake	0.5	0.8	3.9	0.6	0.5	1.6	0.6	0.6	-0.4	-0.2	-2.0	-0.6	-0.2	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	0.1	0.0	0.8	0.1	0.1	0.2	0.4	0.1	0.2	0.2	0.0
Mood swings	1.0	1.7	5.3	-1.1	-1.2	-0.6	-1.1	-1.1	1.3	1.1	-2.3	0.9	0.8	-1.9
Loneliness, isolation	2.5	3.5	4.8	-2.2	-2.1	-1.7	-2.2	-2.2	2.0	1.8	0.1	2.1	2.2	-0.1
Long-standing illness, disability or infirmity	1.3	2.1	3.7	-1.7	-1.6	-0.8	-1.7	-1.7	1.2	1.4	0.2	1.6	1.0	-1.9
Ever had bowel cancer screening	0.4	0.4	0.7	-0.8	-0.7	0.3	-0.8	-0.8	0.3	0.6	0.6	0.8	0.5	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.1	0.2	0.5	0.2	0.2	-0.4	-0.3	0.4	-0.2	-0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.0	0.7	0.7	-0.7	0.8	0.8	-0.5	-0.4	0.4	-0.5	-0.2	1.0
Friendships satisfaction	0.2	0.2	1.1	0.1	0.1	-0.9	0.1	0.1	0.2	-0.2	-0.0	0.4	0.2	1.0
Qualifications: nursing, teaching	0.4	0.7	2.9	-0.5	-0.5	0.1	-0.5	-0.5	0.6	0.7	1.7	0.4	0.3	-1.5
Commuting to job workplace: Walk	0.1	0.1	0.5	-0.2	-0.2	0.4	-0.2	-0.2	0.1	-0.1	-0.7	-0.2	-0.1	-0.6
Eye problems/disorders: Cataract	1.6	1.9	3.4	-1.4	-1.5	-1.2	-1.5	-1.5	1.3	1.4	-1.1	1.1	1.1	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	6.4	-1.1	-1.1	-2.5	-1.1	-1.1	1.1	0.8	0.1	1.0	1.1	-0.9
Medication for cholesterol	0.6	0.9	2.2	0.9	1.0	0.8	1.0	1.0	-0.8	-0.8	-0.7	-0.8	-1.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	9.0	10.6	17.6	-3.3	-3.4	-3.4	-3.2	-3.2	3.8	3.7	2.3	3.3	4.2	-0.6
Back pain experienced in last month	0.1	0.1	0.5	-0.1	-0.2	-0.6	-0.1	-0.1	0.3	0.4	0.7	0.3	0.4	0.1
Mineral and other dietary supplements	1.3	1.8	5.4	-1.3	-1.3	-2.3	-1.3	-1.3	1.2	1.1	-0.4	0.8	2.0	0.3
Breast cancer (self-reported)	0.5	0.6	2.9	-0.7	-0.6	-0.4	-0.7	-0.7	0.2	0.1	-1.7	0.5	0.9	0.6
Asthma (self-reported)	1.0	2.0	8.3	-1.3	-1.2	-2.9	-1.3	-1.3	1.0	0.8	1.2	1.2	1.5	0.4
Osteoporosis (self-reported)	0.2	0.2	0.7	0.4	0.3	0.4	0.4	0.4	-0.5	-0.4	0.5	0.0	-0.5	0.8
Osteoarthritis (self-reported)	0.2	0.2	1.4	0.3	0.4	0.2	0.3	0.3	-0.1	-0.2	0.4	-0.2	-0.5	-1.2
Medication: Aspirin	0.2	0.3	1.9	0.2	0.2	1.4	0.2	0.2	-0.5	-0.1	0.1	-0.1	-0.6	-0.3
Medication: Gliclazide	0.4	0.5	4.5	-0.1	0.0	-0.9	-0.1	-0.1	-0.3	-0.1	-2.1	0.2	-0.1	0.0
Illnesses of father: None of the above (group 1)	3.2	4.0	5.7	2.2	2.2	0.2	2.2	2.2	-2.4	-2.2	0.6	-2.4	-2.1	1.8
Smoking status: Current	0.7	1.1	5.2	1.2	1.0	-0.8	1.2	1.1	-0.4	-0.6	-0.1	-0.8	0.1	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	6.6	2.4	2.5	2.1	2.4	2.4	-2.4	-2.5	-0.3	-2.6	-2.3	1.0
Whole body water mass	1.3	7.5	9.6	3.0	3.0	3.1	3.0	3.0	-2.8	-2.7	-0.2	-3.0	-3.0	1.5
Leg predicted mass (right)	0.5	2.8	3.7	1.9	1.9	1.5	1.9	1.9	-1.7	-1.6	-0.5	-1.8	-1.9	1.0
Arm fat mass (left)	0.1	0.3	1.5	0.2	0.2	-0.7	0.2	0.2	-0.4	-0.1	0.5	-0.4	0.2	1.2
Number of self-reported non-cancer illnesses	2.0	3.5	4.8	-2.0	-2.0	-1.5	-2.0	-2.0	2.2	2.1	0.3	2.1	2.1	-1.2
Average weekly champagne plus white wine intake	0.3	0.5	1.3	0.8	0.8	0.2	0.8	0.8	-0.5	-0.5	-0.6	-0.3	-1.1	-0.5
Miserableness	0.7	1.3	1.7	-1.3	-1.2	-1.0	-1.3	-1.3	1.2	1.1	-0.9	1.0	0.9	-1.0
Guilty feelings	0.4	0.6	1.3	-0.7	-0.7	-0.8	-0.8	-0.8	0.8	0.5	0.5	0.8	1.1	0.8
Wears glasses or contact lenses	0.2	0.2	0.7	0.5	0.4	0.8	0.5	0.5	-0.3	-0.0	0.3	-0.2	-0.1	0.3
Ever taken oral contraceptive pill	1.5	1.7	4.2	1.4	1.3	0.3	1.3	1.3	-1.2	-1.4	2.0	-1.5	-1.4	0.3
Hearing aid user	0.8	0.9	4.6	0.7	0.8	-0.1	0.7	0.7	-1.0	-1.0	0.4	-1.0	0.2	2.1
Mother’s age at death	0.4	0.5	3.6	-0.3	-0.3	1.9	-0.3	-0.3	0.0	0.4	0.3	0.1	-0.2	-1.1
Financial situation satisfaction	0.4	0.5	1.4	-0.4	-0.5	0.1	-0.4	-0.4	1.1	0.9	0.7	1.2	0.2	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.2	-0.3	-0.3	0.0	-0.3	-0.3	0.2	0.2	-1.1	0.8	0.4	1.0
Commuting to job workplace: Public transport	2.1	2.5	7.1	-1.5	-1.4	-1.9	-1.5	-1.5	1.4	1.3	2.7	1.2	1.4	-1.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	-0.2	-0.0	-0.5	-0.2	-0.2	-0.3	-0.4	-0.8	-0.3	-0.1	-0.5
Medication: Blood pressure	0.1	0.3	0.8	-0.4	-0.5	-0.6	-0.5	-0.5	0.4	0.4	0.5	0.2	0.9	0.6
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.2	-0.0	-0.0	-0.5	0.0	-0.0	0.0	-0.2	-0.4	0.1	0.1	0.1
Supplements: Fish oil (including cod liver oil)	1.6	2.1	4.9	1.4	1.5	2.2	1.4	1.4	-1.6	-1.5	0.3	-1.0	-2.0	0.6
High cholesterol (Self-reported)	0.2	0.4	2.1	0.2	0.3	-1.2	0.2	0.2	-0.2	-0.2	-1.4	-0.0	-0.0	0.6
Medication: Bendroflumethiazide	1.1	1.7	3.1	-1.4	-1.5	-0.2	-1.4	-1.4	1.7	1.5	0.5	1.4	1.8	-0.3
Medication: Paracetamol	3.6	5.6	10.4	-2.5	-2.5	-3.0	-2.5	-2.5	2.4	2.3	-0.0	2.4	3.2	0.0
Medication: Lisinopril	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.5	-0.5	0.1	0.3	0.2	0.4	0.3	-0.3
Medication: Atorvastatin	0.4	0.5	0.8	-0.8	-0.7	-0.9	-0.7	-0.7	0.6	0.6	-0.3	0.8	0.8	-0.3
Illnesses of father: High blood pressure	4.2	5.3	7.3	-2.7	-2.6	-1.5	-2.7	-2.7	2.3	2.4	0.1	2.6	2.5	-1.8
Alcohol drinker status: Never	0.3	0.3	2.2	0.3	0.3	-0.4	0.2	0.2	-0.2	-0.5	0.7	-0.2	0.3	1.5
Ever smoked	0.1	0.3	0.7	-0.5	-0.5	0.4	-0.5	-0.5	0.4	0.6	-0.5	0.5	0.1	-0.9
Basal metabolic rate	1.0	5.5	7.0	2.6	2.6	2.5	2.6	2.6	-2.4	-2.3	-0.0	-2.6	-2.5	1.7
Leg fat percentage (left)	0.1	0.5	1.7	-0.5	-0.5	-0.7	-0.5	-0.5	0.4	0.6	0.9	-0.0	1.3	1.2
Arm fat-free mass (left)	1.2	6.0	9.5	2.6	2.7	3.1	2.6	2.6	-2.6	-2.4	0.3	-2.6	-2.5	1.8
Number of operations (self-reported)	4.8	7.2	9.9	-2.9	-3.0	-2.4	-3.0	-3.0	2.7	3.1	-0.8	2.6	2.8	-2.4
Average weekly beer plus cider intake	0.6	0.9	3.7	-0.3	-0.3	-1.9	-0.3	-0.3	0.4	0.1	1.8	-0.1	0.8	1.4
Irritability	0.3	0.5	3.3	-0.5	-0.4	-0.1	-0.5	-0.5	0.6	0.4	-1.8	0.4	0.1	-0.9
Risk taking	0.4	0.7	4.0	-0.6	-0.7	-0.1	-0.6	-0.6	0.4	0.7	0.9	0.2	-0.2	-2.0
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	0.6	0.8	0.7	0.7	0.7	-0.6	-0.7	-1.4	-0.5	-1.4	-1.2
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.6	-0.7	-0.8	-0.6	-0.6	1.1	0.9	0.7	1.2	0.8	0.1
Age started oral contraceptive pill	0.5	0.6	1.7	0.6	0.7	0.4	0.6	0.6	-0.8	-0.8	1.2	-0.6	-0.5	1.3
Diastolic blood pressure, automated reading	1.0	3.2	6.9	-1.6	-1.6	-2.6	-1.6	-1.6	1.8	1.7	0.3	1.7	2.6	1.2
Ever depressed for a whole week	0.5	0.7	3.7	-0.7	-0.6	0.6	-0.6	-0.6	0.6	0.5	0.4	1.0	-0.2	-1.9
Unable to work because of sickness or disability	1.6	2.1	3.4	-1.5	-1.6	-1.7	-1.5	-1.5	1.7	1.5	-0.3	1.6	1.9	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.7	-0.2	-0.2	-0.5	-0.1	-0.1	0.3	0.2	-0.8	0.3	0.3	0.3
Myopia	0.3	0.4	2.8	0.2	0.1	0.6	0.1	0.1	-0.2	-0.0	1.7	-0.6	-0.1	-0.7
Vascular/heart problems diagnosed by doctor	2.0	5.5	8.7	2.6	2.7	2.1	2.7	2.7	-2.3	-2.6	-0.8	-2.4	-3.0	1.0
Cholesterol lowering medication	0.0	0.1	0.2	-0.0	0.1	-0.3	-0.1	-0.1	-0.5	-0.4	-0.2	-0.2	-0.3	0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.9	-1.1	-1.2	-1.2	-1.1	-1.1	1.1	1.2	1.7	1.0	1.0	-1.2
Pain experienced in last month	0.3	0.5	0.8	0.6	0.8	0.6	0.6	0.6	-0.7	-0.8	-0.1	-0.8	-0.9	-0.7
Supplements: Calcium	1.9	2.1	5.8	-1.4	-1.4	-0.2	-1.4	-1.4	1.6	1.3	0.9	1.9	0.5	-2.4
Basal cell carcinoma (self-reported)	3.2	3.8	5.1	2.2	2.2	1.8	2.2	2.2	-2.0	-2.1	0.9	-2.1	-2.1	1.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.8	0.1	0.0	0.1	0.0	0.0	-0.9	-0.2	0.1	-0.5	-0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	2.1	2.6	4.2	1.8	1.8	0.3	1.8	1.8	-1.5	-1.8	-2.0	-1.8	-1.5	1.0
Heart disease (siblings)	0.1	0.1	0.4	0.3	0.5	0.1	0.3	0.3	-0.5	-0.5	0.2	-0.2	-0.6	-0.1
Alcohol drinker status: Previous	0.3	0.3	1.0	-0.6	-0.6	-0.1	-0.6	-0.6	0.6	0.3	-1.0	0.5	0.2	-0.8
Pack years of smoking	0.3	0.4	1.2	0.7	0.6	-0.1	0.7	0.7	-0.5	-0.6	0.0	-1.1	-0.1	1.0
Impedance of whole body	0.0	0.2	1.6	-0.0	0.1	0.1	0.0	0.0	0.1	-0.1	1.3	0.3	-0.2	-0.1
Leg fat mass (left)	0.1	0.5	1.8	0.6	0.6	0.5	0.6	0.6	-0.7	-0.4	0.4	-1.0	-0.1	1.4
Arm predicted mass (left)	1.0	5.1	7.6	2.5	2.5	2.8	2.5	2.5	-2.3	-2.2	0.1	-2.5	-2.2	1.8