Best TWAS P=2.76e-15 · Best GWAS P=3.59e-16 conditioned to 0.0166
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PPM1A | 0.10 | 0.10 | lasso | 2 | 0.10 | 1.1e-08 | 6.6 | 7.1 | 9.2e-13 | 0.68 | 0.93 | 0.07 | FALSE |
2 | GTEx | Esophagus Muscularis | C14orf39 | 0.10 | 0.02 | enet | 9 | 0.02 | 2.9e-02 | 7.2 | 7.1 | 9.4e-13 | 0.73 | 0.06 | 0.59 | FALSE |
3 | GTEx | Liver | MNAT1 | 0.21 | 0.00 | lasso | 4 | -0.01 | 5.4e-01 | 7.5 | -6.5 | 6.7e-11 | -0.74 | 0.07 | 0.27 | FALSE |
4 | GTEx | Nerve Tibial | PPM1A | 0.18 | 0.12 | lasso | 2 | 0.10 | 7.4e-08 | 6.6 | 6.5 | 6.1e-11 | 0.59 | 0.88 | 0.09 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | PPM1A | 0.21 | 0.21 | lasso | 3 | 0.18 | 2.2e-10 | 6.6 | 6.8 | 1.4e-11 | 0.61 | 0.92 | 0.08 | FALSE |
6 | GTEx | Skin Sun Exposed Lower leg | PPM1A | 0.21 | 0.18 | lasso | 3 | 0.15 | 1.2e-12 | 7.5 | 7.9 | 2.8e-15 | 0.90 | 0.34 | 0.66 | TRUE |
7 | GTEx | Testis | PPM1A | 0.50 | 0.25 | enet | 14 | 0.31 | 2.5e-14 | 7.5 | -7.3 | 3.4e-13 | -0.90 | 0.18 | 0.82 | FALSE |