Best TWAS P=8.78e-20 · Best GWAS P=2.22e-22 conditioned to 9.74e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SYNE2 | 0.06 | 0.04 | enet | 5 | 0.04 | 4.7e-06 | 7.2 | 7.0 | 1.8e-12 | 0.67 | 0.96 | 0.02 | FALSE |
| 2 | GTEx | Artery Tibial | SGPP1 | 0.15 | 0.02 | enet | 12 | 0.04 | 2.8e-04 | 8.4 | -9.1 | 8.8e-20 | -0.75 | 0.06 | 0.55 | TRUE |
| 3 | GTEx | Brain Cerebellar Hemisphere | SYNE2 | 0.17 | 0.20 | lasso | 5 | 0.14 | 2.4e-04 | 7.3 | 7.3 | 3.8e-13 | 0.71 | 0.27 | 0.50 | FALSE |
| 4 | GTEx | Thyroid | SYNE2 | 0.11 | 0.09 | lasso | 9 | 0.06 | 2.8e-05 | 7.3 | 6.8 | 1.3e-11 | 0.70 | 0.69 | 0.30 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | SYNE2 | 0.08 | 0.06 | blup | 200 | 0.05 | 6.2e-06 | 6.0 | 6.0 | 1.5e-09 | 0.61 | 0.82 | 0.13 | FALSE |