TWAS hub - SYNE2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0220	3.1e-04	0.039	0.039	0.043	0.042	0.040	1.5e-05	1.3e-05	4.7e-06	6.4e-06	9.7e-06
2	GTEx	Brain Cerebellar Hemisphere	0.1720	0.0760	9.0e-03	0.204	NA	0.125	NA	0.136	5.9e-06	NA	4.3e-04	NA	2.4e-04
3	GTEx	Heart Left Ventricle	0.1990	0.0593	4.0e-05	0.137	NA	0.064	NA	0.090	1.0e-07	NA	2.7e-04	NA	1.6e-05
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1550	0.0530	5.9e-04	-0.004	NA	0.021	NA	-0.005	6.6e-01	NA	2.5e-02	NA	7.6e-01
5	GTEx	Thyroid	0.1100	0.0390	1.2e-04	0.088	NA	0.058	NA	0.058	2.8e-07	NA	2.8e-05	NA	2.8e-05
6	NTR	Blood	0.0796	0.0186	0.0e+00	0.078	0.072	0.075	0.074	0.081	7.4e-24	3.0e-22	3.7e-23	1.2e-22	9.9e-25
7	TCGA	Thyroid Carcinoma	0.0830	0.0350	3.0e-06	0.062	0.053	0.047	NA	0.024	1.1e-06	6.2e-06	2.0e-05	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Major Depression (MDD)	8.2	10.0	24.1	1.1	3.2	4.9	-1.7	3.3	4.0	2.1
Diabetes (father)	8.1	10.0	19.0	-3.3	-3.3	-3.1	0.9	-3.2	-2.8	-4.4
Medication: Gliclazide	5.5	6.3	9.3	-2.6	-3.1	-2.7	1.6	-3.0	-1.8	-2.4
Prostate Cancer	5.1	7.1	10.8	2.4	2.8	3.3	-2.7	2.7	3.1	1.4
Illnesses of siblings: Diabetes	4.8	5.9	8.6	-2.2	-2.6	-2.6	0.0	-2.5	-2.9	-2.8
Ever depressed for a whole week	3.4	4.2	7.4	0.6	2.4	2.7	1.1	2.4	1.8	2.4
Risk taking	3.3	4.9	15.2	0.5	1.0	-3.1	-2.6	1.0	-3.9	0.7
Heart disease (mother)	3.0	3.7	8.1	-1.4	-1.5	-2.9	-0.6	-1.8	-2.1	-2.3
Chronotype (morning person)	2.9	6.6	14.3	-1.5	-2.7	-2.9	2.1	-2.8	-3.8	-1.3
Ever had prostate specific antigen (PSA) test	2.8	3.3	11.4	-3.4	-1.4	0.9	0.8	-1.2	1.1	-2.3
Medication: Metformin	2.7	3.7	6.1	-1.6	-2.5	-2.4	0.9	-2.3	-2.1	-1.3
Pulse rate, automated reading	2.7	8.7	14.0	3.5	3.7	3.4	0.4	3.7	2.2	2.1
Multivitamins +/- minerals	2.5	3.2	7.8	-2.8	-1.8	0.1	-0.7	-1.8	0.5	-2.7
Pulse wave reflection index	2.5	3.1	5.7	-2.3	-2.2	-1.9	0.5	-2.4	-0.4	-1.4
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	8.2	2.9	1.9	-0.6	-0.5	2.1	-1.5	1.4
Medication: Lisinopril	2.5	3.2	10.4	-3.2	-1.8	-0.3	0.2	-1.9	-0.3	-2.2
Eye problems/disorders: None of the above	2.4	2.8	14.1	-0.7	0.2	1.4	3.8	0.2	1.6	-0.7
Knee pain experienced in last month	2.4	3.8	6.5	-2.2	-2.2	-1.7	-1.2	-2.2	-0.8	-2.5
Type 2 Diabetes (T2D) (2018)	2.3	4.3	8.2	-0.9	-2.4	-2.7	0.9	-2.4	-2.9	-1.3
Financial difficulties in last 2 years	2.3	3.1	5.5	-2.2	-2.4	0.0	1.7	-2.3	0.8	-1.5
Worry too long after embarrassment	2.3	3.8	8.7	0.8	2.2	3.0	-1.3	2.2	2.0	1.3
Age at first live birth	2.3	4.0	12.0	-1.3	0.6	2.9	1.8	0.9	3.5	-1.2
Qualifications: None of the above	2.1	4.4	11.1	-0.5	-1.9	-3.2	1.3	-1.9	-3.3	-0.5
Headache pain in last month	2.1	3.6	6.8	2.0	1.7	2.6	0.7	1.6	1.9	2.2
Medication for pain relief, constipation, heartburn	2.1	3.5	6.0	2.1	2.3	-1.4	-1.9	2.5	-1.2	1.2
Heel T-Score	2.0	15.6	48.0	1.2	2.9	6.2	-0.7	3.2	6.9	1.6
Pain all over the body in last month	2.0	2.2	6.2	-1.0	-0.7	-2.5	0.7	-0.8	-1.7	-1.8
Health satisfaction	2.0	2.6	6.6	-1.4	-2.5	-1.0	0.3	-2.6	-0.7	-1.3
Ever had bowel cancer screening	2.0	2.3	7.4	-2.7	-1.6	-0.7	0.0	-1.5	-0.7	-1.7
Pulse rate	1.9	3.2	6.7	2.6	1.9	1.4	0.3	1.9	1.1	2.3
Illnesses of father: Heart disease	1.9	2.6	5.6	2.4	1.6	0.2	-1.8	1.7	-0.1	2.0
Medication: Atorvastatin	1.9	2.4	4.6	-2.0	-2.1	-0.7	-0.2	-2.1	-0.8	-1.5
Pack years adult smoking proportion	1.8	2.7	7.4	2.7	1.7	0.3	0.4	1.6	0.3	2.5
Trunk fat mass	1.8	7.6	10.7	-2.9	-3.3	-2.9	1.4	-3.1	-2.0	-3.3
Had menopause	1.8	2.2	4.2	-1.4	-1.1	-1.8	-1.3	-0.9	-2.0	-1.6
Weight	1.8	8.7	14.7	-2.4	-3.5	-3.8	1.1	-3.5	-2.8	-2.7
Pulse wave Arterial Stiffness index	1.8	2.1	3.4	-1.6	-1.8	-1.2	1.7	-1.8	-0.4	-1.0
Qualifications: College or University degree	1.8	5.8	17.7	-0.3	1.0	4.2	-0.4	1.2	4.2	1.6
Whole body fat mass	1.8	7.4	9.9	-2.6	-3.1	-3.1	1.4	-3.0	-2.2	-3.0
Diabetes diagnosed by doctor	1.8	3.0	5.9	-0.9	-2.4	-1.7	1.7	-2.4	-1.4	-0.7
Eye problems/disorders: Glaucoma	1.8	2.2	5.8	2.0	0.4	-0.2	-2.1	0.5	0.6	2.4
Pack years of smoking	1.8	2.6	6.2	2.5	1.7	0.5	0.3	1.6	0.4	2.4
Blood Red Count	1.7	16.4	48.0	-2.7	-3.6	-5.6	1.4	-3.5	-6.9	0.7
Number of treatments/medications taken	1.7	3.0	7.4	-1.6	-1.7	1.4	2.7	-1.9	1.5	-0.7
Frequency of depressed mood in last 2 weeks	1.7	2.4	8.2	0.7	1.0	2.5	-0.1	1.0	2.9	0.1
Hearing difficulty/problems: Yes	1.7	2.6	5.2	-2.3	-1.1	-1.6	-1.3	-0.5	-1.5	-2.2
Illnesses of siblings	1.7	2.4	5.5	1.6	1.5	1.2	-0.7	1.6	1.4	2.4
Medication: Seretide 50 evohaler	1.7	2.0	4.2	-1.8	-0.7	-2.0	-1.1	-0.4	-0.8	-2.0
Arm predicted mass (right)	1.7	8.6	15.9	-2.1	-3.4	-4.0	0.9	-3.5	-3.5	-1.6
Age at First Birth	1.6	2.3	5.4	-1.9	-1.2	1.0	2.3	-1.2	1.0	-1.6
Waist circumference	1.6	5.9	9.3	-2.3	-3.1	-3.0	1.0	-3.0	-1.9	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	6.2	1.3	1.2	2.3	0.6	1.3	2.5	1.0
Qualifications: A levels/AS levels or equivalent	1.6	3.5	8.7	-0.1	0.8	2.9	-2.6	1.0	2.7	-0.1
Arm fat-free mass (right)	1.6	8.2	16.0	-2.0	-3.3	-4.0	0.6	-3.4	-3.5	-1.7
Exposure to tobacco smoke outside home	1.6	2.1	5.7	-1.6	-2.4	-0.4	-0.9	-2.3	0.5	0.6
Emphysema/chronic bronchitis	1.6	1.8	4.0	0.8	2.0	0.7	-1.0	1.6	0.7	1.8
Ovarian Cancer	1.5	2.0	8.0	-2.8	-0.2	0.6	0.7	-0.1	1.3	-1.9
Medication: Co-codamol	1.5	1.8	4.5	-1.3	-1.5	-1.1	0.9	-1.3	-0.5	-2.1
Trunk fat percentage	1.5	5.9	11.9	-2.8	-2.7	-2.2	1.1	-2.5	-1.4	-3.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	7.7	0.7	0.6	2.1	0.1	0.8	2.8	0.1
Mouth/teeth dental problems	1.5	2.3	10.3	1.4	-0.3	-1.1	3.2	-0.5	-1.0	1.3
Falls in the last year	1.5	2.0	4.2	-1.6	-1.8	-1.0	-0.3	-1.7	-0.3	-2.1
Breastfed as a baby	1.5	1.8	2.7	-1.6	-1.6	1.6	0.4	-1.5	1.6	-0.3
Migraine (self-reported)	1.5	1.9	3.1	1.8	1.7	1.6	-0.4	1.7	1.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	4.1	-1.2	-2.0	0.5	0.3	-1.9	0.9	-1.5
Leg predicted mass (right)	1.5	7.8	17.6	-1.4	-2.9	-4.2	1.0	-3.0	-3.6	-1.7
Hearing aid user	1.5	1.7	2.6	-0.6	-1.5	-1.6	-1.5	-1.4	-1.5	-0.6
Myopia	1.5	2.1	6.0	-0.6	1.3	2.2	0.5	1.0	2.4	0.7
Supplements: Calcium	1.5	1.6	3.8	-1.4	-1.1	-0.2	1.6	-1.2	-0.1	-2.0
Leg fat mass (left)	1.5	5.8	8.5	-2.3	-2.9	-2.7	1.1	-2.9	-2.0	-2.5
Happiness	1.4	1.7	6.7	0.2	0.6	2.6	-0.0	0.8	1.9	0.7
Lung cancer (father)	1.4	1.6	4.7	1.4	0.1	-1.7	2.2	0.2	-0.7	1.2
Standing height	1.4	14.2	40.2	-1.3	-3.5	-6.3	1.1	-3.4	-5.1	-2.5
Leg fat mass (right)	1.4	5.6	8.2	-2.2	-2.9	-2.6	1.2	-2.8	-1.9	-2.4
Leg fat-free mass (right)	1.4	7.7	17.6	-1.3	-2.8	-4.2	1.0	-3.0	-3.7	-1.7
Commuting to job workplace: Walk	1.4	1.5	4.7	-1.6	-0.7	0.9	1.3	-0.8	-0.2	-2.2
Ever taken oral contraceptive pill	1.4	1.6	2.6	1.5	1.6	1.0	-0.6	1.6	0.2	1.5
Basal metabolic rate	1.4	7.7	16.6	-1.5	-3.1	-4.1	1.2	-3.2	-3.3	-1.7
Schizophrenia (2018)	1.3	2.7	3.8	1.1	1.9	1.8	-1.9	1.8	1.7	0.9
Reaction Time	1.3	2.5	8.4	-0.7	-0.8	-1.8	1.4	-1.1	-2.9	-1.2
Relative age of first facial hair	1.3	2.6	7.4	1.0	1.9	1.2	0.1	1.8	1.5	2.7
Medication for hormone replacement therapy	1.3	1.5	3.2	0.9	1.8	0.9	-1.2	1.6	0.9	1.0
Severe depression (siblings)	1.3	1.5	5.4	0.3	0.6	1.9	0.8	0.3	2.3	-0.1
Leg fat-free mass (left)	1.3	6.8	16.3	-1.1	-2.7	-4.0	1.2	-2.8	-3.4	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	5.0	2.2	1.6	1.8	-0.1	1.4	2.0	2.0
Leg predicted mass (left)	1.3	6.9	16.4	-1.2	-2.7	-4.1	1.2	-2.8	-3.3	-1.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	5.1	0.8	1.0	2.3	0.8	1.0	1.3	1.2
Diabetes (self-reported)	1.3	2.1	3.8	-0.6	-1.8	-2.0	1.2	-1.8	-1.5	0.1
Hair/balding pattern: Pattern 4	1.3	3.2	8.7	-2.9	-2.3	-0.5	1.2	-2.1	-0.7	-1.4
Medication: Paracetamol	1.3	2.2	6.9	-0.1	-0.7	2.6	1.2	-0.8	2.4	0.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.8	0.8	1.5	0.4	-1.6	1.4	0.2	1.7
Body fat percentage	1.3	5.2	10.0	-2.5	-2.5	-2.2	1.1	-2.4	-1.5	-3.2
Pulse wave peak to peak time	1.3	1.5	2.4	1.6	1.5	0.7	-1.6	1.5	-0.0	0.8
Medication: Ibuprofen	1.3	1.6	3.0	-1.6	-1.6	0.3	1.2	-1.7	1.1	-0.3
Age at last live birth	1.3	1.9	4.4	-1.9	-0.3	2.1	1.3	-0.1	1.4	-1.3
Family relationship satisfaction	1.3	1.6	3.4	0.8	1.1	1.9	-0.4	1.3	1.7	1.1
Whole body fat-free mass	1.3	7.2	16.2	-1.3	-2.9	-4.0	1.1	-3.1	-3.4	-1.3
Eye problems/disorders: Cataract	1.3	1.5	3.8	-1.0	-0.9	-1.4	-1.4	-0.9	-1.9	-0.5
Medication: Paracetamol	1.3	2.0	6.4	-0.4	-0.5	2.5	0.9	-0.5	2.4	0.6
Arm fat-free mass (left)	1.3	6.5	12.9	-1.7	-2.9	-3.6	0.6	-3.0	-3.2	-1.6
Arm predicted mass (left)	1.3	6.8	15.3	-1.3	-2.8	-3.9	0.4	-3.0	-3.5	-1.2
Depression (Nagel 2018)	1.2	1.8	5.4	0.7	0.8	2.1	-0.9	1.0	2.3	0.5
Neuroticism (Nagel 2018)	1.2	2.8	7.7	-0.1	1.5	2.8	0.1	1.4	2.6	0.8
Height	1.2	23.6	66.3	-2.3	-4.7	-8.1	1.8	-4.0	-5.7	-4.4
Maternal smoking around birth	1.2	1.7	7.7	0.1	1.0	-0.9	-2.8	0.7	-0.4	1.2
Worrier / anxious feelings	1.2	2.3	8.3	-0.5	0.5	2.5	0.6	0.4	2.9	0.3
Depression (self-reported)	1.2	1.4	3.5	0.2	1.1	1.9	0.4	1.0	1.8	0.6
Arm fat mass (right)	1.2	5.1	7.0	-2.0	-2.6	-2.6	1.0	-2.6	-2.1	-2.3
Birth weight	1.2	2.6	5.5	1.1	1.1	2.4	0.8	1.3	2.3	1.7
Wheeze or whistling in the chest in last year	1.2	2.1	4.8	-2.2	-1.0	1.3	-0.8	-1.3	1.4	-1.7
Number of children fathered	1.2	1.3	2.2	1.4	0.9	-1.5	-0.5	1.1	-1.4	1.0
Whole body water mass	1.2	7.1	15.8	-1.3	-2.9	-4.0	1.1	-3.1	-3.3	-1.3
Fractured/broken bones in last 5 years	1.2	1.6	2.5	-1.6	-1.2	-1.5	-1.5	-1.3	-0.9	-0.6
Heart disease (siblings)	1.2	1.5	4.7	-1.1	-0.8	-0.5	-1.0	-0.9	-1.3	-2.2
Vitamin and mineral supplements	1.1	1.4	3.5	1.9	-0.1	-0.6	1.4	-0.0	-1.0	1.8
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.1	-1.8	-1.1	-0.7	0.4	-1.3	0.5	-1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.8	0.7	1.9	0.5	-1.2	1.8	0.4	0.5
Sitting height	1.1	7.6	20.8	-0.3	-2.5	-4.6	0.3	-2.6	-4.0	-1.7
Nervous feelings	1.1	2.0	5.8	-0.6	0.7	2.4	1.2	0.4	2.3	-0.0
Allergy	1.1	2.6	4.8	-0.6	-2.2	-1.1	1.9	-2.0	-1.4	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.7	-1.0	0.4	1.7	-1.5	0.4	1.9	-1.2
Peak expiratory flow (PEF)	1.1	2.4	5.0	2.2	1.8	-0.1	0.1	1.9	-0.4	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.0	0.8	1.0	1.2	-0.1	1.0	1.1	2.0
Number of full sisters	1.1	1.4	4.7	-0.4	-0.4	-1.5	1.1	-0.4	-2.2	-1.1
Medication: Aspirin	1.1	1.4	4.6	-1.5	-1.1	0.4	2.1	-1.2	0.5	-0.7
Supplements: Vitamin C	1.1	1.3	2.8	0.1	1.5	1.3	-0.4	1.3	1.7	0.8
Handedness (chirality/laterality): Left-handed	1.1	1.4	5.0	0.2	0.2	2.0	-0.4	0.3	2.2	0.6
Arm fat mass (left)	1.1	4.7	6.8	-2.0	-2.6	-2.4	1.1	-2.6	-1.8	-2.3
Cholesterol lowering medication	1.1	1.7	5.5	-0.7	-2.3	0.4	0.1	-2.3	0.3	-0.4
Alcohol drinker status: Previous	1.1	1.2	2.7	-0.7	-1.5	-0.7	1.6	-1.3	0.5	-0.9
Bipolar Disorder or Schizophrenia	1.0	2.5	4.4	0.9	2.1	1.4	-2.1	2.1	1.1	1.0
Alzheimer’s Disease (in father)	1.0	1.1	2.9	-1.7	-1.1	-0.0	-0.3	-0.7	0.0	-1.7
Body Mass Index (BMI) (2010)	1.0	1.3	3.8	-0.6	-1.2	-2.0	0.4	-1.2	-1.3	0.4
Mean Putamen Volume	1.0	1.1	4.4	-1.1	-0.5	0.7	-2.1	-0.6	1.1	0.1
Neuroticism	1.0	2.3	6.5	-0.4	1.2	2.5	-0.2	1.2	2.6	0.6
Hair Pigment	1.0	29.7	52.7	7.0	7.3	4.5	0.4	6.8	1.6	6.0
Supplements: Zinc	1.0	1.0	2.7	-1.5	0.2	1.6	-0.2	0.0	1.2	-0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.8	-0.6	-0.3	2.0	-0.7	-0.3	1.5	0.8
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.6	0.5	1.8	0.6	-2.6	1.9	0.4	0.7
Hair/balding pattern: Pattern 2	1.0	1.3	3.7	1.9	0.8	-0.5	0.2	0.6	-1.4	1.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	4.4	-0.1	0.3	1.4	-2.1	0.4	1.6	-0.6
Trunk fat-free mass	1.0	5.7	13.6	-0.9	-2.7	-3.7	1.0	-2.8	-3.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.9	-1.6	-1.5	-0.1	0.7	-1.7	0.6	-0.3
Trunk predicted mass	1.0	5.7	13.8	-0.9	-2.6	-3.7	1.0	-2.8	-3.0	-0.8
Loud music exposure frequency	1.0	1.1	3.8	-0.2	-0.1	0.8	-1.6	-0.3	1.9	0.7
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.6	-1.9	-0.6	0.8	-1.0	-0.5	1.0	-1.4
Medication: Allopurinol	1.0	1.4	3.9	-0.8	-0.2	-1.5	2.0	0.0	-1.7	-0.2
Mean time to correctly identify matches	1.0	2.0	6.2	-1.2	-0.8	-1.1	1.5	-1.0	-2.5	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.8	-0.7	-1.0	-1.2	0.1	-1.2	-0.8	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	6.9	0.1	-0.2	2.6	-0.7	-0.1	2.0	0.4
Back pain experienced in last month	1.0	1.4	4.5	-0.4	0.3	-1.0	-2.0	0.4	-2.1	-0.3
Medication: Aspirin	1.0	1.3	3.6	-1.3	-1.0	-0.4	1.9	-1.1	-0.6	-1.1
Worry (Nagel 2018)	0.9	1.8	6.5	-0.9	0.7	2.1	0.6	0.5	2.5	-0.0
Allergy or Eczema	0.9	2.4	10.8	0.2	1.5	0.6	-3.3	1.5	0.5	0.8
Supplements: Glucosamine	0.9	1.1	2.5	-1.6	-1.4	0.1	-0.9	-1.4	0.3	-0.7
Medication: Ramipril	0.9	1.1	1.9	-1.0	-1.1	-1.4	1.3	-0.8	-1.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	6.1	0.6	0.1	1.1	-2.5	0.1	1.3	0.8
Number of self-reported non-cancer illnesses	0.9	1.6	5.7	-0.3	-0.2	1.9	-0.4	-0.5	2.4	1.1
Average weekly champagne plus white wine intake	0.9	1.3	4.0	-0.8	0.2	1.8	1.0	0.1	2.0	0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.5	-1.6	-0.9	-1.1	0.8	-0.9	-0.4	-1.3
Number of operations (self-reported)	0.9	1.3	4.1	0.4	0.3	2.0	0.2	0.2	1.5	1.6
Depressed Affect (Nagel 2018)	0.8	1.7	5.8	0.6	0.5	2.4	0.2	0.6	2.2	0.7
Crohns Disease (2017)	0.8	1.7	4.2	2.0	1.2	0.9	0.0	0.9	1.1	1.8
Triglycerides	0.8	1.3	4.2	-0.1	-2.1	-1.2	-0.3	-1.8	-0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.5	0.6	-0.6	-1.4	0.4	-0.8	-1.6	0.3
Neuroticism score	0.8	1.7	6.2	-0.4	0.7	2.1	0.5	0.7	2.5	0.1
Hip circumference	0.8	3.6	5.6	-1.8	-2.4	-1.8	0.7	-2.3	-1.7	-2.2
Leg fat percentage (right)	0.8	2.8	4.2	-1.9	-1.9	-1.5	1.2	-2.0	-0.8	-2.0
Alcohol intake frequency.	0.8	1.9	5.2	-0.8	-1.5	-1.5	0.8	-1.3	-2.3	-0.8
Comparative height size at age 10	0.8	4.6	13.3	0.6	-1.5	-3.7	2.0	-1.4	-2.9	-1.2
Chest pain or discomfort	0.8	1.1	2.4	-0.8	-1.1	1.1	0.3	-0.9	1.6	-1.2
Had major operations	0.8	1.0	3.0	-0.9	0.2	1.4	0.4	0.1	1.7	0.9
Arm fat percentage (left)	0.8	3.1	5.9	-1.9	-2.0	-1.6	1.1	-1.9	-1.1	-2.4
Mineral and other dietary supplements	0.8	1.1	2.8	1.7	1.2	0.3	-0.4	1.2	-0.0	1.4
Miserableness	0.8	1.3	4.6	0.2	0.8	1.7	0.0	0.9	2.1	-0.4
Medication: Blood pressure	0.8	1.6	5.2	-0.5	-1.4	0.7	2.3	-1.8	0.1	0.1
Medication: Bendroflumethiazide	0.8	1.2	4.3	-0.5	-0.9	-1.0	2.1	-1.0	-0.9	0.4
Leg fat percentage (left)	0.8	3.1	4.7	-2.1	-2.0	-1.5	0.9	-2.1	-0.9	-2.2
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	-1.0	-1.5	0.2	-0.9	-1.3	0.8	-0.9
Irritable Bowel Disease (IBD)	0.7	1.7	4.6	2.1	1.3	0.2	-0.0	1.0	1.5	1.6
Ulcerative Colitis (UC)	0.7	1.3	3.3	1.4	1.1	0.1	-0.7	1.0	1.8	0.9
Breast Cancer	0.7	1.8	5.5	-2.4	-0.9	-1.0	1.1	-0.6	-0.7	-1.7
Schizophrenia (2014)	0.7	1.6	2.8	0.6	1.7	1.6	-1.0	1.7	1.2	0.3
Waist Hip Ratio (WHR)	0.7	3.3	14.1	0.3	-0.7	-3.8	0.5	-0.6	-2.7	0.5
Sensitivity / hurt feelings	0.7	1.2	3.1	0.7	1.8	0.7	-0.6	1.6	-0.1	1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	-0.2	1.0	0.8	-1.6	1.1	-0.0	0.7
Diabetes (mother)	0.7	0.9	1.5	-1.2	-1.2	0.3	1.1	-1.0	0.4	-0.8
Stomach or abdominal pain in last month	0.7	0.9	1.9	1.1	0.5	-0.6	-1.4	0.9	-0.4	1.2
Forced vital capacity (FVC)	0.7	2.5	5.9	1.6	0.3	-2.3	-2.0	0.3	-2.4	0.2
Fluid intelligence score	0.7	1.5	5.5	0.3	0.5	2.4	-0.5	0.6	1.7	1.2
Arm fat percentage (right)	0.7	2.8	5.5	-1.6	-1.8	-1.6	1.0	-1.8	-1.1	-2.3
Time employed in main current job	0.7	0.8	3.0	-0.1	0.2	1.7	0.9	0.0	1.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.0	1.8	1.0	-1.7	-1.7	1.2	-2.0	0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	5.6	-0.4	0.5	-0.7	-2.4	0.6	-0.2	-1.2
Asthma	0.7	1.3	5.8	-0.7	0.4	1.6	-0.3	0.3	2.4	-0.1
Glaucoma (self-reported)	0.7	0.9	3.9	0.9	0.1	-0.1	-2.0	0.3	0.2	1.1
Neck or shoulder pain in last month	0.7	1.0	3.1	-1.3	-0.7	-0.9	0.3	-0.6	-0.6	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.9	0.8	0.1	0.7	1.2	-0.2	1.7	0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	1.4	0.3	0.2	-1.6	0.3	0.8	0.6
Smoking status: Previous	0.7	1.0	2.3	0.5	1.2	0.5	-1.5	1.3	0.1	1.2
Qualifications: nursing, teaching	0.7	1.1	4.8	-0.8	0.3	1.5	-0.4	0.2	2.2	0.4
Asthma (self-reported)	0.7	1.4	5.7	-0.6	0.5	1.8	-0.3	0.4	2.4	-0.3
Wears glasses or contact lenses	0.7	0.8	3.0	-0.3	0.1	1.2	-0.9	0.2	1.7	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-0.8	-0.8	-0.6	-0.4	-0.7	-1.2	-1.6
Age started oral contraceptive pill	0.7	0.9	2.1	0.5	0.8	-0.9	-1.4	0.8	-1.3	0.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.2	-0.6	-1.5	-0.7	-0.5	-1.2	-0.9
HbA1C	0.6	0.7	1.3	1.1	-0.7	0.6	-0.8	-0.3	-1.1	0.8
Respiratory disease	0.6	1.3	3.9	0.2	1.0	1.8	-0.2	0.8	2.0	0.7
Taking other prescription medications	0.6	0.9	2.8	0.2	-0.0	1.2	1.2	-0.0	1.7	0.6
Age when periods started (menarche)	0.6	1.5	6.0	0.6	1.1	1.0	-1.0	0.8	2.5	0.5
Medication: Atenolol	0.6	0.7	3.3	-0.1	-0.1	0.3	1.8	-0.3	-0.4	1.1
Past tobacco smoking	0.6	1.0	1.9	0.0	-1.2	-0.9	1.4	-1.3	-0.5	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.7	1.3	0.5	1.4	0.6	0.3	2.2	1.0
Alcohol intake versus 10 years previously	0.6	0.9	2.3	0.9	0.7	-1.0	-1.1	0.6	-1.5	0.1
Father’s age at death	0.6	0.9	1.8	-1.4	-1.0	0.9	0.1	-1.1	0.5	-1.0
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	1.0	0.8	-1.3	-0.4	0.9	-0.9	0.9
Number of live births	0.6	0.8	3.7	-0.1	-0.6	-0.8	0.8	-0.6	-1.9	0.2
Noisy workplace	0.6	0.8	2.1	0.2	-1.4	-0.5	0.9	-1.5	0.5	0.3
Exposure to tobacco smoke at home	0.6	0.7	2.4	1.2	0.6	0.5	-0.4	0.4	0.1	1.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.3	1.5	0.9	0.3	-1.5	1.1	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	0.7	-0.6	-1.6	1.0	-0.6	-1.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.3	0.9	0.5	-1.5	-0.4	0.5	-2.1	-1.1
Long-standing illness, disability or infirmity	0.6	1.0	1.8	-0.8	-1.1	-1.3	0.0	-1.4	-0.9	-0.8
Medication for cholesterol	0.6	0.9	2.7	0.4	1.2	-0.3	-1.4	1.6	-0.2	0.1
Breast cancer (self-reported)	0.6	0.7	1.7	0.1	0.4	1.0	1.2	0.1	1.3	0.7
Osteoarthritis (self-reported)	0.6	0.8	2.6	0.1	-1.5	-0.7	-0.1	-1.6	0.3	-0.6
Illnesses of father: None of the above (group 1)	0.6	0.7	2.5	0.7	0.6	0.3	1.6	0.3	0.7	0.8
Irritability	0.6	1.0	3.2	0.8	0.5	0.6	1.8	0.5	0.9	1.3
Diastolic blood pressure, automated reading	0.6	1.8	3.9	1.7	2.0	-0.4	0.5	1.7	-0.7	1.5
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.5	0.0	-0.8	-1.8	-2.3	-0.4	-0.4	-1.2
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.5	-0.2	-0.3	2.0	-1.1	-0.1	2.3	0.6
Bipolar Disorder (2011)	0.5	0.5	1.5	0.5	1.1	0.6	-0.4	1.2	-0.2	-0.4
Rheumatoid Arthritis	0.5	0.6	2.3	0.2	0.1	-1.5	-0.4	0.2	-1.2	-0.7
Systolic Blood Pressure	0.5	2.6	4.7	1.5	2.2	1.5	1.7	1.6	0.3	1.8
Hypothyroidism (self reported)	0.5	1.2	4.4	0.6	-0.5	-1.8	0.3	-0.5	-2.1	0.1
Average weekly spirits intake	0.5	0.7	2.0	0.8	0.3	-1.4	-0.3	0.3	-1.3	-0.2
Hand grip strength (right)	0.5	1.4	3.9	-1.2	-1.2	-1.0	2.0	-1.0	-1.2	-0.2
Townsend deprivation index at recruitment	0.5	0.7	1.8	-1.3	-0.6	-0.9	-0.7	-0.8	0.2	-0.9
High blood pressure	0.5	1.5	5.4	0.1	0.9	1.6	2.3	0.5	-0.0	1.0
Body mass index (BMI)	0.5	2.2	3.9	-1.9	-1.9	-1.1	0.7	-2.0	-0.7	-1.5
Prospective memory result	0.5	0.6	2.6	-0.3	0.7	0.8	1.6	0.6	0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.7	1.7	0.7	-1.9	-1.3	0.8	-1.6	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.5	-0.8	-0.5	-0.6	0.1	-0.5	-0.2	-1.6
Forced vital capacity (FVC), Best measure	0.5	1.8	5.0	1.5	0.2	-2.2	-1.4	0.1	-1.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.6	0.8	0.8	1.0	0.7	0.7	0.9
Medication: Omeprazole	0.5	0.6	1.3	-1.1	-0.4	1.2	-0.3	-0.3	0.6	-1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.1	0.8	1.3	-0.1	0.8	0.9	0.5
Mood swings	0.5	0.8	3.3	0.6	0.2	1.8	-0.1	0.2	1.4	0.4
Friendships satisfaction	0.5	0.7	1.8	0.6	0.1	1.3	0.7	0.3	1.1	0.8
Guilty feelings	0.5	0.7	1.6	-0.4	0.7	1.2	-0.6	0.9	1.3	0.0
Financial situation satisfaction	0.5	0.7	1.7	-0.4	-1.2	0.4	-0.5	-1.0	1.3	-0.2
High cholesterol (Self-reported)	0.5	0.8	2.3	-1.1	-1.5	0.4	-0.1	-1.4	0.3	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.6	-0.7	0.0	1.6	0.1	-0.1	0.5	-1.1
Pain experienced in last month	0.5	0.8	2.1	-0.1	0.5	1.4	1.2	0.5	1.3	0.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.8	0.9	0.1	-0.1	-1.4	0.1	0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.6	-0.9	-0.6	1.6	-0.8	-0.5	1.5	0.0
Crohns Disease (2012)	0.4	0.7	1.3	1.1	1.0	0.6	-1.1	0.6	-0.0	0.9
LDL Cholesterol	0.4	0.7	1.3	-0.5	-1.1	-1.1	0.1	-0.9	-1.1	-0.0
Lupus	0.4	0.6	1.9	-0.1	-0.3	1.4	-0.0	-0.4	1.3	0.1
Blood Eosinophil Count	0.4	3.1	10.6	-0.8	0.1	3.2	-0.3	0.0	3.3	-0.5
Blood Platelet Count	0.4	5.2	11.9	3.5	-0.7	1.4	-3.4	-0.8	3.0	0.3
Smoking Status	0.4	1.1	3.3	0.7	1.2	0.5	-0.7	1.2	0.3	1.8
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-0.1	-0.6	0.8	-1.1	-0.6	0.3	0.5
Medication: Levothyroxine sodium	0.4	0.8	2.3	0.8	-0.1	-1.5	0.8	-0.1	-1.2	0.4
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-1.2	0.0	0.9	-1.2	0.7	0.5	-0.7
Heart attack	0.4	0.5	1.5	0.3	0.6	1.0	1.2	0.8	0.0	0.3
Gout (self-reported)	0.4	0.5	0.9	0.0	0.6	-0.8	0.6	0.8	-1.0	0.8
Medication: Blood pressure	0.4	0.7	2.6	-1.3	-0.0	-0.1	1.6	-0.2	-0.5	-0.0
Hypertension (Self-reported)	0.4	1.1	4.7	-0.4	0.4	1.4	2.2	0.0	-0.2	0.6
Average weekly red wine intake	0.4	0.7	2.9	-0.0	0.2	0.6	-0.2	0.2	1.7	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	0.6	-0.9	0.2	0.6	-0.6	0.8	0.5
Mother’s age at death	0.4	0.5	1.4	0.8	-0.2	1.2	-0.3	-0.1	0.8	0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.2	0.9	0.2	-0.3	1.1	-1.2	0.1
Illnesses of father: High blood pressure	0.4	0.5	2.3	-0.3	-0.0	-0.9	0.3	-0.1	-1.5	-0.4
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.0	0.9	-0.0	-1.0	1.1	-0.4	0.4
Schizophrenia vs Biploar Disorder	0.3	0.3	1.3	-0.1	0.7	0.3	-0.3	0.6	1.1	-0.2
Coronary Artery Disease (CAD)	0.3	0.4	1.0	0.6	0.6	1.0	0.1	0.6	0.7	0.2
HDL Cholesterol	0.3	0.6	1.8	-0.6	-0.1	1.3	0.2	-0.1	0.7	-1.1
Neuroticism (2016)	0.3	0.5	1.5	0.2	0.8	0.2	1.2	0.8	0.7	0.0
Lung FVC	0.3	1.7	7.3	0.8	1.2	0.3	-2.7	1.1	0.1	1.1
Tanning	0.3	3.4	7.5	-2.1	-2.2	-1.3	-0.5	-2.2	0.1	-2.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-1.1	-0.4	-0.9	-0.2	-0.5	-0.7	-0.1
Systolic blood pressure, automated reading	0.3	0.9	2.9	0.6	1.7	0.7	0.3	1.4	-0.4	0.9
Angina	0.3	0.4	1.2	-1.1	-0.3	0.4	-0.2	-0.2	1.0	-0.2
Fed-up feelings	0.3	0.5	1.5	-0.4	0.2	1.2	-0.3	0.3	1.2	-0.7
Relative age voice broke	0.3	0.5	1.5	0.1	1.0	-0.4	-0.1	1.2	-0.2	0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.2	-0.4	1.0	-0.6	-0.2	0.9	0.3
High blood pressure (mother)	0.3	0.4	1.0	1.0	0.5	0.6	0.6	0.2	-0.1	1.0
Had other major operations	0.3	0.4	0.7	-0.5	-0.5	-0.8	0.5	-0.5	-0.8	0.5
Medication: Simvastatin	0.3	0.4	0.9	-0.3	-0.8	0.9	0.1	-0.8	0.9	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.8	-0.6	0.9	-0.5	-0.6	0.6	-1.0
Medication: Cholesterol lowering	0.3	0.5	1.5	-0.6	-0.7	0.8	0.4	-0.6	1.2	0.2
Medication: Lansoprazole	0.3	0.4	1.7	0.0	-0.2	0.8	-0.4	-0.3	1.3	-0.2
Birth weight of first child	0.3	0.5	1.7	1.3	-0.0	-0.7	0.9	0.2	-0.4	-0.2
High blood pressure (siblings)	0.3	0.4	1.1	-0.9	0.1	-0.4	0.7	-0.2	-0.4	-1.0
Number of full brothers	0.3	0.4	0.9	-0.6	-0.8	-1.0	-0.2	-0.7	-0.6	0.1
Leg pain on walking	0.3	0.3	0.6	-0.4	-0.6	-0.8	0.4	-0.7	-0.5	0.5
Unable to work because of sickness or disability	0.3	0.3	1.0	1.0	0.2	-0.6	-0.7	0.3	-0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.3	0.5	0.7	1.1	0.6	-0.1	0.2
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.6	0.5	0.7	0.2	0.4	-0.4	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	0.2	0.2	0.0	0.8	0.1	0.9	0.5
Ulcerative Colitis	0.2	0.4	1.0	0.5	0.5	-1.0	0.2	0.5	0.4	0.7
BMI	0.2	1.2	2.0	-1.2	-1.4	-1.1	0.7	-1.4	-0.5	-0.9
Cardiovascular Disease	0.2	0.8	2.1	-1.1	-0.7	-0.3	1.4	-1.1	-0.7	-0.4
Hand grip strength (left)	0.2	0.5	2.1	-0.2	-0.4	0.3	1.5	-0.2	-0.4	1.0
Impedance of leg (right)	0.2	1.0	2.1	1.3	1.2	0.8	-0.3	1.5	1.0	0.1
Qualifications: CSEs or equivalent	0.2	0.3	1.1	0.2	-0.5	-1.1	0.5	-0.7	-0.0	-0.4
Number of incorrect matches in round	0.2	0.3	1.0	-0.3	0.0	0.8	1.0	-0.0	0.3	-0.7
Alcohol usually taken with meals	0.2	0.3	0.8	0.4	0.6	-0.8	0.3	0.5	0.5	0.9
Impedance of arm (right)	0.2	0.7	2.0	1.2	1.1	0.1	0.2	1.4	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.8	-0.1	0.3	0.4	-0.9	0.3	-0.5	-0.7
Tense / ‘highly strung’	0.2	0.3	0.7	0.0	0.8	0.2	-0.2	0.6	0.8	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.1	-0.1	0.8	0.3	-0.1	0.6	0.7
Medication: Amlodipine	0.2	0.3	1.4	1.2	0.4	0.1	0.0	0.3	-0.2	0.2
Comparative body size at age 10	0.2	0.5	1.5	0.1	0.1	0.8	-1.2	-0.0	0.7	1.0
Shortness of breath walking on level ground	0.2	0.2	0.4	0.0	-0.4	-0.7	-0.4	-0.5	-0.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.9	0.5	0.1	0.3	0.2	-0.3	-0.8
Angina (self-reported)	0.2	0.3	1.0	-1.0	-0.1	0.3	-0.2	-0.0	1.0	-0.2
Suffer from ‘nerves’	0.2	0.3	1.2	-0.5	0.6	0.3	0.0	0.2	1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.0	0.2	0.9	-0.1	-0.4	1.0	-0.4	-0.4
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.4	0.0	0.9	0.4	-0.1	0.8	-0.2
Alcohol drinker status: Never	0.2	0.2	0.6	-0.7	-0.1	0.5	-0.4	-0.4	-0.5	0.7
Ever smoked	0.2	0.4	0.6	-0.7	0.5	0.7	-0.4	0.7	0.6	0.7
Fasting Glucose	0.1	0.1	0.5	-0.1	-0.4	0.1	-0.5	-0.4	0.7	-0.2
Blood White Count	0.1	0.4	0.9	0.6	-0.3	-0.3	0.6	-0.5	-0.9	0.7
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	0.2	0.4	0.4	0.2	-0.3	0.3
Serious illness, injury or assault to yourself	0.1	0.2	0.5	-0.0	-0.3	0.2	-0.7	-0.2	0.3	-0.7
Impedance of leg (left)	0.1	0.6	1.3	0.7	0.8	0.7	-0.6	1.1	0.7	-0.4
Illnesses of mother	0.1	0.2	0.5	0.1	-0.2	-0.0	0.7	0.2	-0.5	0.6
Impedance of arm (left)	0.1	0.7	1.9	0.9	1.0	-0.0	0.4	1.4	-0.2	-0.9
Length of working week for main job	0.1	0.2	0.6	0.4	-0.0	0.2	-0.8	-0.2	0.1	-0.5
Blood clot in the leg (DVT)	0.1	0.2	0.7	-0.1	-0.4	0.3	-0.4	-0.5	0.0	0.8
Overall health rating	0.1	0.3	0.6	-0.2	-0.6	-0.1	-0.6	-0.8	0.5	-0.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.2	0.3	-0.0	-0.4	0.0	-0.3	0.4
Average weekly beer plus cider intake	0.1	0.2	0.5	0.6	-0.1	-0.5	-0.1	0.2	-0.7	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.7	0.1	-0.2	-0.1	0.8	-0.4	-0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	0.0	-0.1	0.2	-0.8	-0.3	-0.1	0.7
Impedance of whole body	0.1	0.6	1.7	0.7	0.9	0.2	-0.2	1.3	0.1	-0.9
Lung FEV1/FVC ratio	0.0	0.2	0.5	-0.2	0.1	0.1	0.7	0.7	-0.2	0.3
Current tobacco smoking	0.0	0.1	0.2	0.2	0.3	-0.1	-0.2	0.1	-0.2	0.5
Loneliness, isolation	0.0	0.1	0.2	-0.1	0.2	0.4	-0.2	0.2	0.5	-0.1
Smoking status: Current	0.0	0.0	0.1	-0.3	0.0	-0.2	0.1	-0.1	-0.3	0.2

Hub : Genes

SYNE2

Models

Trait associations