Hub : Genes

SYNE2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0220	3.1e-04	0.039	0.039	0.043	0.042	0.040	1.5e-05	1.3e-05	4.7e-06	6.4e-06	9.7e-06
2	GTEx	Brain Cerebellar Hemisphere	0.1720	0.0760	9.0e-03	0.204	NA	0.125	NA	0.136	5.9e-06	NA	4.3e-04	NA	2.4e-04
3	GTEx	Heart Left Ventricle	0.1990	0.0593	4.0e-05	0.137	NA	0.064	NA	0.090	1.0e-07	NA	2.7e-04	NA	1.6e-05
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1550	0.0530	5.9e-04	-0.004	NA	0.021	NA	-0.005	6.6e-01	NA	2.5e-02	NA	7.6e-01
5	GTEx	Thyroid	0.1100	0.0390	1.2e-04	0.088	NA	0.058	NA	0.058	2.8e-07	NA	2.8e-05	NA	2.8e-05
6	NTR	Blood	0.0796	0.0186	0.0e+00	0.078	0.072	0.075	0.074	0.081	7.4e-24	3.0e-22	3.7e-23	1.2e-22	9.9e-25
7	TCGA	Thyroid Carcinoma	0.0830	0.0350	3.0e-06	0.062	0.053	0.047	NA	0.024	1.1e-06	6.2e-06	2.0e-05	NA	1.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.0	0.9	-0.0	-1.0	1.1	-0.4	0.4
Bipolar Disorder or Schizophrenia	1.0	2.5	4.4	0.9	2.1	1.4	-2.1	2.1	1.1	1.0
Depressed Affect (Nagel 2018)	0.8	1.7	5.8	0.6	0.5	2.4	0.2	0.6	2.2	0.7
Depression (Nagel 2018)	1.2	1.8	5.4	0.7	0.8	2.1	-0.9	1.0	2.3	0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	5.5	-0.2	-0.3	2.0	-1.1	-0.1	2.3	0.6
Neuroticism (Nagel 2018)	1.2	2.8	7.7	-0.1	1.5	2.8	0.1	1.4	2.6	0.8
Schizophrenia (2018)	1.3	2.7	3.8	1.1	1.9	1.8	-1.9	1.8	1.7	0.9
Schizophrenia vs Biploar Disorder	0.3	0.3	1.3	-0.1	0.7	0.3	-0.3	0.6	1.1	-0.2
Worry (Nagel 2018)	0.9	1.8	6.5	-0.9	0.7	2.1	0.6	0.5	2.5	-0.0
Alzheimer’s Disease (in mother)	0.4	0.4	1.8	0.9	0.1	-0.1	-1.4	0.1	0.4	0.5
Alzheimer’s Disease (in father)	1.0	1.1	2.9	-1.7	-1.1	-0.0	-0.3	-0.7	0.0	-1.7
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	-1.0	-1.5	0.2	-0.9	-1.3	0.8	-0.9
Crohns Disease (2017)	0.8	1.7	4.2	2.0	1.2	0.9	0.0	0.9	1.1	1.8
Irritable Bowel Disease (IBD)	0.7	1.7	4.6	2.1	1.3	0.2	-0.0	1.0	1.5	1.6
Ulcerative Colitis (UC)	0.7	1.3	3.3	1.4	1.1	0.1	-0.7	1.0	1.8	0.9
Major Depression (MDD)	8.2	10.0	24.1	1.1	3.2	4.9	-1.7	3.3	4.0	2.1
Reaction Time	1.3	2.5	8.4	-0.7	-0.8	-1.8	1.4	-1.1	-2.9	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.6	-0.9	-0.6	1.6	-0.8	-0.5	1.5	0.0
Breast Cancer	0.7	1.8	5.5	-2.4	-0.9	-1.0	1.1	-0.6	-0.7	-1.7
Ovarian Cancer	1.5	2.0	8.0	-2.8	-0.2	0.6	0.7	-0.1	1.3	-1.9
Prostate Cancer	5.1	7.1	10.8	2.4	2.8	3.3	-2.7	2.7	3.1	1.4
Age at First Birth	1.6	2.3	5.4	-1.9	-1.2	1.0	2.3	-1.2	1.0	-1.6
Bipolar Disorder (2011)	0.5	0.5	1.5	0.5	1.1	0.6	-0.4	1.2	-0.2	-0.4
Body Mass Index (BMI) (2010)	1.0	1.3	3.8	-0.6	-1.2	-2.0	0.4	-1.2	-1.3	0.4
Coronary Artery Disease (CAD)	0.3	0.4	1.0	0.6	0.6	1.0	0.1	0.6	0.7	0.2
Crohns Disease (2012)	0.4	0.7	1.3	1.1	1.0	0.6	-1.1	0.6	-0.0	0.9
Mean Putamen Volume	1.0	1.1	4.4	-1.1	-0.5	0.7	-2.1	-0.6	1.1	0.1
Fasting Glucose	0.1	0.1	0.5	-0.1	-0.4	0.1	-0.5	-0.4	0.7	-0.2
HbA1C	0.6	0.7	1.3	1.1	-0.7	0.6	-0.8	-0.3	-1.1	0.8
HDL Cholesterol	0.3	0.6	1.8	-0.6	-0.1	1.3	0.2	-0.1	0.7	-1.1
LDL Cholesterol	0.4	0.7	1.3	-0.5	-1.1	-1.1	0.1	-0.9	-1.1	-0.0
Lupus	0.4	0.6	1.9	-0.1	-0.3	1.4	-0.0	-0.4	1.3	0.1
Neuroticism (2016)	0.3	0.5	1.5	0.2	0.8	0.2	1.2	0.8	0.7	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.6	0.5	0.7	0.2	0.4	-0.4	0.8
Rheumatoid Arthritis	0.5	0.6	2.3	0.2	0.1	-1.5	-0.4	0.2	-1.2	-0.7
Schizophrenia (2014)	0.7	1.6	2.8	0.6	1.7	1.6	-1.0	1.7	1.2	0.3
Triglycerides	0.8	1.3	4.2	-0.1	-2.1	-1.2	-0.3	-1.8	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.9	0.2	0.2	0.0	0.8	0.1	0.9	0.5
Ulcerative Colitis	0.2	0.4	1.0	0.5	0.5	-1.0	0.2	0.5	0.4	0.7
Blood Eosinophil Count	0.4	3.1	10.6	-0.8	0.1	3.2	-0.3	0.0	3.3	-0.5
Blood Platelet Count	0.4	5.2	11.9	3.5	-0.7	1.4	-3.4	-0.8	3.0	0.3
Blood Red Count	1.7	16.4	48.0	-2.7	-3.6	-5.6	1.4	-3.5	-6.9	0.7
Blood White Count	0.1	0.4	0.9	0.6	-0.3	-0.3	0.6	-0.5	-0.9	0.7
Heel T-Score	2.0	15.6	48.0	1.2	2.9	6.2	-0.7	3.2	6.9	1.6
BMI	0.2	1.2	2.0	-1.2	-1.4	-1.1	0.7	-1.4	-0.5	-0.9
Height	1.2	23.6	66.3	-2.3	-4.7	-8.1	1.8	-4.0	-5.7	-4.4
Waist Hip Ratio (WHR)	0.7	3.3	14.1	0.3	-0.7	-3.8	0.5	-0.6	-2.7	0.5
Systolic Blood Pressure	0.5	2.6	4.7	1.5	2.2	1.5	1.7	1.6	0.3	1.8
Smoking Status	0.4	1.1	3.3	0.7	1.2	0.5	-0.7	1.2	0.3	1.8
Allergy or Eczema	0.9	2.4	10.8	0.2	1.5	0.6	-3.3	1.5	0.5	0.8
Cardiovascular Disease	0.2	0.8	2.1	-1.1	-0.7	-0.3	1.4	-1.1	-0.7	-0.4
Hypothyroidism (self reported)	0.5	1.2	4.4	0.6	-0.5	-1.8	0.3	-0.5	-2.1	0.1
Respiratory disease	0.6	1.3	3.9	0.2	1.0	1.8	-0.2	0.8	2.0	0.7
Type 2 Diabetes (T2D) (2018)	2.3	4.3	8.2	-0.9	-2.4	-2.7	0.9	-2.4	-2.9	-1.3
Lung FEV1/FVC ratio	0.0	0.2	0.5	-0.2	0.1	0.1	0.7	0.7	-0.2	0.3
Lung FVC	0.3	1.7	7.3	0.8	1.2	0.3	-2.7	1.1	0.1	1.1
Neuroticism	1.0	2.3	6.5	-0.4	1.2	2.5	-0.2	1.2	2.6	0.6
Chronotype (morning person)	2.9	6.6	14.3	-1.5	-2.7	-2.9	2.1	-2.8	-3.8	-1.3
Hair Pigment	1.0	29.7	52.7	7.0	7.3	4.5	0.4	6.8	1.6	6.0
Tanning	0.3	3.4	7.5	-2.1	-2.2	-1.3	-0.5	-2.2	0.1	-2.7
Hand grip strength (left)	0.2	0.5	2.1	-0.2	-0.4	0.3	1.5	-0.2	-0.4	1.0
Number of treatments/medications taken	1.7	3.0	7.4	-1.6	-1.7	1.4	2.7	-1.9	1.5	-0.7
Average weekly spirits intake	0.5	0.7	2.0	0.8	0.3	-1.4	-0.3	0.3	-1.3	-0.2
Sensitivity / hurt feelings	0.7	1.2	3.1	0.7	1.8	0.7	-0.6	1.6	-0.1	1.1
Frequency of depressed mood in last 2 weeks	1.7	2.4	8.2	0.7	1.0	2.5	-0.1	1.0	2.9	0.1
Hearing difficulty/problems: Yes	1.7	2.6	5.2	-2.3	-1.1	-1.6	-1.3	-0.5	-1.5	-2.2
Relative age of first facial hair	1.3	2.6	7.4	1.0	1.9	1.2	0.1	1.8	1.5	2.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-1.1	-0.4	-0.9	-0.2	-0.5	-0.7	-0.1
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	-0.2	1.0	0.8	-1.6	1.1	-0.0	0.7
Ever had hysterectomy (womb removed)	0.4	0.4	1.2	-0.1	-0.6	0.8	-1.1	-0.6	0.3	0.5
Systolic blood pressure, automated reading	0.3	0.9	2.9	0.6	1.7	0.7	0.3	1.4	-0.4	0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.5	0.6	-0.6	-1.4	0.4	-0.8	-1.6	0.3
Angina	0.3	0.4	1.2	-1.1	-0.3	0.4	-0.2	-0.2	1.0	-0.2
Medication for hormone replacement therapy	1.3	1.5	3.2	0.9	1.8	0.9	-1.2	1.6	0.9	1.0
Vitamin and mineral supplements	1.1	1.4	3.5	1.9	-0.1	-0.6	1.4	-0.0	-1.0	1.8
Supplements: Zinc	1.0	1.0	2.7	-1.5	0.2	1.6	-0.2	0.0	1.2	-0.9
Medication: Co-codamol	1.5	1.8	4.5	-1.3	-1.5	-1.1	0.9	-1.3	-0.5	-2.1
Medication: Metformin	2.7	3.7	6.1	-1.6	-2.5	-2.4	0.9	-2.3	-2.1	-1.3
Diabetes (father)	8.1	10.0	19.0	-3.3	-3.3	-3.1	0.9	-3.2	-2.8	-4.4
Diabetes (mother)	0.7	0.9	1.5	-1.2	-1.2	0.3	1.1	-1.0	0.4	-0.8
Severe depression (siblings)	1.3	1.5	5.4	0.3	0.6	1.9	0.8	0.3	2.3	-0.1
Pack years adult smoking proportion	1.8	2.7	7.4	2.7	1.7	0.3	0.4	1.6	0.3	2.5
Impedance of leg (right)	0.2	1.0	2.1	1.3	1.2	0.8	-0.3	1.5	1.0	0.1
Leg fat-free mass (left)	1.3	6.8	16.3	-1.1	-2.7	-4.0	1.2	-2.8	-3.4	-1.5
Trunk fat percentage	1.5	5.9	11.9	-2.8	-2.7	-2.2	1.1	-2.5	-1.4	-3.4
Hand grip strength (right)	0.5	1.4	3.9	-1.2	-1.2	-1.0	2.0	-1.0	-1.2	-0.2
Townsend deprivation index at recruitment	0.5	0.7	1.8	-1.3	-0.6	-0.9	-0.7	-0.8	0.2	-0.9
Current tobacco smoking	0.0	0.1	0.2	0.2	0.3	-0.1	-0.2	0.1	-0.2	0.5
Average weekly fortified wine intake	0.1	0.1	0.2	-0.3	0.2	0.4	0.4	0.2	-0.3	0.3
Maternal smoking around birth	1.2	1.7	7.7	0.1	1.0	-0.9	-2.8	0.7	-0.4	1.2
Fed-up feelings	0.3	0.5	1.5	-0.4	0.2	1.2	-0.3	0.3	1.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	7.7	0.7	0.6	2.1	0.1	0.8	2.8	0.1
Relative age voice broke	0.3	0.5	1.5	0.1	1.0	-0.4	-0.1	1.2	-0.2	0.8
Taking other prescription medications	0.6	0.9	2.8	0.2	-0.0	1.2	1.2	-0.0	1.7	0.6
Age when periods started (menarche)	0.6	1.5	6.0	0.6	1.1	1.0	-1.0	0.8	2.5	0.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.8	-0.6	-0.3	2.0	-0.7	-0.3	1.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	5.0	2.2	1.6	1.8	-0.1	1.4	2.0	2.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.1	-1.8	-1.1	-0.7	0.4	-1.3	0.5	-1.2
Qualifications: CSEs or equivalent	0.2	0.3	1.1	0.2	-0.5	-1.1	0.5	-0.7	-0.0	-0.4
Serious illness, injury or assault to yourself	0.1	0.2	0.5	-0.0	-0.3	0.2	-0.7	-0.2	0.3	-0.7
High blood pressure	0.5	1.5	5.4	0.1	0.9	1.6	2.3	0.5	-0.0	1.0
Hayfever, allergic rhinitis or eczema	1.0	2.1	6.6	0.5	1.8	0.6	-2.6	1.9	0.4	0.7
Multivitamins +/- minerals	2.5	3.2	7.8	-2.8	-1.8	0.1	-0.7	-1.8	0.5	-2.7
Stomach or abdominal pain in last month	0.7	0.9	1.9	1.1	0.5	-0.6	-1.4	0.9	-0.4	1.2
Supplements: Glucosamine	0.9	1.1	2.5	-1.6	-1.4	0.1	-0.9	-1.4	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.8	0.7	1.9	0.5	-1.2	1.8	0.4	0.5
Medication: Atenolol	0.6	0.7	3.3	-0.1	-0.1	0.3	1.8	-0.3	-0.4	1.1
Medication: Levothyroxine sodium	0.4	0.8	2.3	0.8	-0.1	-1.5	0.8	-0.1	-1.2	0.4
Sitting height	1.1	7.6	20.8	-0.3	-2.5	-4.6	0.3	-2.6	-4.0	-1.7
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.2	-0.4	1.0	-0.6	-0.2	0.9	0.3
High blood pressure (mother)	0.3	0.4	1.0	1.0	0.5	0.6	0.6	0.2	-0.1	1.0
Body mass index (BMI)	0.5	2.2	3.9	-1.9	-1.9	-1.1	0.7	-2.0	-0.7	-1.5
Impedance of leg (left)	0.1	0.6	1.3	0.7	0.8	0.7	-0.6	1.1	0.7	-0.4
Leg predicted mass (left)	1.3	6.9	16.4	-1.2	-2.7	-4.1	1.2	-2.8	-3.3	-1.6
Trunk fat mass	1.8	7.6	10.7	-2.9	-3.3	-2.9	1.4	-3.1	-2.0	-3.3
Waist circumference	1.6	5.9	9.3	-2.3	-3.1	-3.0	1.0	-3.0	-1.9	-2.0
Number of incorrect matches in round	0.2	0.3	1.0	-0.3	0.0	0.8	1.0	-0.0	0.3	-0.7
Past tobacco smoking	0.6	1.0	1.9	0.0	-1.2	-0.9	1.4	-1.3	-0.5	-1.0
Alcohol usually taken with meals	0.2	0.3	0.8	0.4	0.6	-0.8	0.3	0.5	0.5	0.9
Nervous feelings	1.1	2.0	5.8	-0.6	0.7	2.4	1.2	0.4	2.3	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	6.2	1.3	1.2	2.3	0.6	1.3	2.5	1.0
Hearing difficulty/problems with background noise	0.4	0.7	1.5	-1.2	0.0	0.9	-1.2	0.7	0.5	-0.7
Hair/balding pattern: Pattern 2	1.0	1.3	3.7	1.9	0.8	-0.5	0.2	0.6	-1.4	1.3
Had menopause	1.8	2.2	4.2	-1.4	-1.1	-1.8	-1.3	-0.9	-2.0	-1.6
Had other major operations	0.3	0.4	0.7	-0.5	-0.5	-0.8	0.5	-0.5	-0.8	0.5
Forced vital capacity (FVC)	0.7	2.5	5.9	1.6	0.3	-2.3	-2.0	0.3	-2.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.7	1.3	0.5	1.4	0.6	0.3	2.2	1.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	5.1	0.8	1.0	2.3	0.8	1.0	1.3	1.2
Qualifications: None of the above	2.1	4.4	11.1	-0.5	-1.9	-3.2	1.3	-1.9	-3.3	-0.5
Financial difficulties in last 2 years	2.3	3.1	5.5	-2.2	-2.4	0.0	1.7	-2.3	0.8	-1.5
Mouth/teeth dental problems	1.5	2.3	10.3	1.4	-0.3	-1.1	3.2	-0.5	-1.0	1.3
Heart attack	0.4	0.5	1.5	0.3	0.6	1.0	1.2	0.8	0.0	0.3
Allergy	1.1	2.6	4.8	-0.6	-2.2	-1.1	1.9	-2.0	-1.4	-1.5
Pain all over the body in last month	2.0	2.2	6.2	-1.0	-0.7	-2.5	0.7	-0.8	-1.7	-1.8
Diabetes (self-reported)	1.3	2.1	3.8	-0.6	-1.8	-2.0	1.2	-1.8	-1.5	0.1
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	4.4	-0.1	0.3	1.4	-2.1	0.4	1.6	-0.6
Medication: Ramipril	0.9	1.1	1.9	-1.0	-1.1	-1.4	1.3	-0.8	-1.2	0.1
Medication: Simvastatin	0.3	0.4	0.9	-0.3	-0.8	0.9	0.1	-0.8	0.9	-0.3
Fluid intelligence score	0.7	1.5	5.5	0.3	0.5	2.4	-0.5	0.6	1.7	1.2
Illnesses of siblings	1.7	2.4	5.5	1.6	1.5	1.2	-0.7	1.6	1.4	2.4
Neuroticism score	0.8	1.7	6.2	-0.4	0.7	2.1	0.5	0.7	2.5	0.1
Weight	1.8	8.7	14.7	-2.4	-3.5	-3.8	1.1	-3.5	-2.8	-2.7
Impedance of arm (right)	0.2	0.7	2.0	1.2	1.1	0.1	0.2	1.4	0.2	-0.6
Arm fat percentage (right)	0.7	2.8	5.5	-1.6	-1.8	-1.6	1.0	-1.8	-1.1	-2.3
Trunk fat-free mass	1.0	5.7	13.6	-0.9	-2.7	-3.7	1.0	-2.8	-3.0	-0.8
Hip circumference	0.8	3.6	5.6	-1.8	-2.4	-1.8	0.7	-2.3	-1.7	-2.2
Time employed in main current job	0.7	0.8	3.0	-0.1	0.2	1.7	0.9	0.0	1.3	0.3
Alcohol intake versus 10 years previously	0.6	0.9	2.3	0.9	0.7	-1.0	-1.1	0.6	-1.5	0.1
Father’s age at death	0.6	0.9	1.8	-1.4	-1.0	0.9	0.1	-1.1	0.5	-1.0
Worrier / anxious feelings	1.2	2.3	8.3	-0.5	0.5	2.5	0.6	0.4	2.9	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.8	-0.6	0.9	-0.5	-0.6	0.6	-1.0
Falls in the last year	1.5	2.0	4.2	-1.6	-1.8	-1.0	-0.3	-1.7	-0.3	-2.1
Hair/balding pattern: Pattern 3	0.6	0.8	1.6	1.0	0.8	-1.3	-0.4	0.9	-0.9	0.9
Number of live births	0.6	0.8	3.7	-0.1	-0.6	-0.8	0.8	-0.6	-1.9	0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.0	1.8	1.0	-1.7	-1.7	1.2	-2.0	0.7
Pulse rate	1.9	3.2	6.7	2.6	1.9	1.4	0.3	1.9	1.1	2.3
Happiness	1.4	1.7	6.7	0.2	0.6	2.6	-0.0	0.8	1.9	0.7
Noisy workplace	0.6	0.8	2.1	0.2	-1.4	-0.5	0.9	-1.5	0.5	0.3
Qualifications: A levels/AS levels or equivalent	1.6	3.5	8.7	-0.1	0.8	2.9	-2.6	1.0	2.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.8	-0.1	0.3	0.4	-0.9	0.3	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	5.6	-0.4	0.5	-0.7	-2.4	0.6	-0.2	-1.2
Asthma	0.7	1.3	5.8	-0.7	0.4	1.6	-0.3	0.3	2.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.9	-1.6	-1.5	-0.1	0.7	-1.7	0.6	-0.3
Medication: Cholesterol lowering	0.3	0.5	1.5	-0.6	-0.7	0.8	0.4	-0.6	1.2	0.2
Depression (self-reported)	1.2	1.4	3.5	0.2	1.1	1.9	0.4	1.0	1.8	0.6
Medication: Lansoprazole	0.3	0.4	1.7	0.0	-0.2	0.8	-0.4	-0.3	1.3	-0.2
Prospective memory result	0.5	0.6	2.6	-0.3	0.7	0.8	1.6	0.6	0.2	0.2
Lung cancer (father)	1.4	1.6	4.7	1.4	0.1	-1.7	2.2	0.2	-0.7	1.2
Illnesses of mother	0.1	0.2	0.5	0.1	-0.2	-0.0	0.7	0.2	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.7	1.7	0.7	-1.9	-1.3	0.8	-1.6	0.1
Pulse wave Arterial Stiffness index	1.8	2.1	3.4	-1.6	-1.8	-1.2	1.7	-1.8	-0.4	-1.0
Impedance of arm (left)	0.1	0.7	1.9	0.9	1.0	-0.0	0.4	1.4	-0.2	-0.9
Arm fat mass (right)	1.2	5.1	7.0	-2.0	-2.6	-2.6	1.0	-2.6	-2.1	-2.3
Trunk predicted mass	1.0	5.7	13.8	-0.9	-2.6	-3.7	1.0	-2.8	-3.0	-0.8
Standing height	1.4	14.2	40.2	-1.3	-3.5	-6.3	1.1	-3.4	-5.1	-2.5
Length of working week for main job	0.1	0.2	0.6	0.4	-0.0	0.2	-0.8	-0.2	0.1	-0.5
Exposure to tobacco smoke at home	0.6	0.7	2.4	1.2	0.6	0.5	-0.4	0.4	0.1	1.6
Breastfed as a baby	1.5	1.8	2.7	-1.6	-1.6	1.6	0.4	-1.5	1.6	-0.3
Tense / ‘highly strung’	0.2	0.3	0.7	0.0	0.8	0.2	-0.2	0.6	0.8	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.7	-1.0	0.4	1.7	-1.5	0.4	1.9	-1.2
Hair/balding pattern: Pattern 4	1.3	3.2	8.7	-2.9	-2.3	-0.5	1.2	-2.1	-0.7	-1.4
Birth weight of first child	0.3	0.5	1.7	1.3	-0.0	-0.7	0.9	0.2	-0.4	-0.2
Peak expiratory flow (PEF)	1.1	2.4	5.0	2.2	1.8	-0.1	0.1	1.9	-0.4	2.2
Pulse wave reflection index	2.5	3.1	5.7	-2.3	-2.2	-1.9	0.5	-2.4	-0.4	-1.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.1	-0.1	0.8	0.3	-0.1	0.6	0.7
Loud music exposure frequency	1.0	1.1	3.8	-0.2	-0.1	0.8	-1.6	-0.3	1.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	6.1	0.6	0.1	1.1	-2.5	0.1	1.3	0.8
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.6	-1.9	-0.6	0.8	-1.0	-0.5	1.0	-1.4
Blood clot in the leg (DVT)	0.1	0.2	0.7	-0.1	-0.4	0.3	-0.4	-0.5	0.0	0.8
Medication: Paracetamol	1.3	2.2	6.9	-0.1	-0.7	2.6	1.2	-0.8	2.4	0.7
Headache pain in last month	2.1	3.6	6.8	2.0	1.7	2.6	0.7	1.6	1.9	2.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.3	1.5	0.9	0.3	-1.5	1.1	0.3	0.2
Glaucoma (self-reported)	0.7	0.9	3.9	0.9	0.1	-0.1	-2.0	0.3	0.2	1.1
Gout (self-reported)	0.4	0.5	0.9	0.0	0.6	-0.8	0.6	0.8	-1.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	0.7	-0.6	-1.6	1.0	-0.6	-1.6	0.4
Medication: Amlodipine	0.2	0.3	1.4	1.2	0.4	0.1	0.0	0.3	-0.2	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.5	-0.8	-0.5	-0.6	0.1	-0.5	-0.2	-1.6
Birth weight	1.2	2.6	5.5	1.1	1.1	2.4	0.8	1.3	2.3	1.7
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.8	0.8	1.5	0.4	-1.6	1.4	0.2	1.7
High blood pressure (siblings)	0.3	0.4	1.1	-0.9	0.1	-0.4	0.7	-0.2	-0.4	-1.0
Forced vital capacity (FVC), Best measure	0.5	1.8	5.0	1.5	0.2	-2.2	-1.4	0.1	-1.9	-0.1
Body fat percentage	1.3	5.2	10.0	-2.5	-2.5	-2.2	1.1	-2.4	-1.5	-3.2
Leg fat percentage (right)	0.8	2.8	4.2	-1.9	-1.9	-1.5	1.2	-2.0	-0.8	-2.0
Arm fat-free mass (right)	1.6	8.2	16.0	-2.0	-3.3	-4.0	0.6	-3.4	-3.5	-1.7
Exposure to tobacco smoke outside home	1.6	2.1	5.7	-1.6	-2.4	-0.4	-0.9	-2.3	0.5	0.6
Comparative body size at age 10	0.2	0.5	1.5	0.1	0.1	0.8	-1.2	-0.0	0.7	1.0
Number of full brothers	0.3	0.4	0.9	-0.6	-0.8	-1.0	-0.2	-0.7	-0.6	0.1
Worry too long after embarrassment	2.3	3.8	8.7	0.8	2.2	3.0	-1.3	2.2	2.0	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.6	0.8	0.8	1.0	0.7	0.7	0.9
Wheeze or whistling in the chest in last year	1.2	2.1	4.8	-2.2	-1.0	1.3	-0.8	-1.3	1.4	-1.7
Number of children fathered	1.2	1.3	2.2	1.4	0.9	-1.5	-0.5	1.1	-1.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.0	0.8	1.0	1.2	-0.1	1.0	1.1	2.0
Age at first live birth	2.3	4.0	12.0	-1.3	0.6	2.9	1.8	0.9	3.5	-1.2
Pulse wave peak to peak time	1.3	1.5	2.4	1.6	1.5	0.7	-1.6	1.5	-0.0	0.8
Health satisfaction	2.0	2.6	6.6	-1.4	-2.5	-1.0	0.3	-2.6	-0.7	-1.3
Shortness of breath walking on level ground	0.2	0.2	0.4	0.0	-0.4	-0.7	-0.4	-0.5	-0.3	-0.2
Qualifications: College or University degree	1.8	5.8	17.7	-0.3	1.0	4.2	-0.4	1.2	4.2	1.6
Eye problems/disorders: None of the above	2.4	2.8	14.1	-0.7	0.2	1.4	3.8	0.2	1.6	-0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.9	0.5	0.1	0.3	0.2	-0.3	-0.8
Emphysema/chronic bronchitis	1.6	1.8	4.0	0.8	2.0	0.7	-1.0	1.6	0.7	1.8
Medication for pain relief, constipation, heartburn	2.1	3.5	6.0	2.1	2.3	-1.4	-1.9	2.5	-1.2	1.2
Neck or shoulder pain in last month	0.7	1.0	3.1	-1.3	-0.7	-0.9	0.3	-0.6	-0.6	-1.8
Medication: Blood pressure	0.4	0.7	2.6	-1.3	-0.0	-0.1	1.6	-0.2	-0.5	-0.0
Angina (self-reported)	0.2	0.3	1.0	-1.0	-0.1	0.3	-0.2	-0.0	1.0	-0.2
Migraine (self-reported)	1.5	1.9	3.1	1.8	1.7	1.6	-0.4	1.7	1.1	0.7
Medication: Ibuprofen	1.3	1.6	3.0	-1.6	-1.6	0.3	1.2	-1.7	1.1	-0.3
Medication: Allopurinol	1.0	1.4	3.9	-0.8	-0.2	-1.5	2.0	0.0	-1.7	-0.2
Medication: Omeprazole	0.5	0.6	1.3	-1.1	-0.4	1.2	-0.3	-0.3	0.6	-1.1
Medication: Seretide 50 evohaler	1.7	2.0	4.2	-1.8	-0.7	-2.0	-1.1	-0.4	-0.8	-2.0
Mean time to correctly identify matches	1.0	2.0	6.2	-1.2	-0.8	-1.1	1.5	-1.0	-2.5	-1.1
Heart disease (mother)	3.0	3.7	8.1	-1.4	-1.5	-2.9	-0.6	-1.8	-2.1	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.9	0.8	0.1	0.7	1.2	-0.2	1.7	0.3
Whole body fat mass	1.8	7.4	9.9	-2.6	-3.1	-3.1	1.4	-3.0	-2.2	-3.0
Leg fat mass (right)	1.4	5.6	8.2	-2.2	-2.9	-2.6	1.2	-2.8	-1.9	-2.4
Arm predicted mass (right)	1.7	8.6	15.9	-2.1	-3.4	-4.0	0.9	-3.5	-3.5	-1.6
Pulse rate, automated reading	2.7	8.7	14.0	3.5	3.7	3.4	0.4	3.7	2.2	2.1
Alcohol intake frequency.	0.8	1.9	5.2	-0.8	-1.5	-1.5	0.8	-1.3	-2.3	-0.8
Comparative height size at age 10	0.8	4.6	13.3	0.6	-1.5	-3.7	2.0	-1.4	-2.9	-1.2
Number of full sisters	1.1	1.4	4.7	-0.4	-0.4	-1.5	1.1	-0.4	-2.2	-1.1
Suffer from ‘nerves’	0.2	0.3	1.2	-0.5	0.6	0.3	0.0	0.2	1.1	-0.6
Overall health rating	0.1	0.3	0.6	-0.2	-0.6	-0.1	-0.6	-0.8	0.5	-0.4
Chest pain or discomfort	0.8	1.1	2.4	-0.8	-1.1	1.1	0.3	-0.9	1.6	-1.2
Had major operations	0.8	1.0	3.0	-0.9	0.2	1.4	0.4	0.1	1.7	0.9
Age at last live birth	1.3	1.9	4.4	-1.9	-0.3	2.1	1.3	-0.1	1.4	-1.3
Family relationship satisfaction	1.3	1.6	3.4	0.8	1.1	1.9	-0.4	1.3	1.7	1.1
Leg pain on walking	0.3	0.3	0.6	-0.4	-0.6	-0.8	0.4	-0.7	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	8.2	2.9	1.9	-0.6	-0.5	2.1	-1.5	1.4
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	1.4	0.3	0.2	-1.6	0.3	0.8	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.1	0.8	1.3	-0.1	0.8	0.9	0.5
Medication: Aspirin	1.1	1.4	4.6	-1.5	-1.1	0.4	2.1	-1.2	0.5	-0.7
Supplements: Vitamin C	1.1	1.3	2.8	0.1	1.5	1.3	-0.4	1.3	1.7	0.8
Knee pain experienced in last month	2.4	3.8	6.5	-2.2	-2.2	-1.7	-1.2	-2.2	-0.8	-2.5
Hypertension (Self-reported)	0.4	1.1	4.7	-0.4	0.4	1.4	2.2	0.0	-0.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	4.1	-1.2	-2.0	0.5	0.3	-1.9	0.9	-1.5
Illnesses of father: Heart disease	1.9	2.6	5.6	2.4	1.6	0.2	-1.8	1.7	-0.1	2.0
Illnesses of siblings: Diabetes	4.8	5.9	8.6	-2.2	-2.6	-2.6	0.0	-2.5	-2.9	-2.8
Smoking status: Previous	0.7	1.0	2.3	0.5	1.2	0.5	-1.5	1.3	0.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.3	0.9	0.5	-1.5	-0.4	0.5	-2.1	-1.1
Whole body fat-free mass	1.3	7.2	16.2	-1.3	-2.9	-4.0	1.1	-3.1	-3.4	-1.3
Leg fat-free mass (right)	1.4	7.7	17.6	-1.3	-2.8	-4.2	1.0	-3.0	-3.7	-1.7
Arm fat percentage (left)	0.8	3.1	5.9	-1.9	-2.0	-1.6	1.1	-1.9	-1.1	-2.4
Average weekly red wine intake	0.4	0.7	2.9	-0.0	0.2	0.6	-0.2	0.2	1.7	1.1
Handedness (chirality/laterality): Left-handed	1.1	1.4	5.0	0.2	0.2	2.0	-0.4	0.3	2.2	0.6
Mood swings	0.5	0.8	3.3	0.6	0.2	1.8	-0.1	0.2	1.4	0.4
Loneliness, isolation	0.0	0.1	0.2	-0.1	0.2	0.4	-0.2	0.2	0.5	-0.1
Long-standing illness, disability or infirmity	0.6	1.0	1.8	-0.8	-1.1	-1.3	0.0	-1.4	-0.9	-0.8
Ever had bowel cancer screening	2.0	2.3	7.4	-2.7	-1.6	-0.7	0.0	-1.5	-0.7	-1.7
Diabetes diagnosed by doctor	1.8	3.0	5.9	-0.9	-2.4	-1.7	1.7	-2.4	-1.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.8	-0.7	-1.0	-1.2	0.1	-1.2	-0.8	-1.7
Friendships satisfaction	0.5	0.7	1.8	0.6	0.1	1.3	0.7	0.3	1.1	0.8
Qualifications: nursing, teaching	0.7	1.1	4.8	-0.8	0.3	1.5	-0.4	0.2	2.2	0.4
Commuting to job workplace: Walk	1.4	1.5	4.7	-1.6	-0.7	0.9	1.3	-0.8	-0.2	-2.2
Eye problems/disorders: Cataract	1.3	1.5	3.8	-1.0	-0.9	-1.4	-1.4	-0.9	-1.9	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	6.9	0.1	-0.2	2.6	-0.7	-0.1	2.0	0.4
Medication for cholesterol	0.6	0.9	2.7	0.4	1.2	-0.3	-1.4	1.6	-0.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	0.6	-0.9	0.2	0.6	-0.6	0.8	0.5
Back pain experienced in last month	1.0	1.4	4.5	-0.4	0.3	-1.0	-2.0	0.4	-2.1	-0.3
Mineral and other dietary supplements	0.8	1.1	2.8	1.7	1.2	0.3	-0.4	1.2	-0.0	1.4
Breast cancer (self-reported)	0.6	0.7	1.7	0.1	0.4	1.0	1.2	0.1	1.3	0.7
Asthma (self-reported)	0.7	1.4	5.7	-0.6	0.5	1.8	-0.3	0.4	2.4	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.2	0.2	0.3	-0.0	-0.4	0.0	-0.3	0.4
Osteoarthritis (self-reported)	0.6	0.8	2.6	0.1	-1.5	-0.7	-0.1	-1.6	0.3	-0.6
Medication: Aspirin	1.0	1.3	3.6	-1.3	-1.0	-0.4	1.9	-1.1	-0.6	-1.1
Medication: Gliclazide	5.5	6.3	9.3	-2.6	-3.1	-2.7	1.6	-3.0	-1.8	-2.4
Illnesses of father: None of the above (group 1)	0.6	0.7	2.5	0.7	0.6	0.3	1.6	0.3	0.7	0.8
Smoking status: Current	0.0	0.0	0.1	-0.3	0.0	-0.2	0.1	-0.1	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.0	0.2	0.9	-0.1	-0.4	1.0	-0.4	-0.4
Whole body water mass	1.2	7.1	15.8	-1.3	-2.9	-4.0	1.1	-3.1	-3.3	-1.3
Leg predicted mass (right)	1.5	7.8	17.6	-1.4	-2.9	-4.2	1.0	-3.0	-3.6	-1.7
Arm fat mass (left)	1.1	4.7	6.8	-2.0	-2.6	-2.4	1.1	-2.6	-1.8	-2.3
Number of self-reported non-cancer illnesses	0.9	1.6	5.7	-0.3	-0.2	1.9	-0.4	-0.5	2.4	1.1
Average weekly champagne plus white wine intake	0.9	1.3	4.0	-0.8	0.2	1.8	1.0	0.1	2.0	0.3
Miserableness	0.8	1.3	4.6	0.2	0.8	1.7	0.0	0.9	2.1	-0.4
Guilty feelings	0.5	0.7	1.6	-0.4	0.7	1.2	-0.6	0.9	1.3	0.0
Wears glasses or contact lenses	0.7	0.8	3.0	-0.3	0.1	1.2	-0.9	0.2	1.7	0.1
Ever taken oral contraceptive pill	1.4	1.6	2.6	1.5	1.6	1.0	-0.6	1.6	0.2	1.5
Hearing aid user	1.5	1.7	2.6	-0.6	-1.5	-1.6	-1.5	-1.4	-1.5	-0.6
Mother’s age at death	0.4	0.5	1.4	0.8	-0.2	1.2	-0.3	-0.1	0.8	0.8
Financial situation satisfaction	0.5	0.7	1.7	-0.4	-1.2	0.4	-0.5	-1.0	1.3	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.2	0.9	0.2	-0.3	1.1	-1.2	0.1
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.4	0.0	0.9	0.4	-0.1	0.8	-0.2
Eye problems/disorders: Glaucoma	1.8	2.2	5.8	2.0	0.4	-0.2	-2.1	0.5	0.6	2.4
Medication: Blood pressure	0.8	1.6	5.2	-0.5	-1.4	0.7	2.3	-1.8	0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.5	-0.8	-0.8	-0.6	-0.4	-0.7	-1.2	-1.6
Supplements: Fish oil (including cod liver oil)	0.9	1.1	2.5	-1.6	-0.9	-1.1	0.8	-0.9	-0.4	-1.3
High cholesterol (Self-reported)	0.5	0.8	2.3	-1.1	-1.5	0.4	-0.1	-1.4	0.3	-0.1
Medication: Bendroflumethiazide	0.8	1.2	4.3	-0.5	-0.9	-1.0	2.1	-1.0	-0.9	0.4
Medication: Paracetamol	1.3	2.0	6.4	-0.4	-0.5	2.5	0.9	-0.5	2.4	0.6
Medication: Lisinopril	2.5	3.2	10.4	-3.2	-1.8	-0.3	0.2	-1.9	-0.3	-2.2
Medication: Atorvastatin	1.9	2.4	4.6	-2.0	-2.1	-0.7	-0.2	-2.1	-0.8	-1.5
Illnesses of father: High blood pressure	0.4	0.5	2.3	-0.3	-0.0	-0.9	0.3	-0.1	-1.5	-0.4
Alcohol drinker status: Never	0.2	0.2	0.6	-0.7	-0.1	0.5	-0.4	-0.4	-0.5	0.7
Ever smoked	0.2	0.4	0.6	-0.7	0.5	0.7	-0.4	0.7	0.6	0.7
Basal metabolic rate	1.4	7.7	16.6	-1.5	-3.1	-4.1	1.2	-3.2	-3.3	-1.7
Leg fat percentage (left)	0.8	3.1	4.7	-2.1	-2.0	-1.5	0.9	-2.1	-0.9	-2.2
Arm fat-free mass (left)	1.3	6.5	12.9	-1.7	-2.9	-3.6	0.6	-3.0	-3.2	-1.6
Number of operations (self-reported)	0.9	1.3	4.1	0.4	0.3	2.0	0.2	0.2	1.5	1.6
Average weekly beer plus cider intake	0.1	0.2	0.5	0.6	-0.1	-0.5	-0.1	0.2	-0.7	0.4
Irritability	0.6	1.0	3.2	0.8	0.5	0.6	1.8	0.5	0.9	1.3
Risk taking	3.3	4.9	15.2	0.5	1.0	-3.1	-2.6	1.0	-3.9	0.7
Ever had prostate specific antigen (PSA) test	2.8	3.3	11.4	-3.4	-1.4	0.9	0.8	-1.2	1.1	-2.3
Fractured/broken bones in last 5 years	1.2	1.6	2.5	-1.6	-1.2	-1.5	-1.5	-1.3	-0.9	-0.6
Age started oral contraceptive pill	0.7	0.9	2.1	0.5	0.8	-0.9	-1.4	0.8	-1.3	0.0
Diastolic blood pressure, automated reading	0.6	1.8	3.9	1.7	2.0	-0.4	0.5	1.7	-0.7	1.5
Ever depressed for a whole week	3.4	4.2	7.4	0.6	2.4	2.7	1.1	2.4	1.8	2.4
Unable to work because of sickness or disability	0.3	0.3	1.0	1.0	0.2	-0.6	-0.7	0.3	-0.0	-0.6
Commuting to job workplace: Cycle	0.1	0.1	0.7	0.1	-0.2	-0.1	0.8	-0.4	-0.2	-0.1
Myopia	1.5	2.1	6.0	-0.6	1.3	2.2	0.5	1.0	2.4	0.7
Vascular/heart problems diagnosed by doctor	0.6	1.6	5.5	0.0	-0.8	-1.8	-2.3	-0.4	-0.4	-1.2
Cholesterol lowering medication	1.1	1.7	5.5	-0.7	-2.3	0.4	0.1	-2.3	0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	2.6	-0.7	0.0	1.6	0.1	-0.1	0.5	-1.1
Pain experienced in last month	0.5	0.8	2.1	-0.1	0.5	1.4	1.2	0.5	1.3	0.4
Supplements: Calcium	1.5	1.6	3.8	-1.4	-1.1	-0.2	1.6	-1.2	-0.1	-2.0
Basal cell carcinoma (self-reported)	0.7	0.8	2.3	-0.2	-0.6	-1.5	-0.7	-0.5	-1.2	-0.9
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.3	0.5	0.7	1.1	0.6	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	0.0	-0.1	0.2	-0.8	-0.3	-0.1	0.7
Heart disease (siblings)	1.2	1.5	4.7	-1.1	-0.8	-0.5	-1.0	-0.9	-1.3	-2.2
Alcohol drinker status: Previous	1.1	1.2	2.7	-0.7	-1.5	-0.7	1.6	-1.3	0.5	-0.9
Pack years of smoking	1.8	2.6	6.2	2.5	1.7	0.5	0.3	1.6	0.4	2.4
Impedance of whole body	0.1	0.6	1.7	0.7	0.9	0.2	-0.2	1.3	0.1	-0.9
Leg fat mass (left)	1.5	5.8	8.5	-2.3	-2.9	-2.7	1.1	-2.9	-2.0	-2.5
Arm predicted mass (left)	1.3	6.8	15.3	-1.3	-2.8	-3.9	0.4	-3.0	-3.5	-1.2