Best TWAS P=1.42e-10 · Best GWAS P=2.2e-23 conditioned to 2.71e-16
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | MSL1 | 0.15 | 0.12 | lasso | 2 | 0.12 | 3.9e-10 | 6.4 | -6.4 | 1.7e-10 | -0.05 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Tibial | MSL1 | 0.19 | 0.14 | lasso | 2 | 0.15 | 4.9e-12 | 6.4 | -5.5 | 3.5e-08 | -0.07 | 0.01 | 0.99 | FALSE |
3 | GTEx | Breast Mammary Tissue | MSL1 | 0.20 | 0.06 | lasso | 6 | 0.07 | 2.2e-04 | 6.4 | -5.4 | 5.9e-08 | -0.05 | 0.01 | 0.98 | FALSE |
4 | GTEx | Colon Transverse | MSL1 | 0.18 | 0.11 | lasso | 3 | 0.05 | 2.1e-03 | 6.4 | -6.1 | 1.0e-09 | -0.06 | 0.01 | 0.96 | FALSE |
5 | GTEx | Esophagus Muscularis | MSL1 | 0.25 | 0.18 | lasso | 8 | 0.22 | 1.7e-13 | 6.5 | -6.1 | 1.0e-09 | -0.07 | 0.00 | 1.00 | FALSE |
6 | GTEx | Nerve Tibial | MSL1 | 0.33 | 0.25 | lasso | 4 | 0.24 | 6.3e-17 | 6.4 | -6.1 | 1.2e-09 | -0.07 | 0.01 | 0.99 | FALSE |
7 | GTEx | Pituitary | MSL1 | 0.40 | 0.27 | lasso | 7 | 0.24 | 1.3e-06 | 4.9 | -6.0 | 2.2e-09 | -0.09 | 0.05 | 0.80 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | MSL1 | 0.18 | 0.15 | lasso | 4 | 0.15 | 2.1e-08 | 6.4 | -6.4 | 1.4e-10 | -0.04 | 0.01 | 0.99 | TRUE |
9 | METSIM | Adipose | MSL1 | 0.12 | 0.06 | lasso | 10 | 0.06 | 1.8e-09 | 6.4 | -5.5 | 4.4e-08 | -0.07 | 0.01 | 0.99 | FALSE |
10 | The Cancer Genome Atlas | Colon Adenocarcinoma | KRT12 | 0.17 | 0.06 | lasso | 2 | 0.06 | 2.7e-04 | -6.2 | -6.2 | 5.0e-10 | 0.55 | 0.00 | 0.96 | TRUE |
11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RAPGEFL1 | 0.13 | 0.02 | enet | 9 | 0.06 | 4.3e-04 | 6.5 | -5.3 | 1.2e-07 | -0.08 | 0.00 | 0.93 | FALSE |