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chr17:17,400,972-18,923,818

Best TWAS P=6.77e-17 · Best GWAS P=1.7e-12 conditioned to 0.381

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC144B	0.21	0.05	enet	30	0.16	1.5e-18	-1.77	-5.6	2.4e-08	0.34	0.24	0.76	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM106A	0.05	0.01	bslmm	278	0.02	8.6e-04	-6.09	-6.6	4.3e-11	0.59	0.04	0.59	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LLGL1	0.09	0.02	enet	14	0.04	4.8e-06	-6.69	-5.9	3.3e-09	0.66	0.02	0.97	FALSE
4	GTEx	Adipose Subcutaneous	CTD-2303H24.2	0.16	0.11	enet	15	0.18	2.4e-14	5.37	-5.3	8.8e-08	0.17	0.83	0.17	FALSE
5	GTEx	Adipose Visceral Omentum	CTD-2303H24.2	0.35	0.10	enet	14	0.23	2.8e-12	-6.64	-5.5	3.6e-08	0.11	0.04	0.96	FALSE
6	GTEx	Adrenal Gland	MIEF2	0.34	0.19	lasso	7	0.26	8.1e-10	-6.12	7.8	6.6e-15	-0.73	0.03	0.97	FALSE
7	GTEx	Adrenal Gland	CTD-2303H24.2	0.31	0.05	lasso	7	0.12	3.6e-05	-6.43	-8.2	1.6e-16	0.52	0.10	0.65	FALSE
8	GTEx	Artery Aorta	LLGL1	0.34	0.05	lasso	9	0.12	4.0e-07	-6.09	-5.7	1.0e-08	0.59	0.05	0.92	FALSE
9	GTEx	Artery Aorta	MIEF2	0.14	0.04	lasso	6	0.07	6.7e-05	2.46	5.8	5.8e-09	-0.66	0.03	0.88	FALSE
10	GTEx	Artery Aorta	CTD-2303H24.2	0.39	0.12	enet	37	0.27	3.7e-15	5.37	-5.9	3.0e-09	0.24	0.07	0.93	FALSE
11	GTEx	Breast Mammary Tissue	CCDC144B	0.19	0.00	enet	18	0.06	4.0e-04	0.84	6.4	1.5e-10	-0.29	0.05	0.13	FALSE
12	GTEx	Breast Mammary Tissue (Female)	CCDC144B	0.31	0.01	lasso	6	0.06	9.1e-03	2.02	5.7	1.2e-08	-0.41	0.03	0.26	FALSE
13	GTEx	Breast Mammary Tissue (Female)	TOP3A	0.29	0.00	lasso	4	0.06	8.0e-03	-7.06	5.6	2.5e-08	-0.63	0.02	0.65	FALSE
14	GTEx	Cells Transformed fibroblasts	ALKBH5	0.16	0.05	lasso	7	0.10	9.2e-08	3.51	6.2	6.5e-10	-0.64	0.11	0.89	FALSE
15	GTEx	Cells Transformed fibroblasts	TOP3A	0.32	0.12	enet	31	0.12	2.3e-09	-6.09	5.5	4.2e-08	-0.68	0.13	0.87	FALSE
16	GTEx	Cells Transformed fibroblasts	RP11-258F1.1	0.18	0.12	lasso	3	0.15	1.7e-11	3.51	5.6	2.2e-08	-0.54	0.82	0.18	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	CTD-2303H24.2	0.33	0.20	lasso	3	0.34	6.0e-13	5.37	-6.6	4.2e-11	0.23	0.08	0.92	FALSE
18	GTEx	Esophagus Mucosa	CTD-2303H24.2	0.21	0.09	enet	29	0.17	2.4e-11	5.37	-6.3	2.3e-10	0.20	0.16	0.84	FALSE
19	GTEx	Esophagus Muscularis	LLGL1	0.19	0.06	lasso	5	0.06	1.1e-04	-6.09	-6.8	1.3e-11	0.42	0.07	0.92	FALSE
20	GTEx	Esophagus Muscularis	CTD-2303H24.2	0.25	0.09	lasso	5	0.16	8.4e-10	5.37	-5.6	2.2e-08	0.18	0.12	0.88	FALSE
21	GTEx	Heart Left Ventricle	CTD-2303H24.2	0.24	0.04	lasso	6	0.10	4.3e-06	-6.64	-5.8	5.5e-09	0.17	0.08	0.91	FALSE
22	GTEx	Liver	SHMT1	0.36	0.22	lasso	4	0.20	3.5e-06	-6.10	-5.9	3.4e-09	0.63	0.06	0.89	FALSE
23	GTEx	Lung	CTD-2303H24.2	0.45	0.12	lasso	6	0.27	1.3e-20	-1.77	-5.2	1.6e-07	0.21	0.97	0.03	FALSE
24	GTEx	Muscle Skeletal	MIEF2	0.19	0.12	lasso	1	0.11	1.6e-10	-6.12	6.1	9.2e-10	-0.64	0.18	0.82	FALSE
25	GTEx	Muscle Skeletal	CTD-2303H24.2	0.23	0.11	enet	23	0.17	5.2e-16	5.37	-6.1	1.1e-09	0.24	0.75	0.25	FALSE
26	GTEx	Nerve Tibial	CTD-2303H24.2	0.23	0.08	enet	15	0.18	9.4e-13	5.37	-5.6	2.0e-08	0.21	0.57	0.43	FALSE
27	GTEx	Skin Sun Exposed Lower leg	CTD-2303H24.2	0.24	0.08	enet	20	0.13	3.9e-11	-1.77	-5.5	3.7e-08	0.14	0.91	0.09	FALSE
28	GTEx	Small Intestine Terminal Ileum	CTD-2303H24.2	0.38	0.28	lasso	9	0.26	1.7e-06	-6.63	-6.9	6.0e-12	0.38	0.06	0.86	FALSE
29	GTEx	Spleen	SHMT1	0.54	0.30	lasso	8	0.24	7.6e-07	-6.43	-6.4	1.5e-10	0.63	0.13	0.81	FALSE
30	GTEx	Spleen	CTD-2303H24.2	0.32	0.02	enet	15	0.12	5.2e-04	-6.64	-5.9	3.2e-09	0.17	0.08	0.47	FALSE
31	GTEx	Testis	CTD-2303H24.2	0.50	0.26	lasso	17	0.36	1.1e-16	5.37	-5.7	1.1e-08	0.19	0.84	0.16	FALSE
32	GTEx	Vagina	SHMT1	0.38	0.02	lasso	4	-0.01	6.6e-01	-6.64	-7.0	2.5e-12	0.37	0.04	0.33	FALSE
33	GTEx	Whole Blood	CTD-2303H24.2	0.04	0.02	lasso	4	0.04	8.4e-05	-6.64	-5.4	6.4e-08	0.18	0.07	0.81	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	LLGL1	0.23	0.07	bslmm	261	0.08	2.3e-10	-7.06	-5.4	5.2e-08	0.72	0.00	1.00	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	RP1-37N7.3	0.06	0.04	lasso	1	0.03	1.4e-04	-6.09	6.1	1.1e-09	-0.62	0.12	0.76	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	USP32P2	0.74	0.61	enet	18	0.65	4.4e-110	5.37	-6.0	2.7e-09	0.20	0.98	0.02	FALSE
37	YFS	Blood	LLGL1	0.21	0.12	lasso	9	0.14	1.9e-43	-6.69	7.7	1.3e-14	-0.81	0.02	0.98	FALSE
38	YFS	Blood	TOP3A	0.04	0.02	enet	20	0.03	9.3e-10	-6.64	-6.4	1.9e-10	0.21	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ALKBH5	0.05	0.02	lasso	2	0.03	3.1e-03	3.57	5.6	1.9e-08	-0.31	0.03	0.56	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FLII	0.04	0.02	blup	48	0.03	2.2e-03	-6.63	5.2	1.5e-07	-0.18	0.02	0.62	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TOP3A	0.05	0.01	blup	53	0.02	1.0e-02	4.28	5.2	2.0e-07	-0.17	0.05	0.26	FALSE
42	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALKBH5	0.06	0.02	blup	63	0.02	7.2e-06	-7.06	8.0	1.0e-15	-0.77	0.00	0.98	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLII	0.04	0.01	blup	47	0.02	7.2e-05	-6.93	7.5	4.3e-14	-0.48	0.02	0.82	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	LLGL1	0.09	0.01	blup	52	0.02	1.1e-05	1.57	5.6	2.6e-08	-0.28	0.09	0.84	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMCR7	0.06	0.00	enet	7	0.02	1.5e-05	-6.09	6.2	6.6e-10	-0.37	0.01	0.70	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMCR8	0.02	0.01	blup	34	0.01	1.5e-02	-6.09	6.3	2.3e-10	-0.40	0.00	0.39	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOP3A	0.05	0.02	enet	8	0.03	1.2e-07	4.12	6.6	5.4e-11	-0.37	0.04	0.96	FALSE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMCR7	0.19	0.03	blup	33	0.06	4.5e-04	-6.09	7.8	6.1e-15	-0.62	0.01	0.83	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR7	0.07	0.02	lasso	3	0.01	8.3e-03	2.46	5.7	1.0e-08	-0.37	0.00	0.89	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SMCR8	0.10	0.02	blup	33	0.03	8.1e-05	1.17	5.7	9.6e-09	-0.28	0.05	0.23	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TOP3A	0.07	0.02	blup	48	0.02	1.3e-03	-6.93	7.8	6.3e-15	-0.46	0.00	0.97	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SMCR7	0.04	0.01	blup	34	0.02	1.0e-03	4.25	5.4	7.3e-08	-0.21	0.05	0.43	FALSE
53	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FLII	0.16	0.00	enet	6	0.06	1.4e-04	-6.40	6.9	4.7e-12	-0.42	0.02	0.32	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TOP3A	0.11	0.01	enet	10	0.05	5.8e-04	-6.93	8.1	5.2e-16	-0.59	0.01	0.83	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	LLGL1	0.06	0.04	enet	2	0.04	3.6e-05	-6.69	-7.2	8.7e-13	0.95	0.00	0.98	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYO15A	0.04	0.02	lasso	3	0.02	2.5e-03	-6.09	6.2	5.2e-10	-0.36	0.06	0.26	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	ALKBH5	0.09	0.02	lasso	3	0.03	1.2e-04	-6.93	8.3	7.3e-17	-0.77	0.01	0.97	FALSE
58	The Cancer Genome Atlas	Lung Adenocarcinoma	FLII	0.04	0.01	blup	47	0.03	5.1e-04	-6.93	6.5	6.6e-11	-0.33	0.01	0.90	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	SMCR7	0.05	0.03	enet	7	0.05	3.7e-06	-6.64	7.8	5.6e-15	-0.49	0.00	0.99	FALSE
60	The Cancer Genome Atlas	Lung Adenocarcinoma	SMCR8	0.06	0.01	enet	9	0.03	3.3e-04	4.12	5.7	1.4e-08	-0.23	0.04	0.15	FALSE
61	The Cancer Genome Atlas	Lung Adenocarcinoma	TOP3A	0.08	0.04	enet	8	0.07	3.7e-08	4.28	7.3	3.4e-13	-0.44	0.06	0.94	FALSE
62	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SMCR8	0.06	0.05	lasso	3	0.05	4.2e-04	-6.12	6.7	2.9e-11	-0.64	0.00	0.89	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TOP3A	0.16	0.06	lasso	4	0.07	1.9e-05	-6.12	6.9	5.6e-12	-0.63	0.07	0.71	FALSE
64	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ALKBH5	0.22	0.10	blup	66	0.12	1.4e-05	-6.09	8.1	6.0e-16	-0.73	0.04	0.79	FALSE
65	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLII	0.20	0.08	blup	54	0.13	7.0e-06	-1.30	5.8	5.7e-09	-0.33	0.06	0.43	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SMCR7	0.13	0.05	enet	11	0.08	4.3e-04	4.03	6.3	3.5e-10	-0.32	0.03	0.61	FALSE
67	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TOP3A	0.13	0.00	enet	12	0.06	2.3e-03	4.03	6.3	2.6e-10	-0.45	0.03	0.10	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	ALKBH5	0.19	0.02	blup	63	0.04	3.4e-05	-6.63	8.3	6.8e-17	-0.68	0.03	0.93	TRUE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	FLII	0.08	0.02	enet	6	0.04	1.9e-05	4.17	6.0	2.0e-09	-0.39	0.06	0.59	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMCR7	0.07	0.04	blup	33	0.03	3.0e-04	-6.93	7.1	1.2e-12	-0.38	0.00	0.98	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	TOP3A	0.15	0.06	lasso	3	0.09	2.9e-09	-6.69	7.5	6.7e-14	-0.73	0.01	0.98	FALSE
72	The Cancer Genome Atlas	Soft Tissue Sarcoma	TOP3A	0.08	0.03	enet	24	0.04	1.6e-03	4.12	6.2	5.0e-10	-0.38	0.03	0.74	FALSE
73	The Cancer Genome Atlas	Stomach Adenocarcinoma	FLII	0.05	0.04	blup	47	0.03	1.7e-03	-6.93	6.7	1.7e-11	-0.37	0.01	0.83	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	SMCR7	0.06	0.02	enet	7	0.04	9.1e-04	1.73	5.7	1.1e-08	-0.41	0.01	0.72	FALSE
75	The Cancer Genome Atlas	Stomach Adenocarcinoma	TOP3A	0.09	0.06	blup	48	0.05	1.8e-04	4.17	6.5	7.4e-11	-0.36	0.30	0.45	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	SMCR7	0.10	0.01	blup	33	0.05	8.9e-06	-6.09	6.8	1.3e-11	-0.64	0.05	0.90	TRUE
77	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SMCR8	0.60	0.03	blup	43	0.02	9.3e-02	-6.40	6.0	2.2e-09	-0.34	0.00	0.47	FALSE