Hub : Genes

KRT12

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.1670	0.0960	0.0056	0.065	0.046	0.044	NA	0.058	0.00013	0.0012	0.0014	NA	0.00027
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0446	0.0255	0.0013	0.022	0.021	0.020	NA	0.020	0.00140	0.0019	0.0023	NA	0.00230

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.1	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	-0.4	-0.4
Depressed Affect (Nagel 2018)	0.7	1.6	2.5	1.6	-0.8
Depression (Nagel 2018)	1.3	2.0	3.2	-0.9	-1.8
Intelligence (Savage-Jansen 2018)	0.8	2.5	3.5	1.9	1.2
Neuroticism (Nagel 2018)	0.2	0.4	0.7	0.8	-0.2
Schizophrenia (2018)	0.1	0.1	0.2	-0.4	-0.3
Schizophrenia vs Biploar Disorder	1.5	2.0	4.0	0.2	2.0
Worry (Nagel 2018)	0.1	0.2	0.2	-0.4	-0.5
Alzheimer’s Disease (in mother)	1.1	1.3	2.3	1.5	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.4	0.2
Alzheimer’s Disease (including proxy)	0.5	0.8	1.3	1.1	0.5
Crohns Disease (2017)	2.8	6.2	9.7	-3.1	-1.6
Irritable Bowel Disease (IBD)	1.7	3.9	7.2	-2.7	-0.8
Ulcerative Colitis (UC)	0.6	1.1	2.2	-1.5	-0.0
Major Depression (MDD)	0.3	0.4	0.7	-0.0	-0.9
Reaction Time	1.3	2.5	4.9	2.2	0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.6	2.7	1.6	0.7
Breast Cancer	0.2	0.6	1.0	1.0	0.4
Ovarian Cancer	0.1	0.1	0.1	0.4	-0.2
Prostate Cancer	0.6	0.8	1.5	1.2	-0.2
Age at First Birth	0.8	1.2	2.0	-1.4	-0.6
Bipolar Disorder (2011)	0.2	0.2	0.3	0.1	0.5
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	-0.0	1.2
Coronary Artery Disease (CAD)	1.5	1.8	3.5	-0.5	-1.9
Crohns Disease (2012)	2.0	3.1	3.5	-1.9	-1.7
Mean Putamen Volume	2.0	2.2	3.3	1.8	1.1
Fasting Glucose	0.4	0.5	1.0	-0.3	-1.0
HbA1C	0.1	0.1	0.2	-0.1	0.5
HDL Cholesterol	0.1	0.1	0.1	-0.4	-0.2
LDL Cholesterol	0.0	0.0	0.0	-0.0	0.1
Lupus	0.0	0.0	0.0	0.2	-0.2
Neuroticism (2016)	2.6	3.7	6.4	2.5	1.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.2	-0.2
Rheumatoid Arthritis	1.2	1.6	3.1	-1.8	0.4
Schizophrenia (2014)	0.0	0.0	0.1	-0.1	0.2
Triglycerides	0.0	0.0	0.1	-0.1	0.3
Type 2 Diabetes (T2D) (2012)	2.6	3.1	4.1	-1.4	-2.0
Ulcerative Colitis	0.9	1.4	2.7	-1.6	-0.2
Blood Eosinophil Count	0.4	2.7	5.1	-0.6	-2.3
Blood Platelet Count	0.2	1.8	3.5	-0.3	1.9
Blood Red Count	0.0	0.4	0.7	-0.8	-0.1
Blood White Count	0.2	1.2	2.5	-0.1	-1.6
Heel T-Score	0.3	2.1	3.5	-1.9	-0.9
BMI	0.1	0.4	0.7	-0.3	0.8
Height	0.1	1.3	2.6	1.6	0.0
Waist Hip Ratio (WHR)	0.1	0.3	0.6	-0.3	-0.8
Systolic Blood Pressure	0.4	1.9	3.8	-0.1	-2.0
Smoking Status	0.8	1.8	3.6	-0.2	-1.9
Allergy or Eczema	0.8	2.1	4.2	-0.0	-2.0
Cardiovascular Disease	0.1	0.4	0.7	-0.3	-0.8
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.3	0.8
Respiratory disease	0.4	1.0	1.7	-0.5	-1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.3	-0.8
Lung FEV1/FVC ratio	0.1	0.3	0.6	0.8	0.1
Lung FVC	0.5	2.4	2.9	-1.7	-1.4
Neuroticism	0.5	1.1	2.3	1.5	0.1
Chronotype (morning person)	0.5	1.2	1.9	-1.4	0.7
Hair Pigment	0.8	22.9	38.7	-6.2	-2.7
Tanning	0.6	7.4	10.2	2.1	3.2
Hand grip strength (left)	0.8	2.0	2.7	-1.2	-1.6
Number of treatments/medications taken	0.2	0.4	0.6	-0.8	-0.5
Average weekly spirits intake	1.7	2.2	2.7	-1.7	-1.3
Sensitivity / hurt feelings	0.4	0.7	1.4	1.2	-0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	0.2	0.1
Hearing difficulty/problems: Yes	0.5	0.7	0.9	0.9	-0.7
Relative age of first facial hair	0.0	0.0	0.0	-0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.1	-1.0	-0.4
Ever used hormone-replacement therapy (HRT)	1.2	1.5	2.0	-1.4	-1.0
Ever had hysterectomy (womb removed)	1.0	1.1	2.0	0.4	1.4
Systolic blood pressure, automated reading	0.3	0.8	1.6	0.1	-1.3
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.0	-0.3
Angina	0.1	0.1	0.2	0.5	0.2
Medication for hormone replacement therapy	1.3	1.5	2.8	1.7	-0.4
Vitamin and mineral supplements	0.0	0.0	0.1	-0.3	0.0
Supplements: Zinc	1.2	1.3	2.2	1.5	0.7
Medication: Co-codamol	2.4	2.8	5.1	2.3	-0.7
Medication: Metformin	0.2	0.3	0.4	-0.4	-0.7
Diabetes (father)	1.1	1.4	2.0	1.4	-0.9
Diabetes (mother)	0.7	0.9	1.0	-1.0	0.9
Severe depression (siblings)	0.6	0.7	1.0	-0.6	-1.0
Pack years adult smoking proportion	1.6	2.4	3.4	1.2	1.8
Impedance of leg (right)	0.1	0.7	0.9	-0.9	-0.7
Leg fat-free mass (left)	0.0	0.1	0.2	0.4	0.0
Trunk fat percentage	0.0	0.0	0.1	-0.2	0.1
Hand grip strength (right)	0.1	0.3	0.6	0.1	-0.8
Townsend deprivation index at recruitment	2.4	3.3	4.9	-1.3	2.2
Current tobacco smoking	1.7	2.8	3.6	-1.4	-1.9
Average weekly fortified wine intake	1.1	1.2	2.0	-0.7	-1.4
Maternal smoking around birth	0.5	0.7	1.2	-1.1	-0.3
Fed-up feelings	2.2	4.0	8.0	2.8	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.5	-1.2	-1.1
Relative age voice broke	0.2	0.3	0.3	-0.6	0.5
Taking other prescription medications	0.1	0.2	0.4	0.2	-0.6
Age when periods started (menarche)	1.0	2.4	3.1	1.3	1.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.2	0.3	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	-0.0	-1.0
Tinnitus: Yes, but not now, but have in the past	2.5	2.6	3.7	-1.9	-1.3
Qualifications: CSEs or equivalent	0.2	0.2	0.4	-0.1	0.6
Serious illness, injury or assault to yourself	0.5	0.7	1.3	0.2	-1.1
High blood pressure	0.3	0.9	0.9	-1.0	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.4	2.7	-0.4	-1.6
Multivitamins +/- minerals	0.1	0.1	0.1	0.3	0.4
Stomach or abdominal pain in last month	0.2	0.3	0.5	0.7	0.3
Supplements: Glucosamine	1.3	1.7	3.1	0.5	-1.8
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.8	0.9	0.8
Medication: Atenolol	1.0	1.2	2.0	-0.7	1.4
Medication: Levothyroxine sodium	0.5	0.9	1.4	0.6	1.2
Sitting height	0.1	0.8	1.6	0.1	-1.3
Chronic bronchitis/emphysema (father)	1.1	1.3	1.7	-0.9	-1.3
High blood pressure (mother)	0.7	1.0	1.5	0.7	-1.2
Body mass index (BMI)	0.1	0.3	0.6	0.8	0.1
Impedance of leg (left)	0.1	0.7	1.4	-1.2	-0.1
Leg predicted mass (left)	0.0	0.1	0.1	0.4	-0.0
Trunk fat mass	0.0	0.0	0.0	-0.1	-0.1
Waist circumference	0.0	0.2	0.2	0.4	-0.4
Number of incorrect matches in round	0.1	0.2	0.4	-0.6	-0.2
Past tobacco smoking	0.8	1.4	1.8	-1.0	1.3
Alcohol usually taken with meals	0.2	0.3	0.7	0.8	0.1
Nervous feelings	0.1	0.2	0.3	-0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	0.4	0.9
Hearing difficulty/problems with background noise	2.0	3.2	4.9	-1.2	-2.2
Hair/balding pattern: Pattern 2	2.1	2.7	3.2	-1.4	-1.8
Had menopause	0.2	0.3	0.4	-0.7	-0.4
Had other major operations	2.0	2.4	4.7	0.3	-2.2
Forced vital capacity (FVC)	0.0	0.0	0.1	0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.6	0.2	-1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	-0.3
Qualifications: None of the above	0.1	0.2	0.3	0.1	0.6
Financial difficulties in last 2 years	1.0	1.3	2.6	-1.6	-0.0
Mouth/teeth dental problems	0.1	0.1	0.2	-0.5	-0.1
Heart attack	0.1	0.1	0.2	-0.5	-0.1
Allergy	0.2	0.6	1.0	0.4	1.0
Pain all over the body in last month	0.4	0.5	0.6	-0.5	0.8
Diabetes (self-reported)	0.3	0.4	0.8	0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	1.8	-1.3	0.9
Medication: Ramipril	1.9	2.5	3.4	1.3	1.9
Medication: Simvastatin	0.4	0.6	1.1	-0.1	-1.1
Fluid intelligence score	0.1	0.1	0.2	0.5	-0.1
Illnesses of siblings	0.9	1.3	1.5	1.2	1.1
Neuroticism score	0.6	1.3	2.2	1.5	0.6
Weight	0.1	0.3	0.5	0.7	-0.2
Impedance of arm (right)	0.0	0.1	0.2	-0.2	0.4
Arm fat percentage (right)	0.0	0.1	0.2	0.4	0.2
Trunk fat-free mass	0.1	0.4	0.6	0.4	-0.7
Hip circumference	0.1	0.2	0.2	0.5	-0.4
Time employed in main current job	0.2	0.2	0.5	0.7	-0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.0	-0.1	-0.1
Father’s age at death	0.2	0.2	0.5	-0.7	0.1
Worrier / anxious feelings	0.6	1.1	1.6	-0.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.1	-0.6
Falls in the last year	0.1	0.1	0.2	0.4	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.2	0.9
Number of live births	0.2	0.3	0.4	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	0.8	0.1
Pulse rate	0.1	0.2	0.2	0.5	0.3
Happiness	0.3	0.4	0.4	-0.6	0.6
Noisy workplace	0.2	0.2	0.3	-0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.7	2.7	0.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	-0.3	1.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.0	0.4
Asthma	0.8	1.7	2.6	-1.6	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.3	-0.5	-0.5
Medication: Cholesterol lowering	0.2	0.3	0.6	0.1	-0.8
Depression (self-reported)	0.2	0.2	0.3	0.6	0.2
Medication: Lansoprazole	2.5	2.9	4.8	1.0	2.2
Prospective memory result	1.7	2.1	2.7	-1.2	-1.6
Lung cancer (father)	0.6	0.7	1.3	0.2	1.1
Illnesses of mother	0.8	1.0	1.9	-1.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	0.7	-0.3
Pulse wave Arterial Stiffness index	1.0	1.2	2.3	-0.3	1.5
Impedance of arm (left)	0.0	0.2	0.3	-0.5	0.3
Arm fat mass (right)	0.0	0.2	0.3	0.5	-0.3
Trunk predicted mass	0.1	0.3	0.6	0.3	-0.8
Standing height	0.0	0.1	0.1	-0.0	-0.4
Length of working week for main job	1.2	1.3	2.0	-1.4	-0.8
Exposure to tobacco smoke at home	0.2	0.2	0.2	-0.4	0.5
Breastfed as a baby	0.8	1.0	1.7	1.3	-0.5
Tense / ‘highly strung’	0.5	0.8	1.6	1.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.8	-0.0
Hair/balding pattern: Pattern 4	2.8	6.8	13.7	-0.1	3.7
Birth weight of first child	1.7	3.2	4.8	-1.3	-2.2
Peak expiratory flow (PEF)	0.7	1.5	2.7	1.6	0.6
Pulse wave reflection index	1.1	1.3	2.4	0.5	1.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	2.3	1.1	1.5
Loud music exposure frequency	0.3	0.4	0.5	-0.7	-0.5
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.3	0.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.6	1.3	0.5
Blood clot in the leg (DVT)	1.2	1.5	2.2	-1.5	-0.9
Medication: Paracetamol	0.5	0.9	1.6	1.3	0.3
Headache pain in last month	0.1	0.2	0.4	-0.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.2	0.2
Glaucoma (self-reported)	0.5	0.6	1.1	1.0	-0.4
Gout (self-reported)	0.2	0.3	0.5	0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	0.4	1.0
Medication: Amlodipine	0.4	0.6	0.9	-0.4	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	-1.0	0.1
Birth weight	0.2	0.3	0.4	0.7	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	0.6	-0.1
High blood pressure (siblings)	0.7	1.0	1.7	-0.5	-1.3
Forced vital capacity (FVC), Best measure	0.1	0.2	0.4	0.2	-0.6
Body fat percentage	0.0	0.0	0.0	-0.1	-0.1
Leg fat percentage (right)	0.0	0.0	0.1	0.2	-0.2
Arm fat-free mass (right)	0.1	0.5	0.7	-0.5	-0.8
Exposure to tobacco smoke outside home	1.2	1.7	1.8	-1.3	1.2
Comparative body size at age 10	0.3	0.8	1.5	-1.2	-0.4
Number of full brothers	1.0	1.3	2.5	-0.3	-1.6
Worry too long after embarrassment	0.1	0.1	0.2	-0.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.4	0.5	0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-0.2	-1.0
Number of children fathered	0.5	0.6	1.2	-0.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.3	0.6
Age at first live birth	1.1	2.0	2.0	-1.4	-1.4
Pulse wave peak to peak time	1.2	1.4	2.7	0.2	-1.6
Health satisfaction	2.3	3.0	5.0	2.2	1.0
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.1	-0.6
Qualifications: College or University degree	0.2	0.6	1.1	-0.3	1.1
Eye problems/disorders: None of the above	1.3	1.5	3.0	0.2	1.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.4	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.3	0.2
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	-0.1	0.4
Neck or shoulder pain in last month	0.0	0.0	0.0	0.1	-0.0
Medication: Blood pressure	0.2	0.4	0.9	-0.9	-0.1
Angina (self-reported)	0.0	0.0	0.0	0.2	0.1
Migraine (self-reported)	0.2	0.3	0.6	0.1	-0.8
Medication: Ibuprofen	1.0	1.2	2.3	-0.4	-1.5
Medication: Allopurinol	0.1	0.1	0.2	0.1	-0.4
Medication: Omeprazole	0.2	0.3	0.5	-0.3	0.7
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-0.5	-1.0
Mean time to correctly identify matches	1.4	2.7	5.5	2.3	-0.1
Heart disease (mother)	0.8	1.0	1.5	1.2	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.9	0.9	-0.3
Whole body fat mass	0.0	0.0	0.0	-0.0	-0.2
Leg fat mass (right)	0.0	0.1	0.1	0.3	-0.3
Arm predicted mass (right)	0.1	0.5	0.6	-0.6	-0.8
Pulse rate, automated reading	0.6	2.1	3.1	1.8	1.1
Alcohol intake frequency.	0.5	1.1	1.4	-0.9	-1.2
Comparative height size at age 10	0.0	0.0	0.0	-0.1	-0.0
Number of full sisters	0.1	0.1	0.1	0.3	0.3
Suffer from ‘nerves’	0.4	0.6	1.2	1.1	0.2
Overall health rating	0.1	0.1	0.2	0.3	-0.5
Chest pain or discomfort	0.5	0.7	1.4	0.1	-1.2
Had major operations	3.4	4.0	7.2	-2.7	-0.8
Age at last live birth	0.6	0.9	1.8	-0.3	-1.3
Family relationship satisfaction	1.1	1.3	2.4	1.6	0.5
Leg pain on walking	0.2	0.2	0.2	-0.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.1	-1.1	-1.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	0.8	0.9	-0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.5	0.4
Medication: Aspirin	0.1	0.1	0.1	0.4	-0.2
Supplements: Vitamin C	0.1	0.1	0.2	0.4	-0.1
Knee pain experienced in last month	0.0	0.1	0.1	0.3	0.1
Hypertension (Self-reported)	0.5	1.4	2.1	-1.4	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.9	1.0	0.4
Illnesses of father: Heart disease	0.2	0.2	0.3	-0.6	0.4
Illnesses of siblings: Diabetes	0.7	0.8	0.9	-0.9	-0.9
Smoking status: Previous	0.6	0.8	1.6	1.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.8	0.2
Whole body fat-free mass	0.0	0.2	0.2	0.3	-0.4
Leg fat-free mass (right)	0.0	0.2	0.4	0.6	0.3
Arm fat percentage (left)	0.0	0.1	0.1	0.2	0.3
Average weekly red wine intake	1.0	1.5	2.4	0.7	1.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.6	-0.1
Mood swings	1.8	3.2	3.6	1.9	1.6
Loneliness, isolation	0.5	0.7	1.4	-0.1	-1.2
Long-standing illness, disability or infirmity	1.2	1.8	3.5	-0.3	-1.9
Ever had bowel cancer screening	1.5	1.8	2.5	1.0	-1.6
Diabetes diagnosed by doctor	0.4	0.7	1.1	0.5	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	0.8	-0.8	-0.9
Friendships satisfaction	0.4	0.5	1.0	-0.2	-1.0
Qualifications: nursing, teaching	1.7	2.6	3.3	-1.4	-1.8
Commuting to job workplace: Walk	1.4	1.5	1.6	-1.2	1.3
Eye problems/disorders: Cataract	1.5	1.7	3.3	0.4	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.6	-0.8	-1.6
Medication for cholesterol	0.3	0.5	0.9	0.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-0.1	-1.2
Back pain experienced in last month	0.1	0.2	0.4	0.6	-0.2
Mineral and other dietary supplements	1.0	1.4	2.7	0.2	1.6
Breast cancer (self-reported)	1.5	1.8	2.5	-1.1	-1.6
Asthma (self-reported)	0.8	1.6	2.4	-1.6	-0.9
Osteoporosis (self-reported)	0.2	0.2	0.5	0.1	0.7
Osteoarthritis (self-reported)	0.2	0.3	0.5	-0.2	-0.7
Medication: Aspirin	0.1	0.1	0.1	0.4	0.1
Medication: Gliclazide	0.8	0.9	1.5	-0.5	-1.2
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.2	0.2
Smoking status: Current	2.1	3.4	4.4	-1.5	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.2	-0.4
Whole body water mass	0.0	0.1	0.2	0.3	-0.4
Leg predicted mass (right)	0.0	0.3	0.4	0.6	0.3
Arm fat mass (left)	0.0	0.1	0.3	0.5	0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	0.1
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.4	-0.8
Miserableness	0.4	0.7	1.4	1.2	-0.1
Guilty feelings	0.4	0.6	0.7	0.7	0.8
Wears glasses or contact lenses	0.2	0.2	0.3	0.4	0.6
Ever taken oral contraceptive pill	0.5	0.5	1.0	-1.0	0.2
Hearing aid user	1.7	1.9	2.6	1.6	-1.1
Mother’s age at death	0.3	0.4	0.4	-0.7	-0.6
Financial situation satisfaction	1.1	1.3	2.3	-1.5	0.6
Tinnitus: Yes, now most or all of the time	3.3	3.9	4.7	-2.2	-1.8
Commuting to job workplace: Public transport	0.9	1.1	1.2	-1.0	-1.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	0.4	-0.6
Medication: Blood pressure	0.3	0.6	0.8	-0.6	-0.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	2.3	-1.3	-1.5
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.9	-0.4	-1.0
High cholesterol (Self-reported)	0.2	0.4	0.6	0.4	-0.8
Medication: Bendroflumethiazide	0.3	0.4	0.5	-0.6	0.7
Medication: Paracetamol	0.6	0.9	1.9	1.4	-0.0
Medication: Lisinopril	2.0	2.5	2.7	-1.6	-1.5
Medication: Atorvastatin	0.5	0.6	0.8	0.7	-0.9
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.4	-0.1
Alcohol drinker status: Never	0.2	0.3	0.3	-0.5	-0.5
Ever smoked	1.0	1.7	2.1	1.2	-1.4
Basal metabolic rate	0.0	0.1	0.1	0.4	-0.2
Leg fat percentage (left)	0.0	0.0	0.1	0.1	0.2
Arm fat-free mass (left)	0.1	0.3	0.5	0.2	-0.7
Number of operations (self-reported)	2.1	3.1	4.6	-1.2	-2.1
Average weekly beer plus cider intake	0.0	0.0	0.0	0.0	0.1
Irritability	0.4	0.7	1.2	0.4	1.1
Risk taking	0.9	1.3	2.7	1.6	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.5	0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.4	0.3
Age started oral contraceptive pill	2.8	3.5	4.6	-1.6	-2.1
Diastolic blood pressure, automated reading	0.0	0.0	0.0	-0.2	0.2
Ever depressed for a whole week	0.6	0.7	1.4	0.3	1.2
Unable to work because of sickness or disability	0.8	1.1	2.2	0.1	-1.5
Commuting to job workplace: Cycle	1.4	1.6	3.0	-1.7	-0.6
Myopia	0.2	0.3	0.5	0.1	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.1	1.5	1.2	0.8
Cholesterol lowering medication	0.6	0.8	1.5	-0.5	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.9	0.1	0.9
Pain experienced in last month	0.0	0.0	0.0	-0.1	-0.1
Supplements: Calcium	0.6	0.7	1.1	-0.5	-1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	0.1	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.4	-0.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	2.8	-1.7	-1.1
Heart disease (siblings)	0.0	0.0	0.0	0.2	0.2
Alcohol drinker status: Previous	1.2	1.4	1.5	-1.2	-1.1
Pack years of smoking	2.6	3.8	4.1	1.9	2.0
Impedance of whole body	0.1	0.3	0.6	-0.8	0.0
Leg fat mass (left)	0.0	0.0	0.1	0.2	0.0
Arm predicted mass (left)	0.1	0.5	0.9	0.0	-1.0