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chr19:16,713,332-18,117,646

Best TWAS P=7.11e-08 · Best GWAS P=1.7e-07 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ABHD8	0.11	0.08	lasso	5	0.08	9.7e-07	5.0	-5.3	9.9e-08	-0.93	0.00	0.99	FALSE
2	GTEx	Adipose Subcutaneous	MRPL34	0.18	0.18	lasso	3	0.17	5.3e-14	5.2	5.2	1.6e-07	1.00	0.00	1.00	FALSE
3	GTEx	Adipose Visceral Omentum	MRPL34	0.30	0.22	lasso	5	0.22	7.0e-12	5.2	5.3	8.6e-08	0.98	0.00	1.00	FALSE
4	GTEx	Artery Aorta	ABHD8	0.17	0.08	lasso	4	0.05	6.7e-04	5.2	-5.2	2.6e-07	-0.95	0.00	0.95	FALSE
5	GTEx	Artery Aorta	MRPL34	0.43	0.36	lasso	6	0.35	4.6e-20	5.2	5.2	1.8e-07	1.00	0.00	1.00	FALSE
6	GTEx	Artery Coronary	MRPL34	0.31	0.22	lasso	3	0.20	3.7e-07	5.2	5.2	1.7e-07	1.00	0.00	1.00	FALSE
7	GTEx	Artery Tibial	MRPL34	0.37	0.36	lasso	6	0.34	2.6e-27	5.2	5.3	1.3e-07	1.00	0.00	1.00	FALSE
8	GTEx	Brain Cortex	MRPL34	0.38	0.29	lasso	3	0.24	2.5e-07	5.2	5.2	2.2e-07	1.00	0.00	1.00	FALSE
9	GTEx	Breast Mammary Tissue	MRPL34	0.22	0.13	lasso	4	0.10	8.8e-06	5.2	5.2	2.4e-07	0.99	0.00	1.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	MRPL34	0.26	0.15	lasso	2	0.10	3.1e-03	5.2	5.2	1.8e-07	1.00	0.01	0.79	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MRPL34	0.18	0.03	lasso	3	0.01	2.1e-01	5.2	5.2	2.3e-07	0.99	0.01	0.80	FALSE
12	GTEx	Cells Transformed fibroblasts	MRPL34	0.16	0.15	lasso	1	0.14	5.6e-11	5.2	5.2	1.8e-07	1.00	0.00	1.00	FALSE
13	GTEx	Colon Sigmoid	MRPL34	0.35	0.21	lasso	4	0.21	5.2e-08	5.2	5.1	2.8e-07	0.95	0.00	1.00	FALSE
14	GTEx	Colon Transverse	MRPL34	0.41	0.28	lasso	5	0.27	4.0e-13	5.2	5.2	2.0e-07	0.99	0.00	1.00	FALSE
15	GTEx	Esophagus Mucosa	MRPL34	0.29	0.30	lasso	3	0.28	5.1e-19	5.2	5.1	2.8e-07	1.00	0.00	1.00	FALSE
16	GTEx	Esophagus Muscularis	MRPL34	0.43	0.40	lasso	3	0.42	2.8e-27	5.2	5.2	2.3e-07	0.99	0.00	1.00	FALSE
17	GTEx	Lung	MRPL34	0.20	0.18	lasso	5	0.16	1.9e-12	5.2	5.2	2.7e-07	0.99	0.00	1.00	FALSE
18	GTEx	Muscle Skeletal	MRPL34	0.23	0.26	lasso	3	0.26	3.7e-25	5.2	5.2	2.7e-07	1.00	0.00	1.00	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	MRPL34	0.29	0.23	lasso	4	0.22	1.7e-12	5.2	5.2	2.2e-07	1.00	0.00	1.00	FALSE
20	GTEx	Skin Sun Exposed Lower leg	MRPL34	0.30	0.33	enet	16	0.33	2.7e-28	5.2	5.4	7.1e-08	0.97	0.00	1.00	TRUE
21	GTEx	Stomach	MRPL34	0.44	0.30	lasso	5	0.28	5.9e-14	5.2	5.1	2.8e-07	0.99	0.00	1.00	FALSE
22	GTEx	Thyroid	MRPL34	0.22	0.24	lasso	2	0.24	1.2e-18	5.2	5.2	1.8e-07	1.00	0.00	1.00	FALSE
23	METSIM	Adipose	MRPL34	0.25	0.26	bslmm	433	0.26	2.8e-39	5.2	5.2	2.1e-07	0.99	0.00	1.00	FALSE
24	NTR	Blood	MRPL34	0.04	0.03	lasso	4	0.03	6.7e-11	5.2	5.3	1.1e-07	1.00	0.00	1.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	MRPL34	0.34	0.42	lasso	3	0.42	2.6e-58	5.2	5.1	2.9e-07	1.00	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	MRPL34	0.20	0.14	lasso	3	0.12	1.2e-04	5.2	5.2	2.2e-07	1.00	0.00	0.97	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	MRPL34	0.10	0.11	lasso	2	0.10	6.5e-12	5.2	5.2	2.6e-07	1.00	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	MRPL34	0.05	0.06	lasso	2	0.05	3.7e-06	5.2	5.2	1.7e-07	1.00	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	PLVAP	0.05	0.00	blup	61	0.01	5.3e-02	5.2	5.2	2.6e-07	0.56	0.00	0.43	FALSE
30	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MRPL34	0.11	0.08	lasso	4	0.08	5.2e-09	5.2	5.2	2.0e-07	0.98	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MRPL34	0.07	0.07	enet	6	0.06	1.1e-04	5.2	5.2	2.6e-07	0.98	0.00	0.99	FALSE
32	The Cancer Genome Atlas	Rectum Adenocarcinoma	MRPL34	0.23	0.14	lasso	6	0.08	8.0e-03	5.2	5.2	1.5e-07	0.98	0.00	0.62	FALSE
33	The Cancer Genome Atlas	Soft Tissue Sarcoma	MRPL34	0.09	0.11	lasso	2	0.10	8.1e-07	5.2	5.4	7.9e-08	0.98	0.00	0.99	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	MRPL34	0.16	0.19	lasso	10	0.19	3.6e-18	5.2	5.2	2.0e-07	0.97	0.00	1.00	FALSE