Best TWAS P=3.68e-35 · Best GWAS P=5.11e-36 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | JAM2 | 0.07 | 0.02 | enet | 16 | 0.04 | 6.3e-06 | -4.6 | -5.7 | 9.2e-09 | 0.48 | 0.45 | 0.10 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MRPL39 | 0.12 | 0.04 | blup | 384 | 0.07 | 1.1e-08 | -6.8 | 6.4 | 1.9e-10 | -0.55 | 0.99 | 0.01 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | MRPL39 | 0.20 | 0.19 | lasso | 6 | 0.22 | 1.2e-17 | -6.8 | 6.9 | 6.2e-12 | -0.49 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Aorta | MRPL39 | 0.24 | 0.24 | lasso | 5 | 0.22 | 2.2e-12 | -6.8 | 6.7 | 2.1e-11 | -0.48 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Coronary | MRPL39 | 0.25 | 0.22 | lasso | 5 | 0.19 | 5.1e-07 | -6.7 | 6.7 | 1.7e-11 | -0.47 | 0.79 | 0.13 | FALSE |
| 6 | GTEx | Artery Tibial | MRPL39 | 0.28 | 0.25 | lasso | 5 | 0.26 | 1.0e-20 | -6.8 | 5.5 | 3.8e-08 | -0.37 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Breast Mammary Tissue | MRPL39 | 0.20 | 0.18 | lasso | 2 | 0.17 | 4.2e-09 | -6.4 | 5.9 | 3.8e-09 | -0.42 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Female) | MRPL39 | 0.14 | 0.06 | lasso | 2 | 0.05 | 1.1e-02 | -6.8 | 5.9 | 3.4e-09 | -0.41 | 0.18 | 0.06 | FALSE |
| 9 | GTEx | Cells EBV-transformed lymphocytes | MRPL39 | 0.40 | 0.31 | lasso | 6 | 0.30 | 1.7e-10 | -6.7 | 6.8 | 8.8e-12 | -0.48 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Cells EBV-transformed lymphocytes | JAM2 | 0.25 | 0.04 | enet | 37 | 0.13 | 4.7e-05 | -5.4 | 5.8 | 7.0e-09 | -0.40 | 0.16 | 0.18 | FALSE |
| 11 | GTEx | Cells Transformed fibroblasts | MRPL39 | 0.21 | 0.20 | lasso | 4 | 0.18 | 1.4e-13 | -6.8 | 5.9 | 4.5e-09 | -0.39 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Colon Sigmoid | MRPL39 | 0.26 | 0.24 | enet | 22 | 0.23 | 1.7e-08 | -6.7 | 6.6 | 3.3e-11 | -0.55 | 0.97 | 0.01 | FALSE |
| 13 | GTEx | Colon Transverse | MRPL39 | 0.24 | 0.21 | lasso | 4 | 0.23 | 2.5e-11 | -6.7 | 5.7 | 1.6e-08 | -0.38 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Esophagus Gastroesophageal Junction | MRPL39 | 0.27 | 0.24 | lasso | 1 | 0.22 | 1.5e-08 | -6.7 | 6.7 | 1.5e-11 | -0.47 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Esophagus Mucosa | MRPL39 | 0.29 | 0.29 | lasso | 7 | 0.30 | 3.9e-20 | -6.7 | 6.0 | 1.5e-09 | -0.40 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Esophagus Muscularis | MRPL39 | 0.34 | 0.38 | lasso | 4 | 0.39 | 9.5e-25 | -6.7 | 6.5 | 6.5e-11 | -0.45 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Lung | MRPL39 | 0.20 | 0.20 | enet | 28 | 0.21 | 3.6e-16 | -6.8 | 5.9 | 3.1e-09 | -0.41 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Muscle Skeletal | MRPL39 | 0.04 | 0.03 | lasso | 4 | 0.01 | 2.9e-02 | -9.9 | 9.5 | 3.3e-21 | -0.71 | 0.36 | 0.48 | FALSE |
| 19 | GTEx | Nerve Tibial | MRPL39 | 0.13 | 0.09 | lasso | 7 | 0.09 | 4.1e-07 | -6.4 | 5.2 | 2.1e-07 | -0.36 | 0.99 | 0.00 | FALSE |
| 20 | GTEx | Pancreas | MRPL39 | 0.13 | 0.06 | enet | 10 | 0.09 | 1.3e-04 | -6.7 | 7.2 | 4.9e-13 | -0.52 | 0.30 | 0.10 | FALSE |
| 21 | GTEx | Prostate | MRPL39 | 0.20 | 0.06 | lasso | 5 | 0.10 | 2.2e-03 | -3.8 | 5.7 | 9.4e-09 | -0.37 | 0.09 | 0.23 | FALSE |
| 22 | GTEx | Skin Not Sun Exposed Suprapubic | MRPL39 | 0.21 | 0.23 | enet | 19 | 0.23 | 7.8e-13 | -6.7 | 6.9 | 5.7e-12 | -0.45 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Skin Sun Exposed Lower leg | MRPL39 | 0.22 | 0.26 | enet | 15 | 0.28 | 6.7e-23 | -6.7 | 7.0 | 3.6e-12 | -0.48 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Stomach | MRPL39 | 0.54 | 0.19 | lasso | 15 | 0.17 | 1.3e-08 | -6.7 | 8.9 | 5.3e-19 | -0.66 | 0.96 | 0.04 | FALSE |
| 25 | GTEx | Testis | MRPL39 | 0.43 | 0.36 | lasso | 4 | 0.43 | 8.5e-21 | -6.7 | 8.9 | 4.9e-19 | -0.67 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Thyroid | MRPL39 | 0.21 | 0.23 | lasso | 4 | 0.24 | 5.8e-18 | -6.7 | 5.6 | 2.2e-08 | -0.37 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Vagina | MRPL39 | 0.24 | 0.21 | lasso | 3 | 0.13 | 6.3e-04 | -12.4 | 12.4 | 3.7e-35 | -0.96 | 0.02 | 0.88 | TRUE |
| 28 | METSIM | Adipose | MRPL39 | 0.08 | 0.10 | lasso | 4 | 0.10 | 2.1e-15 | -6.6 | 6.6 | 4.3e-11 | -0.47 | 1.00 | 0.00 | FALSE |
| 29 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C21orf71 | 0.03 | 0.02 | lasso | 1 | 0.04 | 2.0e-04 | -6.6 | 6.6 | 4.7e-11 | -0.48 | 0.29 | 0.30 | FALSE |
| 30 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MRPL39 | 0.15 | 0.16 | enet | 14 | 0.22 | 8.2e-19 | -6.4 | 6.7 | 2.2e-11 | -0.52 | 1.00 | 0.00 | FALSE |
| 31 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPL39 | 0.06 | 0.13 | lasso | 3 | 0.13 | 8.9e-26 | -6.6 | 6.7 | 1.7e-11 | -0.49 | 1.00 | 0.00 | FALSE |
| 32 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | MRPL39 | 0.11 | 0.11 | enet | 14 | 0.15 | 5.1e-08 | -3.1 | 6.1 | 1.4e-09 | -0.41 | 0.81 | 0.10 | FALSE |
| 33 | The Cancer Genome Atlas | Colon Adenocarcinoma | MRPL39 | 0.08 | 0.08 | lasso | 10 | 0.08 | 1.9e-05 | -6.6 | 5.9 | 2.9e-09 | -0.42 | 0.86 | 0.08 | FALSE |
| 34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MRPL39 | 0.08 | 0.08 | lasso | 2 | 0.09 | 2.8e-10 | -6.6 | 5.8 | 6.3e-09 | -0.41 | 1.00 | 0.00 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MRPL39 | 0.14 | 0.10 | blup | 47 | 0.10 | 1.7e-11 | -6.7 | 7.0 | 2.4e-12 | -0.57 | 1.00 | 0.00 | FALSE |
| 36 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MRPL39 | 0.05 | 0.02 | blup | 47 | 0.05 | 1.2e-03 | -6.6 | 6.9 | 4.0e-12 | -0.50 | 0.13 | 0.32 | FALSE |
| 37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C21orf71 | 0.05 | 0.02 | blup | 36 | 0.05 | 4.8e-06 | -10.0 | 9.6 | 9.3e-22 | -0.75 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRPL39 | 0.03 | 0.00 | blup | 47 | 0.02 | 2.2e-03 | -6.4 | 8.9 | 6.5e-19 | -0.67 | 0.02 | 0.94 | FALSE |
| 39 | The Cancer Genome Atlas | Lung Adenocarcinoma | MRPL39 | 0.05 | 0.03 | enet | 9 | 0.04 | 1.7e-05 | -6.8 | 7.3 | 2.1e-13 | -0.55 | 0.68 | 0.27 | FALSE |
| 40 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C21orf71 | 0.09 | 0.00 | blup | 36 | 0.01 | 2.5e-02 | -3.1 | 5.7 | 1.5e-08 | -0.34 | 0.02 | 0.04 | FALSE |
| 41 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MRPL39 | 0.11 | 0.13 | lasso | 6 | 0.14 | 7.4e-16 | -6.8 | 6.5 | 7.1e-11 | -0.46 | 1.00 | 0.00 | FALSE |
| 42 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MRPL39 | 0.08 | 0.07 | blup | 47 | 0.08 | 3.1e-06 | -6.8 | 7.0 | 2.1e-12 | -0.50 | 0.94 | 0.05 | FALSE |
| 43 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MRPL39 | 0.11 | 0.11 | blup | 47 | 0.10 | 5.2e-05 | -6.8 | 6.2 | 6.5e-10 | -0.43 | 0.62 | 0.13 | FALSE |
| 44 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C21orf71 | 0.17 | 0.15 | lasso | 6 | 0.14 | 2.8e-06 | -6.4 | 6.4 | 1.4e-10 | -0.47 | 0.79 | 0.10 | FALSE |
| 45 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | MRPL39 | 0.19 | 0.30 | lasso | 7 | 0.29 | 6.0e-12 | -6.8 | 6.7 | 1.8e-11 | -0.48 | 1.00 | 0.00 | FALSE |
| 46 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C21orf71 | 0.05 | 0.01 | blup | 36 | 0.03 | 5.3e-04 | -7.0 | 5.4 | 5.9e-08 | -0.45 | 0.06 | 0.10 | FALSE |
| 47 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MRPL39 | 0.14 | 0.14 | lasso | 3 | 0.13 | 1.7e-13 | -6.8 | 6.4 | 2.1e-10 | -0.45 | 1.00 | 0.00 | FALSE |
| 48 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | MRPL39 | 0.18 | 0.09 | lasso | 4 | 0.08 | 4.7e-03 | -6.6 | 6.1 | 1.3e-09 | -0.45 | 0.08 | 0.40 | FALSE |
| 49 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MRPL39 | 0.05 | 0.06 | lasso | 2 | 0.06 | 2.7e-05 | -6.8 | 6.5 | 9.1e-11 | -0.46 | 0.63 | 0.21 | FALSE |
| 50 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | MRPL39 | 0.25 | 0.14 | enet | 10 | 0.17 | 1.5e-06 | -6.6 | 5.8 | 7.2e-09 | -0.40 | 0.91 | 0.05 | FALSE |
| 51 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPL39 | 0.16 | 0.29 | enet | 12 | 0.29 | 1.0e-28 | -6.7 | 6.5 | 6.0e-11 | -0.47 | 1.00 | 0.00 | FALSE |
| 52 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | MRPL39 | 0.11 | 0.07 | enet | 5 | 0.05 | 1.3e-02 | -6.6 | 6.4 | 2.1e-10 | -0.46 | 0.13 | 0.10 | FALSE |