Best TWAS P=7e-14 · Best GWAS P=2.69e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | STAT4 | 0.28 | 0.08 | lasso | 9 | 0.11 | 1.6e-09 | -7.6 | 7.2 | 4.9e-13 | -0.95 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC067945.4 | 0.08 | 0.05 | lasso | 4 | 0.03 | 1.5e-03 | -7.6 | 7.5 | 7.0e-14 | -0.97 | 0.00 | 0.99 | TRUE |
| 3 | GTEx | Artery Tibial | STAT4 | 0.11 | 0.01 | lasso | 2 | 0.01 | 7.8e-02 | -5.7 | 6.1 | 9.8e-10 | -0.80 | 0.03 | 0.79 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | MYO1B | 0.11 | 0.09 | enet | 18 | 0.11 | 8.4e-09 | -5.7 | 6.0 | 1.9e-09 | -0.69 | 0.97 | 0.03 | FALSE |
| 5 | GTEx | Muscle Skeletal | STAT4 | 0.12 | 0.09 | enet | 25 | 0.08 | 2.2e-08 | -7.3 | 6.7 | 1.6e-11 | -0.79 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Muscle Skeletal | AC067945.4 | 0.04 | 0.03 | lasso | 3 | 0.03 | 7.7e-04 | -5.7 | 5.8 | 6.1e-09 | -0.76 | 0.15 | 0.81 | FALSE |
| 7 | GTEx | Nerve Tibial | STAT4 | 0.09 | 0.08 | lasso | 5 | 0.06 | 7.8e-05 | -7.6 | 7.5 | 7.9e-14 | -0.97 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | STAT4 | 0.16 | 0.07 | lasso | 3 | 0.06 | 5.7e-04 | -7.4 | 7.0 | 3.4e-12 | -0.90 | 0.06 | 0.94 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | AC067945.4 | 0.10 | 0.05 | lasso | 1 | 0.03 | 5.7e-03 | -5.6 | 5.6 | 1.8e-08 | -0.74 | 0.05 | 0.56 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | STAT4 | 0.07 | 0.00 | lasso | 3 | 0.00 | 1.5e-01 | -5.6 | 5.9 | 2.9e-09 | -0.82 | 0.02 | 0.76 | FALSE |
| 11 | GTEx | Thyroid | STAT4 | 0.06 | 0.04 | lasso | 3 | 0.05 | 5.2e-05 | -5.6 | 5.5 | 2.9e-08 | -0.67 | 0.46 | 0.26 | FALSE |
| 12 | METSIM | Adipose | STAT4 | 0.09 | 0.08 | bslmm | 410 | 0.08 | 6.0e-12 | -7.6 | 7.2 | 9.0e-13 | -0.97 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Glioblastoma Multiforme | MYO1B | 0.08 | 0.02 | blup | 78 | 0.02 | 7.1e-02 | -5.7 | 5.7 | 1.1e-08 | -0.76 | 0.04 | 0.40 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MYO1B | 0.04 | 0.04 | enet | 7 | 0.03 | 1.4e-04 | -5.6 | 5.3 | 9.5e-08 | -0.69 | 0.37 | 0.38 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MYO1B | 0.19 | 0.12 | blup | 78 | 0.10 | 4.1e-06 | -7.4 | 6.7 | 2.5e-11 | -0.86 | 0.01 | 0.99 | FALSE |