Best TWAS P=1.24e-97 · Best GWAS P=2.53e-217 conditioned to 2.15e-83
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Testis | EPHA4 | 0.45 | 0.04 | enet | 47 | 0.12 | 4.7e-06 | -9.2 | -14.0 | 9.4e-45 | -0.08 | 0.20 | 0.04 | TRUE |
| 2 | GTEx | Thyroid | EPHA4 | 0.10 | 0.02 | enet | 9 | 0.02 | 7.4e-03 | -26.0 | 19.4 | 1.1e-83 | 0.69 | 0.04 | 0.59 | TRUE |
| 3 | METSIM | Adipose | EPHA4 | 0.04 | 0.01 | blup | 521 | 0.02 | 1.6e-04 | -11.3 | 21.0 | 1.2e-97 | 0.25 | 0.22 | 0.10 | TRUE |
| 4 | NTR | Blood | EPHA4 | 0.06 | 0.06 | lasso | 8 | 0.05 | 1.3e-16 | -10.8 | 11.7 | 1.8e-31 | 0.17 | 1.00 | 0.00 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | EPHA4 | 0.04 | 0.03 | blup | 513 | 0.01 | 6.5e-02 | -2.6 | 15.0 | 1.2e-50 | 0.13 | 0.15 | 0.04 | FALSE |
| 6 | YFS | Blood | EPHA4 | 0.09 | 0.10 | lasso | 6 | 0.11 | 1.2e-32 | -10.9 | 9.1 | 1.4e-19 | 0.14 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PAX3 | 0.10 | 0.07 | lasso | 5 | 0.06 | 1.3e-06 | 6.3 | 6.6 | 3.8e-11 | -0.01 | 0.99 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | EPHA4 | 0.25 | 0.13 | enet | 4 | 0.11 | 1.4e-04 | -6.0 | 5.7 | 1.6e-08 | -0.01 | 0.06 | 0.08 | TRUE |