Best TWAS P=1.21e-09 · Best GWAS P=1.54e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HHATL | 0.25 | 0.22 | lasso | 8 | 0.27 | 5.5e-33 | -4.0 | -5.4 | 8.2e-08 | -0.72 | 0.96 | 0.04 | FALSE |
2 | GTEx | Adipose Subcutaneous | CCDC13-AS1 | 0.27 | 0.11 | lasso | 4 | 0.24 | 2.8e-19 | 6.0 | 5.4 | 6.5e-08 | 0.84 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Tibial | ZBTB47 | 0.08 | 0.08 | lasso | 3 | 0.04 | 2.5e-04 | 6.0 | -6.1 | 1.2e-09 | -0.99 | 0.01 | 0.99 | TRUE |
4 | GTEx | Artery Tibial | CCDC13-AS1 | 0.17 | 0.11 | enet | 20 | 0.12 | 4.9e-10 | 6.0 | 5.2 | 2.7e-07 | 0.88 | 0.01 | 0.99 | FALSE |
5 | GTEx | Lung | CCDC13-AS1 | 0.09 | 0.00 | enet | 27 | 0.02 | 7.5e-03 | 6.0 | 5.7 | 1.0e-08 | 0.64 | 0.01 | 0.96 | FALSE |
6 | ROSMAP | Brain Pre-frontal Cortex | HHATL | 0.21 | 0.15 | bslmm | 465 | 0.18 | 1.3e-22 | 6.0 | -6.1 | 1.3e-09 | -0.84 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC13 | 0.06 | 0.00 | blup | 59 | 0.01 | 1.4e-01 | 3.1 | 5.6 | 2.0e-08 | 0.83 | 0.01 | 0.67 | FALSE |
8 | The Cancer Genome Atlas | Glioblastoma Multiforme | HHATL | 0.18 | 0.12 | enet | 7 | 0.21 | 5.2e-07 | 3.6 | -5.5 | 2.8e-08 | -0.81 | 0.01 | 0.95 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC13 | 0.03 | 0.03 | blup | 59 | 0.03 | 3.8e-04 | 5.9 | 5.3 | 8.9e-08 | 0.94 | 0.01 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HHATL | 0.09 | 0.05 | enet | 10 | 0.10 | 7.4e-12 | -4.6 | -5.3 | 9.7e-08 | -0.77 | 0.04 | 0.96 | FALSE |