Best TWAS P=1.24e-11 · Best GWAS P=1.38e-18 conditioned to 3.13e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RAF1 | 0.08 | 0.02 | lasso | 6 | 0.04 | 5.2e-04 | 6.2 | -5.7 | 1.6e-08 | -0.01 | 0.09 | 0.89 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | MKRN2 | 0.32 | 0.26 | lasso | 4 | 0.21 | 1.5e-07 | 5.1 | -5.2 | 1.9e-07 | -0.02 | 0.81 | 0.14 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | MKRN2 | 0.17 | 0.10 | enet | 13 | 0.07 | 1.9e-03 | 6.3 | 6.5 | 8.2e-11 | -0.04 | 0.01 | 0.97 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | MKRN2 | 0.14 | 0.09 | lasso | 3 | 0.08 | 1.5e-04 | 6.7 | 6.8 | 1.2e-11 | -0.01 | 0.00 | 0.99 | TRUE |
| 5 | NTR | Blood | TSEN2 | 0.02 | 0.00 | bslmm | 481 | 0.01 | 1.4e-03 | 1.7 | -5.3 | 9.2e-08 | 0.07 | 0.04 | 0.85 | FALSE |
| 6 | YFS | Blood | RAF1 | 0.02 | 0.03 | lasso | 2 | 0.03 | 2.1e-10 | 6.7 | 6.7 | 1.6e-11 | -0.02 | 0.00 | 1.00 | FALSE |
| 7 | YFS | Blood | TSEN2 | 0.14 | 0.10 | enet | 34 | 0.14 | 2.7e-44 | -3.7 | -5.5 | 4.9e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VGLL4 | 0.06 | 0.01 | blup | 150 | 0.02 | 5.4e-03 | -3.5 | 5.2 | 1.8e-07 | -0.27 | 0.05 | 0.08 | TRUE |