Best TWAS P=1.77e-54 · Best GWAS P=0 conditioned to 0
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ADAMTS12 | 0.09 | 0.00 | bslmm | 529 | 0.01 | 1.0e-02 | 1.71 | -9.5 | 1.5e-21 | 0.11 | 0.08 | 0.05 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | RXFP3 | 0.12 | 0.08 | enet | 21 | 0.08 | 1.3e-09 | 1.19 | -7.3 | 2.4e-13 | 0.11 | 1.00 | 0.00 | TRUE |
3 | GTEx | Artery Aorta | AMACR | 0.34 | 0.21 | enet | 19 | 0.28 | 8.4e-16 | 3.28 | -5.9 | 3.0e-09 | -0.14 | 1.00 | 0.00 | FALSE |
4 | GTEx | Artery Coronary | AMACR | 0.46 | 0.20 | lasso | 6 | 0.27 | 1.7e-09 | 3.28 | -5.2 | 1.7e-07 | -0.15 | 0.98 | 0.00 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | AMACR | 0.72 | 0.43 | enet | 14 | 0.39 | 1.6e-11 | 2.98 | -5.5 | 3.3e-08 | -0.14 | 0.99 | 0.00 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | AMACR | 0.45 | 0.15 | lasso | 10 | 0.17 | 3.9e-06 | 3.28 | -12.8 | 2.8e-37 | 0.01 | 0.32 | 0.03 | FALSE |
7 | YFS | Blood | TARS | 0.03 | 0.00 | bslmm | 456 | 0.01 | 1.0e-03 | 0.10 | -7.4 | 1.3e-13 | 0.14 | 0.09 | 0.02 | TRUE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AMACR | 0.05 | 0.01 | enet | 10 | 0.02 | 1.1e-03 | -0.15 | 5.7 | 1.6e-08 | -0.23 | 0.06 | 0.03 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMACR | 0.42 | 0.42 | enet | 14 | 0.45 | 1.0e-56 | 2.98 | -7.0 | 2.0e-12 | -0.13 | 1.00 | 0.00 | TRUE |
10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AMACR | 0.23 | 0.26 | blup | 72 | 0.25 | 1.0e-16 | 5.24 | 5.2 | 2.0e-07 | -0.30 | 1.00 | 0.00 | TRUE |
11 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | AMACR | 0.31 | 0.23 | enet | 9 | 0.29 | 1.4e-12 | 2.98 | 8.4 | 3.1e-17 | -0.31 | 1.00 | 0.00 | TRUE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | AMACR | 0.09 | 0.03 | blup | 78 | 0.06 | 1.9e-05 | 5.58 | -15.5 | 1.8e-54 | 0.02 | 0.29 | 0.02 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | ADAMTS12 | 0.09 | 0.08 | enet | 11 | 0.08 | 3.1e-08 | 1.64 | 5.8 | 9.1e-09 | -0.06 | 0.98 | 0.01 | TRUE |