Best TWAS P=1.54e-23 · Best GWAS P=1.4e-23 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ZFYVE16 | 0.16 | 0.11 | bslmm | 473 | 0.14 | 2.1e-16 | -9.6 | 8.9 | 7.6e-19 | -0.89 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Colon Transverse | ZFYVE16 | 0.10 | 0.00 | lasso | 8 | -0.01 | 7.5e-01 | -7.1 | -7.1 | 1.4e-12 | 0.75 | 0.06 | 0.41 | FALSE |
| 3 | GTEx | Ovary | DHFR | 0.28 | 0.06 | lasso | 8 | 0.03 | 5.5e-02 | 3.7 | 5.1 | 2.8e-07 | -0.22 | 0.09 | 0.07 | TRUE |
| 4 | GTEx | Thyroid | ZFYVE16 | 0.16 | 0.07 | lasso | 6 | 0.04 | 2.6e-04 | -3.5 | -5.2 | 2.5e-07 | 0.56 | 0.23 | 0.65 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SERINC5 | 0.15 | 0.05 | lasso | 9 | 0.09 | 1.6e-11 | -3.6 | 5.2 | 1.7e-07 | 0.00 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZFYVE16 | 0.03 | 0.01 | blup | 54 | 0.01 | 3.7e-03 | -7.2 | -5.3 | 1.1e-07 | 0.62 | 0.11 | 0.15 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ZFYVE16 | 0.07 | 0.05 | enet | 21 | 0.07 | 2.7e-04 | -10.0 | -8.8 | 1.4e-18 | 0.88 | 0.03 | 0.93 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ZFYVE16 | 0.04 | 0.04 | lasso | 1 | 0.04 | 1.4e-03 | -10.0 | -10.0 | 1.5e-23 | 0.97 | 0.01 | 0.94 | TRUE |
| 9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FAM151B | 0.11 | 0.17 | lasso | 4 | 0.17 | 9.1e-05 | -7.3 | 7.5 | 4.4e-14 | -0.76 | 0.02 | 0.85 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ZFYVE16 | 0.06 | 0.08 | blup | 54 | 0.09 | 8.1e-09 | -6.6 | -7.5 | 4.6e-14 | 0.81 | 0.56 | 0.44 | FALSE |