Hub : Genes

SERINC5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.085	0.0350	3.7e-03	0.053	0.012	0.013	0.036	0.032	4.8e-07	1.2e-02	9.4e-03	2.8e-05	7.0e-05
2	GTEx	Cells Transformed fibroblasts	0.185	0.0610	3.1e-03	0.144	NA	0.105	NA	0.135	6.5e-11	NA	2.9e-08	NA	2.8e-10
3	GTEx	Esophagus Mucosa	0.210	0.0620	2.2e-03	0.067	NA	0.021	NA	0.053	3.1e-05	NA	1.4e-02	NA	1.8e-04
4	GTEx	Lung	0.200	0.0507	6.3e-05	0.005	NA	0.020	NA	0.029	1.3e-01	NA	1.1e-02	NA	2.4e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.153	0.0336	6.1e-09	0.053	0.087	0.082	0.084	0.089	2.0e-07	2.4e-11	1.0e-10	5.5e-11	1.6e-11
6	TCGA	Thyroid Carcinoma	0.157	0.0380	1.8e-10	0.062	0.129	0.107	NA	0.100	1.2e-06	1.6e-12	1.4e-10	NA	6.2e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.9	1.5	3.5	-0.8	1.5	0.9	0.9	-1.9	-0.9
Bipolar Disorder or Schizophrenia	1.0	2.4	5.1	-1.5	2.3	2.0	-0.4	-1.7	0.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.9	-0.0	0.2	-0.2	-0.5	-0.9	-1.4
Depression (Nagel 2018)	0.1	0.2	0.8	0.1	-0.1	-0.2	0.5	-0.9	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.9	0.3	-0.3	-0.0	-1.0	-0.8	0.2
Neuroticism (Nagel 2018)	0.4	1.0	3.0	0.2	0.7	0.2	0.6	-1.7	-1.5
Schizophrenia (2018)	0.9	1.8	3.2	-1.4	1.7	1.8	-1.2	-0.7	0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	3.8	1.3	-0.1	0.2	-1.5	-0.3	2.0
Worry (Nagel 2018)	0.5	1.1	2.7	-0.3	0.6	0.5	1.6	-1.2	-1.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	-0.1	0.8	0.7	0.4	0.2	-0.2
Alzheimer’s Disease (in father)	1.9	2.0	3.9	2.0	-1.4	-2.0	0.1	-0.2	-1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	-0.1	0.7	0.6	0.5	0.8	-0.8
Crohns Disease (2017)	0.3	0.6	1.2	0.1	0.3	0.4	0.8	-1.1	-1.1
Irritable Bowel Disease (IBD)	0.5	1.3	4.2	-0.2	0.4	0.5	0.7	-2.1	-1.6
Ulcerative Colitis (UC)	0.5	1.0	4.5	0.2	0.3	0.3	-0.1	-2.1	-1.1
Major Depression (MDD)	1.7	2.0	6.1	-0.9	-1.0	-0.4	0.1	-2.5	-2.0
Reaction Time	0.4	0.8	1.4	-1.0	0.8	0.9	0.7	0.6	1.2
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	-0.2	0.3	-0.1	0.6	-0.1
Breast Cancer	1.0	2.4	6.1	0.5	-0.1	-0.1	-2.1	2.0	2.5
Ovarian Cancer	0.3	0.4	1.6	-0.3	-0.1	-0.1	0.7	-0.7	-1.3
Prostate Cancer	0.4	0.6	2.0	-1.4	0.0	0.4	-0.5	1.1	-0.1
Age at First Birth	0.1	0.2	0.5	-0.3	-0.7	-0.6	-0.2	0.3	-0.3
Bipolar Disorder (2011)	2.8	2.7	7.7	1.2	2.1	1.6	0.2	-0.5	2.8
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	-0.0	-0.8	-1.0	-1.1	0.1	-0.2
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.1	0.6	0.9	-0.1	-0.6	0.5
Crohns Disease (2012)	0.1	0.1	0.3	0.1	0.2	0.4	0.4	-0.6	-0.1
Mean Putamen Volume	0.8	1.0	3.0	0.7	1.0	0.6	-1.7	0.0	1.0
Fasting Glucose	0.5	0.6	2.4	-0.1	-0.1	-0.1	-1.5	-1.0	0.7
HbA1C	0.9	1.0	4.0	0.0	-0.7	-0.8	-2.0	0.1	-1.0
HDL Cholesterol	1.0	1.7	3.8	-1.9	1.3	1.9	0.2	0.8	0.6
LDL Cholesterol	1.9	2.9	6.0	-2.1	2.2	2.5	1.2	0.6	0.5
Lupus	0.6	0.9	2.6	-0.5	1.0	1.1	-1.6	-0.5	-0.1
Neuroticism (2016)	0.8	1.1	3.9	-0.4	-1.0	-1.1	0.2	-2.0	-0.8
Primary Biliary Cirrhosis	0.7	1.0	2.3	0.5	-1.1	-0.8	-0.9	-1.5	-0.9
Rheumatoid Arthritis	0.2	0.2	0.6	0.3	-0.5	-0.4	0.2	0.5	0.8
Schizophrenia (2014)	1.1	2.4	4.1	-1.1	2.0	1.8	-1.4	-1.7	1.0
Triglycerides	0.8	1.3	3.0	1.7	-0.4	-0.9	-0.9	-1.1	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.2	-0.5	0.4	0.3	-0.6	-1.5	-0.9
Ulcerative Colitis	0.4	0.6	2.9	0.2	0.2	0.3	0.4	-1.7	-0.7
Blood Eosinophil Count	0.0	0.2	0.8	-0.7	0.1	-0.0	-0.0	-0.9	-0.3
Blood Platelet Count	0.0	0.3	1.4	-0.2	-1.2	-0.1	0.5	0.4	0.5
Blood Red Count	0.6	6.0	9.4	3.0	-2.4	-2.6	-1.9	-3.1	-1.2
Blood White Count	0.1	0.7	2.1	-0.4	-0.4	-0.1	-1.0	-1.0	-1.4
Heel T-Score	0.1	0.5	2.0	0.1	-0.8	-1.4	-0.6	-0.4	-0.2
BMI	0.4	2.2	6.2	1.3	-0.6	-1.2	-1.2	-2.5	-1.4
Height	0.1	1.5	4.8	-2.2	-0.2	0.0	-1.2	1.0	-1.4
Waist Hip Ratio (WHR)	0.2	1.1	3.2	-1.8	0.8	1.4	0.3	-0.6	0.3
Systolic Blood Pressure	0.5	2.5	5.6	1.3	-0.8	-0.9	1.8	-1.6	-2.4
Smoking Status	0.4	0.9	2.9	0.3	-0.3	0.1	-1.5	1.7	0.5
Allergy or Eczema	0.4	1.0	1.5	1.1	-1.2	-1.2	-0.3	-0.5	-1.1
Cardiovascular Disease	0.6	2.0	4.8	-0.2	1.1	0.6	2.1	-2.2	-1.0
Hypothyroidism (self reported)	0.5	1.2	4.9	-0.8	0.8	0.2	0.0	-2.2	-1.1
Respiratory disease	0.5	1.1	3.3	1.0	-0.7	-0.7	-1.8	-0.1	-1.1
Type 2 Diabetes (T2D) (2018)	2.2	4.1	9.0	1.1	-3.0	-2.9	-1.8	-0.3	-1.7
Lung FEV1/FVC ratio	0.3	1.5	7.6	0.6	0.2	-0.0	-0.4	-2.8	-0.9
Lung FVC	0.2	1.3	3.2	-0.0	0.6	-0.1	-1.8	-1.8	-0.9
Neuroticism	0.4	1.0	2.8	-0.5	1.1	0.7	0.5	-1.7	-1.0
Chronotype (morning person)	0.3	0.6	2.0	0.7	-0.7	-0.8	0.1	-1.4	-0.0
Hair Pigment	0.5	13.1	27.4	-4.7	2.5	3.8	1.2	5.2	2.8
Tanning	0.2	2.0	5.0	1.0	-1.1	-1.1	0.5	-2.2	-1.9
Hand grip strength (left)	0.6	1.6	4.6	-2.2	0.1	0.0	1.6	1.3	-0.8
Number of treatments/medications taken	0.4	0.6	1.4	-0.6	1.2	0.8	-0.6	-0.5	-1.0
Average weekly spirits intake	0.2	0.3	0.8	-0.6	-0.5	-0.2	0.9	-0.1	-0.3
Sensitivity / hurt feelings	0.7	1.2	2.6	0.8	-0.8	-1.3	0.4	-1.6	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.2	-0.1	-1.0	-0.8	0.8	1.1	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.5	0.5	0.1	-0.7	-0.9	0.1
Relative age of first facial hair	0.4	0.8	3.8	-0.6	0.5	0.4	0.3	0.0	-1.9
Other serious medical condition/disability diagnosed by doctor	4.7	6.1	14.1	-1.8	3.8	3.2	1.7	-2.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	1.1	-0.6	-0.6	-0.3	0.6	0.8
Ever had hysterectomy (womb removed)	2.8	3.2	6.2	1.5	-2.5	-2.2	-0.6	-1.7	-1.5
Systolic blood pressure, automated reading	0.7	2.0	5.6	1.1	0.5	-0.0	2.4	-1.8	-1.4
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	3.7	-0.2	-1.9	-1.6	0.0	-0.9	-1.8
Angina	1.1	1.4	2.7	0.9	-1.3	-1.6	-1.6	0.3	-0.5
Medication for hormone replacement therapy	0.4	0.5	1.5	-0.6	-0.1	-0.3	-0.7	0.7	1.2
Vitamin and mineral supplements	1.1	1.4	4.2	2.0	-1.4	-1.4	-0.0	-0.1	-0.8
Supplements: Zinc	1.8	1.9	7.8	0.8	-0.8	-0.9	0.2	-1.3	-2.8
Medication: Co-codamol	0.2	0.2	0.5	0.6	0.6	0.1	0.7	-0.4	-0.4
Medication: Metformin	1.7	2.3	5.2	1.1	-1.8	-1.9	-0.5	-0.6	-2.3
Diabetes (father)	1.9	2.4	4.4	0.9	-2.0	-2.1	-0.9	0.4	-2.0
Diabetes (mother)	0.1	0.1	0.2	-0.0	-0.5	-0.5	-0.3	-0.3	0.2
Severe depression (siblings)	2.1	2.4	7.5	0.2	-1.0	-1.0	-0.3	-2.7	-2.1
Pack years adult smoking proportion	0.1	0.2	0.9	0.1	-0.1	-0.2	-0.2	-0.9	0.0
Impedance of leg (right)	0.3	1.5	2.4	-1.4	-0.6	0.2	-1.6	1.4	1.5
Leg fat-free mass (left)	0.1	0.7	3.0	0.3	0.7	-0.0	-0.1	-0.7	-1.7
Trunk fat percentage	0.1	0.6	1.4	0.3	-0.3	0.0	-1.2	-1.0	-0.9
Hand grip strength (right)	0.6	1.6	4.4	-1.8	-0.0	-0.0	1.2	2.1	-0.7
Townsend deprivation index at recruitment	0.5	0.7	2.7	-0.5	-1.6	-0.9	0.3	0.2	-0.2
Current tobacco smoking	0.2	0.4	0.8	-0.7	-0.4	0.0	0.1	0.8	-0.9
Average weekly fortified wine intake	0.2	0.2	0.6	-0.5	-0.1	0.1	0.4	0.8	-0.3
Maternal smoking around birth	1.6	2.3	5.3	2.3	-1.2	-1.4	-0.8	0.7	2.0
Fed-up feelings	0.2	0.4	1.3	-0.9	-0.5	-0.3	-0.1	-0.5	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	0.5	-1.2	-1.0	-0.2	-0.4	0.6
Relative age voice broke	0.4	0.7	2.7	0.2	0.6	0.8	0.5	0.4	-1.6
Taking other prescription medications	1.0	1.5	5.3	0.5	-0.5	-1.4	0.7	-1.0	-2.3
Age when periods started (menarche)	0.6	1.5	2.9	-0.6	1.6	1.7	1.2	0.3	1.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.2	0.4	-0.2	-0.1	0.6	-1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.8	-0.2	0.2	0.2	0.2	0.4	1.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.7	-0.5	-0.2	0.9	-0.2	0.1
Qualifications: CSEs or equivalent	1.7	2.2	3.3	0.7	-1.8	-1.8	-1.7	1.6	-0.8
Serious illness, injury or assault to yourself	1.3	1.6	3.9	-0.4	1.4	1.2	1.1	0.7	2.0
High blood pressure	1.0	2.8	7.1	1.2	-1.1	-1.4	0.7	-2.7	-2.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.3	0.7	-1.1	-1.0	-0.4	-0.3	-1.2
Multivitamins +/- minerals	0.3	0.4	1.6	-1.3	-0.2	-0.1	-0.6	0.7	0.4
Stomach or abdominal pain in last month	0.5	0.7	1.4	-0.3	0.9	0.5	1.2	-0.6	1.0
Supplements: Glucosamine	0.9	1.2	3.1	0.6	0.7	0.6	-1.8	0.2	1.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.5	0.7	-1.6	-1.6	-0.5	-0.2	-1.2
Medication: Atenolol	0.3	0.4	0.9	0.5	-0.4	-0.7	0.4	-0.6	-1.0
Medication: Levothyroxine sodium	1.3	2.2	4.9	-1.6	1.8	1.2	-0.1	-2.2	-1.1
Sitting height	0.1	0.6	1.3	0.3	-0.7	-0.9	-1.1	0.9	0.1
Chronic bronchitis/emphysema (father)	0.7	0.8	1.8	-0.5	-1.4	-1.2	0.9	0.5	-0.6
High blood pressure (mother)	1.1	1.6	3.9	1.2	-0.8	-0.7	-1.6	-2.0	0.8
Body mass index (BMI)	0.4	1.5	3.8	1.6	0.1	-0.5	-0.4	-1.9	-1.6
Impedance of leg (left)	0.3	1.3	2.4	-1.6	-1.3	-0.3	-1.4	0.8	1.0
Leg predicted mass (left)	0.1	0.7	3.1	0.3	0.7	0.0	-0.2	-0.8	-1.8
Trunk fat mass	0.2	0.9	2.0	0.5	-0.1	-0.0	-1.4	-1.2	-1.2
Waist circumference	0.3	1.2	5.3	0.8	0.2	0.0	-0.6	-2.3	-1.0
Number of incorrect matches in round	1.0	1.7	3.1	-1.5	1.2	1.4	1.3	-0.1	1.8
Past tobacco smoking	0.5	0.9	2.6	-0.3	0.8	0.5	1.1	-1.6	-0.8
Alcohol usually taken with meals	0.4	0.6	1.8	0.7	0.4	-0.3	-0.7	-1.3	-0.6
Nervous feelings	0.3	0.5	1.0	-0.7	0.9	1.0	0.4	-0.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	-0.2	-0.7	-0.4	0.7	-0.2	-0.3
Hearing difficulty/problems with background noise	0.8	1.2	3.7	-0.8	1.9	1.3	0.5	-1.0	0.5
Hair/balding pattern: Pattern 2	1.1	1.4	3.4	1.0	-0.7	-0.8	-1.3	1.9	1.0
Had menopause	0.9	1.1	2.1	-0.8	0.9	1.2	1.1	0.6	1.5
Had other major operations	0.1	0.2	0.8	-0.1	0.1	-0.3	0.9	-0.2	-0.1
Forced vital capacity (FVC)	0.1	0.4	1.6	-0.2	0.4	-0.2	-1.3	-0.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.4	-0.6	0.4	0.5	0.4	1.0	1.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	-0.5	0.1	-0.0	0.3	-0.1
Qualifications: None of the above	0.4	0.9	1.7	1.0	-1.3	-1.2	-0.0	-0.7	-0.8
Financial difficulties in last 2 years	0.8	1.0	2.6	-1.5	-0.6	0.3	-0.5	0.8	1.6
Mouth/teeth dental problems	0.7	1.0	2.5	-1.1	0.7	0.6	1.6	1.2	0.3
Heart attack	0.5	0.7	3.2	-0.4	0.2	-0.2	1.8	0.2	0.7
Allergy	0.8	1.8	5.0	-0.1	1.6	1.4	0.7	0.7	2.2
Pain all over the body in last month	0.7	0.7	1.7	-0.7	0.7	0.8	0.1	-0.9	1.3
Diabetes (self-reported)	2.9	4.5	9.8	1.9	-2.6	-2.4	-0.6	-0.5	-3.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.1	-0.6	0.1	0.7	1.5	0.2	-1.3
Medication: Ramipril	1.1	1.4	3.7	1.0	-0.9	-0.8	0.2	-1.5	-1.9
Medication: Simvastatin	0.3	0.5	1.7	0.1	0.4	0.3	0.2	-1.3	-1.0
Fluid intelligence score	0.2	0.4	1.0	0.3	-1.0	-0.8	0.6	0.3	-0.5
Illnesses of siblings	0.5	0.6	2.1	-0.8	0.4	0.4	-0.7	0.5	1.5
Neuroticism score	0.4	0.8	2.2	-0.4	0.4	0.3	1.5	-1.0	-1.1
Weight	0.3	1.3	3.5	0.8	0.1	-0.4	-0.8	-1.6	-1.9
Impedance of arm (right)	0.4	1.7	6.6	-2.6	-0.6	0.8	-0.4	1.1	1.2
Arm fat percentage (right)	0.3	1.1	3.4	0.6	-0.1	0.1	-1.1	-1.8	-1.4
Trunk fat-free mass	0.1	0.8	2.8	0.7	0.7	-0.2	-0.8	-0.7	-1.7
Hip circumference	0.4	1.7	4.4	1.4	-0.0	-0.4	-1.1	-2.1	-1.7
Time employed in main current job	1.0	1.2	2.9	-0.1	1.7	1.3	1.0	-0.7	0.9
Alcohol intake versus 10 years previously	0.9	1.3	2.6	-0.5	-0.4	0.4	-1.6	1.5	1.6
Father’s age at death	1.6	2.1	8.4	-0.2	-0.8	-0.9	-2.9	-1.8	0.1
Worrier / anxious feelings	0.5	0.9	1.7	-0.5	0.8	0.9	1.3	0.3	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.0	-0.0	1.0	1.2	-0.2	0.2	1.4
Falls in the last year	0.1	0.1	0.2	0.2	0.4	0.5	-0.1	-0.1	0.1
Hair/balding pattern: Pattern 3	0.6	0.9	2.6	0.2	1.3	0.6	0.6	-1.6	-0.0
Number of live births	0.3	0.4	1.3	0.7	-0.2	0.4	-0.6	0.5	1.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.4	0.4	0.0	-0.8	-1.1	-1.8	-0.0
Pulse rate	1.2	1.9	4.8	-0.8	1.0	0.8	-1.0	-2.2	-1.9
Happiness	1.9	2.4	4.5	-1.7	1.9	2.1	-0.8	0.6	1.5
Noisy workplace	0.6	0.8	1.7	-0.5	1.3	1.2	0.8	-0.1	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.9	-0.8	1.1	1.4	-0.3	-0.2	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.7	1.4	-0.6	-0.5	-1.2	1.0	1.9
Mouth/teeth dental problems: Dentures	0.3	0.6	1.6	0.2	-1.2	-0.8	-0.5	-0.6	-0.7
Asthma	0.7	1.4	3.1	0.5	-0.9	-1.1	-1.5	-0.9	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	3.6	1.2	-1.5	-1.8	-1.9	0.0	-0.2
Medication: Cholesterol lowering	1.2	1.9	5.2	-2.3	1.5	1.6	-0.7	-0.9	-0.2
Depression (self-reported)	0.5	0.6	2.0	-0.5	-0.6	-0.3	0.8	-0.6	-1.4
Medication: Lansoprazole	0.3	0.3	0.8	0.6	-0.2	-0.5	-0.7	0.9	0.4
Prospective memory result	0.3	0.4	1.4	-1.2	0.1	0.5	0.5	-0.6	-0.1
Lung cancer (father)	0.4	0.5	1.5	1.2	-0.9	-0.8	0.2	0.0	-0.1
Illnesses of mother	2.4	3.0	5.0	-2.1	1.7	1.9	0.7	2.2	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.8	0.5	0.2	-0.6	-1.4	-1.2	0.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	0.4	-1.1	-0.8	-0.9	-0.1	-1.1
Impedance of arm (left)	0.6	2.9	9.3	-3.0	-0.6	1.0	-0.9	1.7	1.7
Arm fat mass (right)	0.2	1.0	2.4	0.7	0.2	-0.0	-1.1	-1.5	-1.4
Trunk predicted mass	0.1	0.8	2.9	0.7	0.7	-0.3	-0.7	-0.7	-1.7
Standing height	0.1	1.2	4.1	-2.0	0.1	0.3	-1.3	1.0	-0.7
Length of working week for main job	2.4	2.7	4.2	-0.2	-2.0	-2.0	-2.1	0.1	-1.9
Exposure to tobacco smoke at home	0.2	0.2	1.0	0.0	-0.3	0.1	-0.5	-0.2	-1.0
Breastfed as a baby	0.8	1.0	2.9	-0.3	1.7	1.3	0.4	0.6	0.9
Tense / ‘highly strung’	0.5	0.8	2.3	-1.5	0.6	0.9	0.9	-0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	6.4	-1.5	1.7	2.0	2.5	0.1	0.1
Hair/balding pattern: Pattern 4	0.4	1.1	3.7	0.2	-1.9	-0.9	1.0	0.8	-0.6
Birth weight of first child	0.4	0.8	2.0	0.8	-0.6	-1.0	-0.6	1.4	-0.7
Peak expiratory flow (PEF)	0.6	1.5	5.5	1.4	0.0	-0.6	-1.0	-2.4	-0.4
Pulse wave reflection index	1.4	1.7	4.2	1.3	-2.1	-2.0	-0.1	0.3	-0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	-0.3	-0.6	-0.4	-0.3	0.7	1.0
Loud music exposure frequency	1.4	1.5	2.7	1.6	-1.2	-1.5	1.0	0.1	-1.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.4	-0.8	0.8	1.1	0.9	0.4	1.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	0.4	0.0	0.1	-0.6	-1.1	-0.3
Blood clot in the leg (DVT)	0.3	0.4	1.2	-0.3	-0.5	-0.4	0.1	0.6	-1.1
Medication: Paracetamol	0.7	1.2	4.1	0.2	1.0	1.2	0.2	0.5	2.0
Headache pain in last month	0.2	0.3	0.8	0.9	-0.0	-0.2	0.6	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	2.9	1.7	-1.3	-1.5	0.9	1.2	1.0
Glaucoma (self-reported)	0.4	0.4	1.1	-1.0	-0.4	-0.1	0.4	1.1	-0.3
Gout (self-reported)	0.5	0.7	3.0	0.1	-0.4	-0.2	1.7	1.0	-0.2
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	7.7	-0.8	0.8	-0.1	-0.4	-2.8	-2.0
Medication: Amlodipine	0.9	1.3	3.4	0.5	-1.3	-1.3	-0.1	-0.9	-1.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.6	1.3	-0.6	-0.6	-0.7	-0.4	-0.8
Birth weight	0.3	0.7	2.3	1.0	0.7	-0.4	0.6	1.5	-0.0
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.1	0.3	-1.2	-0.9	1.4	0.9	0.5
High blood pressure (siblings)	1.5	2.2	4.3	1.5	-1.2	-1.6	-2.1	-1.0	-1.1
Forced vital capacity (FVC), Best measure	0.1	0.5	2.0	0.3	0.0	-0.6	-1.4	0.0	0.7
Body fat percentage	0.2	0.8	2.0	0.6	-0.1	0.1	-1.1	-1.4	-1.1
Leg fat percentage (right)	0.4	1.6	2.9	1.7	0.1	-0.2	-1.6	-1.7	-1.2
Arm fat-free mass (right)	0.2	0.9	3.0	0.9	0.1	-0.9	-0.8	-0.5	-1.7
Exposure to tobacco smoke outside home	0.4	0.5	0.8	0.8	-0.8	-0.5	-0.8	0.9	0.1
Comparative body size at age 10	0.3	0.7	2.4	0.8	1.0	0.0	-0.2	-1.6	-0.6
Number of full brothers	0.9	1.1	6.2	-0.3	0.2	0.3	2.5	0.6	-0.1
Worry too long after embarrassment	0.5	0.8	1.8	0.5	0.6	0.6	1.1	-1.3	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.4	-0.0	0.6	0.6	0.2	-1.4	-1.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	-0.1	-0.0	0.5	1.1	1.3	0.1
Number of children fathered	1.1	1.3	2.8	1.5	1.7	0.9	1.1	0.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	9.0	-0.4	-0.0	0.1	-0.7	0.3	3.0
Age at first live birth	0.4	0.7	2.7	-1.7	0.4	0.3	0.5	0.6	-0.8
Pulse wave peak to peak time	0.7	0.8	1.4	-0.7	1.2	0.9	1.0	0.0	1.1
Health satisfaction	0.6	0.8	3.7	-1.9	0.7	0.5	-0.0	-0.2	-0.2
Shortness of breath walking on level ground	0.4	0.5	1.7	-0.1	-0.2	-0.1	-0.2	1.2	1.3
Qualifications: College or University degree	0.6	1.9	3.9	-1.4	2.0	1.6	-0.7	-1.1	1.2
Eye problems/disorders: None of the above	0.8	0.9	3.9	-0.2	0.0	0.2	0.7	1.0	2.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	0.5	-0.3	-0.2	-1.0	-1.2	-0.2
Emphysema/chronic bronchitis	0.4	0.4	1.5	-0.3	0.5	0.6	0.5	1.2	-0.1
Medication for pain relief, constipation, heartburn	1.2	2.1	6.1	-1.1	1.2	1.3	2.5	1.5	-0.2
Neck or shoulder pain in last month	0.5	0.7	2.2	-0.0	-0.1	-0.2	-1.5	0.3	1.3
Medication: Blood pressure	0.7	1.3	4.6	-0.3	-0.5	-0.5	-1.0	-1.3	-2.1
Angina (self-reported)	1.1	1.5	3.0	0.8	-1.3	-1.7	-1.6	0.2	-0.9
Migraine (self-reported)	0.6	0.7	2.2	0.5	-0.3	-0.4	1.5	0.2	1.2
Medication: Ibuprofen	1.3	1.5	3.3	1.2	-1.3	-1.6	-1.8	0.2	-0.2
Medication: Allopurinol	0.5	0.7	1.9	-0.5	-0.2	0.0	1.3	1.4	-0.6
Medication: Omeprazole	0.4	0.5	1.2	-1.1	0.4	0.6	-0.9	0.1	0.9
Medication: Seretide 50 evohaler	1.2	1.4	6.4	-0.6	0.4	-0.3	-0.1	-1.1	-2.5
Mean time to correctly identify matches	0.4	0.7	1.6	-0.6	0.8	0.8	0.6	0.7	1.3
Heart disease (mother)	1.3	1.6	3.9	1.6	-1.7	-2.0	-0.1	-0.3	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	5.8	2.0	-2.4	-2.4	-1.1	-0.0	-0.4
Whole body fat mass	0.2	0.9	1.7	0.7	0.1	0.1	-1.2	-1.2	-1.3
Leg fat mass (right)	0.4	1.7	4.0	1.2	0.2	-0.2	-1.4	-1.7	-2.0
Arm predicted mass (right)	0.2	1.1	3.4	1.0	0.2	-0.9	-0.9	-0.8	-1.9
Pulse rate, automated reading	0.6	2.0	4.6	2.1	-1.4	-1.6	-1.2	-0.2	-1.2
Alcohol intake frequency.	0.5	1.2	3.3	0.4	-0.3	-0.4	0.6	-1.7	-1.8
Comparative height size at age 10	0.1	0.8	4.2	-2.0	0.1	0.4	-0.2	-0.7	-0.2
Number of full sisters	0.6	0.7	2.1	-1.0	-0.6	-0.7	-0.1	-1.5	-0.7
Suffer from ‘nerves’	2.0	3.1	8.9	-1.0	1.0	1.0	3.0	-1.8	-1.9
Overall health rating	0.4	0.9	2.4	-0.1	1.0	1.0	0.9	0.2	1.6
Chest pain or discomfort	0.2	0.2	0.7	0.9	-0.3	-0.6	-0.1	-0.3	-0.1
Had major operations	0.1	0.2	0.6	-0.2	-0.4	-0.1	-0.4	-0.1	-0.8
Age at last live birth	0.6	0.8	1.9	-1.4	1.1	1.2	0.2	-0.3	0.3
Family relationship satisfaction	3.8	4.7	13.4	-3.7	2.1	2.6	1.1	1.3	0.7
Leg pain on walking	1.1	1.3	2.7	0.2	-1.5	-1.2	-1.6	-1.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	-1.2	0.3	0.9	-0.7	0.8	-0.0
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.0	-1.7	0.8	0.8	1.1	0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.8	-1.0	1.2	1.0	-0.9	-0.8	-2.2
Medication: Aspirin	1.2	1.5	4.3	-0.2	-0.1	-0.4	-2.0	-2.1	-0.8
Supplements: Vitamin C	3.9	4.6	8.7	-1.3	2.8	2.9	0.6	2.1	2.1
Knee pain experienced in last month	0.6	1.0	2.6	1.1	-0.9	-0.8	-1.6	-0.5	-0.5
Hypertension (Self-reported)	1.1	2.9	7.1	1.0	-1.4	-1.6	0.4	-2.7	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	-0.0	-0.3	-0.2	-0.9	1.1	-0.1
Illnesses of father: Heart disease	0.8	1.2	2.4	1.2	-1.0	-1.6	0.9	0.7	-0.9
Illnesses of siblings: Diabetes	1.3	1.5	6.8	1.0	0.3	-0.3	-0.3	-2.6	-1.1
Smoking status: Previous	0.6	0.9	1.9	0.8	-0.4	-0.3	-1.3	1.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	2.0	-1.4	0.4	0.2	-0.9	-0.8	-0.4
Whole body fat-free mass	0.1	0.7	2.9	0.6	0.6	-0.2	-0.4	-0.8	-1.7
Leg fat-free mass (right)	0.2	0.9	3.8	0.2	0.5	-0.1	0.2	-1.0	-2.0
Arm fat percentage (left)	0.2	0.9	2.3	0.3	-0.2	0.0	-1.4	-1.5	-1.1
Average weekly red wine intake	0.9	1.4	3.2	-0.3	1.8	1.4	1.3	0.3	1.1
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	-0.0	-1.2	-0.9	0.4	0.6	0.9
Mood swings	0.5	0.9	3.9	-0.6	-0.6	-0.7	0.4	-0.2	-2.0
Loneliness, isolation	0.4	0.5	2.4	0.2	-0.1	-0.4	-0.2	-1.6	-0.6
Long-standing illness, disability or infirmity	0.7	1.1	2.8	-0.8	1.7	1.2	-0.3	-1.3	-0.0
Ever had bowel cancer screening	1.1	1.3	5.1	2.3	-1.1	-0.8	-0.8	-0.1	0.3
Diabetes diagnosed by doctor	2.8	4.7	8.1	2.1	-2.6	-2.5	-1.3	-0.8	-2.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	-0.3	-0.8	-0.5	-0.3	0.9	-0.2
Friendships satisfaction	3.2	4.0	8.8	-3.0	2.4	2.2	-1.9	-0.5	0.7
Qualifications: nursing, teaching	0.6	1.0	2.9	-0.4	1.7	1.3	0.7	-0.8	-0.1
Commuting to job workplace: Walk	1.3	1.4	3.9	1.2	-1.7	-2.0	-0.3	-0.2	0.1
Eye problems/disorders: Cataract	0.4	0.5	1.9	0.2	0.4	0.2	-0.3	-1.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.9	1.4	-0.0	-0.5	-1.2	-0.2	0.0
Medication for cholesterol	0.7	1.0	1.8	-0.8	1.1	1.3	-0.5	0.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	-0.7	-0.3	-0.6	-1.0	-0.4	0.2
Back pain experienced in last month	0.8	1.1	6.3	-0.5	-0.2	0.0	0.3	0.2	2.5
Mineral and other dietary supplements	1.3	1.7	4.5	0.8	-2.1	-1.9	0.4	0.1	-1.1
Breast cancer (self-reported)	0.7	0.9	4.2	0.4	-0.2	-0.4	-2.0	0.5	-0.6
Asthma (self-reported)	0.5	1.0	2.2	0.4	-0.7	-0.7	-1.5	-0.7	-1.4
Osteoporosis (self-reported)	2.0	2.5	4.4	-1.1	1.8	2.1	1.4	1.4	1.6
Osteoarthritis (self-reported)	0.2	0.3	0.8	-0.1	0.3	0.2	-0.9	-0.3	-0.7
Medication: Aspirin	1.2	1.6	4.9	-0.1	-0.3	-0.3	-1.9	-2.2	-0.7
Medication: Gliclazide	0.2	0.3	0.7	-0.3	-0.4	-0.2	-0.6	0.9	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.2	-0.8	0.5	1.1	-0.3	0.7	0.8
Smoking status: Current	0.3	0.5	1.2	-0.9	-0.6	-0.1	-0.1	0.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.6	0.3	0.5	-0.2	-1.6	-1.5	0.1
Whole body water mass	0.2	0.9	3.6	0.8	0.5	-0.4	-0.3	-0.9	-1.9
Leg predicted mass (right)	0.2	0.9	4.0	0.3	0.4	-0.2	0.2	-1.0	-2.0
Arm fat mass (left)	0.2	0.9	2.1	0.7	-0.1	-0.3	-0.9	-1.4	-1.4
Number of self-reported non-cancer illnesses	0.6	1.1	2.7	-0.1	1.6	1.3	1.0	-0.9	-0.7
Average weekly champagne plus white wine intake	0.9	1.2	2.8	-1.6	0.6	0.8	-1.0	1.7	0.2
Miserableness	0.1	0.1	0.3	-0.3	-0.1	-0.1	-0.4	-0.5	-0.1
Guilty feelings	1.2	1.8	7.5	0.7	1.2	1.0	0.3	0.4	2.7
Wears glasses or contact lenses	0.6	0.7	2.8	1.0	0.6	-0.0	0.1	-1.7	0.1
Ever taken oral contraceptive pill	1.5	1.6	3.1	-1.4	-1.5	-0.6	-0.5	1.8	1.3
Hearing aid user	0.8	0.9	2.7	-0.8	1.6	1.4	0.3	0.0	-0.3
Mother’s age at death	2.8	3.5	10.4	0.7	1.2	0.8	-1.0	-3.2	-2.6
Financial situation satisfaction	2.5	3.1	10.0	-3.2	1.6	1.9	0.4	1.5	-0.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.1	-1.3	1.4	1.2	-0.6	-1.8	-0.8
Commuting to job workplace: Public transport	0.7	0.9	3.0	1.3	0.1	0.3	-0.7	0.2	1.7
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	-0.6	-0.5	-0.3	0.3	0.3	-0.9
Medication: Blood pressure	1.6	3.0	5.0	1.6	-1.8	-2.2	1.1	-1.2	-2.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.3	1.8	0.5	0.0	-0.3	-1.3	0.9
Supplements: Fish oil (including cod liver oil)	2.5	3.3	7.7	-1.4	2.8	2.4	-0.9	0.4	1.8
High cholesterol (Self-reported)	1.3	2.4	4.7	-1.0	2.1	2.2	1.4	-1.2	0.8
Medication: Bendroflumethiazide	1.1	1.7	3.4	1.0	-1.0	-1.2	-1.7	-0.5	-1.8
Medication: Paracetamol	0.4	0.5	1.4	0.2	0.8	0.8	-0.6	0.2	1.2
Medication: Lisinopril	0.9	1.2	3.5	1.9	-1.0	-1.3	-0.5	0.7	0.6
Medication: Atorvastatin	0.8	1.0	3.0	-0.8	0.9	0.6	-1.7	-0.8	-0.5
Illnesses of father: High blood pressure	0.7	0.8	2.6	-0.5	-0.1	-0.3	-1.6	-1.0	1.0
Alcohol drinker status: Never	0.8	0.9	3.6	0.3	-0.0	-0.0	1.9	-0.9	-0.9
Ever smoked	0.6	1.0	3.8	0.3	-0.6	-0.2	-0.2	1.9	1.2
Basal metabolic rate	0.2	0.8	3.2	0.7	0.5	-0.3	-0.4	-0.9	-1.8
Leg fat percentage (left)	0.5	2.0	4.5	1.6	-0.3	-0.4	-1.4	-2.1	-1.5
Arm fat-free mass (left)	0.3	1.3	4.4	1.3	0.3	-0.7	-0.2	-1.2	-2.1
Number of operations (self-reported)	0.2	0.3	0.5	-0.7	-0.5	-0.3	0.6	0.7	-0.4
Average weekly beer plus cider intake	0.4	0.5	1.4	-0.2	-1.2	-0.6	0.7	0.9	-0.3
Irritability	0.4	0.6	2.8	-0.6	-0.6	-0.2	-1.7	0.4	-0.3
Risk taking	0.8	1.2	4.5	-2.1	0.0	0.4	-0.6	1.5	0.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.5	0.3	0.3	-0.4	0.4	0.1
Fractured/broken bones in last 5 years	0.8	1.0	1.9	-0.6	1.1	1.4	-1.1	1.2	0.2
Age started oral contraceptive pill	1.1	1.4	4.7	1.0	-0.2	-0.7	-0.6	-2.2	-1.2
Diastolic blood pressure, automated reading	0.4	1.4	3.2	1.2	0.5	0.1	1.2	-1.8	-1.3
Ever depressed for a whole week	0.7	0.8	2.0	-1.4	1.0	1.4	-0.1	0.1	-0.2
Unable to work because of sickness or disability	1.1	1.4	2.5	-1.6	1.0	0.9	1.3	-0.4	-1.5
Commuting to job workplace: Cycle	0.6	0.8	1.7	0.6	-0.6	-0.6	-1.2	1.3	-0.6
Myopia	1.7	2.4	8.1	-0.1	1.8	1.7	0.5	0.2	2.8
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.1	-0.9	0.9	1.3	-0.8	2.5	2.3
Cholesterol lowering medication	0.8	1.2	3.8	0.8	-0.4	-0.4	0.3	-1.9	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	-0.8	-0.0	-0.1	-0.7	0.3	0.5
Pain experienced in last month	0.6	1.0	2.8	-1.0	0.9	0.8	0.5	0.4	-1.7
Supplements: Calcium	1.0	1.2	3.2	-1.8	0.9	1.3	-0.8	0.6	-0.6
Basal cell carcinoma (self-reported)	1.6	1.9	4.8	1.7	-1.0	-1.3	-0.6	-2.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.5	-0.6	0.2	-0.0	1.6	0.1	0.9
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	-0.4	-0.6	-0.6	0.0	0.5	-1.2
Heart disease (siblings)	1.8	2.2	5.3	-0.5	1.0	0.9	2.2	-1.1	-2.3
Alcohol drinker status: Previous	1.4	1.6	4.8	-0.3	2.2	1.6	0.9	-0.9	0.3
Pack years of smoking	0.2	0.2	1.3	-0.1	-0.1	0.1	0.1	-1.1	0.2
Impedance of whole body	0.5	2.4	7.1	-2.7	-1.0	0.5	-0.8	1.6	1.6
Leg fat mass (left)	0.5	1.8	4.2	1.2	-0.0	-0.4	-1.3	-1.9	-2.0
Arm predicted mass (left)	0.3	1.6	5.0	1.4	0.2	-0.8	-0.3	-1.3	-2.2