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chr8:81,877,396-83,452,091

Best TWAS P=1.22e-80 · Best GWAS P=3.33e-77 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SNX16	0.26	0.30	lasso	10	0.34	5.1e-43	18.6	-19.0	1.2e-80	-0.97	0.01	0.99	TRUE
2	GTEx	Adipose Subcutaneous	ZFAND1	0.08	0.00	enet	9	0.00	4.7e-01	5.7	-9.5	2.6e-21	-0.54	0.02	0.57	FALSE
3	GTEx	Adipose Subcutaneous	SNX16	0.36	0.45	enet	30	0.49	7.5e-45	-3.5	-7.6	2.5e-14	-0.68	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	SNX16	0.33	0.29	lasso	7	0.32	1.9e-17	-3.5	-5.6	2.2e-08	-0.58	1.00	0.00	FALSE
5	GTEx	Artery Aorta	ZFAND1	0.24	0.09	enet	21	0.10	3.4e-06	5.7	-6.1	1.3e-09	-0.40	0.47	0.42	TRUE
6	GTEx	Artery Aorta	SNX16	0.46	0.30	lasso	11	0.30	6.9e-17	-3.9	-7.4	1.2e-13	-0.62	1.00	0.00	FALSE
7	GTEx	Artery Aorta	CHMP4C	0.16	0.10	enet	19	0.10	3.1e-06	-3.8	10.4	3.8e-25	0.45	0.37	0.10	FALSE
8	GTEx	Artery Coronary	SNX16	0.25	0.21	lasso	11	0.22	6.2e-08	-3.8	-10.1	3.7e-24	-0.75	0.12	0.87	TRUE
9	GTEx	Artery Tibial	ZFAND1	0.10	0.01	lasso	6	0.02	1.3e-02	1.7	-5.1	2.8e-07	-0.19	0.10	0.12	FALSE
10	GTEx	Artery Tibial	SNX16	0.36	0.37	lasso	9	0.42	1.8e-35	-3.5	-7.2	8.9e-13	-0.63	1.00	0.00	FALSE
11	GTEx	Artery Tibial	CHMP4C	0.16	0.02	lasso	5	0.01	3.4e-02	5.8	6.0	1.7e-09	0.38	0.67	0.04	FALSE
12	GTEx	Brain Cerebellar Hemisphere	SNX16	0.28	0.13	lasso	9	0.24	8.5e-07	-3.8	-9.4	3.8e-21	-0.69	0.06	0.89	FALSE
13	GTEx	Brain Cerebellum	SNX16	0.24	0.05	lasso	13	0.09	1.3e-03	-2.4	-6.9	4.1e-12	-0.60	0.19	0.61	FALSE
14	GTEx	Brain Hippocampus	SNX16	0.21	0.11	lasso	7	0.07	1.0e-02	18.5	-18.5	2.6e-76	-1.00	0.02	0.84	FALSE
15	GTEx	Brain Putamen basal ganglia	SNX16	0.34	0.13	enet	13	0.18	3.9e-05	-3.8	-12.2	4.1e-34	-0.82	0.03	0.86	FALSE
16	GTEx	Breast Mammary Tissue	SNX16	0.27	0.38	enet	24	0.40	8.8e-22	-3.5	-6.5	6.8e-11	-0.61	1.00	0.00	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	SNX16	0.47	0.33	lasso	14	0.37	6.2e-13	18.5	-15.6	5.6e-55	-0.93	0.01	0.99	FALSE
18	GTEx	Cells Transformed fibroblasts	SNX16	0.29	0.38	enet	26	0.40	1.2e-31	-3.8	-6.0	2.2e-09	-0.59	1.00	0.00	FALSE
19	GTEx	Colon Sigmoid	ZFAND1	0.16	0.01	enet	16	0.00	4.2e-01	-5.5	-9.3	1.9e-20	-0.41	0.03	0.49	TRUE
20	GTEx	Esophagus Mucosa	ZFAND1	0.11	0.11	lasso	8	0.10	2.7e-07	6.1	-7.5	8.0e-14	-0.42	0.97	0.02	FALSE
21	GTEx	Esophagus Mucosa	SNX16	0.13	0.18	enet	19	0.17	1.6e-11	-3.5	-6.3	3.5e-10	-0.59	1.00	0.00	FALSE
22	GTEx	Esophagus Mucosa	CHMP4C	0.57	0.42	lasso	4	0.43	3.7e-31	-3.8	5.4	6.0e-08	0.28	1.00	0.00	FALSE
23	GTEx	Esophagus Muscularis	ZFAND1	0.12	0.09	lasso	4	0.11	3.8e-07	5.7	-6.2	5.3e-10	-0.37	0.92	0.01	FALSE
24	GTEx	Esophagus Muscularis	SNX16	0.36	0.34	enet	35	0.37	1.0e-23	-3.5	-5.7	9.5e-09	-0.55	1.00	0.00	FALSE
25	GTEx	Heart Atrial Appendage	CHMP4C	0.13	0.04	lasso	3	0.14	1.2e-06	-3.8	14.6	3.4e-48	0.74	0.01	0.94	FALSE
26	GTEx	Liver	SNX16	0.22	0.19	lasso	7	0.27	3.6e-08	-3.8	-10.2	1.9e-24	-0.74	0.04	0.91	TRUE
27	GTEx	Lung	SNX16	0.40	0.41	lasso	7	0.46	1.8e-38	-3.5	-5.2	2.1e-07	-0.57	1.00	0.00	FALSE
28	GTEx	Muscle Skeletal	SNX16	0.13	0.07	enet	18	0.12	6.3e-12	17.7	-13.0	2.0e-38	-0.71	0.66	0.34	FALSE
29	GTEx	Nerve Tibial	SNX16	0.29	0.29	lasso	4	0.32	2.6e-23	-3.8	-6.5	6.1e-11	-0.62	1.00	0.00	FALSE
30	GTEx	Pituitary	SNX16	0.43	0.19	enet	41	0.28	1.1e-07	-3.8	-9.8	1.4e-22	-0.51	0.15	0.51	FALSE
31	GTEx	Prostate	SNX16	0.42	0.29	lasso	10	0.30	3.3e-08	-3.7	-9.7	4.1e-22	-0.75	0.06	0.92	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	CHMP4C	0.47	0.32	lasso	8	0.32	5.8e-18	-3.8	5.9	4.3e-09	0.25	1.00	0.00	FALSE
33	GTEx	Small Intestine Terminal Ileum	SNX16	0.30	0.10	enet	20	0.10	3.2e-03	-2.5	-7.2	5.7e-13	-0.61	0.08	0.75	FALSE
34	GTEx	Stomach	IMPA1	0.09	0.01	enet	5	0.04	6.2e-03	-4.2	5.1	2.9e-07	0.09	0.36	0.03	FALSE
35	GTEx	Thyroid	ZFAND1	0.07	0.04	lasso	3	0.04	5.9e-04	6.1	-5.9	3.1e-09	-0.36	0.56	0.11	FALSE
36	GTEx	Whole Blood	SNX16	0.09	0.03	enet	14	0.04	1.7e-04	-4.8	-10.1	5.6e-24	-0.76	0.11	0.89	FALSE
37	METSIM	Adipose	CHMP4C	0.09	0.03	bslmm	347	0.05	2.4e-08	2.0	7.4	1.1e-13	0.42	0.79	0.17	FALSE
38	METSIM	Adipose	SNX16	0.21	0.32	bslmm	335	0.32	9.9e-49	-3.4	-6.8	7.4e-12	-0.62	1.00	0.00	FALSE
39	METSIM	Adipose	ZFAND1	0.11	0.11	lasso	5	0.10	1.3e-14	5.7	-5.1	3.1e-07	-0.31	1.00	0.00	FALSE
40	NTR	Blood	SNX16	0.02	0.02	lasso	4	0.02	1.7e-08	18.5	-13.9	1.2e-43	-0.89	0.01	0.99	FALSE
41	YFS	Blood	SNX16	0.13	0.18	lasso	12	0.25	1.5e-81	-3.5	-12.6	2.7e-36	-0.83	0.99	0.01	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SNX16	0.09	0.08	enet	15	0.10	3.4e-09	18.5	-16.6	4.5e-62	-0.92	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHMP4C	0.47	0.24	lasso	4	0.24	2.3e-48	-3.8	5.2	1.8e-07	0.24	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX16	0.10	0.17	lasso	7	0.18	1.1e-35	-3.5	-6.6	4.8e-11	-0.62	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SNX16	0.08	0.10	lasso	4	0.09	2.7e-05	18.6	-17.6	2.8e-69	-0.99	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	SNX16	0.13	0.14	lasso	11	0.14	1.2e-08	-3.4	-6.5	9.0e-11	-0.60	0.82	0.17	FALSE
47	The Cancer Genome Atlas	Esophageal Carcinoma	SNX16	0.12	0.03	blup	65	0.05	1.3e-02	-3.5	-11.8	4.4e-32	-0.76	0.05	0.54	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	SNX16	0.14	0.05	blup	65	0.08	1.8e-03	-4.8	-12.6	3.7e-36	-0.85	0.02	0.76	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNX16	0.10	0.14	lasso	5	0.15	3.5e-16	18.6	-15.6	7.2e-55	-0.93	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX16	0.19	0.32	lasso	7	0.36	7.1e-43	-3.6	-10.5	1.3e-25	-0.75	1.00	0.00	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SNX16	0.18	0.01	enet	13	0.10	2.5e-06	-3.4	-8.0	1.8e-15	-0.54	0.51	0.45	TRUE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHMP4C	0.16	0.02	enet	20	0.06	1.5e-07	-3.8	6.2	7.3e-10	0.34	0.60	0.03	TRUE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNX16	0.26	0.12	blup	65	0.21	1.3e-23	-3.4	-13.5	1.1e-41	-0.78	0.10	0.90	FALSE
54	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNX16	0.23	0.15	lasso	7	0.22	6.6e-11	16.8	-12.6	1.7e-36	-0.76	0.12	0.88	FALSE
55	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZFAND1	0.09	0.03	blup	43	0.05	1.7e-03	-5.9	6.3	3.0e-10	0.22	0.06	0.12	TRUE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	SNX16	0.17	0.20	enet	13	0.29	1.6e-34	-3.4	-13.2	4.7e-40	-0.84	0.05	0.95	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	ZFAND1	0.03	0.04	lasso	1	0.03	2.8e-04	5.7	-5.8	9.1e-09	-0.33	0.32	0.14	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX16	0.11	0.12	blup	65	0.15	4.6e-17	18.5	-16.7	1.4e-62	-0.92	0.01	0.99	TRUE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SNX16	0.06	0.01	blup	65	0.02	2.5e-02	17.1	-14.4	7.4e-47	-0.87	0.02	0.90	FALSE
60	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SNX16	0.23	0.20	lasso	9	0.22	1.3e-09	-2.4	-9.0	2.9e-19	-0.70	0.43	0.57	TRUE
61	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SNX16	0.35	0.20	lasso	8	0.29	3.5e-12	-3.5	-11.4	5.4e-30	-0.78	0.07	0.93	FALSE
62	The Cancer Genome Atlas	Rectum Adenocarcinoma	SNX16	0.31	0.26	blup	65	0.25	1.6e-06	18.5	-16.2	1.1e-58	-0.90	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Soft Tissue Sarcoma	SNX16	0.11	0.06	enet	17	0.10	8.5e-07	-3.6	-10.0	1.2e-23	-0.76	0.04	0.95	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHMP4C	0.52	0.28	lasso	8	0.29	1.7e-21	-3.8	5.9	4.1e-09	0.21	1.00	0.00	TRUE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	SNX16	0.13	0.05	blup	65	0.12	2.5e-09	-3.5	-11.8	2.2e-32	-0.75	0.48	0.51	FALSE
66	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SNX16	0.13	0.04	blup	65	0.05	5.6e-03	16.8	-14.3	1.8e-46	-0.76	0.05	0.73	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	SNX16	0.19	0.21	enet	14	0.25	3.8e-24	-3.5	-8.9	3.4e-19	-0.68	1.00	0.00	TRUE
68	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CHMP4C	0.48	0.24	lasso	2	0.23	3.9e-07	-3.8	6.1	1.4e-09	0.31	0.38	0.08	FALSE
69	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SNX16	0.45	0.06	enet	20	0.15	6.2e-05	17.7	-9.7	3.6e-22	-0.56	0.02	0.47	TRUE