Best TWAS P=1.33e-30 · Best GWAS P=8.35e-27 conditioned to 0.00417
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EIF3E | 0.07 | 0.07 | bslmm | 401 | 0.09 | 1.5e-11 | -7.9 | 8.1 | 4.8e-16 | -0.58 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Brain Cerebellum | EIF3E | 0.16 | 0.04 | lasso | 9 | 0.10 | 7.9e-04 | 8.3 | 7.9 | 2.7e-15 | -0.66 | 0.09 | 0.34 | FALSE |
| 3 | GTEx | Muscle Skeletal | EMC2 | 0.05 | 0.04 | lasso | 3 | 0.02 | 2.7e-03 | 7.3 | 7.3 | 2.6e-13 | -0.27 | 0.71 | 0.01 | FALSE |
| 4 | GTEx | Testis | EMC2 | 0.28 | 0.06 | enet | 70 | 0.03 | 2.3e-02 | -7.9 | 9.3 | 1.0e-20 | -0.38 | 0.22 | 0.16 | FALSE |
| 5 | YFS | Blood | EIF3E | 0.01 | 0.00 | blup | 452 | 0.01 | 1.4e-04 | -7.8 | 11.5 | 1.3e-30 | -0.68 | 0.12 | 0.81 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | EIF3E | 0.02 | 0.01 | blup | 38 | 0.01 | 6.0e-02 | -7.9 | 8.2 | 2.9e-16 | -0.65 | 0.12 | 0.17 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EIF3E | 0.02 | 0.02 | blup | 38 | 0.01 | 1.5e-02 | -7.9 | 6.1 | 1.3e-09 | -0.40 | 0.13 | 0.04 | TRUE |