Best TWAS P=3.01e-125 · Best GWAS P=4.37e-165 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TYRP1 | 0.13 | 0.03 | enet | 19 | 0.07 | 2.0e-09 | -7.89 | 17.1 | 3.4e-65 | -0.58 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Artery Aorta | LURAP1L | 0.25 | 0.00 | enet | 25 | 0.02 | 2.5e-02 | -0.84 | 14.9 | 4.2e-50 | -0.48 | 0.06 | 0.54 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | LURAP1L | 0.23 | 0.07 | lasso | 5 | 0.01 | 1.7e-01 | -22.17 | 22.4 | 3.2e-111 | -0.80 | 0.02 | 0.87 | FALSE |
| 4 | GTEx | Pituitary | MPDZ | 0.44 | -0.01 | enet | 14 | -0.01 | 5.7e-01 | -3.39 | 7.6 | 3.1e-14 | -0.32 | 0.06 | 0.13 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TYRP1 | 0.10 | 0.03 | lasso | 6 | 0.04 | 4.1e-06 | -23.97 | -14.4 | 9.0e-47 | 0.54 | 0.96 | 0.01 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | LURAP1L | 0.31 | 0.32 | lasso | 9 | 0.32 | 1.9e-42 | -23.89 | 23.7 | 2.9e-124 | -0.84 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C9orf150 | 0.06 | 0.04 | lasso | 2 | 0.06 | 6.2e-07 | -11.98 | 20.7 | 6.4e-95 | -0.74 | 0.02 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | TYRP1 | 0.03 | 0.03 | lasso | 3 | 0.03 | 6.7e-05 | -21.58 | -23.8 | 3.0e-125 | 0.81 | 0.29 | 0.55 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TYRP1 | 0.02 | 0.01 | blup | 62 | 0.01 | 1.7e-02 | -19.92 | -19.8 | 6.1e-87 | 0.71 | 0.04 | 0.15 | FALSE |