Best TWAS P=3.01e-11 · Best GWAS P=1.72e-15 conditioned to 0.00504
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | KIAA1432 | 0.04 | 0.00 | blup | 514 | 0.03 | 2.7e-04 | -0.26 | 5.2 | 1.7e-07 | 0.37 | 0.07 | 0.07 | FALSE |
2 | GTEx | Colon Transverse | RANBP6 | 0.09 | 0.03 | enet | 8 | 0.05 | 2.6e-03 | -1.65 | -5.1 | 2.7e-07 | -0.40 | 0.11 | 0.29 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | KIAA1432 | 0.11 | 0.04 | lasso | 5 | 0.03 | 9.2e-04 | 5.72 | 5.7 | 1.5e-08 | 0.43 | 0.57 | 0.04 | FALSE |
4 | GTEx | Testis | ERMP1 | 0.12 | 0.12 | lasso | 4 | 0.12 | 3.6e-06 | 5.49 | -6.0 | 1.4e-09 | -0.39 | 0.72 | 0.14 | FALSE |
5 | GTEx | Testis | RP11-207C16.4 | 0.30 | 0.18 | lasso | 8 | 0.17 | 4.7e-08 | 5.73 | 6.0 | 1.7e-09 | 0.44 | 0.94 | 0.04 | TRUE |
6 | GTEx | Thyroid | KIAA1432 | 0.08 | 0.04 | enet | 10 | 0.04 | 9.5e-04 | 6.03 | 5.8 | 5.7e-09 | 0.41 | 0.58 | 0.02 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | KIAA1432 | 0.05 | 0.00 | blup | 502 | 0.02 | 7.5e-04 | 5.72 | 5.8 | 6.2e-09 | 0.45 | 0.09 | 0.26 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERMP1 | 0.05 | 0.02 | blup | 80 | 0.02 | 3.3e-04 | 6.88 | -6.7 | 3.0e-11 | -0.49 | 0.40 | 0.25 | TRUE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ERMP1 | 0.04 | 0.00 | enet | 10 | 0.02 | 2.4e-03 | 5.72 | -5.8 | 6.1e-09 | -0.33 | 0.29 | 0.05 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RANBP6 | 0.24 | 0.05 | blup | 38 | 0.04 | 6.6e-03 | 4.76 | 5.6 | 2.8e-08 | 0.55 | 0.01 | 0.05 | TRUE |