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chr1:84,694,242-86,289,082

Best TWAS P=3.22e-11 · Best GWAS P=1.2e-10 conditioned to 0.141

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MCOLN3	0.28	0.12	enet	39	0.25	2.6e-30	5.8	-6.1	9.9e-10	-0.78	0.06	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WDR63	0.13	0.08	lasso	5	0.10	3.8e-12	5.8	-6.0	1.6e-09	-0.68	0.11	0.89	FALSE
3	METSIM	Adipose	MCOLN2	0.15	0.13	lasso	4	0.18	3.9e-26	5.7	-5.8	7.8e-09	-0.72	0.07	0.93	FALSE
4	ROSMAP	Brain Pre-frontal Cortex	MCOLN3	0.25	0.21	enet	15	0.29	2.7e-37	5.8	-6.6	3.2e-11	-0.85	0.06	0.94	TRUE
5	ROSMAP	Brain Pre-frontal Cortex	MCOLN2	0.28	0.27	enet	64	0.26	4.1e-33	5.5	-5.4	6.7e-08	-0.70	0.08	0.92	FALSE
6	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MCOLN2	0.07	0.06	lasso	2	0.05	2.9e-05	5.7	-5.8	6.8e-09	-0.80	0.01	0.98	FALSE
7	The Cancer Genome Atlas	Breast Invasive Carcinoma	MCOLN2	0.13	0.20	enet	20	0.19	2.2e-38	5.7	-5.8	5.4e-09	-0.78	0.01	0.99	FALSE
8	The Cancer Genome Atlas	Breast Invasive Carcinoma	MCOLN3	0.03	0.00	enet	9	0.01	4.5e-04	5.8	-6.2	6.8e-10	-0.79	0.05	0.88	FALSE
9	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MCOLN2	0.08	0.05	blup	84	0.01	6.4e-02	5.7	-5.4	6.0e-08	-0.68	0.01	0.88	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	MCOLN2	0.12	0.14	lasso	3	0.14	2.4e-08	5.8	-5.7	9.4e-09	-0.78	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MCOLN2	0.09	0.14	enet	7	0.14	1.1e-15	5.7	-6.2	7.2e-10	-0.80	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MCOLN2	0.07	0.02	blup	89	0.05	1.1e-03	5.2	-6.2	8.0e-10	-0.71	0.02	0.88	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	MCOLN2	0.04	0.06	enet	11	0.05	7.9e-07	5.5	-5.8	7.5e-09	-0.75	0.01	0.99	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	MCOLN3	0.05	0.03	blup	66	0.04	2.2e-05	5.5	-6.3	3.4e-10	-0.92	0.01	0.98	FALSE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	MCOLN2	0.09	0.12	lasso	3	0.12	3.2e-14	5.7	-5.8	5.0e-09	-0.76	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MCOLN2	0.09	0.16	enet	7	0.17	1.6e-18	5.7	-5.9	4.6e-09	-0.78	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MCOLN3	0.02	0.01	blup	66	0.02	5.4e-03	4.3	-6.0	1.8e-09	-0.76	0.01	0.93	FALSE
18	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MCOLN2	0.14	0.17	lasso	2	0.15	3.1e-10	5.7	-5.7	1.3e-08	-0.78	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MCOLN2	0.12	0.00	blup	89	0.01	1.7e-01	5.2	-5.4	7.3e-08	-0.73	0.02	0.64	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MCOLN3	0.11	0.11	enet	10	0.12	1.0e-05	5.8	-6.2	4.2e-10	-0.87	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	MCOLN2	0.23	0.37	lasso	4	0.37	4.3e-40	5.7	-5.8	8.6e-09	-0.80	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	MCOLN3	0.09	0.09	lasso	2	0.07	3.1e-08	5.8	-6.3	2.1e-10	-0.82	0.06	0.94	FALSE
23	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WDR63	0.26	0.06	lasso	4	0.07	5.3e-03	4.7	5.7	9.5e-09	0.67	0.02	0.73	FALSE
24	The Cancer Genome Atlas	Stomach Adenocarcinoma	MCOLN2	0.11	0.07	enet	10	0.04	8.3e-04	5.7	-5.6	1.7e-08	-0.80	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	MCOLN2	0.21	0.35	lasso	5	0.35	8.8e-35	5.7	-5.8	7.9e-09	-0.80	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	MCOLN3	0.20	0.22	enet	24	0.22	6.7e-21	6.4	-6.5	1.1e-10	-0.90	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MCOLN2	0.30	0.22	enet	9	0.21	1.9e-06	5.7	-5.9	4.7e-09	-0.80	0.01	0.99	FALSE