Best TWAS P=3.73e-10 · Best GWAS P=1.23e-07 conditioned to 0.179
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | -3.4 | -5.2 | 1.6e-07 | -0.71 | 0.03 | 0.95 | FALSE |
| 2 | GTEx | Colon Transverse | SV2A | 0.09 | 0.00 | lasso | 9 | 0.00 | 2.2e-01 | 3.9 | -5.7 | 9.7e-09 | -0.50 | 0.03 | 0.30 | FALSE |
| 3 | GTEx | Esophagus Muscularis | BOLA1 | 0.07 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 5.3 | -6.3 | 3.7e-10 | -0.92 | 0.01 | 0.70 | TRUE |
| 4 | GTEx | Esophagus Muscularis | HIST2H2AA3 | 0.18 | 0.02 | lasso | 4 | 0.03 | 5.4e-03 | 3.9 | -5.9 | 4.7e-09 | -0.54 | 0.03 | 0.33 | FALSE |
| 5 | GTEx | Esophagus Muscularis | RP11-196G18.22 | 0.18 | 0.02 | enet | 9 | 0.01 | 1.2e-01 | 4.6 | -5.6 | 2.7e-08 | -0.45 | 0.03 | 0.31 | FALSE |
| 6 | GTEx | Esophagus Muscularis | RP11-196G18.24 | 0.15 | 0.00 | enet | 17 | 0.00 | 7.3e-01 | 4.6 | -6.0 | 2.3e-09 | -0.50 | 0.02 | 0.19 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | MTMR11 | 0.03 | 0.01 | lasso | 5 | 0.00 | 1.2e-01 | 5.3 | 5.7 | 1.1e-08 | 0.95 | 0.01 | 0.75 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPRD2 | 0.05 | 0.02 | enet | 5 | 0.02 | 1.6e-03 | 3.8 | 5.6 | 1.7e-08 | 0.34 | 0.00 | 0.57 | FALSE |