Hub : Genes

WDR63

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1340	0.0310	2.9e-09	0.081	0.099	0.096	0.098	0.100	4.4e-10	4.9e-12	1.0e-11	6.4e-12	3.8e-12
2	METSIM	Adipose	0.0770	0.0234	5.0e-05	0.027	0.021	0.045	0.023	0.025	4.9e-05	3.6e-04	2.5e-07	1.6e-04	1.1e-04
3	TCGA	Brain Lower Grade Glioma	0.0432	0.0236	6.8e-03	0.027	0.010	0.008	NA	0.013	4.4e-04	2.5e-02	3.6e-02	NA	1.2e-02
4	TCGA	Lung Adenocarcinoma	0.0319	0.0166	2.0e-03	0.008	0.023	0.022	NA	0.015	3.1e-02	8.6e-04	1.1e-03	NA	6.2e-03
5	TCGA	Skin Cutaneous Melanoma	0.2610	0.1040	1.8e-03	0.055	0.070	0.061	NA	0.073	1.4e-02	6.2e-03	1.0e-02	NA	5.3e-03
6	TCGA	Thyroid Carcinoma	0.0730	0.0340	7.6e-04	-0.003	0.018	0.004	NA	-0.002	9.1e-01	6.6e-03	1.2e-01	NA	5.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.3	2.0	4.0	-2.0	0.4	-1.3	-1.3	1.1	-1.8
Bipolar Disorder or Schizophrenia	1.4	3.4	6.8	-2.1	0.8	-2.6	-0.9	1.8	-2.2
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	0.4	1.2	1.1	0.0	-0.7	1.0
Depression (Nagel 2018)	0.2	0.3	0.9	-0.2	0.1	1.0	-0.1	0.4	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.7	-0.1	-1.6	0.2	-0.8	-0.8	0.3
Neuroticism (Nagel 2018)	0.4	1.0	1.9	0.6	1.1	1.4	0.5	-0.6	1.4
Schizophrenia (2018)	0.8	1.8	5.4	-1.1	0.7	-2.3	-0.1	1.4	-1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	3.2	0.3	-0.1	1.1	1.6	0.1	1.8
Worry (Nagel 2018)	0.3	0.7	2.2	-0.1	0.8	1.5	1.0	-0.2	0.5
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.2	-0.1	-0.7	-0.5	-0.6	0.8
Alzheimer’s Disease (in father)	0.4	0.5	1.5	-0.2	0.0	-1.1	-1.2	0.3	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.8	2.3	0.4	-0.1	-1.5	-1.1	-0.8	0.5
Crohns Disease (2017)	0.1	0.2	0.3	-0.6	-0.4	-0.4	0.3	0.3	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	-0.9	-0.8	-0.9	-0.4	1.2	-0.7
Ulcerative Colitis (UC)	0.4	0.8	1.3	-0.9	-0.9	-0.8	-0.8	1.1	-0.6
Major Depression (MDD)	0.4	0.5	2.2	-1.5	0.7	-0.2	-0.3	0.2	-0.3
Reaction Time	0.6	1.1	4.7	-0.6	-2.2	-0.7	-1.1	0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.2	-0.3	-0.4	0.0	-0.5	0.5	0.4
Breast Cancer	0.1	0.2	0.7	-0.4	0.0	0.1	0.8	-0.2	0.6
Ovarian Cancer	0.5	0.7	1.6	0.6	0.6	-0.3	0.4	-1.3	1.2
Prostate Cancer	0.7	1.0	2.6	-0.0	-0.0	-1.3	0.6	1.1	1.6
Age at First Birth	0.1	0.1	0.3	-0.6	-0.1	0.1	0.3	0.4	-0.4
Bipolar Disorder (2011)	1.2	1.1	4.0	-2.0	0.6	-0.7	-0.9	0.6	-0.8
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	0.0	0.1	0.8	-0.3	0.6	0.4
Coronary Artery Disease (CAD)	0.3	0.3	1.0	0.3	0.1	1.0	-0.6	-0.6	-0.4
Crohns Disease (2012)	0.3	0.5	2.4	0.2	0.4	-1.5	0.3	-0.1	-0.3
Mean Putamen Volume	0.2	0.3	0.9	-0.9	0.0	0.6	0.1	0.4	-0.3
Fasting Glucose	0.2	0.2	0.8	0.9	-0.2	0.3	-0.3	0.1	0.3
HbA1C	0.4	0.5	1.4	1.2	1.1	0.1	0.1	-0.6	-0.1
HDL Cholesterol	0.3	0.4	0.9	0.1	0.9	-0.9	0.6	-0.3	-0.7
LDL Cholesterol	0.6	1.0	3.2	-1.0	-0.2	-0.3	-0.5	1.1	-1.8
Lupus	0.4	0.6	1.1	0.9	0.1	0.9	0.9	-1.0	0.3
Neuroticism (2016)	0.6	0.8	1.3	-1.1	1.1	-0.0	-0.4	1.1	-1.1
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.1	-0.6	-0.2	-0.8	0.7	0.2
Rheumatoid Arthritis	1.1	1.5	3.5	1.9	-1.4	0.5	-0.5	-1.3	1.1
Schizophrenia (2014)	0.2	0.5	0.8	-0.7	0.6	-0.9	0.5	0.7	-0.9
Triglycerides	0.3	0.4	1.8	-0.4	-0.1	0.6	0.2	1.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	-0.1	0.6	0.3	-0.1	-0.3	-0.5
Ulcerative Colitis	0.8	1.2	3.1	-0.4	-0.5	-1.6	-1.0	1.8	-0.4
Blood Eosinophil Count	0.1	0.5	2.3	-0.3	-0.5	-0.2	-0.2	0.3	1.5
Blood Platelet Count	0.0	0.4	1.8	1.3	-0.4	-0.4	0.3	-0.6	0.4
Blood Red Count	0.1	1.4	6.2	0.1	-2.5	-0.2	-1.3	-0.6	-0.5
Blood White Count	0.1	0.6	2.2	0.7	-1.5	0.0	-1.0	-0.4	0.2
Heel T-Score	0.4	3.6	6.6	-2.0	-2.6	-2.1	-1.0	1.3	-1.9
BMI	0.1	0.6	1.6	1.3	1.0	-0.2	-0.6	-0.4	0.5
Height	0.4	7.0	15.5	-3.5	2.5	-0.5	0.9	3.9	-2.6
Waist Hip Ratio (WHR)	1.4	6.3	16.8	3.6	-1.3	-0.3	0.9	-4.1	2.4
Systolic Blood Pressure	0.2	1.2	4.5	-1.1	-2.1	-0.4	-0.9	0.7	0.4
Smoking Status	0.8	1.8	8.7	-0.1	-3.0	-0.4	-1.3	-0.6	-0.3
Allergy or Eczema	0.7	1.8	3.1	-1.0	-1.0	-1.2	-1.6	1.8	-1.2
Cardiovascular Disease	0.3	0.9	4.2	-0.5	-2.1	-0.1	-0.9	-0.3	-0.6
Hypothyroidism (self reported)	0.2	0.6	1.2	-0.8	0.1	-0.4	-0.5	1.1	-1.1
Respiratory disease	1.0	2.2	5.4	-1.6	0.6	-1.5	-1.1	1.2	-2.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	0.6	-1.3	-0.3	-1.1	0.2	1.0
Lung FEV1/FVC ratio	0.5	2.3	5.5	1.8	-2.3	1.0	-0.0	-0.6	2.0
Lung FVC	0.2	1.2	3.1	-1.8	0.1	-1.8	0.4	0.8	-0.4
Neuroticism	0.2	0.4	1.5	0.1	1.2	0.8	-0.1	0.1	0.1
Chronotype (morning person)	0.3	0.6	1.7	-1.2	1.3	-0.4	0.3	0.3	-0.1
Hair Pigment	0.5	15.5	36.5	-6.0	3.3	-1.5	0.4	5.7	-3.2
Tanning	0.1	0.9	1.8	-1.3	1.2	-0.4	0.2	0.5	-1.3
Hand grip strength (left)	0.1	0.2	0.5	-0.4	0.5	0.5	0.7	0.1	0.2
Number of treatments/medications taken	0.7	1.2	3.2	-0.8	-1.3	-0.9	-1.8	0.0	-0.9
Average weekly spirits intake	0.5	0.6	1.0	-1.0	-0.7	0.8	0.2	0.7	-1.0
Sensitivity / hurt feelings	0.3	0.5	1.4	0.2	-0.1	-0.9	-1.2	-0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	0.3	0.3	-0.2	-0.5	-0.4	1.3
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.4	0.6	0.8	0.3	-0.5	-0.6
Relative age of first facial hair	1.1	2.2	3.4	-1.8	-1.6	-1.4	-1.3	1.9	-0.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.6	-0.6	-0.5	-0.4	-0.2	-0.1
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.7	-1.9	0.4	-0.2	-0.4	1.5	-1.0
Ever had hysterectomy (womb removed)	1.4	1.6	5.0	1.1	-2.2	0.2	-0.9	-1.4	-0.7
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.4	-0.7	0.5	0.5	0.4	0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.3	5.4	-0.4	-2.3	-0.2	-1.1	0.4	-0.8
Angina	0.3	0.4	0.9	0.8	-0.6	-0.7	-0.2	-1.0	-0.3
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.2	-0.3	-0.7	-0.5	0.9	0.7
Vitamin and mineral supplements	0.7	0.9	3.0	-1.0	-1.7	-0.5	-0.4	1.0	-0.3
Supplements: Zinc	1.3	1.4	3.2	1.8	0.6	0.7	1.3	-1.3	1.2
Medication: Co-codamol	0.4	0.5	1.5	-0.1	-0.8	1.2	0.1	0.3	-0.7
Medication: Metformin	0.7	1.0	2.0	0.2	-1.4	-1.1	-1.4	0.2	0.8
Diabetes (father)	0.3	0.4	0.8	-0.6	0.1	-0.9	-0.4	0.8	-0.6
Diabetes (mother)	1.3	1.6	3.3	-0.6	-1.8	-0.7	-1.8	0.6	-1.4
Severe depression (siblings)	0.4	0.5	2.1	0.2	-0.1	-0.5	0.6	-0.5	1.4
Pack years adult smoking proportion	1.7	2.6	7.1	-0.5	-1.2	-2.7	-2.1	0.3	-1.4
Impedance of leg (right)	0.3	1.4	2.4	1.1	-1.4	-0.8	0.5	-1.6	1.4
Leg fat-free mass (left)	0.5	2.6	6.3	-2.2	1.2	0.2	-0.1	2.5	-1.7
Trunk fat percentage	0.0	0.0	0.1	-0.1	-0.2	-0.3	-0.0	-0.2	-0.3
Hand grip strength (right)	0.0	0.1	0.3	-0.5	0.3	-0.0	-0.1	0.4	-0.2
Townsend deprivation index at recruitment	0.6	0.8	1.4	-0.8	-0.6	-0.7	-0.8	1.2	-1.1
Current tobacco smoking	2.0	3.3	7.3	-1.0	-2.3	-1.4	-2.0	0.4	-2.7
Average weekly fortified wine intake	0.6	0.7	3.6	-0.2	0.6	-0.5	-0.2	0.0	-1.9
Maternal smoking around birth	0.9	1.3	3.0	-0.3	1.0	1.7	1.3	-1.1	0.8
Fed-up feelings	0.5	1.0	2.0	-1.4	-0.3	0.3	-1.3	1.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	0.1	-0.7	0.5	-0.3	-0.3	0.6
Relative age voice broke	0.6	0.9	2.8	-1.1	-0.8	-0.5	-0.4	1.7	-0.5
Taking other prescription medications	0.7	1.0	2.5	-0.2	-1.5	-0.3	-1.6	-0.3	-1.0
Age when periods started (menarche)	0.1	0.2	0.9	0.6	0.1	0.1	0.0	0.2	1.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.8	-0.3	-1.4	0.6	-0.9	-0.2	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.3	1.5	0.2	-1.2	0.2	0.5	-0.4	-0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	-0.8	-0.6	-0.0	0.2	1.2	-0.3
Qualifications: CSEs or equivalent	1.0	1.3	4.0	2.0	-0.0	-0.8	-0.4	-1.4	0.9
Serious illness, injury or assault to yourself	0.6	0.7	2.3	0.0	-0.8	-0.6	-1.5	-0.4	-1.0
High blood pressure	0.3	0.9	3.9	-0.5	-2.0	-0.3	-0.9	-0.3	0.4
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.3	-1.0	-0.4	-0.6	-1.5	1.8	-1.1
Multivitamins +/- minerals	0.7	0.8	3.4	-0.6	1.9	-0.6	-0.6	0.4	-0.6
Stomach or abdominal pain in last month	1.6	2.0	4.1	-0.9	-1.1	-1.3	-2.0	1.4	-1.5
Supplements: Glucosamine	1.0	1.3	4.1	0.7	2.0	1.1	1.1	-0.2	0.7
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.4	-0.6	0.6	-0.2	0.3	0.3	-0.2
Medication: Atenolol	2.8	3.5	7.2	0.3	-2.2	-2.4	-2.7	-1.0	-1.4
Medication: Levothyroxine sodium	0.6	1.0	2.1	-0.7	-1.3	-0.4	-0.9	1.5	-0.7
Sitting height	1.1	7.7	19.2	-4.4	0.7	-1.3	-0.9	3.5	-3.4
Chronic bronchitis/emphysema (father)	0.2	0.2	1.3	-0.3	-1.1	0.0	0.1	-0.0	0.2
High blood pressure (mother)	0.5	0.6	2.9	0.1	-1.7	-0.0	-0.2	-0.9	0.2
Body mass index (BMI)	0.0	0.2	0.5	-0.3	0.6	0.3	-0.2	0.7	-0.4
Impedance of leg (left)	0.4	1.9	3.6	1.5	-1.6	-1.0	0.1	-1.9	1.3
Leg predicted mass (left)	0.5	2.7	6.6	-2.2	1.2	0.2	-0.1	2.6	-1.8
Trunk fat mass	0.1	0.3	0.6	-0.8	0.5	-0.1	0.1	0.6	-0.8
Waist circumference	0.0	0.1	0.4	-0.0	0.5	-0.2	0.6	-0.1	0.0
Number of incorrect matches in round	1.6	2.6	4.2	1.3	1.4	1.5	1.5	-2.0	1.7
Past tobacco smoking	0.2	0.4	2.0	0.2	0.4	-0.1	-0.4	-0.2	-1.4
Alcohol usually taken with meals	0.6	1.0	2.6	1.0	0.0	0.8	0.7	-1.1	1.6
Nervous feelings	0.5	0.9	1.8	0.8	0.5	1.0	1.4	-0.4	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	4.8	-0.4	1.9	2.2	2.2	0.1	1.1
Hearing difficulty/problems with background noise	0.4	0.7	1.0	0.6	-1.0	-1.0	-1.0	-0.6	-0.7
Hair/balding pattern: Pattern 2	0.8	1.1	4.0	-0.5	0.9	-2.0	-1.1	-0.2	0.3
Had menopause	0.6	0.8	2.1	0.3	0.1	0.8	1.2	-0.7	1.5
Had other major operations	0.5	0.6	2.4	-0.2	-0.6	-0.1	-1.6	0.3	-1.0
Forced vital capacity (FVC)	0.4	1.6	4.2	-2.0	1.4	-1.2	-0.0	1.3	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.9	-0.6	-1.7	0.3	0.1	1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	0.5	0.6	-0.1	-0.8	0.0	-0.4
Qualifications: None of the above	0.8	1.6	2.8	0.7	-1.6	1.7	1.0	-1.6	0.5
Financial difficulties in last 2 years	0.6	0.8	4.0	0.7	-2.0	-0.5	-0.4	-0.1	0.4
Mouth/teeth dental problems	0.9	1.3	2.8	-1.0	1.3	-0.6	-0.6	1.7	-1.3
Heart attack	0.4	0.5	1.2	1.1	-0.3	0.5	-0.6	-1.0	0.5
Allergy	0.8	1.7	3.5	1.5	0.1	0.4	1.5	-1.9	1.6
Pain all over the body in last month	1.1	1.1	3.1	1.8	-0.2	0.3	0.5	-1.1	1.5
Diabetes (self-reported)	0.5	0.8	2.2	0.0	-1.2	-0.8	-1.5	0.7	-0.1
Hayfever/allergic rhinitis (self-reported)	3.9	5.2	12.3	-2.5	0.9	-2.6	-2.0	3.5	-0.8
Medication: Ramipril	0.5	0.6	2.5	0.3	0.0	1.0	0.4	-0.3	1.6
Medication: Simvastatin	1.9	2.8	6.9	-2.6	-1.2	-0.9	-1.5	1.9	-1.3
Fluid intelligence score	0.2	0.4	1.4	0.6	-1.2	0.5	-0.4	-0.4	-0.0
Illnesses of siblings	0.3	0.4	1.8	0.1	-0.3	-0.4	-0.7	0.1	-1.4
Neuroticism score	0.2	0.5	1.9	-0.6	1.4	0.4	-0.2	0.6	-0.2
Weight	0.3	1.7	3.6	-1.9	1.0	-0.0	0.0	1.9	-1.5
Impedance of arm (right)	0.3	1.3	2.4	0.8	-1.6	-1.4	0.3	-1.6	0.5
Arm fat percentage (right)	0.0	0.2	0.5	-0.1	0.3	-0.7	-0.2	0.2	-0.4
Trunk fat-free mass	0.5	2.9	6.9	-2.2	1.5	0.4	0.4	2.6	-1.8
Hip circumference	0.4	1.8	4.1	-2.0	1.0	-0.1	0.1	2.0	-1.2
Time employed in main current job	1.0	1.1	3.4	-1.9	0.5	-0.2	-0.2	1.6	0.6
Alcohol intake versus 10 years previously	0.6	0.9	1.8	0.5	0.8	1.3	1.3	-0.9	-0.3
Father’s age at death	0.4	0.5	2.0	0.0	0.4	1.4	0.7	0.5	0.5
Worrier / anxious feelings	0.4	0.7	1.9	-0.8	1.4	0.8	0.2	0.6	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	0.4	-1.1	-0.8	-1.1	-0.5	-0.4
Falls in the last year	0.4	0.5	1.2	1.0	0.4	0.6	0.8	-1.1	0.0
Hair/balding pattern: Pattern 3	0.6	1.0	2.4	-0.3	1.6	1.4	1.1	-0.0	0.2
Number of live births	0.5	0.7	1.4	1.0	-1.2	1.0	0.4	-0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.5	-1.2	0.9	-0.7	0.0	0.7	-0.3
Pulse rate	0.9	1.4	2.5	-1.6	1.2	-1.0	-0.7	1.5	-0.9
Happiness	1.6	2.0	7.8	0.8	-2.8	-0.5	-1.6	-0.7	0.5
Noisy workplace	0.8	1.0	3.5	1.2	-0.8	0.0	-0.2	-1.9	0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	0.2	-0.3	-1.3	-1.2	0.4	-0.6
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.9	-1.6	1.4	1.6	0.5	1.6	-2.0
Mouth/teeth dental problems: Dentures	0.5	0.9	2.7	1.0	-0.7	0.6	0.4	-1.6	0.7
Asthma	0.9	1.7	3.3	-1.5	-0.6	-1.2	-1.2	1.3	-1.8
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	6.2	-2.5	0.4	-0.5	-1.2	2.1	-2.3
Medication: Cholesterol lowering	0.9	1.4	4.2	-2.0	-0.0	-0.8	-1.1	1.1	-1.1
Depression (self-reported)	0.3	0.3	0.8	-0.6	0.9	-0.2	-0.2	0.6	-0.5
Medication: Lansoprazole	0.7	0.7	2.0	-0.1	-1.4	-0.9	-1.0	-0.7	-0.4
Prospective memory result	0.4	0.5	2.2	-0.5	0.1	-0.1	1.5	-0.5	0.5
Lung cancer (father)	0.2	0.3	0.6	-0.6	-0.6	-0.2	0.3	-0.3	0.8
Illnesses of mother	0.3	0.4	1.3	0.8	0.1	-0.3	-0.3	0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.1	-1.1	0.3	-0.4	0.2	0.7	-0.2
Pulse wave Arterial Stiffness index	0.4	0.5	2.2	-0.5	-1.5	-0.4	-0.6	0.0	-0.4
Impedance of arm (left)	0.2	0.8	2.2	0.1	-1.5	-1.0	0.1	-1.2	0.5
Arm fat mass (right)	0.1	0.4	0.9	-0.7	0.7	-0.0	0.3	0.9	-0.8
Trunk predicted mass	0.5	2.7	6.2	-2.1	1.5	0.5	0.6	2.5	-1.7
Standing height	0.4	4.3	11.0	-3.3	1.2	-0.3	0.7	2.7	-2.4
Length of working week for main job	0.5	0.5	1.8	-0.7	1.3	0.0	0.6	0.6	0.6
Exposure to tobacco smoke at home	0.7	0.8	1.6	-1.3	0.2	-0.4	-0.3	1.2	-1.1
Breastfed as a baby	0.2	0.2	0.3	-0.5	0.6	0.4	-0.4	0.4	0.4
Tense / ‘highly strung’	0.3	0.4	1.8	-0.5	0.5	0.5	0.1	0.0	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	-1.3	-0.6	0.2	0.0	1.4	-0.7
Hair/balding pattern: Pattern 4	0.3	0.8	2.0	-0.5	1.4	0.1	1.0	1.1	-0.7
Birth weight of first child	0.4	0.7	2.4	-0.5	1.5	-0.7	0.3	0.6	-0.7
Peak expiratory flow (PEF)	0.7	1.7	3.7	-1.6	0.3	-1.2	-1.3	0.7	-1.9
Pulse wave reflection index	0.4	0.5	0.9	0.5	-0.6	0.4	1.0	-0.8	0.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.4	0.7	0.1	-0.4	-0.2	-0.6
Loud music exposure frequency	0.4	0.4	1.0	1.0	-0.4	0.1	-0.6	-0.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.2	-0.0	-0.3	-1.6	-1.4	1.8	0.2
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.2	-1.0	-1.5	-0.8	-1.1	0.6	-0.5
Blood clot in the leg (DVT)	0.6	0.8	2.1	0.7	-0.8	1.4	0.7	-0.6	0.7
Medication: Paracetamol	0.1	0.2	0.4	-0.5	0.6	-0.4	-0.4	0.4	-0.1
Headache pain in last month	0.4	0.7	2.3	0.9	0.1	-0.2	0.6	-0.9	1.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	4.4	2.1	0.8	0.4	1.6	-1.5	1.6
Glaucoma (self-reported)	1.3	1.5	3.1	1.8	-0.2	1.5	0.3	-1.7	0.6
Gout (self-reported)	0.3	0.3	0.6	-0.7	0.4	0.8	0.8	-0.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.7	-1.2	0.0	-0.1	-0.4	1.2	-1.3
Medication: Amlodipine	0.5	0.7	1.9	-1.4	0.1	-0.4	0.1	0.8	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.8	-1.2	-0.6	-0.5	-0.9	1.4	-0.9
Birth weight	1.0	2.1	4.0	1.1	0.9	1.6	2.0	-1.1	1.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.8	-0.9	0.3	-0.6	0.5	0.6	-0.4
High blood pressure (siblings)	0.2	0.2	0.5	-0.7	0.2	-0.6	0.1	0.5	0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	3.5	-1.9	0.8	-0.9	0.1	1.2	-0.9
Body fat percentage	0.0	0.0	0.1	-0.0	-0.1	-0.3	-0.1	-0.1	0.0
Leg fat percentage (right)	0.0	0.1	0.2	-0.3	0.4	-0.5	0.1	0.2	0.2
Arm fat-free mass (right)	0.5	2.7	6.8	-2.2	1.2	0.5	-0.2	2.6	-1.7
Exposure to tobacco smoke outside home	0.6	0.9	2.2	1.5	-0.4	-0.5	0.2	-1.4	0.8
Comparative body size at age 10	0.3	0.9	3.7	0.6	-0.4	1.0	-0.3	0.3	-1.9
Number of full brothers	1.2	1.5	3.1	0.5	-1.8	-1.6	-1.7	0.1	0.4
Worry too long after embarrassment	0.4	0.7	2.0	0.4	0.5	-1.4	-1.1	-0.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.3	0.2	-1.5	-1.5	-1.1	0.5	-0.3
Wheeze or whistling in the chest in last year	0.4	0.7	2.2	0.5	-0.4	-0.7	-1.5	-0.5	-1.0
Number of children fathered	0.8	0.9	2.3	-1.0	0.9	0.3	1.5	1.0	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	0.8	0.9	0.4	0.7	-0.9	1.3
Age at first live birth	0.1	0.2	0.8	-0.2	-0.6	0.1	-0.0	-0.2	-0.9
Pulse wave peak to peak time	0.4	0.5	2.3	0.3	1.5	0.3	0.6	0.1	0.2
Health satisfaction	0.7	0.9	1.9	1.3	-1.4	0.1	-0.2	-0.0	1.3
Shortness of breath walking on level ground	0.4	0.5	2.2	0.0	-1.5	0.5	-0.6	-0.4	-0.2
Qualifications: College or University degree	0.3	0.8	3.5	-0.7	0.6	-0.3	-0.4	0.6	-1.9
Eye problems/disorders: None of the above	0.6	0.7	3.9	0.4	2.0	-0.2	0.3	0.1	-0.0
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.4	-0.3	0.1	-0.0	0.6	0.5
Emphysema/chronic bronchitis	0.6	0.7	2.6	-0.9	0.2	-0.3	-0.6	0.2	-1.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.8	0.4	0.3	0.4	0.9	0.1	0.4
Neck or shoulder pain in last month	1.3	1.9	4.9	0.8	1.4	1.7	2.2	-0.4	1.0
Medication: Blood pressure	1.4	2.5	4.3	-1.9	-0.4	-1.3	-2.1	1.5	-1.6
Angina (self-reported)	0.3	0.4	1.5	0.9	-0.4	-0.4	-0.1	-1.2	-0.1
Migraine (self-reported)	2.3	2.8	4.6	1.9	0.6	0.9	2.1	-1.9	2.1
Medication: Ibuprofen	2.5	3.0	6.8	-2.4	-0.1	-0.4	-1.2	2.6	-2.0
Medication: Allopurinol	0.3	0.4	0.9	0.2	-0.9	-0.3	-0.8	-0.9	-0.3
Medication: Omeprazole	0.3	0.3	0.8	-0.3	-0.7	0.6	-0.9	-0.3	-0.5
Medication: Seretide 50 evohaler	1.4	1.6	3.6	-1.5	0.1	-0.5	-1.0	1.6	-1.9
Mean time to correctly identify matches	0.3	0.6	2.5	-0.7	-1.6	-0.2	-0.5	0.4	-0.2
Heart disease (mother)	0.5	0.6	2.5	-0.4	-0.9	-0.2	-0.4	-0.4	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.3	1.5	-0.6	0.2	-1.1	-1.0	0.4
Whole body fat mass	0.1	0.3	0.6	-0.6	0.8	0.1	0.4	0.7	-0.5
Leg fat mass (right)	0.1	0.3	1.0	-0.5	1.0	0.0	0.1	0.8	-0.1
Arm predicted mass (right)	0.4	2.2	6.2	-2.0	1.0	0.3	-0.3	2.5	-1.4
Pulse rate, automated reading	0.1	0.3	0.8	-0.0	0.9	-0.4	0.6	0.2	0.6
Alcohol intake frequency.	0.3	0.7	1.5	1.2	0.2	0.7	0.7	-1.2	-0.2
Comparative height size at age 10	0.3	1.5	3.5	-1.5	1.4	0.1	1.1	0.3	-1.9
Number of full sisters	1.3	1.6	2.4	1.4	-1.4	1.6	0.4	-1.4	0.9
Suffer from ‘nerves’	0.3	0.5	0.9	-0.8	0.4	0.6	1.0	0.5	0.8
Overall health rating	0.4	0.8	1.6	0.6	-0.9	-1.3	-1.2	-0.7	-0.4
Chest pain or discomfort	0.7	1.1	2.6	1.1	-1.4	-0.1	-0.4	-1.6	0.7
Had major operations	1.1	1.3	5.0	-0.0	0.3	-2.2	-0.5	-0.4	-1.6
Age at last live birth	1.0	1.4	3.7	1.2	-1.9	-0.8	-1.2	-1.1	-0.2
Family relationship satisfaction	2.2	2.7	8.9	1.3	-3.0	0.5	-1.6	-1.3	1.0
Leg pain on walking	0.7	0.9	2.2	-0.0	1.1	1.1	1.5	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.0	0.4	-1.0	-0.4	-0.5	-0.6	0.2
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.1	0.9	-1.5	0.3	-0.4	-0.7	1.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	2.8	0.1	1.1	0.5	1.3	-0.4	1.7
Medication: Aspirin	0.1	0.1	0.2	-0.4	0.0	0.4	0.0	-0.1	0.2
Supplements: Vitamin C	0.5	0.6	1.3	1.2	0.5	0.7	0.8	-1.1	0.2
Knee pain experienced in last month	2.0	3.2	5.6	-2.0	-0.7	-1.5	-1.8	2.4	-1.9
Hypertension (Self-reported)	0.5	1.3	4.8	-0.6	-2.2	-0.9	-1.4	-0.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	0.2	-1.1	0.8	0.3	-1.0	0.5
Illnesses of father: Heart disease	1.1	1.5	3.4	-1.5	0.2	-0.2	-0.3	1.7	-1.9
Illnesses of siblings: Diabetes	0.9	1.1	1.8	-1.2	-0.7	-0.7	-0.9	1.4	-1.1
Smoking status: Previous	0.7	1.0	3.5	-0.1	0.7	0.2	1.4	0.3	1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	3.7	-1.9	0.1	-1.4	-0.7	1.4	-1.6
Whole body fat-free mass	0.5	3.0	7.2	-2.3	1.4	0.5	0.3	2.7	-1.9
Leg fat-free mass (right)	0.6	3.0	6.9	-2.2	1.2	-0.1	-0.4	2.6	-2.1
Arm fat percentage (left)	0.1	0.2	0.4	-0.5	0.2	-0.6	-0.5	0.4	-0.5
Average weekly red wine intake	0.3	0.4	0.9	0.7	-0.2	-0.9	-0.9	-0.6	-0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	0.5	0.4	0.8	1.1	0.6	0.7
Mood swings	0.2	0.4	1.1	-0.5	0.1	-0.8	-1.1	0.3	-0.7
Loneliness, isolation	0.4	0.6	2.3	0.4	1.5	-0.0	-0.7	-0.5	-0.5
Long-standing illness, disability or infirmity	0.3	0.4	1.4	0.1	-0.5	-0.8	-1.2	-0.0	-0.3
Ever had bowel cancer screening	0.3	0.3	0.4	-0.4	0.6	0.6	0.6	0.6	0.3
Diabetes diagnosed by doctor	0.8	1.3	4.4	0.3	-2.1	-0.7	-1.6	0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.4	0.2	0.5	0.3	-0.1	-1.2	-0.2
Friendships satisfaction	0.2	0.3	0.7	-0.2	-0.8	0.6	-0.5	0.3	-0.3
Qualifications: nursing, teaching	0.8	1.3	2.4	0.4	1.4	1.2	1.6	1.3	0.4
Commuting to job workplace: Walk	0.7	0.8	3.3	-0.4	1.8	-0.3	0.8	0.3	-0.6
Eye problems/disorders: Cataract	0.9	1.0	2.5	-1.4	-0.1	1.6	0.2	1.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.0	0.2	-1.4	-0.5	-0.9	-1.0	-0.7
Medication for cholesterol	1.3	2.0	5.9	-1.1	2.4	0.4	0.7	1.6	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	5.3	-0.6	-0.1	0.1	-0.2	0.5	-2.3
Back pain experienced in last month	1.4	2.0	4.9	0.0	-1.9	-1.6	-2.2	0.9	-0.3
Mineral and other dietary supplements	1.2	1.7	5.0	0.7	-2.2	-1.6	-1.4	-0.5	-0.0
Breast cancer (self-reported)	0.6	0.7	3.1	0.2	-1.8	-0.0	-1.0	0.1	-0.1
Asthma (self-reported)	0.9	1.7	3.0	-1.6	-0.3	-1.3	-1.1	1.4	-1.7
Osteoporosis (self-reported)	0.8	1.0	4.8	0.5	2.2	-0.9	-0.1	-0.5	-0.2
Osteoarthritis (self-reported)	0.9	1.1	3.5	0.1	-1.1	-0.9	-1.1	-0.1	-1.9
Medication: Aspirin	0.1	0.1	0.3	-0.6	0.1	0.3	0.1	0.3	0.3
Medication: Gliclazide	0.5	0.6	1.9	0.5	-0.0	-0.8	0.6	0.7	1.4
Illnesses of father: None of the above (group 1)	0.7	0.8	1.7	1.3	-0.1	0.1	-0.1	-1.2	1.3
Smoking status: Current	1.8	2.8	7.1	-0.3	-2.7	-1.0	-2.1	-0.3	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.2	-0.0	1.2	0.3	1.5	0.1	0.9
Whole body water mass	0.5	3.1	7.3	-2.3	1.5	0.4	0.2	2.7	-1.9
Leg predicted mass (right)	0.6	2.9	6.7	-2.2	1.2	-0.0	-0.4	2.6	-2.1
Arm fat mass (left)	0.1	0.4	0.7	-0.9	0.7	-0.1	-0.0	0.8	-0.8
Number of self-reported non-cancer illnesses	0.4	0.6	2.4	-0.0	-1.5	-0.3	-1.1	-0.3	0.3
Average weekly champagne plus white wine intake	0.4	0.6	1.1	0.6	0.2	1.1	0.6	-0.7	1.1
Miserableness	0.2	0.4	1.3	-0.2	1.1	0.5	0.4	-0.1	0.9
Guilty feelings	0.3	0.5	1.5	-0.7	1.2	-0.3	-0.5	0.8	-0.4
Wears glasses or contact lenses	0.9	1.0	2.7	-0.2	1.6	0.3	1.1	0.2	1.4
Ever taken oral contraceptive pill	3.0	3.4	8.6	1.9	-2.9	-0.7	-1.7	-2.0	0.8
Hearing aid user	0.9	1.0	3.0	1.5	0.2	-0.9	0.1	-1.7	-0.1
Mother’s age at death	0.7	0.9	2.4	-1.5	-0.2	1.6	0.5	0.6	-0.6
Financial situation satisfaction	2.2	2.8	5.5	2.3	-2.4	-0.2	-1.0	-1.6	1.4
Tinnitus: Yes, now most or all of the time	1.0	1.1	3.4	0.4	1.1	0.6	1.8	-1.2	0.3
Commuting to job workplace: Public transport	0.4	0.5	1.8	-0.4	-0.1	1.3	0.0	0.9	-0.5
Eye problems/disorders: Glaucoma	1.4	1.7	5.2	1.4	-1.3	0.9	0.5	-2.3	0.8
Medication: Blood pressure	0.8	1.4	3.5	0.9	-1.9	0.6	0.1	-1.5	1.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.0	0.5	-1.3	1.4	-0.5	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.5	-1.5	0.4	2.1	1.6	1.0	-0.0
High cholesterol (Self-reported)	0.5	0.9	3.7	-1.9	-1.2	0.4	0.2	0.4	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.8	-0.7	0.1	-0.2	-0.1	0.2
Medication: Paracetamol	0.7	1.1	1.6	-1.3	0.9	-1.0	-0.9	1.2	-0.9
Medication: Lisinopril	1.3	1.7	4.4	-0.2	-2.1	-1.0	-1.6	-1.2	-1.0
Medication: Atorvastatin	1.9	2.4	5.3	2.3	-0.8	0.5	-0.1	-2.2	1.9
Illnesses of father: High blood pressure	0.7	0.9	4.5	-0.4	2.1	-0.2	0.7	0.5	-0.4
Alcohol drinker status: Never	1.2	1.4	3.8	-1.7	-0.3	-0.0	-1.1	0.5	-2.0
Ever smoked	0.1	0.2	0.9	0.3	-0.4	-0.2	0.3	-0.1	1.0
Basal metabolic rate	0.5	2.7	6.4	-2.1	1.3	0.3	0.1	2.5	-1.8
Leg fat percentage (left)	0.0	0.1	0.4	-0.1	0.3	-0.6	-0.2	0.0	0.1
Arm fat-free mass (left)	0.4	2.1	4.6	-1.9	1.1	0.5	0.1	2.1	-1.8
Number of operations (self-reported)	0.2	0.4	1.1	0.2	-0.8	0.0	-1.1	-0.5	-0.4
Average weekly beer plus cider intake	1.0	1.4	2.7	-1.0	-0.5	-1.4	-1.6	1.3	-1.0
Irritability	0.4	0.7	2.2	1.0	-0.2	1.5	0.3	-0.1	0.9
Risk taking	0.5	0.7	1.2	-0.8	-1.0	-1.1	-0.6	0.2	-1.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.4	0.2	0.2	1.1	1.6	0.1	1.3
Fractured/broken bones in last 5 years	0.6	0.8	4.1	-0.6	2.0	-0.1	0.0	-0.0	-0.6
Age started oral contraceptive pill	0.4	0.4	1.0	-0.2	0.8	0.5	0.3	-0.8	-1.0
Diastolic blood pressure, automated reading	0.2	0.6	2.2	-1.5	0.2	-0.0	0.7	1.0	-0.4
Ever depressed for a whole week	0.8	1.0	2.4	1.6	-0.3	0.7	0.6	-1.2	1.2
Unable to work because of sickness or disability	0.4	0.5	2.1	-0.3	-0.0	1.5	0.8	-0.3	-0.3
Commuting to job workplace: Cycle	0.3	0.4	1.1	-0.8	-0.0	0.5	1.0	0.2	0.5
Myopia	0.7	1.0	4.7	-0.9	0.3	-0.4	-0.1	2.2	-0.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.4	0.6	2.1	0.4	1.1	0.3	-0.4
Cholesterol lowering medication	0.3	0.4	1.3	-0.1	-1.1	0.4	-0.5	-0.6	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	-0.1	-0.5	0.6	-0.5	-0.4	-0.2
Pain experienced in last month	0.8	1.4	3.8	-1.9	0.6	0.3	-0.2	0.8	-1.9
Supplements: Calcium	0.3	0.3	1.2	0.1	-0.3	0.3	-0.3	-1.1	-0.5
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	0.6	0.7	0.0	0.3	-0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.3	1.1	-0.1	0.7	-0.4	-1.1	0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.6	-0.7	1.3	0.7	-0.5	0.6
Heart disease (siblings)	0.3	0.4	0.8	0.6	0.8	0.2	0.2	-0.4	0.9
Alcohol drinker status: Previous	0.6	0.7	2.8	-0.1	-1.7	1.0	-0.4	0.6	0.2
Pack years of smoking	1.8	2.6	6.3	-0.6	-1.2	-2.5	-2.3	0.3	-1.5
Impedance of whole body	0.3	1.5	3.0	0.9	-1.7	-1.2	-0.2	-1.7	0.8
Leg fat mass (left)	0.1	0.2	0.6	-0.4	0.8	-0.1	-0.0	0.7	-0.2
Arm predicted mass (left)	0.5	2.5	5.7	-2.0	1.3	0.5	0.1	2.4	-1.8