Best TWAS P=1.34e-13 · Best GWAS P=3.37e-12 conditioned to 0.00293
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | C9orf72 | 0.19 | 0.02 | enet | 18 | 0.04 | 4.6e-03 | 5.1 | -6.0 | 1.6e-09 | 0.57 | 0.05 | 0.75 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | C9orf72 | 0.38 | 0.13 | enet | 18 | 0.12 | 6.4e-04 | -6.0 | -6.2 | 7.3e-10 | 0.61 | 0.22 | 0.53 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | C9orf72 | 0.35 | 0.07 | lasso | 8 | 0.16 | 6.5e-05 | -6.0 | -7.0 | 3.2e-12 | 0.68 | 0.04 | 0.83 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | C9orf72 | 0.27 | 0.08 | enet | 25 | 0.15 | 8.3e-05 | 4.2 | -6.6 | 3.2e-11 | 0.72 | 0.02 | 0.96 | FALSE |
| 5 | GTEx | Brain Putamen basal ganglia | C9orf72 | 0.62 | 0.01 | lasso | 14 | 0.06 | 1.5e-02 | 5.1 | -5.6 | 2.1e-08 | 0.57 | 0.04 | 0.73 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | C9orf72 | 0.39 | 0.07 | lasso | 10 | 0.14 | 3.5e-04 | -6.9 | -6.6 | 4.9e-11 | 0.95 | 0.01 | 0.96 | FALSE |
| 7 | GTEx | Colon Transverse | C9orf72 | 0.17 | 0.06 | enet | 9 | 0.08 | 1.6e-04 | -6.3 | -7.0 | 3.2e-12 | 0.86 | 0.03 | 0.96 | FALSE |
| 8 | GTEx | Esophagus Mucosa | C9orf72 | 0.21 | 0.06 | lasso | 7 | 0.11 | 5.4e-08 | -3.9 | -5.8 | 6.4e-09 | 0.78 | 0.06 | 0.94 | FALSE |
| 9 | GTEx | Nerve Tibial | C9orf72 | 0.30 | 0.24 | lasso | 6 | 0.24 | 6.6e-17 | -5.9 | -6.4 | 1.7e-10 | 0.92 | 0.36 | 0.64 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | C9orf72 | 0.15 | 0.02 | enet | 25 | 0.04 | 2.0e-04 | -6.4 | -6.1 | 1.2e-09 | 0.66 | 0.16 | 0.82 | FALSE |
| 11 | GTEx | Stomach | C9orf72 | 0.25 | 0.05 | enet | 32 | 0.07 | 3.8e-04 | -6.0 | -5.9 | 4.7e-09 | 0.74 | 0.19 | 0.78 | FALSE |
| 12 | GTEx | Testis | C9orf72 | 0.24 | 0.07 | lasso | 5 | 0.13 | 2.1e-06 | -6.3 | -6.5 | 1.0e-10 | 0.87 | 0.06 | 0.94 | FALSE |
| 13 | GTEx | Thyroid | C9orf72 | 0.22 | 0.08 | lasso | 6 | 0.11 | 5.2e-09 | 5.1 | -6.7 | 1.6e-11 | 0.70 | 0.10 | 0.90 | FALSE |
| 14 | METSIM | Adipose | C9orf72 | 0.15 | 0.11 | enet | 40 | 0.12 | 4.4e-17 | 5.1 | -7.4 | 1.3e-13 | 0.63 | 0.99 | 0.01 | TRUE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | C9orf72 | 0.28 | 0.25 | bslmm | 709 | 0.30 | 5.3e-39 | 5.1 | -6.3 | 2.7e-10 | 0.58 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C9orf72 | 0.10 | 0.10 | lasso | 3 | 0.09 | 4.9e-06 | -6.0 | -6.5 | 7.0e-11 | 0.79 | 0.12 | 0.88 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MOBKL2B | 0.05 | 0.05 | lasso | 3 | 0.04 | 1.8e-05 | -7.0 | 6.9 | 4.7e-12 | -0.97 | 0.01 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf72 | 0.05 | 0.02 | blup | 96 | 0.04 | 1.3e-04 | -6.0 | -6.0 | 1.6e-09 | 0.66 | 0.12 | 0.73 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf72 | 0.09 | 0.07 | blup | 92 | 0.10 | 2.4e-10 | -6.3 | -7.3 | 2.4e-13 | 0.74 | 0.08 | 0.92 | FALSE |