Best TWAS P=6.41e-33 · Best GWAS P=1.01e-34 conditioned to 1.97e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | C9orf156 | 0.19 | 0.15 | lasso | 4 | 0.11 | 1.6e-06 | 9.10 | 8.8 | 1.4e-18 | -0.42 | 0.85 | 0.08 | FALSE |
| 2 | GTEx | Brain Caudate basal ganglia | C9orf156 | 0.40 | 0.40 | lasso | 4 | 0.39 | 3.1e-12 | 8.80 | 8.5 | 2.8e-17 | -0.45 | 0.90 | 0.09 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | C9orf156 | 0.26 | 0.22 | lasso | 2 | 0.14 | 1.9e-04 | 9.10 | 9.1 | 9.4e-20 | -0.43 | 0.22 | 0.18 | FALSE |
| 4 | GTEx | Brain Cerebellum | C9orf156 | 0.30 | 0.27 | lasso | 7 | 0.24 | 8.1e-08 | 8.80 | 9.2 | 5.8e-20 | -0.47 | 0.79 | 0.12 | FALSE |
| 5 | GTEx | Brain Cortex | C9orf156 | 0.51 | 0.32 | enet | 11 | 0.29 | 8.1e-09 | 9.10 | 8.1 | 5.4e-16 | -0.48 | 0.74 | 0.21 | FALSE |
| 6 | GTEx | Brain Frontal Cortex BA9 | C9orf156 | 0.15 | 0.28 | lasso | 1 | 0.26 | 1.1e-07 | 9.10 | 9.1 | 9.3e-20 | -0.43 | 0.34 | 0.36 | FALSE |
| 7 | GTEx | Brain Nucleus accumbens basal ganglia | C9orf156 | 0.26 | 0.32 | lasso | 3 | 0.30 | 7.9e-09 | 8.80 | 8.6 | 6.4e-18 | -0.45 | 0.63 | 0.21 | FALSE |
| 8 | GTEx | Brain Putamen basal ganglia | C9orf156 | 0.27 | 0.24 | lasso | 1 | 0.24 | 2.6e-06 | 8.80 | 8.8 | 1.3e-18 | -0.47 | 0.19 | 0.22 | FALSE |
| 9 | GTEx | Breast Mammary Tissue | C9orf156 | 0.30 | 0.20 | enet | 16 | 0.21 | 3.3e-11 | 8.80 | 7.3 | 3.7e-13 | -0.42 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Male) | C9orf156 | 0.13 | -0.01 | enet | 1 | -0.01 | 5.6e-01 | 9.10 | 9.1 | 9.3e-20 | -0.43 | 0.05 | 0.06 | FALSE |
| 11 | GTEx | Breast Mammary Tissue (Female) | C9orf156 | 0.42 | 0.22 | lasso | 10 | 0.23 | 1.5e-07 | 9.10 | 9.1 | 6.9e-20 | -0.40 | 0.42 | 0.16 | FALSE |
| 12 | GTEx | Cells EBV-transformed lymphocytes | C9orf156 | 0.29 | 0.23 | lasso | 3 | 0.19 | 1.1e-06 | 8.80 | 8.7 | 2.9e-18 | -0.48 | 0.52 | 0.32 | FALSE |
| 13 | GTEx | Colon Sigmoid | C9orf156 | 0.19 | 0.17 | lasso | 5 | 0.15 | 7.4e-06 | 8.80 | 7.2 | 5.8e-13 | -0.35 | 0.52 | 0.03 | FALSE |
| 14 | GTEx | Colon Transverse | C9orf156 | 0.21 | 0.22 | lasso | 4 | 0.20 | 4.5e-10 | 8.80 | 8.5 | 1.8e-17 | -0.45 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Esophagus Mucosa | C9orf156 | 0.19 | 0.13 | lasso | 4 | 0.14 | 2.6e-09 | 9.10 | 5.7 | 9.2e-09 | -0.27 | 0.99 | 0.00 | FALSE |
| 16 | GTEx | Heart Left Ventricle | C9orf156 | 0.23 | 0.18 | enet | 13 | 0.16 | 9.3e-09 | 9.10 | 8.8 | 1.1e-18 | -0.44 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Muscle Skeletal | C9orf156 | 0.35 | 0.23 | lasso | 9 | 0.25 | 7.5e-25 | 8.80 | 5.7 | 1.5e-08 | -0.25 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Nerve Tibial | C9orf156 | 0.20 | 0.17 | lasso | 4 | 0.15 | 7.9e-11 | 9.10 | 6.5 | 9.7e-11 | -0.25 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Ovary | C9orf156 | 0.39 | 0.23 | enet | 15 | 0.18 | 3.9e-05 | 9.10 | 8.2 | 3.1e-16 | -0.37 | 0.26 | 0.09 | FALSE |
| 20 | GTEx | Skin Not Sun Exposed Suprapubic | C9orf156 | 0.16 | 0.11 | lasso | 2 | 0.10 | 5.1e-06 | 9.10 | 7.2 | 7.4e-13 | -0.30 | 0.65 | 0.13 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | C9orf156 | 0.22 | 0.12 | enet | 16 | 0.18 | 1.3e-14 | 9.10 | 6.4 | 1.7e-10 | -0.32 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Stomach | C9orf156 | 0.18 | 0.19 | lasso | 1 | 0.18 | 5.9e-09 | 9.10 | 9.1 | 9.3e-20 | -0.43 | 0.96 | 0.03 | FALSE |
| 23 | GTEx | Testis | C9orf156 | 0.39 | 0.40 | enet | 14 | 0.41 | 1.1e-19 | 9.10 | 8.8 | 1.1e-18 | -0.42 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Thyroid | C9orf156 | 0.21 | 0.26 | lasso | 1 | 0.26 | 7.9e-20 | 9.10 | 9.1 | 9.3e-20 | -0.43 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Thyroid | XPA | 0.24 | 0.01 | enet | 29 | 0.08 | 1.2e-06 | -11.94 | -5.5 | 3.0e-08 | 0.32 | 0.07 | 0.91 | FALSE |
| 26 | METSIM | Adipose | C9orf156 | 0.15 | 0.17 | lasso | 5 | 0.17 | 4.3e-25 | 9.10 | 8.9 | 4.3e-19 | -0.43 | 1.00 | 0.00 | FALSE |
| 27 | NTR | Blood | C9orf156 | 0.01 | 0.01 | lasso | 5 | 0.01 | 1.5e-03 | -11.49 | -12.0 | 6.4e-33 | 0.60 | 0.27 | 0.51 | TRUE |
| 28 | YFS | Blood | ANP32B | 0.03 | 0.02 | lasso | 9 | 0.02 | 1.9e-08 | 5.14 | -9.8 | 1.2e-22 | 0.46 | 0.76 | 0.24 | FALSE |
| 29 | YFS | Blood | CORO2A | 0.03 | 0.01 | bslmm | 606 | 0.01 | 1.4e-04 | 0.66 | -6.3 | 2.6e-10 | 0.32 | 0.10 | 0.24 | FALSE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C9orf156 | 0.06 | 0.06 | lasso | 5 | 0.07 | 4.3e-14 | 9.10 | 5.2 | 2.4e-07 | -0.24 | 1.00 | 0.00 | FALSE |
| 31 | The Cancer Genome Atlas | Glioblastoma Multiforme | C9orf156 | 0.24 | 0.19 | blup | 46 | 0.20 | 1.4e-06 | 8.80 | 5.5 | 5.1e-08 | -0.24 | 0.36 | 0.16 | FALSE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C9orf156 | 0.03 | 0.03 | enet | 2 | 0.03 | 1.1e-04 | 8.80 | 8.8 | 1.3e-18 | -0.48 | 0.08 | 0.31 | FALSE |
| 33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C9orf156 | 0.18 | 0.23 | lasso | 4 | 0.23 | 1.9e-25 | 9.10 | 9.6 | 1.1e-21 | -0.47 | 1.00 | 0.00 | FALSE |
| 34 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf156 | 0.07 | 0.03 | lasso | 2 | 0.03 | 2.1e-04 | 9.10 | 9.1 | 7.0e-20 | -0.46 | 0.36 | 0.10 | FALSE |
| 35 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C9orf156 | 0.09 | 0.07 | blup | 46 | 0.08 | 8.4e-06 | 9.10 | 5.2 | 2.2e-07 | -0.18 | 0.46 | 0.17 | FALSE |
| 36 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C9orf156 | 0.12 | 0.03 | blup | 46 | 0.09 | 9.0e-05 | 9.10 | 7.6 | 2.4e-14 | -0.29 | 0.30 | 0.33 | FALSE |
| 37 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C9orf156 | 0.31 | 0.12 | enet | 7 | 0.11 | 3.4e-05 | 8.97 | 8.3 | 1.1e-16 | -0.49 | 0.20 | 0.17 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf156 | 0.29 | 0.15 | lasso | 5 | 0.13 | 1.0e-12 | 9.10 | 8.8 | 8.8e-19 | -0.42 | 1.00 | 0.00 | FALSE |