Best TWAS P=7.98e-11 · Best GWAS P=1.92e-10 conditioned to 0.267
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RALGPS1 | 0.08 | 0.07 | enet | 27 | 0.09 | 3.8e-11 | 5.1 | 6.5 | 8.0e-11 | 0.91 | 0.04 | 0.96 | TRUE |
2 | GTEx | Brain Cerebellum | RALGPS1 | 0.28 | 0.17 | lasso | 7 | 0.19 | 2.8e-06 | 6.0 | 6.3 | 3.4e-10 | 0.99 | 0.04 | 0.96 | FALSE |
3 | GTEx | Esophagus Mucosa | RALGPS1 | 0.05 | 0.01 | lasso | 6 | 0.02 | 2.7e-02 | -5.5 | -6.3 | 3.7e-10 | -0.69 | 0.18 | 0.56 | FALSE |
4 | GTEx | Skin Sun Exposed Lower leg | RALGPS1 | 0.06 | 0.02 | lasso | 6 | 0.01 | 2.5e-02 | -5.5 | -6.5 | 8.0e-11 | -0.81 | 0.09 | 0.88 | FALSE |
5 | GTEx | Testis | RALGPS1 | 0.23 | 0.32 | lasso | 9 | 0.29 | 2.7e-13 | -6.1 | -6.3 | 2.7e-10 | -0.93 | 0.04 | 0.96 | FALSE |
6 | GTEx | Whole Blood | RALGPS1 | 0.10 | 0.10 | enet | 10 | 0.08 | 1.2e-07 | 6.1 | -5.9 | 3.2e-09 | -0.99 | 0.04 | 0.96 | FALSE |
7 | METSIM | Adipose | RALGPS1 | 0.04 | 0.04 | lasso | 3 | 0.04 | 2.8e-06 | -5.5 | -5.9 | 3.0e-09 | -0.63 | 0.55 | 0.45 | FALSE |
8 | YFS | Blood | RALGPS1 | 0.08 | 0.13 | lasso | 18 | 0.15 | 1.1e-45 | -5.6 | -6.5 | 9.1e-11 | -0.82 | 0.54 | 0.46 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ANGPTL2 | 0.02 | 0.01 | lasso | 2 | 0.01 | 6.2e-02 | 6.2 | -5.8 | 6.0e-09 | -0.98 | 0.02 | 0.75 | FALSE |
10 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ANGPTL2 | 0.10 | 0.08 | blup | 38 | 0.09 | 2.8e-04 | 6.4 | 6.0 | 1.9e-09 | 0.93 | 0.02 | 0.93 | FALSE |