Best TWAS P=2e-132 · Best GWAS P=9.14e-170 conditioned to 1.56e-95
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DENND1A | 0.10 | 0.00 | enet | 22 | 0.00 | 3.3e-01 | -7.04 | -5.2 | 2.1e-07 | -0.09 | 0.13 | 0.03 | TRUE |
| 2 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | -1.82 | -6.3 | 2.7e-10 | 0.12 | 0.20 | 0.06 | TRUE |
| 3 | NTR | Blood | NEK6 | 0.13 | 0.08 | bslmm | 401 | 0.09 | 5.0e-28 | 1.89 | -6.1 | 1.3e-09 | -0.13 | 1.00 | 0.00 | TRUE |
| 4 | NTR | Blood | PSMB7 | 0.03 | 0.01 | blup | 387 | 0.01 | 3.5e-05 | 9.27 | -6.3 | 3.1e-10 | -0.11 | 0.38 | 0.01 | TRUE |
| 5 | YFS | Blood | NEK6 | 0.12 | 0.06 | enet | 17 | 0.08 | 9.9e-26 | 1.89 | -5.2 | 1.9e-07 | -0.10 | 1.00 | 0.00 | FALSE |
| 6 | YFS | Blood | PSMB7 | 0.04 | 0.04 | bslmm | 390 | 0.04 | 3.9e-13 | -7.15 | 7.8 | 7.1e-15 | -0.08 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK6 | 0.04 | 0.02 | blup | 87 | 0.02 | 2.5e-05 | 0.12 | -5.3 | 9.3e-08 | 0.05 | 0.91 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LHX2 | 0.04 | 0.04 | lasso | 2 | 0.03 | 6.8e-04 | -17.60 | -17.5 | 8.0e-69 | 0.65 | 0.12 | 0.72 | TRUE |
| 9 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DENND1A | 0.07 | 0.06 | lasso | 5 | 0.05 | 5.7e-04 | -3.70 | -5.3 | 1.2e-07 | 0.08 | 0.31 | 0.08 | TRUE |
| 10 | The Cancer Genome Atlas | Stomach Adenocarcinoma | LHX2 | 0.05 | 0.03 | enet | 12 | 0.04 | 1.3e-03 | -8.76 | -8.0 | 1.4e-15 | -0.08 | 0.10 | 0.04 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | LHX2 | 0.07 | 0.01 | blup | 70 | 0.02 | 1.6e-03 | 18.08 | -24.5 | 2.0e-132 | 0.35 | 0.10 | 0.08 | TRUE |