Best TWAS P=1.41e-57 · Best GWAS P=2.98e-61 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PPFIBP2 | 0.10 | 0.07 | lasso | 5 | 0.06 | 1.9e-07 | -16.5 | -16.0 | 1.4e-57 | 0.95 | 0.00 | 1.00 | TRUE |
2 | GTEx | Artery Aorta | CTD-2516F10.2 | 0.31 | 0.30 | lasso | 3 | 0.30 | 4.6e-17 | -13.9 | -14.6 | 3.1e-48 | 0.79 | 0.94 | 0.06 | TRUE |
3 | GTEx | Artery Tibial | CTD-2516F10.2 | 0.40 | 0.32 | enet | 28 | 0.34 | 2.4e-27 | -13.9 | -13.1 | 3.5e-39 | 0.71 | 1.00 | 0.00 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | CTD-2516F10.2 | 0.52 | 0.33 | lasso | 10 | 0.36 | 8.6e-28 | -13.9 | -13.7 | 5.6e-43 | 0.74 | 1.00 | 0.00 | FALSE |
5 | GTEx | Nerve Tibial | PPFIBP2 | 0.17 | 0.00 | enet | 27 | 0.02 | 1.0e-02 | 3.3 | -7.3 | 3.3e-13 | 0.41 | 0.02 | 0.72 | FALSE |
6 | GTEx | Nerve Tibial | CTD-2516F10.2 | 0.26 | 0.13 | enet | 21 | 0.14 | 6.8e-10 | -13.1 | -11.0 | 4.3e-28 | 0.66 | 0.69 | 0.31 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | CTD-2516F10.2 | 0.12 | 0.07 | lasso | 3 | 0.11 | 3.4e-09 | -13.9 | -11.5 | 7.6e-31 | 0.70 | 0.40 | 0.58 | FALSE |
8 | GTEx | Thyroid | CTD-2516F10.2 | 0.22 | 0.10 | lasso | 4 | 0.16 | 2.9e-12 | -13.9 | -12.1 | 1.0e-33 | 0.70 | 0.98 | 0.02 | FALSE |
9 | GTEx | Whole Blood | CTD-2516F10.2 | 0.29 | 0.09 | enet | 49 | 0.09 | 2.7e-08 | -13.9 | -10.2 | 1.5e-24 | 0.50 | 0.24 | 0.76 | FALSE |
10 | NTR | Blood | PPFIBP2 | 0.06 | 0.01 | lasso | 10 | 0.03 | 1.6e-10 | -2.7 | 9.0 | 2.2e-19 | -0.41 | 0.99 | 0.00 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | PPFIBP2 | 0.10 | 0.01 | bslmm | 723 | 0.05 | 3.2e-07 | -16.5 | -9.5 | 2.6e-21 | 0.41 | 0.00 | 0.99 | FALSE |
12 | YFS | Blood | PPFIBP2 | 0.67 | 0.27 | enet | 135 | 0.51 | 2.6e-197 | -11.6 | 5.4 | 6.5e-08 | -0.33 | 1.00 | 0.00 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | OLFML1 | 0.20 | 0.03 | blup | 95 | 0.07 | 1.0e-04 | 2.9 | 11.1 | 1.0e-28 | -0.54 | 0.00 | 0.83 | FALSE |