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chr6:145,125,929-146,983,441

Best TWAS P=2.41e-10 · Best GWAS P=9.52e-12 conditioned to 0.00979

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC100507557	0.09	0.18	enet	22	0.21	1.3e-24	6.0	6.2	5.8e-10	-0.76	0.39	0.61	FALSE
2	GTEx	Adrenal Gland	RP11-545I5.3	0.08	0.09	enet	10	0.03	2.5e-02	5.9	6.0	2.4e-09	-0.77	0.14	0.48	FALSE
3	GTEx	Cells Transformed fibroblasts	FBXO30	0.04	0.04	lasso	1	0.04	4.6e-04	5.9	-5.9	4.4e-09	0.80	0.21	0.34	FALSE
4	GTEx	Cells Transformed fibroblasts	RP11-545I5.3	0.04	0.03	lasso	2	0.03	2.0e-03	-4.3	5.3	1.3e-07	-0.64	0.14	0.68	FALSE
5	GTEx	Esophagus Mucosa	RP11-545I5.3	0.07	0.03	lasso	4	0.04	1.4e-03	-4.3	5.3	1.5e-07	-0.66	0.09	0.73	FALSE
6	GTEx	Esophagus Muscularis	EPM2A	0.11	0.09	enet	21	0.10	7.0e-07	6.0	5.4	6.1e-08	-0.77	0.17	0.83	FALSE
7	GTEx	Esophagus Muscularis	RP11-545I5.3	0.10	0.13	lasso	6	0.12	5.9e-08	5.9	5.5	3.8e-08	-0.72	0.41	0.59	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	EPM2A	0.19	0.15	lasso	5	0.15	2.0e-08	6.4	-6.2	5.5e-10	0.88	0.05	0.95	FALSE
9	GTEx	Skin Sun Exposed Lower leg	EPM2A	0.03	0.03	enet	10	0.01	2.4e-02	6.5	-6.3	2.4e-10	0.89	0.13	0.74	TRUE
10	GTEx	Testis	EPM2A	0.14	0.14	lasso	3	0.13	1.8e-06	5.9	6.1	1.2e-09	-0.82	0.28	0.68	FALSE
11	NTR	Blood	EPM2A	0.02	0.02	lasso	3	0.02	2.7e-06	6.5	-5.7	1.2e-08	0.82	0.03	0.97	FALSE
12	YFS	Blood	SHPRH	0.01	0.01	blup	307	0.01	1.0e-04	5.8	6.0	2.6e-09	-0.84	0.17	0.82	FALSE
13	The Cancer Genome Atlas	Breast Invasive Carcinoma	FBXO30	0.02	0.02	blup	27	0.01	4.6e-04	6.0	5.3	9.1e-08	-0.64	0.03	0.79	FALSE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EPM2A	0.03	0.01	enet	10	0.01	1.2e-02	6.3	-5.2	1.9e-07	0.81	0.01	0.82	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EPM2A	0.04	0.04	enet	9	0.02	1.5e-03	6.2	-5.8	5.2e-09	0.84	0.01	0.98	FALSE
16	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EPM2A	0.28	0.04	enet	7	0.03	1.3e-02	5.8	-5.5	4.9e-08	0.72	0.01	0.49	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	EPM2A	0.21	0.07	blup	44	0.07	4.6e-07	6.2	-6.2	4.2e-10	0.83	0.01	0.99	FALSE