Best TWAS P=9.23e-63 · Best GWAS P=3.03e-81 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TYRP1 | 0.13 | 0.03 | enet | 19 | 0.07 | 2.0e-09 | 8.96 | -14.1 | 3.7e-45 | -0.58 | 0.99 | 0.01 | TRUE |
| 2 | GTEx | Artery Aorta | LURAP1L | 0.25 | 0.00 | enet | 25 | 0.02 | 2.5e-02 | -1.68 | -7.7 | 1.7e-14 | -0.48 | 0.06 | 0.55 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | LURAP1L | 0.23 | 0.07 | lasso | 5 | 0.01 | 1.7e-01 | 15.78 | -16.4 | 2.9e-60 | -0.80 | 0.02 | 0.86 | FALSE |
| 4 | GTEx | Pituitary | MPDZ | 0.44 | -0.01 | enet | 14 | -0.01 | 5.7e-01 | 0.74 | -7.1 | 1.4e-12 | -0.32 | 0.06 | 0.13 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | TYRP1 | 0.10 | 0.03 | lasso | 6 | 0.04 | 4.1e-06 | 14.95 | 7.1 | 9.9e-13 | 0.54 | 0.96 | 0.01 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | LURAP1L | 0.31 | 0.32 | lasso | 9 | 0.32 | 1.9e-42 | 16.73 | -16.7 | 9.2e-63 | -0.84 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C9orf150 | 0.06 | 0.04 | lasso | 2 | 0.06 | 6.2e-07 | 9.72 | -15.4 | 9.0e-54 | -0.74 | 0.01 | 0.99 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | TYRP1 | 0.03 | 0.03 | lasso | 3 | 0.03 | 6.7e-05 | 13.22 | 14.7 | 5.6e-49 | 0.81 | 0.24 | 0.62 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TYRP1 | 0.02 | 0.01 | blup | 62 | 0.01 | 1.7e-02 | 13.37 | 11.4 | 4.3e-30 | 0.71 | 0.04 | 0.15 | FALSE |