Best TWAS P=2.17e-09 · Best GWAS P=7.46e-08 conditioned to 0.31
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PLEC | 0.05 | 0.07 | enet | 9 | 0.07 | 8.5e-09 | -5.2 | 5.7 | 1.5e-08 | -0.95 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | PLEC | 0.14 | 0.14 | enet | 13 | 0.16 | 6.2e-13 | -5.1 | 5.2 | 1.6e-07 | -0.93 | 0.02 | 0.98 | FALSE |
3 | GTEx | Artery Aorta | PLEC | 0.18 | 0.16 | lasso | 3 | 0.16 | 2.6e-09 | -5.3 | 5.3 | 1.4e-07 | -0.92 | 0.01 | 0.99 | FALSE |
4 | GTEx | Artery Tibial | PLEC | 0.19 | 0.17 | lasso | 2 | 0.20 | 2.2e-15 | -5.3 | 5.2 | 1.7e-07 | -0.92 | 0.01 | 0.99 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | PLEC | 0.20 | 0.21 | enet | 12 | 0.22 | 2.2e-06 | -4.9 | 5.4 | 5.7e-08 | -0.93 | 0.02 | 0.97 | FALSE |
6 | GTEx | Brain Cerebellum | PLEC | 0.33 | 0.15 | enet | 16 | 0.15 | 2.6e-05 | -5.4 | 5.2 | 1.9e-07 | -0.96 | 0.01 | 0.99 | FALSE |
7 | GTEx | Breast Mammary Tissue | PLEC | 0.17 | 0.20 | lasso | 4 | 0.22 | 1.3e-11 | -5.2 | 5.2 | 2.6e-07 | -0.94 | 0.02 | 0.98 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | PLEC | 0.24 | 0.19 | lasso | 4 | 0.18 | 5.3e-05 | -5.1 | 5.2 | 1.8e-07 | -0.94 | 0.02 | 0.95 | FALSE |
9 | GTEx | Breast Mammary Tissue (Female) | PLEC | 0.19 | 0.17 | lasso | 2 | 0.17 | 7.9e-06 | -4.9 | 5.2 | 2.5e-07 | -0.94 | 0.02 | 0.94 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | PLEC | 0.30 | 0.30 | lasso | 4 | 0.40 | 4.0e-32 | -5.2 | 5.2 | 2.0e-07 | -0.93 | 0.02 | 0.98 | FALSE |
11 | GTEx | Esophagus Mucosa | PARP10 | 0.08 | 0.03 | enet | 17 | 0.04 | 1.0e-03 | -4.6 | 6.0 | 2.2e-09 | -0.80 | 0.08 | 0.80 | TRUE |
12 | GTEx | Lung | PLEC | 0.26 | 0.29 | lasso | 6 | 0.30 | 2.6e-23 | -5.3 | 5.2 | 2.1e-07 | -0.92 | 0.01 | 0.99 | FALSE |
13 | GTEx | Pituitary | PLEC | 0.31 | 0.39 | lasso | 4 | 0.44 | 2.7e-12 | -4.9 | 5.2 | 2.2e-07 | -0.96 | 0.02 | 0.98 | FALSE |
14 | GTEx | Skin Sun Exposed Lower leg | PLEC | 0.05 | 0.03 | lasso | 4 | 0.03 | 2.4e-03 | -5.3 | 5.2 | 2.2e-07 | -0.95 | 0.03 | 0.87 | FALSE |
15 | GTEx | Testis | PLEC | 0.25 | 0.23 | lasso | 7 | 0.27 | 1.9e-12 | -5.2 | 5.2 | 2.1e-07 | -0.95 | 0.02 | 0.98 | FALSE |
16 | GTEx | Thyroid | PLEC | 0.20 | 0.26 | lasso | 7 | 0.29 | 9.2e-23 | -4.8 | 5.2 | 2.6e-07 | -0.92 | 0.02 | 0.98 | FALSE |
17 | GTEx | Whole Blood | PLEC | 0.15 | 0.15 | enet | 9 | 0.19 | 2.1e-17 | -5.4 | 5.3 | 1.2e-07 | -0.98 | 0.01 | 0.99 | FALSE |