Best TWAS P=1.13e-54 · Best GWAS P=1.73e-232 conditioned to 4.9e-125
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CNTLN | 0.11 | 0.08 | lasso | 1 | 0.05 | 7.6e-05 | 6.6 | 6.6 | 4.6e-11 | 0.08 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | CNTLN | 0.18 | 0.07 | lasso | 8 | 0.04 | 2.4e-03 | 3.9 | 6.5 | 1.0e-10 | 0.08 | 0.92 | 0.00 | TRUE |
| 3 | GTEx | Colon Transverse | CNTLN | 0.16 | 0.02 | enet | 21 | 0.06 | 1.3e-03 | 3.9 | 9.5 | 1.4e-21 | 0.19 | 0.32 | 0.05 | TRUE |
| 4 | GTEx | Muscle Skeletal | BNC2 | 0.13 | 0.03 | lasso | 6 | 0.02 | 2.1e-03 | 16.8 | 15.6 | 1.1e-54 | 0.38 | 0.32 | 0.09 | TRUE |
| 5 | METSIM | Adipose | CNTLN | 0.07 | 0.06 | bslmm | 789 | 0.06 | 1.1e-09 | 6.6 | 9.3 | 1.1e-20 | 0.20 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CNTLN | 0.06 | 0.07 | lasso | 1 | 0.05 | 5.1e-05 | 6.1 | 6.0 | 1.4e-09 | 0.08 | 0.43 | 0.52 | TRUE |
| 7 | The Cancer Genome Atlas | Glioblastoma Multiforme | BNC2 | 0.27 | -0.01 | enet | 14 | 0.09 | 1.2e-03 | 8.5 | 9.5 | 2.4e-21 | 0.28 | 0.04 | 0.18 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CNTLN | 0.07 | 0.09 | lasso | 4 | 0.09 | 4.6e-10 | 6.4 | 6.4 | 1.2e-10 | 0.08 | 0.30 | 0.70 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CNTLN | 0.11 | 0.08 | enet | 16 | 0.10 | 7.9e-12 | 3.8 | 5.4 | 6.3e-08 | 0.06 | 0.61 | 0.39 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CNTLN | 0.15 | 0.04 | enet | 10 | 0.11 | 1.0e-07 | 5.0 | 6.3 | 3.9e-10 | 0.09 | 0.51 | 0.46 | FALSE |