Best TWAS P=3.49e-10 · Best GWAS P=9.86e-10 conditioned to 0.0911
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C9orf72 | 0.25 | 0.14 | bslmm | 725 | 0.14 | 7.0e-17 | -5.4 | 5.9 | 3.3e-09 | 0.64 | 0.14 | 0.86 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | C9orf72 | 0.19 | 0.02 | enet | 18 | 0.04 | 4.6e-03 | -5.4 | 5.7 | 1.4e-08 | 0.63 | 0.06 | 0.70 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | C9orf72 | 0.38 | 0.13 | enet | 18 | 0.12 | 6.4e-04 | 5.9 | 5.8 | 5.5e-09 | 0.82 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | C9orf72 | 0.35 | 0.07 | lasso | 8 | 0.16 | 6.5e-05 | 6.0 | 5.4 | 5.4e-08 | 0.67 | 0.02 | 0.90 | FALSE |
| 5 | GTEx | Colon Transverse | C9orf72 | 0.17 | 0.06 | enet | 9 | 0.08 | 1.6e-04 | 6.1 | 5.4 | 6.5e-08 | 0.85 | 0.01 | 0.98 | FALSE |
| 6 | GTEx | Thyroid | C9orf72 | 0.22 | 0.08 | lasso | 6 | 0.11 | 5.2e-09 | -5.4 | 5.5 | 4.5e-08 | 0.72 | 0.21 | 0.79 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | C9orf72 | 0.28 | 0.25 | bslmm | 709 | 0.30 | 5.3e-39 | -5.4 | 6.3 | 3.5e-10 | 0.82 | 0.15 | 0.85 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C9orf72 | 0.10 | 0.10 | lasso | 3 | 0.09 | 4.9e-06 | 5.9 | 5.5 | 2.8e-08 | 0.85 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | C9orf72 | 0.09 | 0.07 | blup | 92 | 0.10 | 2.4e-10 | 6.1 | 6.0 | 1.6e-09 | 0.76 | 0.01 | 0.99 | FALSE |