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chr10:5,039,564-6,576,881

Best TWAS P=8.44e-14 · Best GWAS P=9.46e-13 conditioned to 0.534

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C10orf18	0.09	0.03	bslmm	703	0.05	1.6e-06	-2.1	-5.3	1.5e-07	-0.39	0.12	0.86	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GDI2	0.30	0.28	bslmm	733	0.28	1.0e-34	7.1	-6.7	2.4e-11	-0.94	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	GDI2	0.28	0.16	enet	12	0.16	3.1e-13	7.1	-7.1	9.0e-13	-0.98	0.01	0.99	FALSE
4	GTEx	Adipose Visceral Omentum	GDI2	0.16	0.11	lasso	4	0.11	3.9e-06	6.6	-6.8	7.8e-12	-0.88	0.02	0.98	FALSE
5	GTEx	Artery Aorta	GDI2	0.23	0.13	lasso	5	0.12	6.1e-07	6.6	-6.1	9.9e-10	-0.93	0.01	0.99	FALSE
6	GTEx	Artery Tibial	GDI2	0.32	0.20	lasso	6	0.19	6.6e-15	7.1	-7.2	6.4e-13	-0.98	0.01	0.99	FALSE
7	GTEx	Brain Cerebellum	GDI2	0.31	0.14	lasso	4	0.09	1.4e-03	6.6	-6.8	8.7e-12	-0.95	0.01	0.96	FALSE
8	GTEx	Breast Mammary Tissue	GDI2	0.21	0.14	lasso	2	0.12	6.9e-07	6.6	-6.9	3.7e-12	-0.98	0.01	0.99	FALSE
9	GTEx	Breast Mammary Tissue (Male)	GDI2	0.29	0.00	lasso	7	0.01	1.6e-01	7.1	-7.1	1.3e-12	-0.93	0.03	0.74	FALSE
10	GTEx	Breast Mammary Tissue (Female)	GDI2	0.26	0.02	lasso	2	0.05	1.7e-02	6.6	-6.7	2.7e-11	-0.94	0.02	0.87	FALSE
11	GTEx	Esophagus Mucosa	GDI2	0.12	0.05	enet	15	0.08	3.4e-06	4.1	-5.8	7.0e-09	-0.76	0.01	0.98	FALSE
12	GTEx	Esophagus Muscularis	GDI2	0.18	0.10	lasso	6	0.12	5.5e-08	6.5	-7.3	3.1e-13	-0.80	0.06	0.94	FALSE
13	GTEx	Lung	GDI2	0.19	0.10	lasso	4	0.09	2.8e-07	7.1	-7.2	4.5e-13	-0.99	0.01	0.99	FALSE
14	GTEx	Nerve Tibial	GDI2	0.14	0.08	lasso	5	0.08	3.1e-06	7.1	-6.5	6.8e-11	-0.95	0.01	0.99	FALSE
15	GTEx	Pancreas	GDI2	0.30	0.23	lasso	4	0.20	4.9e-09	6.6	-6.7	2.1e-11	-0.94	0.02	0.98	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	GDI2	0.15	0.10	lasso	2	0.08	5.6e-05	7.1	-7.1	1.2e-12	-1.00	0.01	0.99	FALSE
17	GTEx	Thyroid	GDI2	0.12	0.11	lasso	2	0.11	1.5e-08	6.6	-6.6	3.2e-11	-0.94	0.08	0.92	FALSE
18	METSIM	Adipose	GDI2	0.08	0.10	lasso	2	0.10	2.2e-14	6.5	-6.7	2.2e-11	-0.90	0.02	0.98	FALSE
19	NTR	Blood	GDI2	0.04	0.02	lasso	3	0.02	1.6e-07	6.6	-6.8	9.4e-12	-0.95	0.01	0.99	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	GDI2	0.06	0.04	lasso	5	0.05	1.2e-06	6.4	-7.2	6.9e-13	-0.79	0.06	0.94	FALSE
21	YFS	Blood	GDI2	0.23	0.21	bslmm	734	0.24	1.8e-75	7.1	-6.4	1.2e-10	-0.91	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf18	0.02	0.01	blup	98	0.02	1.3e-04	6.9	6.2	4.5e-10	0.50	0.04	0.96	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	GDI2	0.03	0.01	blup	59	0.02	4.8e-05	6.5	-7.5	8.4e-14	-0.92	0.02	0.98	TRUE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GDI2	0.03	0.02	lasso	2	0.02	1.5e-03	6.5	-6.8	7.4e-12	-0.86	0.02	0.80	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	GDI2	0.05	0.03	blup	63	0.03	1.0e-04	6.5	-5.7	1.2e-08	-0.89	0.01	0.96	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	GDI2	0.12	0.10	lasso	2	0.09	7.5e-10	7.1	-7.0	1.9e-12	-0.98	0.01	0.99	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	GDI2	0.07	0.06	enet	8	0.06	1.1e-06	6.6	-7.4	1.3e-13	-0.96	0.01	0.99	FALSE