Best TWAS P=2.22e-12 · Best GWAS P=1.39e-15 conditioned to 1.99e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ERCC4 | 0.13 | 0.16 | lasso | 1 | 0.17 | 1.0e-19 | 5.6 | 5.6 | 1.8e-08 | -0.05 | 0.96 | 0.04 | FALSE |
| 2 | GTEx | Artery Tibial | ERCC4 | 0.08 | 0.06 | lasso | 2 | 0.05 | 6.2e-05 | 7.0 | -7.0 | 3.4e-12 | 0.05 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Muscle Skeletal | ERCC4 | 0.11 | 0.10 | lasso | 1 | 0.08 | 1.5e-08 | 7.0 | -7.0 | 2.2e-12 | 0.05 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Nerve Tibial | ERCC4 | 0.09 | 0.07 | lasso | 4 | 0.05 | 2.5e-04 | 5.7 | -5.7 | 1.3e-08 | 0.03 | 0.18 | 0.73 | FALSE |