Best TWAS P=4.52e-10 · Best GWAS P=3.65e-12 conditioned to 0.00127
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | DHX38 | 0.09 | -0.01 | enet | 8 | 0.00 | 4.5e-01 | 6.8 | -6.0 | 2.2e-09 | -0.82 | 0.04 | 0.73 | FALSE |
| 2 | GTEx | Muscle Skeletal | IST1 | 0.09 | 0.05 | lasso | 4 | 0.08 | 4.2e-08 | -3.6 | 6.2 | 4.5e-10 | 0.81 | 0.02 | 0.97 | TRUE |
| 3 | GTEx | Nerve Tibial | PHLPP2 | 0.17 | 0.10 | enet | 21 | 0.13 | 2.5e-09 | 4.0 | 5.3 | 1.3e-07 | 0.64 | 0.96 | 0.03 | FALSE |
| 4 | GTEx | Spleen | PHLPP2 | 0.18 | 0.11 | lasso | 13 | 0.09 | 2.2e-03 | 4.3 | 5.5 | 5.1e-08 | 0.82 | 0.06 | 0.70 | FALSE |
| 5 | GTEx | Thyroid | IST1 | 0.06 | 0.03 | lasso | 6 | 0.03 | 4.6e-03 | 6.6 | 5.9 | 3.8e-09 | 0.95 | 0.04 | 0.93 | FALSE |