Hub : Genes

ERCC4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1310	0.0300	6.2e-10	0.164	0.081	0.154	0.148	0.166	1.8e-19	3.8e-10	2.9e-18	1.4e-17	1.0e-19
2	GTEx	Artery Tibial	0.0769	0.0313	8.4e-03	0.058	NA	0.029	NA	0.052	2.6e-05	NA	2.4e-03	NA	6.2e-05
3	GTEx	Muscle Skeletal	0.1100	0.0353	7.3e-05	0.098	NA	0.061	NA	0.083	7.9e-10	NA	1.3e-06	NA	1.5e-08
4	GTEx	Nerve Tibial	0.0929	0.0377	3.6e-03	0.068	NA	0.017	NA	0.048	1.5e-05	NA	2.1e-02	NA	2.5e-04
5	TCGA	Prostate Adenocarcinoma	0.0230	0.0153	9.6e-03	0.010	0.013	0.005	NA	0.008	2.9e-02	1.4e-02	9.8e-02	NA	4.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.9	0.8	0.4	0.9	0.3
Bipolar Disorder or Schizophrenia	0.7	1.6	3.3	1.0	-0.9	-1.3	-1.1	-1.8
Depressed Affect (Nagel 2018)	1.9	3.9	5.0	2.2	-2.0	-2.2	-1.9	-1.4
Depression (Nagel 2018)	4.1	6.2	8.0	2.6	-2.8	-2.7	-2.3	-1.9
Intelligence (Savage-Jansen 2018)	2.5	7.8	10.8	-3.3	2.4	2.2	3.3	2.6
Neuroticism (Nagel 2018)	0.8	1.8	3.4	1.8	-0.8	-1.2	-1.3	-1.3
Schizophrenia (2018)	2.2	4.6	6.9	2.1	-1.8	-2.0	-2.1	-2.6
Schizophrenia vs Biploar Disorder	1.8	2.4	3.9	1.7	-1.4	-1.5	-2.0	-0.8
Worry (Nagel 2018)	0.2	0.4	1.2	0.6	-0.2	-0.6	-0.4	-1.1
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-1.0	0.9	0.3	0.9	-0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.1	-0.6	-0.7	-0.3	-0.1
Alzheimer’s Disease (including proxy)	0.8	1.1	2.0	-1.3	1.4	0.9	0.9	0.6
Crohns Disease (2017)	0.0	0.0	0.1	0.1	0.2	-0.2	-0.1	0.4
Irritable Bowel Disease (IBD)	0.9	2.1	2.9	1.7	-0.9	-1.4	-1.5	-1.6
Ulcerative Colitis (UC)	2.5	4.6	6.2	2.5	-1.4	-2.0	-2.2	-2.5
Major Depression (MDD)	0.8	1.0	2.8	0.3	1.7	1.4	0.1	0.5
Reaction Time	0.4	0.8	2.2	1.1	-0.1	-0.3	-0.8	-1.5
Verbal and Numeric Reasoning (VNR)	2.5	6.0	8.4	-2.9	2.4	2.0	2.9	1.9
Breast Cancer	1.2	2.8	3.8	1.9	-1.4	-1.2	-2.0	-1.8
Ovarian Cancer	0.2	0.3	0.4	0.5	0.6	0.3	-0.5	0.7
Prostate Cancer	0.7	1.0	1.6	-1.1	1.1	1.0	1.3	-0.2
Age at First Birth	0.2	0.3	0.7	-0.2	0.8	0.7	0.4	-0.7
Bipolar Disorder (2011)	1.1	1.0	2.3	-1.4	0.9	0.4	1.5	-0.2
Body Mass Index (BMI) (2010)	3.0	4.1	7.3	-2.1	1.6	1.4	2.1	2.7
Coronary Artery Disease (CAD)	3.3	3.9	6.5	1.0	-2.2	-2.0	-1.7	-2.5
Crohns Disease (2012)	0.1	0.2	0.7	-0.2	0.4	-0.1	0.3	0.8
Mean Putamen Volume	0.3	0.3	0.9	-1.0	0.1	0.0	0.7	0.3
Fasting Glucose	0.1	0.2	0.7	0.8	-0.3	0.3	-0.3	0.1
HbA1C	0.5	0.5	1.5	0.2	-1.2	-0.5	-0.9	0.1
HDL Cholesterol	4.1	6.9	9.7	3.1	-2.3	-2.3	-3.0	-2.2
LDL Cholesterol	0.5	0.7	1.3	-0.9	0.6	0.6	1.0	1.1
Lupus	4.0	6.1	8.5	2.3	-2.5	-2.1	-2.4	-2.9
Neuroticism (2016)	0.5	0.8	1.3	-1.1	1.1	0.6	1.0	-0.2
Primary Biliary Cirrhosis	0.4	0.5	0.9	-0.8	0.6	0.3	1.0	0.8
Rheumatoid Arthritis	0.5	0.6	2.1	0.4	0.7	0.5	-0.3	1.5
Schizophrenia (2014)	1.3	2.9	3.4	1.4	-1.7	-1.8	-1.7	-1.8
Triglycerides	4.6	7.6	9.0	-2.9	2.2	2.8	3.0	2.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	0.4	0.3	-0.4	-0.5	0.5
Ulcerative Colitis	3.8	5.5	7.6	2.8	-1.7	-2.3	-2.5	-2.4
Blood Eosinophil Count	0.1	0.6	1.0	-0.3	0.8	1.0	0.7	0.9
Blood Platelet Count	0.4	4.2	7.3	-2.7	1.6	1.6	2.3	1.7
Blood Red Count	0.0	0.1	0.3	-0.3	0.5	0.2	-0.1	0.1
Blood White Count	0.2	1.5	3.0	-1.7	1.0	0.9	1.6	0.4
Heel T-Score	1.0	7.7	9.9	-3.1	3.0	2.7	2.9	2.0
BMI	0.0	0.3	0.4	0.2	-0.6	-0.6	-0.5	-0.5
Height	0.1	1.0	1.4	1.0	-0.9	-1.2	-1.1	-0.7
Waist Hip Ratio (WHR)	0.3	1.5	1.9	-1.2	1.3	1.2	1.0	1.4
Systolic Blood Pressure	0.5	2.7	4.8	-2.2	1.7	1.4	1.9	0.4
Smoking Status	0.4	1.1	1.9	1.1	-0.8	-0.7	-1.0	-1.4
Allergy or Eczema	1.5	4.0	6.9	2.6	-1.9	-1.9	-2.4	-0.8
Cardiovascular Disease	1.7	5.7	7.2	-2.6	2.6	2.3	2.7	1.4
Hypothyroidism (self reported)	2.1	4.8	6.0	-2.0	2.2	2.4	1.7	2.5
Respiratory disease	0.4	0.8	1.4	1.2	-0.7	-0.9	-1.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.4	0.3	0.2	0.3	-0.8
Lung FEV1/FVC ratio	0.7	3.4	6.0	-2.0	1.3	1.6	1.6	2.5
Lung FVC	3.2	16.2	19.2	-4.2	3.8	4.0	4.4	3.7
Neuroticism	0.8	1.9	2.9	1.5	-1.0	-1.3	-1.3	-1.7
Chronotype (morning person)	0.1	0.3	1.0	0.6	-0.4	0.1	-0.2	-1.0
Hair Pigment	0.1	4.2	5.8	-2.3	1.8	2.2	2.4	1.5
Tanning	3.1	37.6	49.3	5.6	-7.0	-7.0	-5.7	-5.1
Hand grip strength (left)	0.6	1.5	6.2	-0.6	0.2	0.6	0.6	2.5
Number of treatments/medications taken	0.5	0.8	3.1	0.7	0.6	0.1	-0.5	-1.8
Average weekly spirits intake	0.2	0.2	0.5	-0.7	-0.4	-0.2	0.6	0.1
Sensitivity / hurt feelings	0.5	0.9	1.6	-0.6	1.3	1.0	1.2	0.5
Frequency of depressed mood in last 2 weeks	3.6	5.1	5.9	2.3	-2.4	-2.4	-1.9	-2.2
Hearing difficulty/problems: Yes	0.0	0.0	0.1	0.3	0.2	0.1	0.1	0.3
Relative age of first facial hair	3.2	6.7	7.8	-2.8	2.6	2.6	2.6	2.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	0.8	0.1	-0.2	-0.7	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	1.0	-0.2	-0.1	-0.8	-0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	-0.4	-0.3	-0.4	0.0
Systolic blood pressure, automated reading	0.1	0.2	0.5	-0.6	-0.0	-0.1	0.0	-0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.8	-0.2	0.2	0.5	0.2
Angina	1.5	1.9	6.3	1.0	-0.9	-1.0	-0.7	-2.5
Medication for hormone replacement therapy	0.4	0.5	0.8	-0.5	0.9	0.7	0.7	0.7
Vitamin and mineral supplements	1.0	1.4	1.9	1.4	-0.9	-0.9	-1.2	-1.3
Supplements: Zinc	3.7	4.0	5.3	-2.1	1.9	2.0	2.3	1.8
Medication: Co-codamol	0.3	0.3	0.7	-0.8	0.3	0.5	0.7	0.5
Medication: Metformin	0.4	0.5	2.6	-0.0	0.2	0.0	0.2	-1.6
Diabetes (father)	0.4	0.5	1.0	-0.6	1.0	0.7	0.7	0.7
Diabetes (mother)	0.6	0.7	1.4	-0.6	0.8	1.2	0.4	1.0
Severe depression (siblings)	1.7	1.9	3.2	0.9	-1.8	-1.7	-1.2	-1.0
Pack years adult smoking proportion	2.6	4.0	7.8	1.9	-1.7	-2.0	-1.3	-2.8
Impedance of leg (right)	1.0	4.7	5.6	-2.3	2.4	1.9	2.2	2.0
Leg fat-free mass (left)	0.2	1.0	1.6	0.9	-1.3	-1.1	-1.0	-0.5
Trunk fat percentage	0.0	0.1	0.2	-0.3	0.1	0.0	-0.0	-0.5
Hand grip strength (right)	0.8	2.1	5.9	-1.2	0.6	0.9	1.5	2.4
Townsend deprivation index at recruitment	0.4	0.5	1.3	0.8	-0.0	-0.2	-0.7	-1.2
Current tobacco smoking	1.3	2.1	5.3	1.3	-1.1	-1.0	-1.1	-2.3
Average weekly fortified wine intake	0.1	0.1	0.3	0.1	-0.2	-0.3	-0.4	-0.5
Maternal smoking around birth	2.9	4.3	5.7	2.1	-2.0	-2.0	-1.7	-2.4
Fed-up feelings	4.7	8.5	11.1	2.9	-3.1	-3.3	-2.7	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.2	6.8	2.6	-1.8	-1.9	-2.3	-1.6
Relative age voice broke	2.8	4.3	5.8	-2.4	2.1	1.9	2.2	1.8
Taking other prescription medications	0.1	0.2	0.6	-0.1	0.6	0.2	0.1	-0.8
Age when periods started (menarche)	2.3	5.5	6.5	-2.4	2.2	2.1	2.5	2.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	0.5	0.2	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	0.8	-0.8	0.9	0.5	0.7	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.0	-0.7	0.4	0.2	1.0	-0.3
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.6	0.5	0.5	0.9	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.6	0.2	0.8	0.6	-0.0	0.4
High blood pressure	0.1	0.2	0.5	-0.1	0.4	0.3	0.3	-0.7
Hayfever, allergic rhinitis or eczema	0.7	1.4	3.3	1.8	-0.8	-0.9	-1.5	-0.2
Multivitamins +/- minerals	0.6	0.8	1.6	-1.1	0.4	0.3	1.0	1.2
Stomach or abdominal pain in last month	0.5	0.6	1.8	0.5	-0.6	-0.5	-0.5	-1.4
Supplements: Glucosamine	0.2	0.2	0.5	-0.5	0.4	0.4	0.7	0.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.2	3.1	1.2	-1.8	-1.7	-1.3	-1.3
Medication: Atenolol	2.1	2.7	4.1	1.9	-1.3	-1.3	-1.6	-2.0
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.3	0.7	0.7	0.3	0.4
Sitting height	0.0	0.0	0.1	-0.2	-0.2	-0.4	0.0	0.2
Chronic bronchitis/emphysema (father)	1.1	1.3	2.7	0.8	-1.3	-1.6	-0.9	-0.7
High blood pressure (mother)	2.3	3.3	4.5	-1.8	1.9	1.8	1.4	2.1
Body mass index (BMI)	0.1	0.5	0.6	0.6	-0.6	-0.7	-0.8	-0.7
Impedance of leg (left)	0.9	4.6	5.9	-2.2	2.4	2.0	2.2	1.8
Leg predicted mass (left)	0.2	1.0	1.6	0.9	-1.2	-1.1	-1.0	-0.5
Trunk fat mass	0.0	0.1	0.4	-0.0	-0.2	-0.3	-0.3	-0.6
Waist circumference	0.0	0.1	0.1	0.2	-0.0	-0.3	-0.3	-0.3
Number of incorrect matches in round	0.9	1.6	3.3	0.2	-1.3	-1.8	-0.5	-1.6
Past tobacco smoking	0.3	0.5	1.4	-1.2	0.0	0.1	1.0	0.4
Alcohol usually taken with meals	0.2	0.4	0.8	0.6	0.3	0.9	-0.4	0.6
Nervous feelings	0.2	0.4	0.8	-0.9	-0.3	-0.3	0.9	-0.0
Frequency of tenseness / restlessness in last 2 weeks	3.4	5.2	7.7	2.8	-1.7	-1.8	-2.2	-2.7
Hearing difficulty/problems with background noise	0.9	1.4	2.5	1.6	-0.9	-1.2	-1.1	-1.2
Hair/balding pattern: Pattern 2	0.6	0.8	1.0	-1.0	0.9	1.0	1.0	0.1
Had menopause	0.5	0.6	1.1	1.0	-0.6	-0.5	-1.0	-0.7
Had other major operations	0.1	0.2	0.3	-0.4	-0.3	-0.3	0.4	0.5
Forced vital capacity (FVC)	2.0	7.6	10.2	-2.9	2.1	2.5	3.0	3.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	1.8	-1.2	1.3	1.1	1.1	1.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	5.6	0.5	-0.6	-0.6	-0.5	-2.4
Qualifications: None of the above	1.5	3.2	7.2	1.2	-1.5	-2.0	-1.0	-2.7
Financial difficulties in last 2 years	3.2	4.3	5.9	2.2	-2.1	-1.9	-2.4	-1.7
Mouth/teeth dental problems	0.4	0.6	2.8	0.0	0.5	0.1	-0.0	1.7
Heart attack	1.0	1.2	2.1	-0.9	1.5	1.4	1.1	0.0
Allergy	1.0	2.3	4.5	-2.1	1.1	1.2	1.8	0.9
Pain all over the body in last month	0.4	0.5	0.7	0.8	0.8	0.6	-0.6	0.6
Diabetes (self-reported)	0.1	0.2	0.7	-0.2	0.4	0.4	0.2	-0.8
Hayfever/allergic rhinitis (self-reported)	3.5	4.7	6.0	-2.1	2.1	2.1	2.1	2.4
Medication: Ramipril	1.4	1.8	3.5	-1.3	1.3	1.4	1.9	-0.5
Medication: Simvastatin	0.3	0.5	1.0	0.3	0.9	0.4	0.3	-1.0
Fluid intelligence score	4.5	9.3	13.0	-3.6	3.0	2.6	3.4	2.5
Illnesses of siblings	0.1	0.2	0.6	-0.1	0.4	0.4	0.1	0.8
Neuroticism score	0.7	1.5	2.2	1.5	-0.9	-1.3	-1.0	-1.5
Weight	0.1	0.4	0.6	0.5	-0.6	-0.8	-0.8	-0.6
Impedance of arm (right)	0.1	0.3	0.5	-0.7	0.4	0.3	0.7	0.5
Arm fat percentage (right)	0.0	0.1	0.3	0.2	-0.4	-0.4	-0.6	-0.1
Trunk fat-free mass	0.1	0.7	1.1	0.6	-1.1	-1.0	-1.0	-0.2
Hip circumference	0.2	0.9	1.4	0.5	-1.1	-1.2	-0.7	-0.9
Time employed in main current job	1.0	1.1	2.9	-1.4	0.4	0.7	1.7	-0.4
Alcohol intake versus 10 years previously	0.6	0.9	1.4	-0.6	1.1	0.7	0.8	1.2
Father’s age at death	1.6	2.2	4.6	-1.3	1.4	1.3	0.9	2.1
Worrier / anxious feelings	0.2	0.3	1.0	-0.4	0.3	0.2	0.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	4.4	7.2	8.4	2.9	-2.3	-2.9	-2.6	-2.7
Falls in the last year	1.0	1.4	3.6	1.1	-0.7	-0.6	-1.0	-1.9
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.4	-0.5	-0.7	-0.4	-0.0
Number of live births	0.1	0.1	0.1	-0.4	-0.3	-0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	3.6	12.3	16.0	-3.9	2.4	3.1	3.8	4.0
Pulse rate	0.8	1.3	4.2	0.5	-0.7	-1.1	-0.6	-2.0
Happiness	2.7	3.3	6.2	1.6	-2.5	-2.2	-1.2	-1.1
Noisy workplace	1.9	2.3	3.4	1.2	-1.8	-1.8	-1.1	-1.6
Qualifications: A levels/AS levels or equivalent	0.5	1.0	1.9	-0.7	0.9	1.2	0.8	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.6	0.8	-1.1	-0.9	-1.1	-1.2
Mouth/teeth dental problems: Dentures	0.3	0.4	1.8	-0.2	0.0	0.4	0.5	-1.3
Asthma	0.3	0.5	0.9	1.0	-0.5	-0.8	-0.8	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.3	-0.7	-0.4	-0.3	-0.4
Medication: Cholesterol lowering	0.2	0.4	0.7	-0.5	0.9	0.5	0.6	-0.3
Depression (self-reported)	0.2	0.2	0.9	0.1	0.5	0.2	0.0	-0.9
Medication: Lansoprazole	0.4	0.5	0.8	0.6	-0.9	-0.7	-0.6	-0.7
Prospective memory result	0.3	0.4	1.9	0.4	-0.2	-0.2	-0.1	-1.4
Lung cancer (father)	4.9	5.8	8.3	2.0	-2.5	-2.5	-2.0	-2.9
Illnesses of mother	2.0	2.5	4.0	1.7	-2.0	-1.7	-1.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.1	9.9	12.4	-3.5	2.4	2.9	3.3	3.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.2	-0.3	0.1	-0.5	-0.1
Impedance of arm (left)	0.2	1.1	1.8	-1.3	1.0	0.8	1.3	0.8
Arm fat mass (right)	0.0	0.2	0.3	0.3	-0.5	-0.5	-0.5	-0.2
Trunk predicted mass	0.1	0.6	0.9	0.6	-0.9	-0.9	-0.9	0.0
Standing height	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.0	0.2
Length of working week for main job	0.5	0.5	1.3	-0.6	0.5	0.6	0.7	1.1
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.1	0.5	0.6	0.2	0.7
Breastfed as a baby	2.7	3.3	7.0	-1.6	1.4	1.6	1.6	2.6
Tense / ‘highly strung’	0.5	0.8	2.9	0.7	-0.2	-0.5	-0.7	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.2	1.2	0.6	0.2	-0.8	-1.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	1.1	-0.5	-0.4	-0.9	-0.4
Birth weight of first child	1.1	2.0	3.5	1.2	-1.8	-1.9	-1.1	-0.9
Peak expiratory flow (PEF)	3.2	7.5	11.4	-2.8	1.9	2.6	2.9	3.4
Pulse wave reflection index	1.4	1.7	2.8	1.2	-1.7	-1.2	-1.6	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.3	0.2	0.1	0.6	-0.5
Loud music exposure frequency	2.5	2.8	5.1	1.3	-1.7	-1.7	-1.2	-2.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	3.1	-0.9	1.2	1.1	0.9	1.8
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	2.2	1.3	-1.1	-1.2	-1.5	-1.5
Blood clot in the leg (DVT)	0.6	0.7	1.5	1.2	-0.8	-0.4	-1.0	-0.5
Medication: Paracetamol	0.1	0.1	0.5	-0.1	0.0	-0.3	0.2	-0.7
Headache pain in last month	0.1	0.1	0.2	-0.3	0.2	0.1	0.4	-0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.3	-0.9	-0.8	-0.3	0.5
Glaucoma (self-reported)	0.1	0.2	0.8	-0.0	-0.1	-0.0	0.1	-0.9
Gout (self-reported)	0.5	0.7	0.9	0.9	-0.5	-0.8	-0.9	-0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.4	-1.1	1.1	1.6	1.0	1.2
Medication: Amlodipine	0.2	0.3	0.7	0.8	0.1	-0.2	-0.7	-0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.3	1.1	-0.5	-0.7	-1.2	-1.1
Birth weight	0.4	0.8	1.6	-1.3	0.6	0.2	1.2	0.7
Chronic bronchitis/emphysema (mother)	3.8	4.4	5.6	2.3	-1.6	-1.9	-2.1	-2.4
High blood pressure (siblings)	0.9	1.3	1.7	-1.0	1.1	1.1	1.1	1.3
Forced vital capacity (FVC), Best measure	1.8	6.7	8.7	-2.8	2.0	2.3	2.8	3.0
Body fat percentage	0.0	0.1	0.1	-0.3	0.3	0.1	0.0	-0.3
Leg fat percentage (right)	0.0	0.1	0.2	-0.4	0.4	0.1	0.2	-0.1
Arm fat-free mass (right)	0.0	0.1	0.2	0.1	-0.4	-0.4	-0.3	-0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.6	0.2	-0.4	-0.8	-0.4
Comparative body size at age 10	0.0	0.1	0.2	0.0	0.5	0.5	0.3	0.4
Number of full brothers	2.6	3.3	6.5	-1.5	1.7	1.8	1.4	2.5
Worry too long after embarrassment	0.0	0.0	0.1	0.3	0.3	0.0	-0.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.5	0.3	0.2	-0.1	0.1	-1.2
Wheeze or whistling in the chest in last year	1.7	3.0	4.0	2.0	-1.5	-2.0	-1.8	-1.4
Number of children fathered	1.4	1.6	2.0	-1.3	1.4	1.4	1.2	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	0.7	-0.1	-0.3	-0.7	0.1
Age at first live birth	0.0	0.1	0.3	-0.3	0.1	0.2	-0.1	0.5
Pulse wave peak to peak time	0.1	0.1	0.3	0.1	0.5	0.1	0.6	0.3
Health satisfaction	1.3	1.7	2.5	0.9	-1.5	-1.5	-0.8	-1.6
Shortness of breath walking on level ground	2.2	2.6	5.1	1.4	-1.6	-1.5	-1.0	-2.2
Qualifications: College or University degree	0.4	1.3	2.9	-1.2	0.8	0.7	0.9	1.7
Eye problems/disorders: None of the above	0.6	0.7	1.1	1.0	-0.8	-0.7	-1.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.3	0.5	-1.1	-1.0	-0.1	-0.4
Emphysema/chronic bronchitis	0.5	0.6	1.0	0.8	-0.9	-1.0	-0.6	-0.3
Medication for pain relief, constipation, heartburn	1.0	1.7	7.1	-0.8	0.3	0.7	0.6	2.7
Neck or shoulder pain in last month	2.3	3.3	7.2	1.4	-1.2	-1.7	-1.7	-2.7
Medication: Blood pressure	0.3	0.5	2.0	0.6	0.1	0.1	-0.5	-1.4
Angina (self-reported)	1.4	1.9	6.8	0.9	-0.9	-0.9	-0.5	-2.6
Migraine (self-reported)	0.2	0.2	0.5	0.6	0.0	0.1	-0.7	-0.6
Medication: Ibuprofen	0.2	0.2	0.6	0.1	-0.7	-0.4	-0.1	-0.5
Medication: Allopurinol	0.3	0.4	0.9	0.5	-0.3	-0.9	-0.4	-0.8
Medication: Omeprazole	5.1	6.0	9.9	2.6	-2.0	-1.9	-2.4	-3.2
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.3	0.3	0.3	0.7	-0.6
Mean time to correctly identify matches	0.9	1.8	4.4	1.5	-0.6	-0.8	-1.1	-2.1
Heart disease (mother)	0.4	0.4	0.7	-0.8	0.7	0.7	0.6	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.2	-0.2	-0.0	0.1	-0.4	0.2
Whole body fat mass	0.0	0.1	0.1	-0.0	-0.2	-0.3	-0.3	-0.4
Leg fat mass (right)	0.0	0.2	0.3	0.3	-0.3	-0.6	-0.5	-0.4
Arm predicted mass (right)	0.0	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.2
Pulse rate, automated reading	0.1	0.4	0.8	0.5	-0.4	-0.8	-0.5	-0.9
Alcohol intake frequency.	0.0	0.1	0.3	0.5	-0.0	-0.3	-0.4	-0.2
Comparative height size at age 10	0.1	0.4	0.7	0.3	-0.8	-0.9	-0.3	-0.8
Number of full sisters	1.4	1.7	2.6	-0.9	1.6	1.2	1.2	1.4
Suffer from ‘nerves’	0.2	0.3	0.7	-0.2	0.8	0.6	0.5	-0.2
Overall health rating	2.3	4.9	9.9	1.8	-2.0	-2.3	-1.6	-3.1
Chest pain or discomfort	0.4	0.5	1.7	0.4	-0.5	-0.7	-0.3	-1.3
Had major operations	0.7	0.8	1.7	1.0	-0.7	-0.6	-1.3	-0.9
Age at last live birth	0.9	1.3	2.0	-1.1	1.3	1.4	0.9	0.9
Family relationship satisfaction	0.2	0.3	0.8	-0.4	-0.5	-0.4	0.9	-0.2
Leg pain on walking	1.7	2.1	3.6	0.9	-1.9	-1.9	-0.9	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.3	1.1	-1.2	-1.5	-1.2	-1.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	3.7	0.9	-1.9	-1.7	-1.2	-1.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.7	-0.2	-0.1	-0.4	0.8	0.2
Medication: Aspirin	1.4	1.9	3.2	-1.3	1.8	1.4	1.4	-0.9
Supplements: Vitamin C	1.0	1.1	2.1	-1.5	1.1	0.8	1.3	0.2
Knee pain experienced in last month	4.2	6.6	8.8	2.1	-2.9	-3.0	-1.6	-3.0
Hypertension (Self-reported)	0.1	0.3	0.6	-0.5	0.4	0.4	0.8	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.9	4.6	7.6	1.8	-2.2	-2.2	-1.4	-2.8
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.5	0.2	0.2	0.7	0.5
Illnesses of siblings: Diabetes	0.1	0.2	0.7	0.2	0.3	0.3	-0.2	-0.8
Smoking status: Previous	0.2	0.2	0.5	0.7	0.1	0.1	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.0	-1.0	0.6	0.6	0.9	1.0
Whole body fat-free mass	0.1	0.6	0.9	0.6	-1.0	-0.8	-0.9	-0.2
Leg fat-free mass (right)	0.2	1.2	1.8	1.1	-1.4	-1.1	-1.1	-0.8
Arm fat percentage (left)	0.0	0.0	0.0	-0.2	-0.0	-0.0	-0.1	0.1
Average weekly red wine intake	0.1	0.2	0.4	0.2	0.4	0.7	-0.2	0.3
Handedness (chirality/laterality): Left-handed	2.5	3.0	4.2	1.5	-1.8	-2.1	-1.6	-1.6
Mood swings	0.8	1.5	2.0	1.3	-1.3	-1.4	-0.8	-1.3
Loneliness, isolation	3.7	5.1	8.5	2.1	-1.7	-2.2	-2.2	-2.9
Long-standing illness, disability or infirmity	1.2	1.8	5.6	1.1	-0.6	-0.9	-1.0	-2.4
Ever had bowel cancer screening	8.1	9.5	11.3	3.1	-2.7	-3.4	-3.1	-3.2
Diabetes diagnosed by doctor	0.3	0.5	2.2	0.3	-0.2	-0.3	-0.3	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	4.8	5.1	7.2	-2.6	2.1	2.7	2.3	1.4
Friendships satisfaction	0.2	0.2	0.9	0.4	-0.0	-0.2	0.1	-1.0
Qualifications: nursing, teaching	0.6	0.9	2.6	-0.7	0.7	0.9	0.4	1.6
Commuting to job workplace: Walk	1.2	1.3	2.4	-1.6	0.7	0.5	1.3	1.4
Eye problems/disorders: Cataract	1.4	1.6	2.0	-1.2	1.4	1.4	1.4	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.1	-1.0	0.8	1.0	0.9	0.4
Medication for cholesterol	2.7	4.1	6.2	1.8	-2.5	-2.2	-2.5	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	-0.7	0.1	0.3	0.5	-1.1
Back pain experienced in last month	1.3	1.9	3.5	1.4	-1.1	-1.3	-1.1	-1.9
Mineral and other dietary supplements	0.7	1.0	1.3	1.0	-1.1	-1.0	-1.0	-0.7
Breast cancer (self-reported)	0.1	0.2	0.3	0.4	0.0	-0.4	-0.6	-0.4
Asthma (self-reported)	0.0	0.1	0.2	0.5	-0.1	-0.3	-0.2	-0.0
Osteoporosis (self-reported)	0.4	0.4	0.8	0.7	-0.2	-0.6	-0.7	-0.9
Osteoarthritis (self-reported)	2.8	3.7	5.0	2.2	-1.9	-1.7	-2.2	-1.4
Medication: Aspirin	1.7	2.2	4.1	-1.3	2.0	1.6	1.5	-0.7
Medication: Gliclazide	0.3	0.3	1.4	-0.0	0.0	-0.5	-0.2	-1.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	0.7	-0.3	-0.2	-0.7	-1.0
Smoking status: Current	1.8	2.9	6.9	1.4	-1.4	-1.4	-1.3	-2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.6	-1.7	0.6	1.0	1.1	1.9
Whole body water mass	0.1	0.7	1.1	0.7	-1.1	-0.9	-0.9	-0.3
Leg predicted mass (right)	0.2	1.3	2.0	1.1	-1.4	-1.2	-1.2	-0.8
Arm fat mass (left)	0.0	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.0
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	-0.2	1.0	0.7	0.6	-1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.2	-0.6	-0.1	0.2	0.5
Miserableness	1.9	3.3	5.3	2.3	-1.4	-1.7	-1.8	-1.7
Guilty feelings	1.6	2.4	4.9	1.8	-0.8	-1.3	-1.3	-2.2
Wears glasses or contact lenses	0.8	0.9	1.7	0.9	-0.5	-1.0	-1.3	-0.8
Ever taken oral contraceptive pill	0.8	0.9	2.7	-0.1	-1.6	-1.3	0.2	-0.3
Hearing aid user	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.3	-0.2
Mother’s age at death	2.5	3.2	5.0	-2.2	1.3	1.6	1.5	2.1
Financial situation satisfaction	1.5	1.9	3.1	1.4	-1.8	-1.4	-1.1	-1.2
Tinnitus: Yes, now most or all of the time	0.6	0.8	2.2	-0.0	-1.5	-1.1	0.1	-0.7
Commuting to job workplace: Public transport	3.1	3.6	6.7	-1.5	2.6	2.4	1.6	0.9
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.4	0.2	0.3	0.5	0.2
Medication: Blood pressure	0.9	1.8	4.0	-1.4	1.1	1.2	2.0	-0.2
Pain type(s) experienced in last month: Hip pain	2.5	3.2	4.5	2.0	-1.4	-1.5	-1.8	-2.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.2	-1.1	0.8	0.8	1.0	0.4
High cholesterol (Self-reported)	4.3	7.6	10.7	-2.5	3.3	2.9	3.0	1.9
Medication: Bendroflumethiazide	0.4	0.6	2.9	0.2	-0.3	-0.4	0.0	-1.7
Medication: Paracetamol	0.2	0.2	0.9	-0.3	0.3	0.1	0.4	-0.9
Medication: Lisinopril	0.8	1.0	2.1	-1.4	0.7	0.7	1.3	0.4
Medication: Atorvastatin	5.4	6.7	9.8	-3.0	2.1	2.7	3.1	1.5
Illnesses of father: High blood pressure	2.1	2.6	3.6	-1.4	1.7	1.9	1.6	1.4
Alcohol drinker status: Never	0.2	0.3	0.6	-0.3	0.7	0.2	0.2	0.7
Ever smoked	0.3	0.5	1.5	1.2	0.2	0.2	-0.8	-0.4
Basal metabolic rate	0.1	0.6	0.9	0.6	-0.9	-0.9	-0.9	-0.2
Leg fat percentage (left)	0.0	0.2	0.3	-0.5	0.6	0.3	0.4	-0.2
Arm fat-free mass (left)	0.1	0.3	0.5	0.4	-0.6	-0.6	-0.7	-0.1
Number of operations (self-reported)	0.1	0.2	0.4	0.1	-0.2	-0.1	-0.6	0.6
Average weekly beer plus cider intake	0.4	0.6	1.1	1.0	-0.3	-0.6	-1.1	-0.6
Irritability	0.4	0.7	1.2	0.9	-0.7	-0.8	-0.6	-1.1
Risk taking	0.4	0.5	0.8	-0.9	0.8	0.7	0.7	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.1	0.1	0.1	-0.3	-0.5
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.6	0.1	0.0	-0.5	-0.4
Age started oral contraceptive pill	0.1	0.1	0.2	0.4	-0.2	-0.3	-0.3	-0.5
Diastolic blood pressure, automated reading	0.2	0.6	1.2	0.3	-0.8	-1.1	-1.0	0.0
Ever depressed for a whole week	0.3	0.4	1.3	-0.1	0.5	0.3	0.4	-1.2
Unable to work because of sickness or disability	8.7	11.2	16.9	3.2	-3.0	-3.2	-3.1	-4.1
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.4	0.6	0.4	-0.7	0.5
Myopia	0.3	0.5	1.1	0.8	-0.4	-0.4	-0.5	-1.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.2	0.8	-0.9	-0.8	-1.1	0.8
Cholesterol lowering medication	2.3	3.3	5.8	-1.3	2.4	2.2	2.1	0.2
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	6.0	1.6	-1.0	-1.0	-1.4	-2.4
Pain experienced in last month	1.4	2.3	5.3	-1.6	0.5	1.1	1.5	2.3
Supplements: Calcium	2.8	3.1	4.2	-1.8	1.6	1.5	2.1	1.8
Basal cell carcinoma (self-reported)	2.1	2.5	3.5	1.8	-0.9	-1.4	-1.9	-1.8
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.3	-1.0	1.5	1.4	1.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.1	1.1	-0.8	-0.4	-0.9	-0.5
Heart disease (siblings)	0.6	0.8	1.3	0.9	-0.1	-0.9	-0.9	-1.2
Alcohol drinker status: Previous	0.3	0.4	0.5	0.6	-0.7	-0.6	-0.6	-0.5
Pack years of smoking	2.6	3.9	7.6	1.9	-1.6	-2.0	-1.3	-2.7
Impedance of whole body	0.4	2.0	2.6	-1.6	1.5	1.2	1.6	1.1
Leg fat mass (left)	0.0	0.1	0.2	0.2	-0.2	-0.4	-0.4	-0.4
Arm predicted mass (left)	0.1	0.4	0.7	0.6	-0.7	-0.6	-0.8	-0.1