Hub : Genes

ERCC4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1310 0.0300 6.2e-10 0.164 0.081 0.154 0.148 0.166 1.8e-19 3.8e-10 2.9e-18 1.4e-17 1.0e-19
2 GTEx Artery Tibial 0.0769 0.0313 8.4e-03 0.058 NA 0.029 NA 0.052 2.6e-05 NA 2.4e-03 NA 6.2e-05
3 GTEx Muscle Skeletal 0.1100 0.0353 7.3e-05 0.098 NA 0.061 NA 0.083 7.9e-10 NA 1.3e-06 NA 1.5e-08
4 GTEx Nerve Tibial 0.0929 0.0377 3.6e-03 0.068 NA 0.017 NA 0.048 1.5e-05 NA 2.1e-02 NA 2.5e-04
5 TCGA Prostate Adenocarcinoma 0.0230 0.0153 9.6e-03 0.010 0.013 0.005 NA 0.008 2.9e-02 1.4e-02 9.8e-02 NA 4.7e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 0.9 -0.9 0.8 0.4 0.9 0.3
Bipolar Disorder or Schizophrenia 0.7 1.6 3.3 1.0 -0.9 -1.3 -1.1 -1.8
Depressed Affect (Nagel 2018) 1.9 3.9 5.0 2.2 -2.0 -2.2 -1.9 -1.4
Depression (Nagel 2018) 4.1 6.2 8.0 2.6 -2.8 -2.7 -2.3 -1.9
Intelligence (Savage-Jansen 2018) 2.5 7.8 10.8 -3.3 2.4 2.2 3.3 2.6
Neuroticism (Nagel 2018) 0.8 1.8 3.4 1.8 -0.8 -1.2 -1.3 -1.3
Schizophrenia (2018) 2.2 4.6 6.9 2.1 -1.8 -2.0 -2.1 -2.6
Schizophrenia vs Biploar Disorder 1.8 2.4 3.9 1.7 -1.4 -1.5 -2.0 -0.8
Worry (Nagel 2018) 0.2 0.4 1.2 0.6 -0.2 -0.6 -0.4 -1.1
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -1.0 0.9 0.3 0.9 -0.2
Alzheimer’s Disease (in father) 0.2 0.2 0.5 -0.1 -0.6 -0.7 -0.3 -0.1
Alzheimer’s Disease (including proxy) 0.8 1.1 2.0 -1.3 1.4 0.9 0.9 0.6
Crohns Disease (2017) 0.0 0.0 0.1 0.1 0.2 -0.2 -0.1 0.4
Irritable Bowel Disease (IBD) 0.9 2.1 2.9 1.7 -0.9 -1.4 -1.5 -1.6
Ulcerative Colitis (UC) 2.5 4.6 6.2 2.5 -1.4 -2.0 -2.2 -2.5
Major Depression (MDD) 0.8 1.0 2.8 0.3 1.7 1.4 0.1 0.5
Reaction Time 0.4 0.8 2.2 1.1 -0.1 -0.3 -0.8 -1.5
Verbal and Numeric Reasoning (VNR) 2.5 6.0 8.4 -2.9 2.4 2.0 2.9 1.9
Breast Cancer 1.2 2.8 3.8 1.9 -1.4 -1.2 -2.0 -1.8
Ovarian Cancer 0.2 0.3 0.4 0.5 0.6 0.3 -0.5 0.7
Prostate Cancer 0.7 1.0 1.6 -1.1 1.1 1.0 1.3 -0.2
Age at First Birth 0.2 0.3 0.7 -0.2 0.8 0.7 0.4 -0.7
Bipolar Disorder (2011) 1.1 1.0 2.3 -1.4 0.9 0.4 1.5 -0.2
Body Mass Index (BMI) (2010) 3.0 4.1 7.3 -2.1 1.6 1.4 2.1 2.7
Coronary Artery Disease (CAD) 3.3 3.9 6.5 1.0 -2.2 -2.0 -1.7 -2.5
Crohns Disease (2012) 0.1 0.2 0.7 -0.2 0.4 -0.1 0.3 0.8
Mean Putamen Volume 0.3 0.3 0.9 -1.0 0.1 0.0 0.7 0.3
Fasting Glucose 0.1 0.2 0.7 0.8 -0.3 0.3 -0.3 0.1
HbA1C 0.5 0.5 1.5 0.2 -1.2 -0.5 -0.9 0.1
HDL Cholesterol 4.1 6.9 9.7 3.1 -2.3 -2.3 -3.0 -2.2
LDL Cholesterol 0.5 0.7 1.3 -0.9 0.6 0.6 1.0 1.1
Lupus 4.0 6.1 8.5 2.3 -2.5 -2.1 -2.4 -2.9
Neuroticism (2016) 0.5 0.8 1.3 -1.1 1.1 0.6 1.0 -0.2
Primary Biliary Cirrhosis 0.4 0.5 0.9 -0.8 0.6 0.3 1.0 0.8
Rheumatoid Arthritis 0.5 0.6 2.1 0.4 0.7 0.5 -0.3 1.5
Schizophrenia (2014) 1.3 2.9 3.4 1.4 -1.7 -1.8 -1.7 -1.8
Triglycerides 4.6 7.6 9.0 -2.9 2.2 2.8 3.0 2.9
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.3 0.4 0.3 -0.4 -0.5 0.5
Ulcerative Colitis 3.8 5.5 7.6 2.8 -1.7 -2.3 -2.5 -2.4
Blood Eosinophil Count 0.1 0.6 1.0 -0.3 0.8 1.0 0.7 0.9
Blood Platelet Count 0.4 4.2 7.3 -2.7 1.6 1.6 2.3 1.7
Blood Red Count 0.0 0.1 0.3 -0.3 0.5 0.2 -0.1 0.1
Blood White Count 0.2 1.5 3.0 -1.7 1.0 0.9 1.6 0.4
Heel T-Score 1.0 7.7 9.9 -3.1 3.0 2.7 2.9 2.0
BMI 0.0 0.3 0.4 0.2 -0.6 -0.6 -0.5 -0.5
Height 0.1 1.0 1.4 1.0 -0.9 -1.2 -1.1 -0.7
Waist Hip Ratio (WHR) 0.3 1.5 1.9 -1.2 1.3 1.2 1.0 1.4
Systolic Blood Pressure 0.5 2.7 4.8 -2.2 1.7 1.4 1.9 0.4
Smoking Status 0.4 1.1 1.9 1.1 -0.8 -0.7 -1.0 -1.4
Allergy or Eczema 1.5 4.0 6.9 2.6 -1.9 -1.9 -2.4 -0.8
Cardiovascular Disease 1.7 5.7 7.2 -2.6 2.6 2.3 2.7 1.4
Hypothyroidism (self reported) 2.1 4.8 6.0 -2.0 2.2 2.4 1.7 2.5
Respiratory disease 0.4 0.8 1.4 1.2 -0.7 -0.9 -1.1 -0.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.6 -0.4 0.3 0.2 0.3 -0.8
Lung FEV1/FVC ratio 0.7 3.4 6.0 -2.0 1.3 1.6 1.6 2.5
Lung FVC 3.2 16.2 19.2 -4.2 3.8 4.0 4.4 3.7
Neuroticism 0.8 1.9 2.9 1.5 -1.0 -1.3 -1.3 -1.7
Chronotype (morning person) 0.1 0.3 1.0 0.6 -0.4 0.1 -0.2 -1.0
Hair Pigment 0.1 4.2 5.8 -2.3 1.8 2.2 2.4 1.5
Tanning 3.1 37.6 49.3 5.6 -7.0 -7.0 -5.7 -5.1
Hand grip strength (left) 0.6 1.5 6.2 -0.6 0.2 0.6 0.6 2.5
Number of treatments/medications taken 0.5 0.8 3.1 0.7 0.6 0.1 -0.5 -1.8
Average weekly spirits intake 0.2 0.2 0.5 -0.7 -0.4 -0.2 0.6 0.1
Sensitivity / hurt feelings 0.5 0.9 1.6 -0.6 1.3 1.0 1.2 0.5
Frequency of depressed mood in last 2 weeks 3.6 5.1 5.9 2.3 -2.4 -2.4 -1.9 -2.2
Hearing difficulty/problems: Yes 0.0 0.0 0.1 0.3 0.2 0.1 0.1 0.3
Relative age of first facial hair 3.2 6.7 7.8 -2.8 2.6 2.6 2.6 2.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.8 0.8 0.1 -0.2 -0.7 -0.9
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.9 1.0 -0.2 -0.1 -0.8 -0.5
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.4 -0.4 -0.3 -0.4 0.0
Systolic blood pressure, automated reading 0.1 0.2 0.5 -0.6 -0.0 -0.1 0.0 -0.7
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.6 -0.8 -0.2 0.2 0.5 0.2
Angina 1.5 1.9 6.3 1.0 -0.9 -1.0 -0.7 -2.5
Medication for hormone replacement therapy 0.4 0.5 0.8 -0.5 0.9 0.7 0.7 0.7
Vitamin and mineral supplements 1.0 1.4 1.9 1.4 -0.9 -0.9 -1.2 -1.3
Supplements: Zinc 3.7 4.0 5.3 -2.1 1.9 2.0 2.3 1.8
Medication: Co-codamol 0.3 0.3 0.7 -0.8 0.3 0.5 0.7 0.5
Medication: Metformin 0.4 0.5 2.6 -0.0 0.2 0.0 0.2 -1.6
Diabetes (father) 0.4 0.5 1.0 -0.6 1.0 0.7 0.7 0.7
Diabetes (mother) 0.6 0.7 1.4 -0.6 0.8 1.2 0.4 1.0
Severe depression (siblings) 1.7 1.9 3.2 0.9 -1.8 -1.7 -1.2 -1.0
Pack years adult smoking proportion 2.6 4.0 7.8 1.9 -1.7 -2.0 -1.3 -2.8
Impedance of leg (right) 1.0 4.7 5.6 -2.3 2.4 1.9 2.2 2.0
Leg fat-free mass (left) 0.2 1.0 1.6 0.9 -1.3 -1.1 -1.0 -0.5
Trunk fat percentage 0.0 0.1 0.2 -0.3 0.1 0.0 -0.0 -0.5
Hand grip strength (right) 0.8 2.1 5.9 -1.2 0.6 0.9 1.5 2.4
Townsend deprivation index at recruitment 0.4 0.5 1.3 0.8 -0.0 -0.2 -0.7 -1.2
Current tobacco smoking 1.3 2.1 5.3 1.3 -1.1 -1.0 -1.1 -2.3
Average weekly fortified wine intake 0.1 0.1 0.3 0.1 -0.2 -0.3 -0.4 -0.5
Maternal smoking around birth 2.9 4.3 5.7 2.1 -2.0 -2.0 -1.7 -2.4
Fed-up feelings 4.7 8.5 11.1 2.9 -3.1 -3.3 -2.7 -2.5
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.2 6.8 2.6 -1.8 -1.9 -2.3 -1.6
Relative age voice broke 2.8 4.3 5.8 -2.4 2.1 1.9 2.2 1.8
Taking other prescription medications 0.1 0.2 0.6 -0.1 0.6 0.2 0.1 -0.8
Age when periods started (menarche) 2.3 5.5 6.5 -2.4 2.2 2.1 2.5 2.5
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.4 0.5 0.2 0.4 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.6 0.8 -0.8 0.9 0.5 0.7 0.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.4 1.0 -0.7 0.4 0.2 1.0 -0.3
Qualifications: CSEs or equivalent 0.3 0.4 0.9 -0.6 0.5 0.5 0.9 0.2
Serious illness, injury or assault to yourself 0.2 0.2 0.6 0.2 0.8 0.6 -0.0 0.4
High blood pressure 0.1 0.2 0.5 -0.1 0.4 0.3 0.3 -0.7
Hayfever, allergic rhinitis or eczema 0.7 1.4 3.3 1.8 -0.8 -0.9 -1.5 -0.2
Multivitamins +/- minerals 0.6 0.8 1.6 -1.1 0.4 0.3 1.0 1.2
Stomach or abdominal pain in last month 0.5 0.6 1.8 0.5 -0.6 -0.5 -0.5 -1.4
Supplements: Glucosamine 0.2 0.2 0.5 -0.5 0.4 0.4 0.7 0.3
Diverticular disease/diverticulitis (self-reported) 1.8 2.2 3.1 1.2 -1.8 -1.7 -1.3 -1.3
Medication: Atenolol 2.1 2.7 4.1 1.9 -1.3 -1.3 -1.6 -2.0
Medication: Levothyroxine sodium 0.2 0.3 0.6 -0.3 0.7 0.7 0.3 0.4
Sitting height 0.0 0.0 0.1 -0.2 -0.2 -0.4 0.0 0.2
Chronic bronchitis/emphysema (father) 1.1 1.3 2.7 0.8 -1.3 -1.6 -0.9 -0.7
High blood pressure (mother) 2.3 3.3 4.5 -1.8 1.9 1.8 1.4 2.1
Body mass index (BMI) 0.1 0.5 0.6 0.6 -0.6 -0.7 -0.8 -0.7
Impedance of leg (left) 0.9 4.6 5.9 -2.2 2.4 2.0 2.2 1.8
Leg predicted mass (left) 0.2 1.0 1.6 0.9 -1.2 -1.1 -1.0 -0.5
Trunk fat mass 0.0 0.1 0.4 -0.0 -0.2 -0.3 -0.3 -0.6
Waist circumference 0.0 0.1 0.1 0.2 -0.0 -0.3 -0.3 -0.3
Number of incorrect matches in round 0.9 1.6 3.3 0.2 -1.3 -1.8 -0.5 -1.6
Past tobacco smoking 0.3 0.5 1.4 -1.2 0.0 0.1 1.0 0.4
Alcohol usually taken with meals 0.2 0.4 0.8 0.6 0.3 0.9 -0.4 0.6
Nervous feelings 0.2 0.4 0.8 -0.9 -0.3 -0.3 0.9 -0.0
Frequency of tenseness / restlessness in last 2 weeks 3.4 5.2 7.7 2.8 -1.7 -1.8 -2.2 -2.7
Hearing difficulty/problems with background noise 0.9 1.4 2.5 1.6 -0.9 -1.2 -1.1 -1.2
Hair/balding pattern: Pattern 2 0.6 0.8 1.0 -1.0 0.9 1.0 1.0 0.1
Had menopause 0.5 0.6 1.1 1.0 -0.6 -0.5 -1.0 -0.7
Had other major operations 0.1 0.2 0.3 -0.4 -0.3 -0.3 0.4 0.5
Forced vital capacity (FVC) 2.0 7.6 10.2 -2.9 2.1 2.5 3.0 3.2
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 1.8 -1.2 1.3 1.1 1.1 1.0
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 5.6 0.5 -0.6 -0.6 -0.5 -2.4
Qualifications: None of the above 1.5 3.2 7.2 1.2 -1.5 -2.0 -1.0 -2.7
Financial difficulties in last 2 years 3.2 4.3 5.9 2.2 -2.1 -1.9 -2.4 -1.7
Mouth/teeth dental problems 0.4 0.6 2.8 0.0 0.5 0.1 -0.0 1.7
Heart attack 1.0 1.2 2.1 -0.9 1.5 1.4 1.1 0.0
Allergy 1.0 2.3 4.5 -2.1 1.1 1.2 1.8 0.9
Pain all over the body in last month 0.4 0.5 0.7 0.8 0.8 0.6 -0.6 0.6
Diabetes (self-reported) 0.1 0.2 0.7 -0.2 0.4 0.4 0.2 -0.8
Hayfever/allergic rhinitis (self-reported) 3.5 4.7 6.0 -2.1 2.1 2.1 2.1 2.4
Medication: Ramipril 1.4 1.8 3.5 -1.3 1.3 1.4 1.9 -0.5
Medication: Simvastatin 0.3 0.5 1.0 0.3 0.9 0.4 0.3 -1.0
Fluid intelligence score 4.5 9.3 13.0 -3.6 3.0 2.6 3.4 2.5
Illnesses of siblings 0.1 0.2 0.6 -0.1 0.4 0.4 0.1 0.8
Neuroticism score 0.7 1.5 2.2 1.5 -0.9 -1.3 -1.0 -1.5
Weight 0.1 0.4 0.6 0.5 -0.6 -0.8 -0.8 -0.6
Impedance of arm (right) 0.1 0.3 0.5 -0.7 0.4 0.3 0.7 0.5
Arm fat percentage (right) 0.0 0.1 0.3 0.2 -0.4 -0.4 -0.6 -0.1
Trunk fat-free mass 0.1 0.7 1.1 0.6 -1.1 -1.0 -1.0 -0.2
Hip circumference 0.2 0.9 1.4 0.5 -1.1 -1.2 -0.7 -0.9
Time employed in main current job 1.0 1.1 2.9 -1.4 0.4 0.7 1.7 -0.4
Alcohol intake versus 10 years previously 0.6 0.9 1.4 -0.6 1.1 0.7 0.8 1.2
Father’s age at death 1.6 2.2 4.6 -1.3 1.4 1.3 0.9 2.1
Worrier / anxious feelings 0.2 0.3 1.0 -0.4 0.3 0.2 0.5 -1.0
Frequency of tiredness / lethargy in last 2 weeks 4.4 7.2 8.4 2.9 -2.3 -2.9 -2.6 -2.7
Falls in the last year 1.0 1.4 3.6 1.1 -0.7 -0.6 -1.0 -1.9
Hair/balding pattern: Pattern 3 0.1 0.2 0.5 0.4 -0.5 -0.7 -0.4 -0.0
Number of live births 0.1 0.1 0.1 -0.4 -0.3 -0.1 0.3 -0.3
Forced expiratory volume in 1-second (FEV1) 3.6 12.3 16.0 -3.9 2.4 3.1 3.8 4.0
Pulse rate 0.8 1.3 4.2 0.5 -0.7 -1.1 -0.6 -2.0
Happiness 2.7 3.3 6.2 1.6 -2.5 -2.2 -1.2 -1.1
Noisy workplace 1.9 2.3 3.4 1.2 -1.8 -1.8 -1.1 -1.6
Qualifications: A levels/AS levels or equivalent 0.5 1.0 1.9 -0.7 0.9 1.2 0.8 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 1.6 0.8 -1.1 -0.9 -1.1 -1.2
Mouth/teeth dental problems: Dentures 0.3 0.4 1.8 -0.2 0.0 0.4 0.5 -1.3
Asthma 0.3 0.5 0.9 1.0 -0.5 -0.8 -0.8 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 0.3 -0.7 -0.4 -0.3 -0.4
Medication: Cholesterol lowering 0.2 0.4 0.7 -0.5 0.9 0.5 0.6 -0.3
Depression (self-reported) 0.2 0.2 0.9 0.1 0.5 0.2 0.0 -0.9
Medication: Lansoprazole 0.4 0.5 0.8 0.6 -0.9 -0.7 -0.6 -0.7
Prospective memory result 0.3 0.4 1.9 0.4 -0.2 -0.2 -0.1 -1.4
Lung cancer (father) 4.9 5.8 8.3 2.0 -2.5 -2.5 -2.0 -2.9
Illnesses of mother 2.0 2.5 4.0 1.7 -2.0 -1.7 -1.4 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 9.9 12.4 -3.5 2.4 2.9 3.3 3.5
Pulse wave Arterial Stiffness index 0.1 0.1 0.2 -0.2 -0.3 0.1 -0.5 -0.1
Impedance of arm (left) 0.2 1.1 1.8 -1.3 1.0 0.8 1.3 0.8
Arm fat mass (right) 0.0 0.2 0.3 0.3 -0.5 -0.5 -0.5 -0.2
Trunk predicted mass 0.1 0.6 0.9 0.6 -0.9 -0.9 -0.9 0.0
Standing height 0.0 0.0 0.1 -0.2 -0.2 -0.2 0.0 0.2
Length of working week for main job 0.5 0.5 1.3 -0.6 0.5 0.6 0.7 1.1
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.1 0.5 0.6 0.2 0.7
Breastfed as a baby 2.7 3.3 7.0 -1.6 1.4 1.6 1.6 2.6
Tense / ‘highly strung’ 0.5 0.8 2.9 0.7 -0.2 -0.5 -0.7 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.2 1.2 0.6 0.2 -0.8 -1.5
Hair/balding pattern: Pattern 4 0.2 0.5 1.3 1.1 -0.5 -0.4 -0.9 -0.4
Birth weight of first child 1.1 2.0 3.5 1.2 -1.8 -1.9 -1.1 -0.9
Peak expiratory flow (PEF) 3.2 7.5 11.4 -2.8 1.9 2.6 2.9 3.4
Pulse wave reflection index 1.4 1.7 2.8 1.2 -1.7 -1.2 -1.6 -0.6
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 -0.3 0.2 0.1 0.6 -0.5
Loud music exposure frequency 2.5 2.8 5.1 1.3 -1.7 -1.7 -1.2 -2.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 3.1 -0.9 1.2 1.1 0.9 1.8
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 2.2 1.3 -1.1 -1.2 -1.5 -1.5
Blood clot in the leg (DVT) 0.6 0.7 1.5 1.2 -0.8 -0.4 -1.0 -0.5
Medication: Paracetamol 0.1 0.1 0.5 -0.1 0.0 -0.3 0.2 -0.7
Headache pain in last month 0.1 0.1 0.2 -0.3 0.2 0.1 0.4 -0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.8 0.3 -0.9 -0.8 -0.3 0.5
Glaucoma (self-reported) 0.1 0.2 0.8 -0.0 -0.1 -0.0 0.1 -0.9
Gout (self-reported) 0.5 0.7 0.9 0.9 -0.5 -0.8 -0.9 -0.8
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.4 -1.1 1.1 1.6 1.0 1.2
Medication: Amlodipine 0.2 0.3 0.7 0.8 0.1 -0.2 -0.7 -0.6
Medication: Ventolin 100micrograms inhaler 0.7 0.9 1.3 1.1 -0.5 -0.7 -1.2 -1.1
Birth weight 0.4 0.8 1.6 -1.3 0.6 0.2 1.2 0.7
Chronic bronchitis/emphysema (mother) 3.8 4.4 5.6 2.3 -1.6 -1.9 -2.1 -2.4
High blood pressure (siblings) 0.9 1.3 1.7 -1.0 1.1 1.1 1.1 1.3
Forced vital capacity (FVC), Best measure 1.8 6.7 8.7 -2.8 2.0 2.3 2.8 3.0
Body fat percentage 0.0 0.1 0.1 -0.3 0.3 0.1 0.0 -0.3
Leg fat percentage (right) 0.0 0.1 0.2 -0.4 0.4 0.1 0.2 -0.1
Arm fat-free mass (right) 0.0 0.1 0.2 0.1 -0.4 -0.4 -0.3 -0.1
Exposure to tobacco smoke outside home 0.2 0.3 0.6 0.6 0.2 -0.4 -0.8 -0.4
Comparative body size at age 10 0.0 0.1 0.2 0.0 0.5 0.5 0.3 0.4
Number of full brothers 2.6 3.3 6.5 -1.5 1.7 1.8 1.4 2.5
Worry too long after embarrassment 0.0 0.0 0.1 0.3 0.3 0.0 -0.0 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 1.5 0.3 0.2 -0.1 0.1 -1.2
Wheeze or whistling in the chest in last year 1.7 3.0 4.0 2.0 -1.5 -2.0 -1.8 -1.4
Number of children fathered 1.4 1.6 2.0 -1.3 1.4 1.4 1.2 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.5 0.7 -0.1 -0.3 -0.7 0.1
Age at first live birth 0.0 0.1 0.3 -0.3 0.1 0.2 -0.1 0.5
Pulse wave peak to peak time 0.1 0.1 0.3 0.1 0.5 0.1 0.6 0.3
Health satisfaction 1.3 1.7 2.5 0.9 -1.5 -1.5 -0.8 -1.6
Shortness of breath walking on level ground 2.2 2.6 5.1 1.4 -1.6 -1.5 -1.0 -2.2
Qualifications: College or University degree 0.4 1.3 2.9 -1.2 0.8 0.7 0.9 1.7
Eye problems/disorders: None of the above 0.6 0.7 1.1 1.0 -0.8 -0.7 -1.1 -0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.3 0.5 -1.1 -1.0 -0.1 -0.4
Emphysema/chronic bronchitis 0.5 0.6 1.0 0.8 -0.9 -1.0 -0.6 -0.3
Medication for pain relief, constipation, heartburn 1.0 1.7 7.1 -0.8 0.3 0.7 0.6 2.7
Neck or shoulder pain in last month 2.3 3.3 7.2 1.4 -1.2 -1.7 -1.7 -2.7
Medication: Blood pressure 0.3 0.5 2.0 0.6 0.1 0.1 -0.5 -1.4
Angina (self-reported) 1.4 1.9 6.8 0.9 -0.9 -0.9 -0.5 -2.6
Migraine (self-reported) 0.2 0.2 0.5 0.6 0.0 0.1 -0.7 -0.6
Medication: Ibuprofen 0.2 0.2 0.6 0.1 -0.7 -0.4 -0.1 -0.5
Medication: Allopurinol 0.3 0.4 0.9 0.5 -0.3 -0.9 -0.4 -0.8
Medication: Omeprazole 5.1 6.0 9.9 2.6 -2.0 -1.9 -2.4 -3.2
Medication: Seretide 50 evohaler 0.2 0.2 0.5 -0.3 0.3 0.3 0.7 -0.6
Mean time to correctly identify matches 0.9 1.8 4.4 1.5 -0.6 -0.8 -1.1 -2.1
Heart disease (mother) 0.4 0.4 0.7 -0.8 0.7 0.7 0.6 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.1 0.2 -0.2 -0.0 0.1 -0.4 0.2
Whole body fat mass 0.0 0.1 0.1 -0.0 -0.2 -0.3 -0.3 -0.4
Leg fat mass (right) 0.0 0.2 0.3 0.3 -0.3 -0.6 -0.5 -0.4
Arm predicted mass (right) 0.0 0.1 0.1 0.1 -0.3 -0.3 -0.4 0.2
Pulse rate, automated reading 0.1 0.4 0.8 0.5 -0.4 -0.8 -0.5 -0.9
Alcohol intake frequency. 0.0 0.1 0.3 0.5 -0.0 -0.3 -0.4 -0.2
Comparative height size at age 10 0.1 0.4 0.7 0.3 -0.8 -0.9 -0.3 -0.8
Number of full sisters 1.4 1.7 2.6 -0.9 1.6 1.2 1.2 1.4
Suffer from ‘nerves’ 0.2 0.3 0.7 -0.2 0.8 0.6 0.5 -0.2
Overall health rating 2.3 4.9 9.9 1.8 -2.0 -2.3 -1.6 -3.1
Chest pain or discomfort 0.4 0.5 1.7 0.4 -0.5 -0.7 -0.3 -1.3
Had major operations 0.7 0.8 1.7 1.0 -0.7 -0.6 -1.3 -0.9
Age at last live birth 0.9 1.3 2.0 -1.1 1.3 1.4 0.9 0.9
Family relationship satisfaction 0.2 0.3 0.8 -0.4 -0.5 -0.4 0.9 -0.2
Leg pain on walking 1.7 2.1 3.6 0.9 -1.9 -1.9 -0.9 -1.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 2.3 1.1 -1.2 -1.5 -1.2 -1.0
Commuting to job workplace: Car/motor vehicle 1.9 2.2 3.7 0.9 -1.9 -1.7 -1.2 -1.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.2 -0.1 -0.4 0.8 0.2
Medication: Aspirin 1.4 1.9 3.2 -1.3 1.8 1.4 1.4 -0.9
Supplements: Vitamin C 1.0 1.1 2.1 -1.5 1.1 0.8 1.3 0.2
Knee pain experienced in last month 4.2 6.6 8.8 2.1 -2.9 -3.0 -1.6 -3.0
Hypertension (Self-reported) 0.1 0.3 0.6 -0.5 0.4 0.4 0.8 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.9 4.6 7.6 1.8 -2.2 -2.2 -1.4 -2.8
Illnesses of father: Heart disease 0.2 0.2 0.5 -0.5 0.2 0.2 0.7 0.5
Illnesses of siblings: Diabetes 0.1 0.2 0.7 0.2 0.3 0.3 -0.2 -0.8
Smoking status: Previous 0.2 0.2 0.5 0.7 0.1 0.1 -0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.0 -1.0 0.6 0.6 0.9 1.0
Whole body fat-free mass 0.1 0.6 0.9 0.6 -1.0 -0.8 -0.9 -0.2
Leg fat-free mass (right) 0.2 1.2 1.8 1.1 -1.4 -1.1 -1.1 -0.8
Arm fat percentage (left) 0.0 0.0 0.0 -0.2 -0.0 -0.0 -0.1 0.1
Average weekly red wine intake 0.1 0.2 0.4 0.2 0.4 0.7 -0.2 0.3
Handedness (chirality/laterality): Left-handed 2.5 3.0 4.2 1.5 -1.8 -2.1 -1.6 -1.6
Mood swings 0.8 1.5 2.0 1.3 -1.3 -1.4 -0.8 -1.3
Loneliness, isolation 3.7 5.1 8.5 2.1 -1.7 -2.2 -2.2 -2.9
Long-standing illness, disability or infirmity 1.2 1.8 5.6 1.1 -0.6 -0.9 -1.0 -2.4
Ever had bowel cancer screening 8.1 9.5 11.3 3.1 -2.7 -3.4 -3.1 -3.2
Diabetes diagnosed by doctor 0.3 0.5 2.2 0.3 -0.2 -0.3 -0.3 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 4.8 5.1 7.2 -2.6 2.1 2.7 2.3 1.4
Friendships satisfaction 0.2 0.2 0.9 0.4 -0.0 -0.2 0.1 -1.0
Qualifications: nursing, teaching 0.6 0.9 2.6 -0.7 0.7 0.9 0.4 1.6
Commuting to job workplace: Walk 1.2 1.3 2.4 -1.6 0.7 0.5 1.3 1.4
Eye problems/disorders: Cataract 1.4 1.6 2.0 -1.2 1.4 1.4 1.4 0.8
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.1 -1.0 0.8 1.0 0.9 0.4
Medication for cholesterol 2.7 4.1 6.2 1.8 -2.5 -2.2 -2.5 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.1 -0.7 0.1 0.3 0.5 -1.1
Back pain experienced in last month 1.3 1.9 3.5 1.4 -1.1 -1.3 -1.1 -1.9
Mineral and other dietary supplements 0.7 1.0 1.3 1.0 -1.1 -1.0 -1.0 -0.7
Breast cancer (self-reported) 0.1 0.2 0.3 0.4 0.0 -0.4 -0.6 -0.4
Asthma (self-reported) 0.0 0.1 0.2 0.5 -0.1 -0.3 -0.2 -0.0
Osteoporosis (self-reported) 0.4 0.4 0.8 0.7 -0.2 -0.6 -0.7 -0.9
Osteoarthritis (self-reported) 2.8 3.7 5.0 2.2 -1.9 -1.7 -2.2 -1.4
Medication: Aspirin 1.7 2.2 4.1 -1.3 2.0 1.6 1.5 -0.7
Medication: Gliclazide 0.3 0.3 1.4 -0.0 0.0 -0.5 -0.2 -1.2
Illnesses of father: None of the above (group 1) 0.3 0.4 1.0 0.7 -0.3 -0.2 -0.7 -1.0
Smoking status: Current 1.8 2.9 6.9 1.4 -1.4 -1.4 -1.3 -2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 3.6 -1.7 0.6 1.0 1.1 1.9
Whole body water mass 0.1 0.7 1.1 0.7 -1.1 -0.9 -0.9 -0.3
Leg predicted mass (right) 0.2 1.3 2.0 1.1 -1.4 -1.2 -1.2 -0.8
Arm fat mass (left) 0.0 0.1 0.1 0.1 -0.3 -0.4 -0.3 0.0
Number of self-reported non-cancer illnesses 0.4 0.6 1.2 -0.2 1.0 0.7 0.6 -1.1
Average weekly champagne plus white wine intake 0.1 0.2 0.4 -0.2 -0.6 -0.1 0.2 0.5
Miserableness 1.9 3.3 5.3 2.3 -1.4 -1.7 -1.8 -1.7
Guilty feelings 1.6 2.4 4.9 1.8 -0.8 -1.3 -1.3 -2.2
Wears glasses or contact lenses 0.8 0.9 1.7 0.9 -0.5 -1.0 -1.3 -0.8
Ever taken oral contraceptive pill 0.8 0.9 2.7 -0.1 -1.6 -1.3 0.2 -0.3
Hearing aid user 0.1 0.1 0.2 0.4 -0.2 -0.4 -0.3 -0.2
Mother’s age at death 2.5 3.2 5.0 -2.2 1.3 1.6 1.5 2.1
Financial situation satisfaction 1.5 1.9 3.1 1.4 -1.8 -1.4 -1.1 -1.2
Tinnitus: Yes, now most or all of the time 0.6 0.8 2.2 -0.0 -1.5 -1.1 0.1 -0.7
Commuting to job workplace: Public transport 3.1 3.6 6.7 -1.5 2.6 2.4 1.6 0.9
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.4 0.2 0.3 0.5 0.2
Medication: Blood pressure 0.9 1.8 4.0 -1.4 1.1 1.2 2.0 -0.2
Pain type(s) experienced in last month: Hip pain 2.5 3.2 4.5 2.0 -1.4 -1.5 -1.8 -2.1
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.2 -1.1 0.8 0.8 1.0 0.4
High cholesterol (Self-reported) 4.3 7.6 10.7 -2.5 3.3 2.9 3.0 1.9
Medication: Bendroflumethiazide 0.4 0.6 2.9 0.2 -0.3 -0.4 0.0 -1.7
Medication: Paracetamol 0.2 0.2 0.9 -0.3 0.3 0.1 0.4 -0.9
Medication: Lisinopril 0.8 1.0 2.1 -1.4 0.7 0.7 1.3 0.4
Medication: Atorvastatin 5.4 6.7 9.8 -3.0 2.1 2.7 3.1 1.5
Illnesses of father: High blood pressure 2.1 2.6 3.6 -1.4 1.7 1.9 1.6 1.4
Alcohol drinker status: Never 0.2 0.3 0.6 -0.3 0.7 0.2 0.2 0.7
Ever smoked 0.3 0.5 1.5 1.2 0.2 0.2 -0.8 -0.4
Basal metabolic rate 0.1 0.6 0.9 0.6 -0.9 -0.9 -0.9 -0.2
Leg fat percentage (left) 0.0 0.2 0.3 -0.5 0.6 0.3 0.4 -0.2
Arm fat-free mass (left) 0.1 0.3 0.5 0.4 -0.6 -0.6 -0.7 -0.1
Number of operations (self-reported) 0.1 0.2 0.4 0.1 -0.2 -0.1 -0.6 0.6
Average weekly beer plus cider intake 0.4 0.6 1.1 1.0 -0.3 -0.6 -1.1 -0.6
Irritability 0.4 0.7 1.2 0.9 -0.7 -0.8 -0.6 -1.1
Risk taking 0.4 0.5 0.8 -0.9 0.8 0.7 0.7 0.4
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.1 0.1 0.1 -0.3 -0.5
Fractured/broken bones in last 5 years 0.1 0.2 0.4 0.6 0.1 0.0 -0.5 -0.4
Age started oral contraceptive pill 0.1 0.1 0.2 0.4 -0.2 -0.3 -0.3 -0.5
Diastolic blood pressure, automated reading 0.2 0.6 1.2 0.3 -0.8 -1.1 -1.0 0.0
Ever depressed for a whole week 0.3 0.4 1.3 -0.1 0.5 0.3 0.4 -1.2
Unable to work because of sickness or disability 8.7 11.2 16.9 3.2 -3.0 -3.2 -3.1 -4.1
Commuting to job workplace: Cycle 0.2 0.3 0.6 0.4 0.6 0.4 -0.7 0.5
Myopia 0.3 0.5 1.1 0.8 -0.4 -0.4 -0.5 -1.0
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.2 0.8 -0.9 -0.8 -1.1 0.8
Cholesterol lowering medication 2.3 3.3 5.8 -1.3 2.4 2.2 2.1 0.2
Medication: Omeprazole (e.g. Zanprol) 2.1 2.5 6.0 1.6 -1.0 -1.0 -1.4 -2.4
Pain experienced in last month 1.4 2.3 5.3 -1.6 0.5 1.1 1.5 2.3
Supplements: Calcium 2.8 3.1 4.2 -1.8 1.6 1.5 2.1 1.8
Basal cell carcinoma (self-reported) 2.1 2.5 3.5 1.8 -0.9 -1.4 -1.9 -1.8
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.3 -1.0 1.5 1.4 1.1 0.3
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.1 1.1 -0.8 -0.4 -0.9 -0.5
Heart disease (siblings) 0.6 0.8 1.3 0.9 -0.1 -0.9 -0.9 -1.2
Alcohol drinker status: Previous 0.3 0.4 0.5 0.6 -0.7 -0.6 -0.6 -0.5
Pack years of smoking 2.6 3.9 7.6 1.9 -1.6 -2.0 -1.3 -2.7
Impedance of whole body 0.4 2.0 2.6 -1.6 1.5 1.2 1.6 1.1
Leg fat mass (left) 0.0 0.1 0.2 0.2 -0.2 -0.4 -0.4 -0.4
Arm predicted mass (left) 0.1 0.4 0.7 0.6 -0.7 -0.6 -0.8 -0.1