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chr17:78,810,687-80,357,420

Best TWAS P=4.33e-12 · Best GWAS P=1.69e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MRPL12	0.04	0.02	lasso	4	0.03	3.8e-04	3.6	6.3	3.2e-10	-0.49	0.21	0.36	TRUE
2	GTEx	Artery Aorta	C17orf70	0.14	0.03	lasso	7	0.01	5.3e-02	6.3	-6.8	1.3e-11	0.67	0.09	0.60	TRUE
3	GTEx	Cells EBV-transformed lymphocytes	NPLOC4	0.20	0.01	enet	13	0.01	1.7e-01	3.2	5.5	3.4e-08	-0.43	0.12	0.34	FALSE
4	GTEx	Cells Transformed fibroblasts	HGS	0.09	0.11	lasso	3	0.10	5.9e-08	4.7	-5.4	8.1e-08	0.47	0.96	0.02	FALSE
5	GTEx	Esophagus Muscularis	NPLOC4	0.12	0.00	lasso	3	0.00	4.4e-01	5.3	5.2	1.7e-07	-0.49	0.06	0.05	FALSE
6	GTEx	Testis	NPLOC4	0.52	0.23	lasso	6	0.35	1.6e-16	4.1	-5.2	2.6e-07	0.52	1.00	0.00	FALSE
7	The Cancer Genome Atlas	Colon Adenocarcinoma	NPLOC4	0.08	0.04	blup	65	0.06	3.4e-04	6.2	-6.5	7.7e-11	0.67	0.18	0.44	TRUE
8	The Cancer Genome Atlas	Colon Adenocarcinoma	TSPAN10	0.21	0.11	lasso	3	0.13	4.2e-08	6.3	6.0	1.6e-09	-0.53	0.98	0.01	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TSPAN10	0.04	0.02	blup	43	0.03	3.1e-04	6.3	6.9	4.3e-12	-0.72	0.02	0.82	TRUE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDE6G	0.11	0.01	blup	46	0.04	9.2e-06	6.3	-5.6	1.8e-08	0.44	0.31	0.08	FALSE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSPAN10	0.16	0.10	enet	11	0.13	1.6e-14	6.3	5.7	1.3e-08	-0.50	1.00	0.00	TRUE
12	The Cancer Genome Atlas	Lung Adenocarcinoma	TSPAN10	0.14	0.11	lasso	5	0.13	3.8e-15	5.2	5.7	9.3e-09	-0.52	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC25A10	0.03	0.02	enet	6	0.03	5.1e-04	7.2	6.3	3.6e-10	-0.60	0.30	0.07	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TSPAN10	0.09	0.10	lasso	7	0.09	1.6e-10	6.3	6.4	1.2e-10	-0.56	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TSPAN10	0.11	0.14	lasso	5	0.14	1.9e-09	6.3	6.3	4.0e-10	-0.55	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Rectum Adenocarcinoma	TSPAN10	0.23	0.22	blup	43	0.21	1.0e-05	6.3	6.0	2.2e-09	-0.52	0.28	0.09	FALSE
17	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TSPAN10	0.26	0.22	lasso	6	0.22	3.7e-08	6.3	5.7	1.0e-08	-0.52	0.94	0.03	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	TSPAN10	0.28	0.25	blup	43	0.24	1.1e-23	6.3	5.1	3.0e-07	-0.45	1.00	0.00	FALSE