Best TWAS P=2.5e-36 · Best GWAS P=1.82e-65 conditioned to 1.71e-21
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100506714 | 0.07 | 0.01 | bslmm | 672 | 0.03 | 1.6e-04 | -1.436 | 8.1 | 4.4e-16 | 0.40 | 0.16 | 0.28 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | KIAA0930 | 0.22 | 0.02 | enet | 25 | 0.05 | 2.9e-03 | -2.264 | -6.4 | 2.0e-10 | -0.37 | 0.20 | 0.06 | FALSE |
| 3 | GTEx | Liver | NUP50 | 0.64 | 0.02 | enet | 53 | 0.11 | 5.2e-04 | -9.358 | -5.5 | 3.8e-08 | -0.14 | 0.10 | 0.06 | TRUE |
| 4 | GTEx | Muscle Skeletal | CTA-217C2.1 | 0.11 | 0.10 | lasso | 2 | 0.13 | 4.6e-13 | -2.064 | 5.2 | 2.4e-07 | 0.32 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Nerve Tibial | CTA-217C2.1 | 0.16 | 0.01 | lasso | 6 | 0.04 | 1.2e-03 | -2.064 | 5.8 | 8.5e-09 | 0.30 | 0.17 | 0.03 | FALSE |
| 6 | GTEx | Whole Blood | KIAA0930 | 0.17 | 0.00 | enet | 42 | 0.02 | 1.4e-02 | 0.063 | -6.1 | 9.2e-10 | -0.33 | 0.06 | 0.39 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C22orf9 | 0.03 | 0.03 | lasso | 1 | 0.02 | 7.6e-06 | 10.310 | -10.3 | 6.4e-25 | -0.62 | 0.64 | 0.03 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C22orf9 | 0.04 | 0.01 | blup | 100 | 0.01 | 3.7e-02 | 10.369 | -10.9 | 1.2e-27 | -0.61 | 0.13 | 0.16 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C22orf9 | 0.09 | 0.03 | blup | 100 | 0.06 | 1.4e-06 | 10.386 | -12.6 | 2.5e-36 | -0.69 | 0.13 | 0.84 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | C22orf9 | 0.07 | 0.00 | blup | 100 | 0.03 | 7.4e-04 | -3.539 | -11.6 | 2.6e-31 | -0.58 | 0.03 | 0.62 | FALSE |