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chr22:37,337,772-40,479,448

Best TWAS P=1.64e-12 · Best GWAS P=5.21e-13 conditioned to 0.852

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	BAIAP2L2	0.11	0.03	lasso	5	0.04	1.8e-04	5.5	-5.8	8.8e-09	-0.69	0.07	0.72	FALSE
2	GTEx	Artery Aorta	SYNGR1	0.16	0.08	lasso	3	0.09	9.3e-06	5.9	-5.6	1.8e-08	-0.02	0.00	1.00	FALSE
3	GTEx	Brain Cortex	TMEM184B	0.29	0.12	lasso	7	0.09	1.6e-03	6.7	-6.3	2.5e-10	-0.90	0.02	0.81	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	PLA2G6	0.28	0.17	enet	13	0.18	1.3e-06	-5.2	5.9	4.5e-09	0.74	0.06	0.91	FALSE
5	GTEx	Cells Transformed fibroblasts	PLA2G6	0.23	0.09	lasso	9	0.10	9.9e-08	6.0	6.4	1.2e-10	0.84	0.07	0.93	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	PLA2G6	0.28	0.24	lasso	5	0.23	1.1e-08	-5.2	5.6	1.8e-08	0.69	0.20	0.77	FALSE
7	GTEx	Esophagus Mucosa	PLA2G6	0.22	0.02	lasso	6	0.04	1.9e-03	6.0	6.3	3.5e-10	0.77	0.13	0.84	FALSE
8	GTEx	Nerve Tibial	PLA2G6	0.34	0.08	lasso	8	0.11	2.9e-08	-5.2	6.1	9.8e-10	0.75	0.03	0.97	FALSE
9	GTEx	Nerve Tibial	MAFF	0.14	0.06	lasso	3	0.05	1.2e-04	7.0	-7.1	1.6e-12	-0.94	0.01	0.98	TRUE
10	GTEx	Pancreas	PLA2G6	0.28	0.00	lasso	6	0.01	1.4e-01	-5.2	6.6	4.5e-11	0.44	0.08	0.25	FALSE
11	GTEx	Pituitary	SYNGR1	0.38	0.30	enet	11	0.25	6.3e-07	5.9	-5.8	7.5e-09	-0.01	0.00	1.00	FALSE
12	GTEx	Skin Sun Exposed Lower leg	BAIAP2L2	0.09	0.09	lasso	4	0.09	5.5e-08	5.0	-5.5	4.7e-08	-0.72	0.31	0.69	FALSE
13	GTEx	Thyroid	SYNGR1	0.14	0.17	enet	6	0.15	1.6e-11	5.9	-5.8	7.1e-09	-0.02	0.00	1.00	FALSE
14	GTEx	Thyroid	PLA2G6	0.34	0.20	lasso	5	0.18	4.5e-14	-5.2	5.7	1.0e-08	0.75	0.64	0.36	FALSE
15	GTEx	Thyroid	AL021977.1	0.20	0.11	lasso	6	0.12	2.7e-09	3.5	-5.2	1.6e-07	-0.69	0.54	0.46	FALSE
16	NTR	Blood	SH3BP1	0.02	0.00	blup	497	0.01	5.0e-03	-2.8	-5.7	9.6e-09	-0.12	0.07	0.25	TRUE
17	YFS	Blood	SYNGR1	0.31	0.36	bslmm	371	0.38	3.9e-135	4.5	5.4	8.3e-08	-0.09	0.86	0.14	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLA2G6	0.05	0.01	blup	76	0.01	7.7e-02	6.4	6.7	1.9e-11	0.76	0.02	0.66	FALSE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SYNGR1	0.09	0.05	enet	3	0.06	3.9e-04	-6.1	-6.4	2.0e-10	0.02	0.00	0.98	TRUE
20	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYNGR1	0.12	0.04	lasso	4	0.03	3.5e-04	5.9	-5.8	7.4e-09	0.02	0.00	0.95	FALSE
21	The Cancer Genome Atlas	Thyroid Carcinoma	PLA2G6	0.03	0.02	lasso	2	0.03	6.5e-04	6.6	6.5	1.1e-10	0.90	0.01	0.88	FALSE