Best TWAS P=4.89e-09 · Best GWAS P=2.86e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ACE | 0.08 | 0.05 | lasso | 4 | 0.04 | 1.0e-05 | -5.5 | -5.8 | 6.4e-09 | 0.82 | 0 | 1.00 | FALSE |
| 2 | GTEx | Colon Transverse | ACE | 0.31 | 0.28 | lasso | 2 | 0.28 | 1.8e-13 | -5.5 | 5.9 | 4.9e-09 | -0.98 | 0 | 1.00 | TRUE |
| 3 | The Cancer Genome Atlas | Colon Adenocarcinoma | ACE | 0.34 | 0.22 | lasso | 5 | 0.22 | 6.5e-13 | -4.6 | 5.2 | 2.1e-07 | -0.94 | 0 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACE | 0.16 | 0.08 | lasso | 2 | 0.07 | 5.8e-05 | -4.6 | 5.3 | 1.3e-07 | -0.96 | 0 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ACE | 0.13 | 0.14 | lasso | 1 | 0.10 | 6.6e-05 | -5.5 | 5.5 | 2.9e-08 | -1.00 | 0 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ACE | 0.16 | 0.14 | lasso | 6 | 0.13 | 5.1e-04 | -5.5 | 5.5 | 3.1e-08 | -0.95 | 0 | 0.84 | FALSE |