[Hub]/) : Traits : Alzheimer’s Disease (including proxy) :

chr19:44,190,626-46,967,227

Best TWAS P=1.89e-197 · Best GWAS P=1.75e-208 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CLPTM1 0.11 0.09 enet 10 0.08 2.0e-10 5.71 -9.2 2.3e-20 -0.01 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex PVR 0.22 0.17 enet 26 0.17 2.3e-20 -7.57 -5.7 1.6e-08 0.06 1.00 0.00 TRUE
3 CommonMind Brain Pre-frontal Cortex PVRL2 0.10 0.03 lasso 2 0.03 9.2e-05 -3.37 -13.5 1.4e-41 -0.07 0.68 0.03 TRUE
4 GTEx Adipose Subcutaneous CEACAM19 0.13 0.11 enet 9 0.12 4.6e-10 9.31 9.5 1.7e-21 -0.11 0.98 0.00 FALSE
5 GTEx Adipose Visceral Omentum ZNF285 0.17 0.05 enet 20 0.07 1.3e-04 -2.20 -20.1 1.9e-89 0.17 0.39 0.15 TRUE
6 GTEx Adrenal Gland CEACAM19 0.31 0.17 lasso 5 0.18 5.8e-07 9.31 8.4 4.9e-17 -0.12 0.21 0.06 FALSE
7 GTEx Artery Coronary CEACAM19 0.28 0.23 lasso 4 0.22 4.4e-08 9.31 8.4 5.7e-17 -0.11 0.62 0.02 FALSE
8 GTEx Artery Tibial VASP 0.08 0.00 enet 19 0.00 5.5e-01 -2.83 6.7 2.1e-11 -0.07 0.09 0.05 TRUE
9 GTEx Artery Tibial ZNF229 0.20 0.06 enet 40 0.05 7.2e-05 2.85 5.7 1.2e-08 -0.08 0.23 0.04 TRUE
10 GTEx Artery Tibial CEACAM19 0.26 0.14 lasso 12 0.20 2.7e-15 9.31 8.5 2.2e-17 -0.16 1.00 0.00 FALSE
11 GTEx Cells Transformed fibroblasts PVR 0.27 0.09 lasso 8 0.12 1.2e-09 -8.22 -6.2 4.3e-10 0.08 1.00 0.00 FALSE
12 GTEx Cells Transformed fibroblasts CEACAM19 0.35 0.26 lasso 2 0.28 8.7e-21 9.31 9.0 2.6e-19 -0.12 1.00 0.00 TRUE
13 GTEx Cells Transformed fibroblasts CTB-179K24.3 0.15 0.12 enet 7 0.09 1.6e-07 -3.08 -6.9 5.0e-12 0.10 0.99 0.00 TRUE
14 GTEx Colon Transverse CEACAM19 0.34 0.24 lasso 5 0.25 3.6e-12 9.31 8.6 9.6e-18 -0.15 1.00 0.00 FALSE
15 GTEx Esophagus Muscularis CEACAM19 0.19 0.06 lasso 5 0.08 8.6e-06 9.31 6.1 1.1e-09 -0.06 0.54 0.02 FALSE
16 GTEx Esophagus Muscularis CTB-179K24.3 0.15 0.10 enet 12 0.07 4.5e-05 -3.08 -5.2 1.8e-07 -0.05 0.44 0.02 TRUE
17 GTEx Liver PVRL2 0.29 0.24 lasso 4 0.21 1.4e-06 -9.68 9.6 8.9e-22 0.12 0.21 0.05 TRUE
18 GTEx Nerve Tibial CEACAM19 0.19 0.04 lasso 7 0.09 7.4e-07 9.31 7.0 2.5e-12 -0.14 0.27 0.03 FALSE
19 GTEx Pancreas BCAM 0.29 0.01 lasso 6 0.00 2.6e-01 3.49 -5.2 2.1e-07 0.11 0.04 0.09 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic ZNF229 0.28 0.09 enet 58 0.08 2.2e-05 -2.97 -21.4 6.2e-102 -0.03 0.17 0.16 FALSE
21 GTEx Skin Sun Exposed Lower leg PVR 0.11 0.05 lasso 2 0.06 2.1e-05 -7.57 -6.0 2.4e-09 0.04 0.84 0.01 FALSE
22 GTEx Stomach BCAM 0.33 0.00 enet 3 0.01 9.6e-02 2.58 -7.0 2.7e-12 0.09 0.07 0.07 FALSE
23 GTEx Testis CEACAM19 0.26 0.05 enet 33 0.06 1.1e-03 -7.57 8.2 1.8e-16 -0.15 0.18 0.05 TRUE
24 GTEx Thyroid CEACAM19 0.34 0.28 enet 26 0.30 9.9e-24 9.31 14.9 2.6e-50 -0.18 1.00 0.00 TRUE
25 METSIM Adipose CEACAM19 0.24 0.07 enet 29 0.12 7.7e-18 -2.39 7.9 2.3e-15 -0.13 1.00 0.00 FALSE
26 NTR Blood KLC3 0.02 0.00 blup 367 0.00 2.6e-02 -2.92 -6.8 1.5e-11 0.14 0.31 0.02 TRUE
27 NTR Blood SIX5 0.03 0.00 blup 381 0.00 2.6e-02 2.00 5.2 2.2e-07 -0.09 0.01 0.10 TRUE
28 YFS Blood TOMM40 0.04 0.00 bslmm 371 0.01 2.6e-04 -15.34 14.4 2.6e-47 0.09 0.03 0.36 TRUE
29 The Cancer Genome Atlas Breast Invasive Carcinoma APOC1 0.08 0.07 lasso 2 0.07 1.5e-13 7.50 7.5 5.3e-14 -0.02 1.00 0.00 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma APOC4 0.09 0.12 enet 6 0.11 5.9e-22 7.50 6.4 2.0e-10 0.01 1.00 0.00 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma APOE 0.06 0.05 lasso 2 0.04 7.9e-09 7.50 7.5 8.8e-14 -0.03 1.00 0.00 FALSE
32 The Cancer Genome Atlas Breast Invasive Carcinoma BLOC1S3 0.03 0.01 blup 31 0.02 1.4e-05 -0.87 7.7 1.3e-14 0.00 0.10 0.12 TRUE
33 The Cancer Genome Atlas Glioblastoma Multiforme GEMIN7 0.24 0.05 lasso 3 0.13 9.6e-05 11.02 10.0 1.6e-23 -0.14 0.01 0.64 TRUE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CEACAM16 0.04 0.00 enet 6 0.02 1.4e-03 -9.55 10.1 3.9e-24 -0.17 0.03 0.16 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma APOC1 0.05 0.03 enet 4 0.04 5.4e-05 7.50 6.5 9.0e-11 -0.01 0.55 0.01 TRUE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma APOC1P1 0.05 0.03 blup 37 0.03 5.2e-04 -20.91 28.3 1.3e-175 0.53 0.14 0.20 FALSE
37 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma APOC4 0.11 0.10 lasso 8 0.12 9.3e-14 3.99 7.3 3.7e-13 -0.04 1.00 0.00 FALSE
38 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PVR 0.08 0.10 lasso 4 0.09 9.8e-11 -8.32 -7.8 4.1e-15 0.06 0.90 0.10 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TOMM40 0.04 0.03 lasso 2 0.02 1.4e-03 -30.09 30.0 1.9e-197 0.65 0.12 0.09 TRUE
40 The Cancer Genome Atlas Brain Lower Grade Glioma APOC1P1 0.17 0.04 enet 10 0.09 3.2e-10 -25.35 6.2 4.1e-10 0.60 1.00 0.00 FALSE
41 The Cancer Genome Atlas Brain Lower Grade Glioma APOC4 0.06 0.03 blup 34 0.04 8.4e-06 3.66 12.2 4.3e-34 0.14 0.70 0.02 TRUE
42 The Cancer Genome Atlas Brain Lower Grade Glioma CEACAM19 0.08 0.05 lasso 4 0.05 3.3e-06 9.31 9.5 2.5e-21 -0.13 0.01 0.98 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma PVR 0.14 0.01 blup 51 0.06 3.4e-07 -8.22 -6.3 2.4e-10 -0.04 0.01 0.90 TRUE
44 The Cancer Genome Atlas Brain Lower Grade Glioma PVRL2 0.04 0.01 blup 55 0.02 1.5e-03 -7.34 8.3 8.0e-17 -0.26 0.04 0.04 FALSE
45 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PVRL2 0.09 0.01 blup 57 0.04 4.0e-03 -9.68 -5.7 1.1e-08 -0.23 0.06 0.04 TRUE
46 The Cancer Genome Atlas Lung Adenocarcinoma APOC1P1 0.03 0.00 blup 37 0.01 1.5e-02 -7.68 6.0 2.1e-09 0.51 0.02 0.03 FALSE
47 The Cancer Genome Atlas Lung Adenocarcinoma APOC4 0.09 0.07 blup 34 0.09 1.2e-10 4.56 6.1 9.2e-10 -0.04 1.00 0.00 TRUE
48 The Cancer Genome Atlas Lung Adenocarcinoma APOE 0.04 0.04 lasso 4 0.04 2.2e-05 7.50 7.2 6.3e-13 -0.02 0.58 0.02 FALSE
49 The Cancer Genome Atlas Lung Adenocarcinoma NKPD1 0.03 0.00 blup 37 0.01 4.5e-02 6.82 -8.7 4.2e-18 0.12 0.02 0.47 FALSE
50 The Cancer Genome Atlas Lung Adenocarcinoma PVR 0.03 0.02 blup 51 0.02 1.4e-03 -8.22 -6.2 5.9e-10 0.06 0.08 0.03 TRUE
51 The Cancer Genome Atlas Lung Squamous Cell Carcinoma APOC1 0.05 0.00 blup 47 0.01 4.3e-02 -1.06 -22.7 3.4e-114 0.32 0.01 0.06 TRUE
52 The Cancer Genome Atlas Lung Squamous Cell Carcinoma APOE 0.06 0.00 blup 49 0.01 4.5e-02 -1.06 -18.3 6.5e-75 0.19 0.02 0.06 FALSE
53 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma APOC2 0.27 0.18 enet 12 0.29 1.1e-19 5.48 -7.4 1.0e-13 -0.15 1.00 0.00 TRUE
54 The Cancer Genome Atlas Pancreatic Adenocarcinoma APOC2 0.18 0.12 enet 14 0.13 5.2e-06 3.66 10.3 8.9e-25 -0.11 0.65 0.03 FALSE
55 The Cancer Genome Atlas Prostate Adenocarcinoma APOE 0.10 0.08 lasso 4 0.07 6.7e-08 7.50 7.2 8.6e-13 -0.01 0.98 0.00 FALSE
56 The Cancer Genome Atlas Prostate Adenocarcinoma CEACAM19 0.15 0.08 lasso 3 0.07 4.0e-08 9.31 9.3 1.4e-20 -0.12 0.01 0.99 FALSE
57 The Cancer Genome Atlas Prostate Adenocarcinoma PVR 0.09 0.02 enet 18 0.07 1.4e-07 -4.09 -6.7 2.6e-11 0.05 0.24 0.28 FALSE
58 The Cancer Genome Atlas Prostate Adenocarcinoma PVRL2 0.10 0.04 blup 56 0.04 1.8e-05 -7.34 -7.8 6.7e-15 0.07 0.93 0.00 TRUE
59 The Cancer Genome Atlas Prostate Adenocarcinoma TOMM40 0.08 0.07 enet 13 0.07 2.2e-07 -30.09 18.9 4.7e-80 0.67 1.00 0.00 TRUE
60 The Cancer Genome Atlas Prostate Adenocarcinoma TRAPPC6A 0.03 0.02 blup 37 0.01 3.2e-02 7.02 -6.9 4.0e-12 0.08 0.07 0.17 TRUE
61 The Cancer Genome Atlas Soft Tissue Sarcoma APOC4 0.13 0.10 blup 34 0.13 3.2e-08 8.09 14.7 7.5e-49 -0.03 0.96 0.00 TRUE
62 The Cancer Genome Atlas Stomach Adenocarcinoma APOC4 0.07 0.09 lasso 2 0.09 3.2e-07 7.50 8.3 8.0e-17 -0.03 0.78 0.01 FALSE
63 The Cancer Genome Atlas Testicular Germ Cell Tumors APOC1P1 0.14 0.01 blup 36 0.06 3.8e-03 -3.37 19.3 3.6e-83 0.51 0.01 0.07 TRUE
64 The Cancer Genome Atlas Testicular Germ Cell Tumors APOC2 0.14 0.15 enet 5 0.16 3.5e-06 3.66 -5.2 2.1e-07 -0.07 0.43 0.03 FALSE
65 The Cancer Genome Atlas Testicular Germ Cell Tumors CEACAM19 0.17 0.11 enet 7 0.14 1.3e-05 9.31 8.1 4.2e-16 -0.16 0.01 0.86 FALSE
66 The Cancer Genome Atlas Thyroid Carcinoma BLOC1S3 0.08 0.06 blup 31 0.08 4.2e-08 -0.91 7.7 1.7e-14 -0.05 0.62 0.19 FALSE
67 The Cancer Genome Atlas Thyroid Carcinoma CEACAM19 0.26 0.13 lasso 3 0.14 4.0e-13 9.31 8.7 4.3e-18 -0.14 0.01 0.99 FALSE
68 The Cancer Genome Atlas Thyroid Carcinoma PVRL2 0.09 0.05 blup 55 0.03 4.6e-04 -2.73 -12.9 6.2e-38 0.45 0.48 0.05 TRUE
69 The Cancer Genome Atlas Thyroid Carcinoma TOMM40 0.05 0.07 lasso 3 0.06 1.1e-06 -26.50 25.1 1.4e-139 0.62 0.89 0.01 FALSE
70 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma APOC2 0.20 0.14 enet 10 0.14 7.9e-05 5.48 -13.7 7.1e-43 0.12 0.15 0.05 FALSE