Hub : Genes

ACE

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0810	0.0320	2.0e-05	0.049	0.034	0.035	0.035	0.040	1.1e-06	4.3e-05	3.3e-05	4.2e-05	1.0e-05
2	GTEx	Colon Transverse	0.3060	0.0880	2.8e-06	0.280	NA	0.240	NA	0.275	9.6e-14	NA	9.4e-12	NA	1.8e-13
3	GTEx	Lung	0.1802	0.0662	2.2e-05	0.074	NA	0.050	NA	0.071	2.5e-06	NA	9.8e-05	NA	3.9e-06
4	TCGA	Breast Invasive Carcinoma	0.0165	0.0097	5.2e-03	0.014	0.007	0.012	NA	0.011	6.2e-04	1.4e-02	1.3e-03	NA	2.4e-03
5	TCGA	Colon Adenocarcinoma	0.3370	0.0890	3.5e-10	0.219	0.168	0.217	NA	0.221	8.0e-13	5.6e-10	1.1e-12	NA	6.5e-13
6	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1550	0.0890	7.0e-03	0.076	0.029	0.064	NA	0.073	4.1e-05	8.8e-03	1.5e-04	NA	5.8e-05
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0400	0.0220	2.7e-03	0.046	0.041	0.033	NA	0.039	4.5e-04	9.4e-04	2.7e-03	NA	1.2e-03
8	TCGA	Pancreatic Adenocarcinoma	0.1260	0.0660	5.9e-04	0.143	0.052	0.093	NA	0.098	1.4e-06	3.2e-03	1.0e-04	NA	6.6e-05
9	TCGA	Rectum Adenocarcinoma	0.1630	0.0830	3.3e-03	0.139	0.102	0.113	NA	0.133	3.8e-04	2.3e-03	1.3e-03	NA	5.1e-04
10	TCGA	Stomach Adenocarcinoma	0.0630	0.0340	2.3e-03	0.032	0.022	0.020	NA	0.007	2.0e-03	9.3e-03	1.3e-02	NA	9.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.7	1.1	-0.7	1.1	0.7	-1.0	1.0	1.0	-0.2	1.0	0.7	0.5
Bipolar Disorder or Schizophrenia	2.9	7.0	9.3	-2.6	3.0	2.2	-2.8	2.8	2.8	-2.2	3.0	3.0	2.0
Depressed Affect (Nagel 2018)	0.2	0.3	1.9	0.5	-0.1	-1.4	0.4	-0.4	-0.3	-0.3	0.2	0.1	-0.8
Depression (Nagel 2018)	0.2	0.3	0.7	-0.5	-0.3	-0.3	0.8	-0.6	-0.6	-0.8	-0.4	-0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.9	-0.6	1.1	0.7	-1.1	1.0	1.2	0.3	1.1	1.4	0.7
Neuroticism (Nagel 2018)	0.1	0.3	1.3	0.4	-0.3	-1.2	0.5	-0.7	-0.5	0.2	-0.1	0.0	-0.6
Schizophrenia (2018)	3.7	7.7	10.5	-2.7	3.1	2.2	-2.8	2.9	2.8	-2.6	3.0	3.2	2.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	-1.0	0.4	0.8	-0.1	0.2	0.1	-1.3	0.3	0.9	0.4
Worry (Nagel 2018)	1.3	2.8	5.1	1.9	-1.6	-1.9	1.4	-1.8	-1.5	2.3	-1.4	-1.5	-1.2
Alzheimer’s Disease (in mother)	7.0	8.2	10.9	-3.3	3.3	2.4	-2.6	2.8	2.8	-2.2	3.2	3.2	2.5
Alzheimer’s Disease (in father)	12.0	13.0	17.5	-4.2	4.0	3.5	-3.2	3.3	3.4	-3.3	3.8	3.8	3.3
Alzheimer’s Disease (including proxy)	19.1	27.8	34.2	-5.8	5.9	5.1	-5.0	5.2	5.3	-4.3	5.5	5.5	4.9
Crohns Disease (2017)	0.5	1.1	2.1	-1.5	1.1	1.2	-0.8	0.7	0.8	-0.6	0.9	1.0	1.4
Irritable Bowel Disease (IBD)	1.8	4.3	6.6	-2.5	2.1	2.1	-1.9	1.9	1.9	-1.7	1.9	2.1	2.6
Ulcerative Colitis (UC)	2.6	4.9	5.9	-2.4	2.3	2.1	-2.1	2.2	2.1	-2.1	2.0	2.3	2.4
Major Depression (MDD)	1.1	1.4	2.2	0.9	-1.4	-0.3	1.4	-1.4	-1.5	0.2	-1.5	-1.4	-0.6
Reaction Time	1.5	2.9	8.4	-1.4	1.2	2.3	-1.4	1.6	1.3	-2.9	0.8	1.5	1.4
Verbal and Numeric Reasoning (VNR)	1.2	3.0	4.3	-1.8	1.8	1.8	-1.6	1.5	1.6	-1.5	1.4	2.1	2.0
Breast Cancer	0.4	1.1	1.8	-0.9	1.1	0.8	-1.0	1.1	1.1	-1.3	1.2	1.0	0.6
Ovarian Cancer	0.2	0.3	0.6	-0.4	0.6	-0.1	-0.4	0.4	0.6	0.8	0.8	0.3	0.3
Prostate Cancer	1.8	2.6	5.8	-1.6	1.3	1.8	-1.5	1.7	1.5	-2.4	1.2	1.6	1.1
Age at First Birth	0.2	0.2	1.1	-0.6	0.4	-0.3	-0.2	0.1	0.2	0.2	0.5	1.0	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.9	-0.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.3	3.2	3.9	1.8	-1.6	-2.0	1.8	-1.9	-1.7	1.9	-1.4	-2.0	-1.8
Coronary Artery Disease (CAD)	0.3	0.4	0.8	0.4	-0.5	-0.6	0.7	-0.8	-0.7	0.8	0.0	-0.4	-0.9
Crohns Disease (2012)	0.3	0.5	1.3	-0.6	0.8	0.7	-0.7	0.5	0.7	-0.1	0.8	0.5	1.1
Mean Putamen Volume	0.1	0.1	0.2	-0.5	0.5	0.4	-0.4	0.4	0.4	-0.2	0.4	0.4	0.3
Fasting Glucose	1.6	1.9	3.5	1.3	-1.5	-1.9	1.5	-1.5	-1.4	0.9	-1.2	-1.1	-1.4
HbA1C	0.1	0.1	0.2	-0.1	0.2	0.3	-0.4	0.4	0.4	0.1	0.2	-0.1	0.4
HDL Cholesterol	0.2	0.4	0.8	-0.9	0.4	0.8	-0.2	0.3	0.3	-0.9	0.3	0.5	0.9
LDL Cholesterol	1.7	2.6	3.6	1.8	-1.7	-1.4	1.7	-1.9	-1.8	1.3	-1.7	-1.7	-1.1
Lupus	0.3	0.5	0.8	0.9	-0.8	-0.9	0.6	-0.7	-0.6	0.4	-0.7	-0.4	-0.8
Neuroticism (2016)	1.0	1.5	2.6	0.4	-1.2	-0.8	1.6	-1.6	-1.5	1.3	-1.2	-1.0	-1.2
Primary Biliary Cirrhosis	1.4	2.0	4.3	-0.9	1.2	2.0	-1.5	1.4	1.4	-1.6	0.8	0.9	2.1
Rheumatoid Arthritis	0.2	0.3	0.9	-0.8	0.6	0.3	-0.1	0.2	0.2	-0.9	0.7	0.9	-0.0
Schizophrenia (2014)	4.2	9.2	14.0	-3.2	3.4	2.3	-2.9	3.0	3.0	-2.9	3.4	3.7	2.2
Triglycerides	0.7	1.2	2.3	1.2	-0.9	-1.3	1.0	-1.0	-1.0	1.3	-0.7	-0.8	-1.5
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	0.8	-0.4	-0.6	0.2	-0.3	-0.3	0.7	-0.3	-0.7	-0.4
Ulcerative Colitis	0.1	0.1	0.3	0.1	0.3	-0.2	-0.4	0.3	0.3	0.5	0.2	0.0	0.4
Blood Eosinophil Count	0.2	1.3	2.1	0.8	-1.2	-0.3	1.4	-1.5	-1.4	1.1	-1.2	-1.3	-0.8
Blood Platelet Count	0.4	4.5	7.2	2.7	-2.3	-2.2	1.8	-1.9	-1.9	1.8	-2.1	-2.5	-1.8
Blood Red Count	0.5	4.9	21.1	2.5	-1.6	-1.8	1.1	-1.5	-1.2	4.6	-1.3	-2.8	-1.0
Blood White Count	1.6	11.7	16.8	3.3	-3.3	-3.0	3.5	-3.8	-3.4	4.1	-3.0	-4.0	-2.6
Heel T-Score	0.1	0.5	2.2	0.5	0.2	0.5	-0.4	0.3	0.4	-1.1	0.1	-0.2	1.5
BMI	1.4	8.2	17.6	3.4	-3.4	-1.5	2.4	-2.6	-2.7	2.4	-3.4	-4.2	-1.5
Height	1.2	22.8	38.1	-4.5	5.1	4.2	-5.4	5.6	5.4	-1.7	5.0	6.2	3.0
Waist Hip Ratio (WHR)	0.8	3.4	11.6	-1.6	1.6	1.8	-1.5	1.6	1.5	-3.4	1.4	1.7	1.5
Systolic Blood Pressure	7.1	35.6	56.9	6.1	-7.0	-3.2	6.0	-6.2	-6.4	4.3	-7.5	-7.5	-3.5
Smoking Status	2.4	5.7	7.7	-2.4	2.5	1.7	-2.3	2.4	2.4	-2.8	2.5	2.7	1.9
Allergy or Eczema	0.1	0.3	1.4	1.2	-0.3	-0.8	-0.0	0.1	-0.0	0.6	0.0	-0.4	-0.7
Cardiovascular Disease	24.3	80.4	108.2	8.5	-10.1	-6.0	9.5	-9.8	-9.8	7.2	-10.3	-10.4	-6.6
Hypothyroidism (self reported)	0.8	1.9	3.5	0.6	-1.5	-0.7	1.9	-1.8	-1.8	0.4	-1.6	-1.0	-1.6
Respiratory disease	0.0	0.1	0.2	-0.0	0.1	-0.1	0.1	-0.2	-0.1	0.5	0.2	-0.2	0.5
Type 2 Diabetes (T2D) (2018)	12.3	23.1	27.1	4.8	-4.9	-5.2	4.8	-4.9	-4.8	4.4	-4.4	-4.8	-5.1
Lung FEV1/FVC ratio	0.5	2.3	6.6	1.7	-2.0	-0.3	1.1	-1.1	-1.4	0.4	-2.2	-2.6	-0.2
Lung FVC	0.2	1.0	2.7	-0.5	1.2	-0.8	-0.8	0.8	1.0	1.4	1.6	0.9	-0.2
Neuroticism	0.4	0.9	2.7	0.8	-0.7	-1.6	1.0	-1.1	-0.9	0.3	-0.6	-0.3	-1.2
Chronotype (morning person)	2.7	6.1	9.2	2.0	-2.4	-2.1	2.8	-3.0	-2.8	2.6	-2.4	-2.1	-2.2
Hair Pigment	0.1	4.0	7.2	-2.6	2.1	1.2	-1.4	1.6	1.6	-2.7	2.2	2.6	1.0
Tanning	0.3	3.7	6.4	-1.3	2.1	0.8	-2.5	2.5	2.5	-0.8	2.3	2.1	1.2
Hand grip strength (left)	1.1	2.9	6.0	2.1	-1.4	-2.4	1.1	-1.0	-1.1	2.4	-1.1	-1.5	-2.1
Number of treatments/medications taken	10.5	18.8	25.8	3.6	-5.0	-2.9	4.9	-4.9	-5.0	2.4	-5.1	-4.6	-4.0
Average weekly spirits intake	0.1	0.1	0.2	-0.1	-0.0	-0.2	0.5	-0.5	-0.4	0.2	-0.0	0.1	-0.2
Sensitivity / hurt feelings	0.9	1.5	2.5	1.1	-1.1	-1.6	1.3	-1.3	-1.2	1.0	-1.1	-1.1	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.2	-0.5	-0.6	0.6	-0.6	-0.6	-0.2	-0.5	-0.6	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	1.0	-0.9	0.5	0.2	-0.2	0.3	0.2	-1.0	0.4	0.9	0.2
Relative age of first facial hair	0.2	0.4	1.7	0.6	-0.2	-1.3	-0.1	0.2	0.1	0.0	0.2	0.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.3	0.2	-1.2	1.3	0.9	-0.8	-1.0	-0.9	-1.5	-1.1	0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.8	0.9	-0.2	-1.7	0.3	-0.3	-0.3	1.5	0.2	-0.3	-1.6
Ever had hysterectomy (womb removed)	0.2	0.2	1.0	-0.0	0.0	-0.4	0.1	0.2	0.0	-1.0	0.3	0.6	-0.9
Systolic blood pressure, automated reading	2.7	7.9	13.4	3.1	-3.3	-1.7	2.6	-2.7	-2.8	2.3	-3.5	-3.7	-1.6
Eye problems/disorders: Diabetes related eye disease	9.4	10.4	19.7	3.5	-3.1	-3.0	2.8	-3.0	-2.8	4.4	-2.8	-3.7	-2.7
Angina	0.3	0.4	1.9	0.0	-0.5	1.0	0.1	-0.1	-0.3	-1.4	-0.8	-0.4	0.5
Medication for hormone replacement therapy	0.8	0.9	2.2	0.8	-0.7	-1.3	1.1	-1.0	-1.0	0.8	-0.6	-0.6	-1.5
Vitamin and mineral supplements	0.1	0.2	0.7	-0.3	0.5	0.2	-0.3	0.2	0.3	0.8	0.4	0.1	0.6
Supplements: Zinc	0.3	0.3	0.7	-0.4	0.6	-0.1	-0.6	0.7	0.6	-0.6	0.7	0.8	-0.1
Medication: Co-codamol	0.5	0.6	1.0	0.5	-0.8	-0.6	0.8	-0.8	-0.9	0.0	-0.9	-0.7	-1.0
Medication: Metformin	3.9	5.5	9.1	2.1	-2.4	-2.7	2.4	-2.4	-2.4	1.9	-2.0	-1.9	-3.0
Diabetes (father)	0.5	0.6	0.8	0.6	-0.8	-0.8	0.9	-0.8	-0.9	0.1	-0.8	-0.6	-0.9
Diabetes (mother)	0.7	0.9	1.5	0.6	-1.0	-0.6	1.2	-1.2	-1.2	-0.0	-1.1	-0.6	-0.9
Severe depression (siblings)	0.1	0.1	0.6	-0.8	0.3	0.2	0.1	-0.0	-0.0	-0.5	0.2	0.6	0.2
Pack years adult smoking proportion	2.3	3.5	6.1	-2.5	2.2	1.9	-1.3	1.3	1.5	-1.5	2.0	2.1	2.1
Impedance of leg (right)	0.1	0.5	2.2	0.7	-0.4	-1.4	0.4	-0.4	-0.3	0.0	-0.1	-0.1	-1.5
Leg fat-free mass (left)	0.0	0.2	1.0	0.2	-0.3	0.4	-0.2	0.3	0.0	1.0	-0.4	-0.2	-0.1
Trunk fat percentage	2.4	9.7	12.9	3.3	-3.6	-2.6	2.9	-2.9	-3.1	1.9	-3.4	-3.5	-3.5
Hand grip strength (right)	1.0	2.8	7.8	2.2	-1.1	-2.5	0.7	-0.6	-0.7	2.8	-0.7	-1.5	-2.0
Townsend deprivation index at recruitment	0.9	1.2	2.2	-0.9	1.4	0.3	-1.2	1.2	1.2	-1.1	1.5	1.2	0.7
Current tobacco smoking	2.2	3.5	6.2	-2.0	2.0	1.6	-1.5	1.6	1.6	-2.5	1.9	2.2	1.5
Average weekly fortified wine intake	0.6	0.7	1.3	-0.6	0.9	1.1	-0.8	0.7	0.8	-0.4	0.8	0.9	1.0
Maternal smoking around birth	0.3	0.4	1.2	-0.2	-0.4	0.6	0.7	-0.9	-0.7	1.1	-0.5	-0.6	0.4
Fed-up feelings	2.2	3.9	5.5	1.7	-1.9	-2.4	2.2	-2.4	-2.1	1.6	-1.5	-1.8	-2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.1	-0.2	-0.4	0.7	-0.7	-0.6	-0.1	-0.3	-0.4	-0.0
Relative age voice broke	0.3	0.5	2.1	0.5	0.4	-1.4	-0.4	0.5	0.5	0.0	0.8	0.5	-1.0
Taking other prescription medications	1.9	2.9	6.4	1.2	-2.2	0.1	1.9	-1.9	-2.1	-0.7	-2.5	-1.9	-0.8
Age when periods started (menarche)	2.7	6.5	11.9	2.3	-2.3	-3.3	2.4	-2.3	-2.3	2.4	-1.8	-2.3	-3.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.6	0.4	-0.4	0.2	-0.1	-0.1	-0.2	0.5	0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	2.9	1.5	-1.6	-1.5	1.6	-1.7	-1.6	1.1	-1.4	-1.7	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	0.1	-0.7	-0.0	1.0	-0.7	-0.9	-1.4	-0.8	-0.4	-0.8
Qualifications: CSEs or equivalent	4.6	6.1	9.3	2.1	-2.6	-2.2	2.7	-2.6	-2.6	1.7	-2.4	-2.5	-3.0
Serious illness, injury or assault to yourself	0.3	0.4	2.7	-0.6	0.3	0.1	0.2	0.1	-0.1	-1.6	0.3	0.7	-0.2
High blood pressure	16.8	46.8	63.8	5.9	-7.8	-4.4	7.7	-7.8	-7.9	4.5	-8.0	-7.6	-5.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.5	1.2	-0.7	-0.3	0.4	-0.4	-0.5	0.5	-0.6	-0.8	-0.5
Multivitamins +/- minerals	0.4	0.5	1.2	0.7	-0.8	-0.6	0.5	-0.5	-0.6	0.2	-0.7	-0.7	-1.1
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.5	0.0	-0.0	0.6	-0.5	-0.5	-0.6	0.0	0.4	-0.2
Supplements: Glucosamine	0.1	0.1	0.4	0.7	-0.0	-0.7	0.0	0.0	0.0	0.1	0.2	0.1	-0.5
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	0.6	-0.3	-0.5	0.1	-0.2	-0.1	0.1	-0.1	-0.1	-0.6
Medication: Atenolol	2.8	3.5	6.7	0.9	-2.2	-0.3	2.4	-2.3	-2.5	0.0	-2.6	-2.1	-0.7
Medication: Levothyroxine sodium	0.2	0.4	0.6	0.4	-0.8	-0.3	0.8	-0.8	-0.8	0.0	-0.7	-0.4	-0.6
Sitting height	0.2	1.1	3.2	-0.2	0.8	0.3	-1.3	1.1	1.2	1.8	0.8	0.9	1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.4	-1.0	0.2	1.6	-0.2	0.1	0.1	-0.8	-0.1	0.2	1.4
High blood pressure (mother)	3.8	5.3	8.6	2.2	-2.7	-1.4	2.4	-2.5	-2.5	1.5	-2.8	-2.9	-1.5
Body mass index (BMI)	1.2	5.1	9.1	2.4	-2.8	-1.3	2.1	-2.1	-2.3	1.2	-2.8	-3.0	-1.7
Impedance of leg (left)	0.0	0.2	0.8	0.3	0.1	-0.8	-0.0	0.0	0.1	-0.6	0.3	0.3	-0.9
Leg predicted mass (left)	0.0	0.2	1.0	0.2	-0.3	0.3	-0.2	0.3	0.0	1.0	-0.4	-0.3	-0.1
Trunk fat mass	1.2	5.2	7.3	2.6	-2.7	-1.8	1.9	-1.9	-2.1	1.6	-2.6	-2.6	-2.6
Waist circumference	0.1	0.5	1.2	0.6	-1.0	0.3	0.5	-0.5	-0.6	-0.5	-1.1	-1.0	-0.3
Number of incorrect matches in round	0.8	1.3	2.8	-1.5	1.5	0.3	-0.8	0.9	1.0	-0.5	1.7	1.5	0.5
Past tobacco smoking	1.4	2.5	3.6	1.1	-1.6	-1.0	1.9	-1.9	-1.9	1.7	-1.7	-1.4	-1.3
Alcohol usually taken with meals	1.4	2.2	3.7	1.9	-1.4	-1.9	1.1	-1.1	-1.2	1.8	-1.1	-1.4	-1.5
Nervous feelings	0.4	0.7	1.0	-0.6	0.9	0.5	-0.9	0.8	1.0	-0.8	0.9	1.0	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	0.4	-0.2	-0.6	0.3	-0.4	-0.3	0.0	-0.1	-0.1	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.6	-0.3	0.1	0.1	0.0	-0.0	-0.1	-0.8	-0.0	0.6	0.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	0.4	-0.2	-0.7	0.1	-0.1	-0.0	0.6	-0.1	-0.3	-0.3
Had menopause	0.1	0.2	0.3	0.4	-0.5	-0.2	0.4	-0.4	-0.4	0.5	-0.5	-0.5	-0.1
Had other major operations	0.2	0.2	0.6	0.6	-0.4	0.4	-0.1	0.0	-0.1	0.4	-0.6	-0.8	0.4
Forced vital capacity (FVC)	0.2	0.6	3.2	0.3	0.1	-1.0	0.2	-0.1	-0.1	1.8	0.4	0.2	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.4	-0.5	-0.5	0.7	-0.6	-0.6	-0.1	-0.5	-0.5	-0.4
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	5.3	1.1	-2.1	-0.3	2.1	-2.1	-2.1	0.4	-2.3	-1.9	-1.0
Qualifications: None of the above	0.6	1.3	2.2	0.8	-1.1	-0.6	1.2	-1.3	-1.2	1.2	-1.2	-1.5	-0.7
Financial difficulties in last 2 years	0.2	0.3	1.2	-0.5	0.7	0.5	-0.3	0.2	0.3	-0.6	0.6	0.4	1.1
Mouth/teeth dental problems	3.8	5.9	10.2	2.3	-3.0	-1.2	2.7	-2.6	-2.8	0.9	-3.2	-2.8	-1.6
Heart attack	0.2	0.3	1.2	-0.3	-0.0	0.9	-0.0	0.1	-0.0	-1.1	-0.3	-0.2	0.8
Allergy	0.0	0.1	0.3	-0.4	0.3	-0.1	-0.3	0.3	0.3	-0.5	0.3	0.5	-0.1
Pain all over the body in last month	0.0	0.1	0.3	-0.2	0.0	0.1	-0.1	0.1	0.1	-0.5	0.0	0.2	0.3
Diabetes (self-reported)	7.1	11.0	13.9	2.9	-3.6	-3.0	3.6	-3.7	-3.6	2.6	-3.5	-3.4	-3.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.0	-0.3	0.7	1.0	-1.1	1.1	1.0	-1.4	0.5	0.5	1.4
Medication: Ramipril	6.2	7.9	13.9	2.5	-3.4	-0.9	3.2	-3.1	-3.2	1.1	-3.7	-3.5	-1.8
Medication: Simvastatin	6.1	8.9	10.3	2.7	-3.1	-2.8	3.2	-3.2	-3.1	2.6	-2.8	-3.0	-3.2
Fluid intelligence score	0.0	0.1	0.4	0.1	-0.4	0.3	0.2	-0.4	-0.3	0.2	-0.6	-0.1	0.2
Illnesses of siblings	0.7	1.1	1.9	-1.4	1.1	0.6	-0.9	1.0	1.0	-1.0	1.1	1.4	0.3
Neuroticism score	0.3	0.6	1.9	0.6	-0.4	-1.4	0.8	-1.0	-0.7	0.7	-0.2	-0.2	-0.8
Weight	0.2	0.8	1.5	1.1	-1.2	-0.3	0.5	-0.5	-0.7	1.0	-1.2	-1.2	-0.8
Impedance of arm (right)	0.3	1.3	4.8	0.4	-0.8	-1.4	1.4	-1.2	-1.2	-0.1	-0.8	-0.3	-2.2
Arm fat percentage (right)	2.9	11.3	15.3	3.4	-3.9	-2.6	3.3	-3.3	-3.5	2.1	-3.8	-3.9	-3.4
Trunk fat-free mass	0.3	1.9	3.5	-0.8	1.3	1.2	-1.8	1.9	1.7	0.5	1.2	1.3	1.4
Hip circumference	1.1	4.6	8.1	2.2	-2.6	-1.1	1.8	-1.8	-2.0	2.2	-2.7	-2.8	-1.7
Time employed in main current job	0.4	0.4	1.2	-1.1	0.5	1.1	0.1	-0.2	-0.0	-0.1	0.2	0.7	1.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.1	0.3	0.5	-0.3	0.3	0.4	-0.5	0.3	0.0	0.5
Father’s age at death	0.1	0.2	0.9	0.3	-0.2	-0.8	0.4	-0.2	-0.3	-0.1	-0.1	0.2	-0.9
Worrier / anxious feelings	0.6	1.2	3.3	1.1	-1.0	-0.8	0.9	-1.2	-1.0	1.8	-1.1	-1.2	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	3.2	-0.8	0.2	1.0	0.3	-0.2	-0.3	-1.8	-0.0	0.3	0.6
Falls in the last year	0.1	0.2	0.5	0.7	-0.5	0.1	0.1	-0.2	-0.3	0.1	-0.6	-0.7	-0.1
Hair/balding pattern: Pattern 3	0.4	0.7	1.5	-0.6	0.6	0.7	-0.8	0.8	0.7	-1.2	0.7	1.2	0.2
Number of live births	0.2	0.3	0.5	-0.7	0.6	0.3	-0.5	0.5	0.5	-0.4	0.6	0.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	5.5	1.3	-0.9	-2.0	1.1	-0.9	-0.9	2.4	-0.6	-1.0	-1.9
Pulse rate	0.2	0.4	0.7	-0.7	0.6	0.3	-0.7	0.7	0.7	-0.8	0.6	0.5	0.8
Happiness	0.1	0.1	0.1	-0.2	0.4	-0.3	-0.4	0.2	0.4	0.2	0.4	0.3	0.3
Noisy workplace	0.1	0.1	0.2	-0.4	0.3	0.4	-0.2	0.3	0.2	-0.2	0.4	0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.0	0.2	-0.6	1.0	0.4	-0.2	-0.4	-0.3	-0.8	-0.2	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-0.0	0.7	0.5	-1.1	1.1	1.0	-0.4	0.8	0.5	0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	0.5	0.6	-1.3	-0.9	0.7	0.9	1.1	1.0	0.3	-0.4
Asthma	0.0	0.1	0.4	-0.3	0.2	0.1	0.0	-0.0	0.0	-0.2	0.2	0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.1	0.5	-1.2	0.9	1.1	-1.2	-1.3	0.4	-1.8	-1.4	0.6
Medication: Cholesterol lowering	7.1	11.1	12.6	3.4	-3.5	-3.3	3.3	-3.4	-3.4	3.0	-3.2	-3.4	-3.2
Depression (self-reported)	0.4	0.5	1.2	0.5	-0.9	0.1	0.8	-0.7	-0.8	0.2	-1.1	-0.9	-0.1
Medication: Lansoprazole	0.5	0.5	1.2	-0.2	-0.5	-0.5	1.1	-1.0	-1.0	0.5	-0.5	-0.6	-0.8
Prospective memory result	0.5	0.6	1.4	-1.2	1.1	0.2	-0.5	0.6	0.7	-0.0	1.2	0.9	0.4
Lung cancer (father)	6.8	8.0	11.8	-3.4	2.9	3.3	-2.1	2.2	2.2	-3.2	2.4	3.0	3.0
Illnesses of mother	0.5	0.6	2.1	0.4	0.5	-0.7	-0.8	0.7	0.8	1.5	0.7	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	7.1	1.5	-1.4	-1.8	1.6	-1.4	-1.5	2.7	-1.2	-1.6	-1.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.7	-0.8	0.6	0.6	-0.5	0.4	0.5	-0.3	0.5	0.3	0.8
Impedance of arm (left)	0.2	0.9	3.4	0.2	-0.5	-1.3	1.1	-1.0	-0.9	-0.0	-0.5	-0.1	-1.8
Arm fat mass (right)	1.7	7.1	10.6	2.9	-3.1	-1.9	2.4	-2.4	-2.6	2.1	-3.1	-3.3	-2.6
Trunk predicted mass	0.3	1.7	3.1	-0.8	1.2	1.1	-1.7	1.8	1.6	0.6	1.2	1.2	1.3
Standing height	0.6	6.0	10.6	-2.1	2.7	1.4	-2.9	3.0	3.0	0.2	2.8	3.3	1.3
Length of working week for main job	3.2	3.5	6.3	-2.5	2.0	1.8	-1.4	1.5	1.5	-1.6	2.0	2.1	2.0
Exposure to tobacco smoke at home	1.0	1.1	1.6	-1.0	1.0	1.1	-1.2	1.1	1.1	-1.1	1.0	0.8	1.3
Breastfed as a baby	0.5	0.6	2.0	-0.4	0.6	0.3	-0.9	1.0	0.8	-1.4	0.7	0.8	0.4
Tense / ‘highly strung’	1.9	3.2	4.8	1.7	-1.7	-2.2	1.8	-1.9	-1.7	2.0	-1.3	-1.7	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.2	1.1	-1.4	-0.3	1.3	-1.3	-1.4	0.8	-1.5	-1.5	-0.5
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.4	-0.5	0.7	0.1	-0.2	-0.3	0.1	-0.9	-0.8	0.8
Birth weight of first child	0.1	0.1	0.5	-0.5	0.2	0.6	-0.2	0.2	0.2	-0.0	0.2	0.2	0.7
Peak expiratory flow (PEF)	4.5	10.4	21.7	3.5	-2.9	-3.7	2.6	-2.8	-2.6	4.7	-2.3	-3.2	-3.3
Pulse wave reflection index	0.1	0.2	0.4	0.2	-0.2	0.4	0.2	-0.4	-0.2	0.5	-0.3	-0.7	0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.2	-0.1	-0.5	0.1	-0.1	-0.1	0.2	-0.0	-0.1	-0.5
Loud music exposure frequency	1.6	1.8	3.1	-1.6	1.5	0.8	-1.2	1.4	1.3	-1.3	1.5	1.8	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.7	-0.6	0.4	1.3	-0.5	0.6	0.5	-1.1	0.2	0.5	1.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.2	-2.0	1.5	1.8	-1.1	1.1	1.2	-1.1	1.2	1.4	2.1
Blood clot in the leg (DVT)	1.1	1.4	2.2	-1.2	1.4	0.8	-1.3	1.3	1.4	-0.4	1.5	0.9	1.2
Medication: Paracetamol	4.7	7.7	11.6	2.3	-3.3	-1.5	3.1	-3.1	-3.2	1.5	-3.4	-3.3	-2.1
Headache pain in last month	3.6	6.2	8.7	2.1	-2.8	-1.7	2.9	-2.8	-2.9	1.2	-2.9	-2.6	-2.4
Medication for cholesterol, blood pressure or diabetes	19.9	33.0	41.2	-5.1	6.2	4.9	-6.3	6.4	6.3	-4.8	6.0	6.0	5.2
Glaucoma (self-reported)	0.7	0.9	2.7	1.1	-0.7	-1.6	0.5	-0.5	-0.5	0.6	-0.4	-0.7	-1.6
Gout (self-reported)	0.2	0.2	1.2	0.7	-0.3	-0.3	0.1	-0.2	-0.1	1.1	-0.2	-0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	3.9	1.0	-1.8	-0.6	2.0	-1.9	-2.0	0.6	-1.9	-1.4	-1.6
Medication: Amlodipine	6.2	8.7	13.2	2.2	-3.4	-1.7	3.6	-3.6	-3.6	1.4	-3.5	-3.1	-2.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.9	0.7	0.8	-0.5	0.4	0.5	-0.5	0.6	0.8	0.6
Birth weight	3.7	8.1	9.4	-2.9	2.9	2.6	-2.9	3.0	2.9	-2.5	2.9	3.1	2.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.6	-0.8	0.3	0.1	0.3	-0.3	-0.1	0.5	0.4	0.4	0.1
High blood pressure (siblings)	5.2	7.5	10.6	2.8	-2.9	-2.1	2.7	-2.9	-2.8	3.0	-2.8	-3.2	-1.9
Forced vital capacity (FVC), Best measure	0.3	1.0	4.6	0.5	-0.3	-1.2	0.7	-0.6	-0.5	2.1	-0.1	-0.5	-1.3
Body fat percentage	2.6	10.1	13.6	3.5	-3.7	-2.6	3.0	-3.0	-3.1	1.8	-3.6	-3.7	-3.4
Leg fat percentage (right)	1.7	6.2	9.4	2.9	-3.0	-1.9	2.2	-2.2	-2.4	1.3	-2.9	-3.1	-2.4
Arm fat-free mass (right)	0.2	0.8	1.8	-0.2	0.7	0.7	-1.3	1.4	1.2	0.8	0.7	0.6	0.7
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.2	0.6	0.2	-1.0	0.8	1.0	0.2	0.8	0.1	0.8
Comparative body size at age 10	1.4	4.0	7.5	-2.6	1.6	2.6	-1.3	1.5	1.3	-2.7	1.4	2.3	1.8
Number of full brothers	1.0	1.3	1.8	1.1	-1.1	-1.2	1.4	-1.2	-1.3	0.1	-1.2	-1.0	-1.2
Worry too long after embarrassment	0.7	1.1	5.5	-1.4	0.6	0.9	-0.1	0.3	0.1	-2.4	0.4	1.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.9	1.1	-1.3	-0.7	1.4	-1.3	-1.4	0.3	-1.3	-1.1	-1.0
Wheeze or whistling in the chest in last year	0.9	1.7	4.5	-2.1	1.4	1.1	-0.5	0.6	0.6	-1.8	1.2	1.6	1.0
Number of children fathered	0.2	0.2	0.7	0.2	0.1	-0.7	-0.0	0.1	0.1	0.8	0.3	-0.1	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.3	-1.0	1.0	0.2	-0.8	0.8	0.9	-1.1	1.1	1.5	0.4
Age at first live birth	0.1	0.2	0.4	-0.4	0.4	0.3	-0.3	0.3	0.3	-0.3	0.4	0.4	0.7
Pulse wave peak to peak time	0.4	0.5	1.1	1.0	-0.7	-0.8	0.6	-0.4	-0.6	0.7	-0.6	-0.4	-1.1
Health satisfaction	0.5	0.7	1.3	0.1	-0.9	-0.1	1.1	-1.1	-1.1	0.4	-1.1	-1.0	-0.6
Shortness of breath walking on level ground	1.9	2.3	4.2	-2.0	1.5	2.0	-1.2	1.3	1.3	-1.4	1.2	1.1	1.7
Qualifications: College or University degree	0.2	0.6	2.3	-0.5	0.1	1.2	-0.5	0.6	0.4	-1.5	-0.1	0.8	0.6
Eye problems/disorders: None of the above	0.1	0.2	0.6	-0.7	0.5	0.3	0.2	-0.2	-0.1	0.2	0.4	0.8	0.0
Mouth/teeth dental problems: Loose teeth	5.3	6.3	9.6	-3.1	2.9	2.1	-2.2	2.3	2.4	-2.2	2.8	2.9	1.9
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	-0.1	-0.2	0.5	-0.5	-0.4	0.4	-0.2	-0.3	0.2
Medication for pain relief, constipation, heartburn	6.5	11.2	18.1	-2.7	4.0	1.6	-3.8	3.9	4.0	-1.6	4.3	3.7	2.3
Neck or shoulder pain in last month	1.3	1.8	4.6	-1.9	0.8	2.1	-0.4	0.6	0.5	-2.1	0.5	1.3	1.5
Medication: Blood pressure	17.3	30.5	40.5	4.7	-6.0	-4.3	6.3	-6.4	-6.3	3.7	-6.0	-5.8	-4.9
Angina (self-reported)	0.3	0.4	1.7	0.1	-0.7	0.7	0.3	-0.2	-0.4	-1.3	-0.9	-0.5	0.3
Migraine (self-reported)	0.2	0.2	0.4	-0.4	0.4	0.2	-0.6	0.5	0.5	-0.3	0.6	0.7	-0.0
Medication: Ibuprofen	0.6	0.8	2.2	0.4	-1.1	0.8	0.8	-0.9	-1.0	-0.3	-1.5	-0.9	0.4
Medication: Allopurinol	0.5	0.6	1.7	0.6	-0.8	-0.2	0.8	-0.9	-0.8	1.3	-0.8	-0.8	-0.5
Medication: Omeprazole	0.1	0.1	0.7	-0.4	0.1	-0.0	-0.3	0.4	0.3	-0.9	0.2	0.3	-0.2
Medication: Seretide 50 evohaler	1.3	1.5	2.6	-1.0	1.1	1.3	-1.2	1.2	1.2	-1.6	1.1	1.1	1.1
Mean time to correctly identify matches	2.9	5.6	12.2	-2.5	2.2	2.5	-1.9	2.2	1.9	-3.5	1.9	2.9	1.5
Heart disease (mother)	0.7	0.9	2.0	0.9	-1.2	0.2	1.0	-1.0	-1.1	-0.3	-1.4	-1.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.0	1.3	-1.0	-1.3	1.2	-1.0	-1.1	0.4	-0.8	-0.7	-1.7
Whole body fat mass	1.6	6.5	9.2	3.0	-3.0	-2.0	2.1	-2.1	-2.3	1.9	-2.9	-3.0	-2.7
Leg fat mass (right)	0.8	3.0	4.9	2.1	-2.2	-1.2	1.4	-1.4	-1.5	1.1	-2.1	-2.2	-1.7
Arm predicted mass (right)	0.1	0.6	1.5	-0.0	0.4	0.8	-1.2	1.2	1.0	0.7	0.4	0.4	0.8
Pulse rate, automated reading	0.2	0.7	1.4	1.2	-1.1	-0.5	0.6	-0.7	-0.7	0.1	-1.1	-1.1	-0.4
Alcohol intake frequency.	0.2	0.5	1.2	1.1	-0.9	0.1	0.5	-0.4	-0.6	-0.3	-1.0	-1.1	-0.4
Comparative height size at age 10	1.0	5.8	9.4	-2.1	2.6	1.9	-2.8	2.9	2.8	-0.7	2.5	3.1	1.7
Number of full sisters	4.4	5.4	7.6	2.3	-2.5	-1.7	2.4	-2.3	-2.4	2.2	-2.4	-2.8	-2.1
Suffer from ‘nerves’	0.1	0.2	0.3	0.4	-0.5	0.4	0.4	-0.5	-0.4	0.0	-0.6	-0.4	0.5
Overall health rating	2.0	4.2	7.9	1.1	-2.5	-0.2	2.6	-2.6	-2.7	-0.2	-2.8	-2.3	-0.9
Chest pain or discomfort	0.5	0.7	2.4	-0.8	0.7	0.8	-0.5	0.5	0.5	-1.5	0.5	0.8	1.2
Had major operations	0.1	0.1	0.4	-0.4	0.1	0.6	0.1	0.0	-0.1	-0.2	-0.0	0.2	0.1
Age at last live birth	0.1	0.1	0.7	0.0	0.3	-0.6	-0.0	-0.1	0.1	0.8	0.5	0.0	0.1
Family relationship satisfaction	0.0	0.0	0.1	-0.3	0.0	-0.3	0.2	-0.2	-0.1	0.2	0.0	0.3	-0.1
Leg pain on walking	0.0	0.0	0.1	-0.4	0.2	0.0	-0.1	0.1	0.1	0.0	0.1	0.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.7	-0.1	0.4	-0.3	-0.7	0.8	0.7	-0.4	0.7	0.5	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.5	-0.6	-0.3	0.6	-0.4	-0.6	-0.3	-0.6	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.2	-0.0	-0.8	0.6	0.8	-0.8	-0.8	0.2	-1.1	-0.6	0.1
Medication: Aspirin	3.1	4.1	6.2	1.4	-2.2	-1.6	2.5	-2.5	-2.4	1.3	-2.2	-2.0	-1.6
Supplements: Vitamin C	1.5	1.8	3.4	-1.1	1.4	1.1	-1.2	1.4	1.2	-1.8	1.3	1.6	1.2
Knee pain experienced in last month	0.2	0.3	0.7	-0.2	-0.4	0.8	0.3	-0.5	-0.4	-0.8	-0.7	-0.2	0.7
Hypertension (Self-reported)	17.1	47.6	64.5	6.0	-7.8	-4.5	7.8	-7.8	-7.9	4.6	-8.0	-7.6	-5.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.8	0.4	-0.7	-1.3	1.0	-1.0	-0.9	0.4	-0.6	-0.7	-1.1
Illnesses of father: Heart disease	1.2	1.6	4.1	1.7	-1.7	0.2	0.8	-0.9	-1.1	0.2	-2.0	-2.0	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.0	1.0	-0.9	-0.6	0.8	-0.8	-0.8	0.2	-1.0	-1.0	-0.3
Smoking status: Previous	0.2	0.3	0.8	0.2	0.3	-0.0	-0.9	0.9	0.8	-0.3	0.5	0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.1	0.1	0.1	-1.0	-0.0	0.2	0.1	0.7	0.3	0.3	-0.9
Whole body fat-free mass	0.2	0.9	1.8	-0.5	0.8	1.0	-1.3	1.4	1.2	0.6	0.7	0.8	0.9
Leg fat-free mass (right)	0.1	0.3	0.8	-0.3	0.2	0.9	-0.7	0.8	0.6	0.5	0.1	0.3	0.5
Arm fat percentage (left)	2.6	10.5	14.4	3.3	-3.8	-2.6	3.1	-3.1	-3.3	2.1	-3.7	-3.8	-3.3
Average weekly red wine intake	0.9	1.3	2.2	-0.8	1.3	0.5	-1.5	1.3	1.4	0.7	1.4	0.9	1.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.3	-1.1	0.9	1.1	-0.8	0.8	0.8	-1.5	0.7	1.0	0.9
Mood swings	0.2	0.4	1.7	0.2	-0.1	-1.3	0.7	-0.7	-0.5	0.4	0.1	-0.2	-0.7
Loneliness, isolation	0.7	1.0	1.9	-0.9	1.3	-0.1	-1.2	1.0	1.3	0.1	1.4	0.8	1.1
Long-standing illness, disability or infirmity	0.8	1.2	2.9	0.8	-1.5	-0.0	1.1	-1.2	-1.3	-0.2	-1.7	-1.4	-0.0
Ever had bowel cancer screening	0.4	0.4	1.2	-1.1	0.6	0.7	0.2	-0.2	-0.1	-0.9	0.5	1.0	0.4
Diabetes diagnosed by doctor	10.2	16.7	19.9	3.9	-4.3	-4.3	4.2	-4.3	-4.2	3.5	-3.9	-3.9	-4.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.6	-0.2	-0.5	0.6	0.6	-0.5	-0.6	-0.6	-0.7	-0.3	0.1
Friendships satisfaction	0.7	0.8	3.4	0.6	-0.3	-1.9	0.5	-0.6	-0.4	1.4	0.0	-0.3	-1.2
Qualifications: nursing, teaching	0.5	0.8	2.3	-0.7	0.5	1.5	-0.5	0.5	0.4	-1.2	-0.0	0.5	1.5
Commuting to job workplace: Walk	0.3	0.4	0.7	0.7	-0.7	-0.3	0.4	-0.5	-0.5	0.7	-0.6	-0.8	-0.4
Eye problems/disorders: Cataract	1.1	1.3	2.1	-0.8	0.9	1.0	-1.4	1.4	1.3	-1.4	0.8	0.8	1.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.1	-0.5	1.1	0.4	-1.2	1.2	1.2	-0.5	1.3	1.5	-0.3
Medication for cholesterol	9.9	15.0	19.1	-3.2	4.2	3.0	-4.4	4.3	4.3	-2.9	4.1	4.3	3.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.9	0.2	0.4	-1.0	-0.3	0.4	0.4	-0.1	0.6	0.4	-0.5
Back pain experienced in last month	0.4	0.5	1.4	-1.2	1.0	0.4	-0.4	0.5	0.6	-0.3	1.0	0.7	0.5
Mineral and other dietary supplements	0.1	0.1	0.5	-0.3	-0.0	0.6	-0.1	-0.1	-0.0	0.1	-0.2	-0.3	0.7
Breast cancer (self-reported)	0.3	0.3	2.2	0.2	-0.1	0.5	-0.2	0.1	0.2	1.5	-0.1	-0.5	0.5
Asthma (self-reported)	0.0	0.1	0.3	-0.3	0.1	0.2	0.3	-0.2	-0.2	-0.1	0.0	-0.0	0.5
Osteoporosis (self-reported)	0.1	0.1	0.2	0.0	0.1	-0.3	-0.3	0.4	0.3	0.5	0.3	0.4	-0.1
Osteoarthritis (self-reported)	1.9	2.5	2.9	-1.6	1.5	1.3	-1.6	1.6	1.6	-1.7	1.4	1.7	1.7
Medication: Aspirin	3.7	4.8	6.7	1.8	-2.4	-1.7	2.5	-2.6	-2.5	1.5	-2.5	-2.3	-1.7
Medication: Gliclazide	2.4	2.7	5.2	0.7	-1.4	-2.3	2.1	-1.9	-1.9	0.8	-1.1	-0.8	-2.2
Illnesses of father: None of the above (group 1)	0.8	1.0	2.7	-0.6	1.3	-0.3	-1.1	1.2	1.2	0.3	1.7	1.2	-0.2
Smoking status: Current	2.4	3.7	6.3	-2.1	2.1	1.5	-1.5	1.7	1.7	-2.5	2.0	2.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.7	0.4	-0.0	-0.7	-0.0	-0.0	0.1	1.6	0.1	-0.4	-0.0
Whole body water mass	0.1	0.8	1.7	-0.4	0.7	0.9	-1.2	1.3	1.1	0.7	0.6	0.7	0.8
Leg predicted mass (right)	0.0	0.2	0.6	-0.2	0.1	0.8	-0.6	0.6	0.4	0.6	-0.0	0.1	0.4
Arm fat mass (left)	1.6	6.4	8.9	2.7	-3.0	-2.0	2.3	-2.2	-2.4	2.0	-2.8	-3.0	-2.6
Number of self-reported non-cancer illnesses	2.7	4.7	7.6	1.9	-2.7	-0.9	2.4	-2.5	-2.5	0.9	-2.8	-2.5	-1.6
Average weekly champagne plus white wine intake	0.9	1.3	2.6	1.6	-1.3	-1.0	0.9	-1.0	-0.9	1.3	-1.1	-1.3	-0.6
Miserableness	0.8	1.4	2.2	1.4	-1.0	-1.5	1.2	-1.2	-1.2	0.3	-0.9	-1.0	-1.5
Guilty feelings	4.7	7.1	10.8	-3.3	2.6	3.0	-2.3	2.3	2.3	-2.8	2.4	3.0	2.5
Wears glasses or contact lenses	0.4	0.5	0.8	0.6	-0.8	-0.4	0.9	-0.9	-0.9	0.1	-0.9	-0.6	-0.3
Ever taken oral contraceptive pill	1.9	2.1	3.4	-0.7	1.7	0.7	-1.9	1.7	1.8	-1.3	1.7	1.4	1.1
Hearing aid user	0.1	0.2	0.3	-0.2	0.4	-0.6	-0.3	0.5	0.4	-0.2	0.5	0.3	-0.0
Mother’s age at death	2.0	2.5	4.0	-1.9	1.6	2.0	-1.3	1.4	1.4	-1.4	1.3	1.6	1.8
Financial situation satisfaction	0.2	0.3	0.6	0.8	-0.5	-0.5	0.3	-0.4	-0.4	0.4	-0.5	-0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.1	0.1	0.1	0.1	-0.0	0.1	0.0	0.3	0.1	0.1	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.1	0.0	0.2	-0.3	-0.4	0.2	0.4	0.4	0.4	0.3	0.2
Eye problems/disorders: Glaucoma	0.3	0.4	1.4	0.8	-0.5	-1.2	0.2	-0.2	-0.2	0.2	-0.2	-0.4	-1.2
Medication: Blood pressure	12.0	22.9	32.7	3.8	-5.5	-2.8	5.5	-5.5	-5.6	3.1	-5.7	-5.5	-3.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	-1.2	0.7	0.8	-0.3	0.2	0.3	-0.6	0.6	0.8	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.8	0.6	-0.5	-0.7	0.2	-0.1	-0.2	0.1	-0.4	-0.1	-0.9
High cholesterol (Self-reported)	3.9	7.0	10.0	2.7	-2.8	-2.3	2.7	-2.8	-2.7	2.5	-2.6	-3.2	-1.9
Medication: Bendroflumethiazide	3.5	5.3	7.8	1.5	-2.6	-1.5	2.8	-2.8	-2.8	1.4	-2.7	-2.5	-1.9
Medication: Paracetamol	3.9	6.1	8.9	2.4	-3.0	-1.6	2.6	-2.5	-2.7	0.9	-3.0	-2.9	-2.2
Medication: Lisinopril	6.4	8.2	13.1	2.0	-3.2	-2.0	3.6	-3.5	-3.5	1.5	-3.3	-2.8	-2.5
Medication: Atorvastatin	1.0	1.2	2.2	0.7	-1.2	-0.0	1.4	-1.4	-1.4	0.4	-1.4	-1.5	0.0
Illnesses of father: High blood pressure	11.3	13.9	18.7	3.7	-4.3	-3.0	4.0	-4.0	-4.1	2.4	-4.2	-3.8	-3.2
Alcohol drinker status: Never	0.8	0.9	3.7	-0.7	0.6	1.3	-0.8	0.9	0.7	-1.9	0.4	0.7	0.7
Ever smoked	2.4	4.2	5.4	-1.6	2.2	1.4	-2.3	2.3	2.3	-2.1	2.3	1.9	1.7
Basal metabolic rate	0.0	0.3	0.9	0.1	0.1	0.5	-0.7	0.7	0.6	0.9	0.0	0.1	0.3
Leg fat percentage (left)	1.3	4.9	7.9	2.6	-2.7	-1.5	1.9	-2.0	-2.1	0.9	-2.7	-2.8	-2.0
Arm fat-free mass (left)	0.1	0.3	1.0	0.2	0.2	0.2	-0.8	0.9	0.7	1.0	0.3	0.2	0.3
Number of operations (self-reported)	0.1	0.2	0.7	-0.3	0.3	0.8	-0.4	0.4	0.3	-0.8	0.1	0.2	0.3
Average weekly beer plus cider intake	0.3	0.5	1.7	-1.1	0.1	0.7	0.5	-0.5	-0.4	-1.3	-0.2	-0.0	0.9
Irritability	0.3	0.6	1.8	-0.6	1.0	-0.7	-0.4	0.2	0.5	-0.4	1.3	1.3	-0.2
Risk taking	5.0	7.4	12.0	-2.8	2.6	3.5	-2.2	2.5	2.2	-3.5	2.2	2.5	2.8
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.4	0.7	-1.0	-0.6	1.0	-1.1	-1.1	1.2	-1.0	-0.9	-0.8
Fractured/broken bones in last 5 years	0.8	1.0	2.3	-1.5	1.3	0.5	-0.7	0.8	0.9	-0.1	1.4	1.4	0.6
Age started oral contraceptive pill	0.3	0.4	0.6	0.8	-0.7	-0.7	0.5	-0.5	-0.6	-0.2	-0.7	-0.5	-0.5
Diastolic blood pressure, automated reading	3.1	9.7	17.3	3.3	-3.8	-0.8	2.9	-3.1	-3.2	2.5	-4.2	-4.0	-1.6
Ever depressed for a whole week	0.6	0.7	1.5	0.1	-0.9	0.4	1.2	-1.2	-1.2	0.4	-1.2	-0.8	0.0
Unable to work because of sickness or disability	0.3	0.4	1.9	-0.7	0.4	0.6	-0.3	0.4	0.3	-1.4	0.2	0.5	0.5
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.1	-0.3	0.3	0.5	-0.5	-0.4	0.7	-0.5	-0.4	0.0
Myopia	0.1	0.2	0.4	-0.5	0.4	0.6	-0.2	0.1	0.2	-0.6	0.3	0.2	0.7
Vascular/heart problems diagnosed by doctor	15.9	43.4	61.3	-5.7	7.5	4.1	-7.4	7.5	7.6	-4.1	7.8	7.4	5.0
Cholesterol lowering medication	0.5	0.7	1.3	0.4	-0.8	-0.5	1.1	-1.1	-1.0	0.5	-0.8	-1.1	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.1	-0.5	0.2	0.3	-0.3	-0.4	-0.4	-0.5	-0.3	-0.5
Pain experienced in last month	0.2	0.4	0.6	0.6	0.3	-0.8	-0.8	0.8	0.7	0.3	0.6	0.4	-0.6
Supplements: Calcium	0.1	0.2	0.6	0.3	-0.1	-0.7	0.1	0.0	-0.0	0.6	0.2	0.1	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.7	0.9	0.9	-0.9	0.8	0.9	-0.3	0.8	0.5	1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.2	-0.2	-0.2	0.7	0.1	0.0	-0.1	-1.1	-0.4	-0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.1	-1.1	1.3	0.7	-1.4	1.3	1.4	-0.3	1.4	0.8	1.0
Heart disease (siblings)	0.5	0.6	0.9	-0.2	0.8	0.7	-1.0	1.0	0.9	-0.7	0.8	0.8	0.7
Alcohol drinker status: Previous	0.3	0.3	1.7	0.4	0.0	-1.1	0.3	-0.2	-0.2	0.1	0.3	0.0	-1.3
Pack years of smoking	2.7	3.9	6.3	-2.5	2.3	2.0	-1.5	1.5	1.7	-1.6	2.1	2.1	2.3
Impedance of whole body	0.2	0.9	3.4	0.6	-0.6	-1.5	0.9	-0.8	-0.8	-0.0	-0.4	-0.2	-1.8
Leg fat mass (left)	0.8	3.1	5.2	2.2	-2.2	-1.1	1.4	-1.4	-1.6	1.1	-2.2	-2.3	-1.7
Arm predicted mass (left)	0.1	0.4	0.9	-0.0	0.3	0.6	-0.9	1.0	0.8	0.8	0.3	0.2	0.6